The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old | Scientific Reports – Nature.com

By daniellenierenberg

Garagnani, P. et al. Whole-genome sequencing analysis of semi-supercentenarians. Elife 10, e57849 (2021).

PubMed PubMed Central Article Google Scholar

Sorrentino, J. A., Sanoff, H. K. & Sharpless, N. E. Defining the toxicology of aging. Trends Mol. Med. 20, 375384 (2014).

CAS PubMed PubMed Central Article Google Scholar

Stohs, S. J. & Bagchi, D. Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med. 18, 321336 (1995).

CAS PubMed Article PubMed Central Google Scholar

Crespo-Lopez, M. E. et al. Mercury and human genotoxicity: Critical considerations and possible molecular mechanisms. Pharmacol. Res. 60, 212220 (2009).

CAS PubMed Article Google Scholar

Pollard, K. M., Cauvi, D. M., Toomey, C. B., Hultman, P. & Kono, D. H. Mercury-induced inflammation and autoimmunity. Biochim. Biophys. Acta Gen. Subj. 1863, 129299 (2019).

CAS PubMed PubMed Central Article Google Scholar

Kennedy, B. K. et al. Geroscience: Linking aging to chronic disease. Cell 159, 709713 (2014).

CAS PubMed PubMed Central Article Google Scholar

Franceschi, C. et al. The continuum of aging and age-related diseases: Common mechanisms but different rates. Front. Med. (Lausanne) 5, 61 (2018).

Article Google Scholar

Streets, D. G. et al. All-time releases of mercury to the atmosphere from human activities. Environ. Sci. Technol. 45, 1048510491 (2011).

ADS CAS PubMed PubMed Central Article Google Scholar

Clarkson, T. W. & Magos, L. The toxicology of mercury and its chemical compounds. Crit. Rev. Toxicol. 36, 609662 (2006).

CAS PubMed Article Google Scholar

Charleston, J. S. et al. Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following subclinical long-term methyl mercury exposure. Toxicol. Appl. Pharmacol. 129, 196206 (1994).

CAS PubMed Article PubMed Central Google Scholar

Vahter, M. et al. Speciation of mercury in the primate blood and brain following long-term exposure to methyl mercury. Toxicol. Appl. Pharmacol. 124, 221229 (1994).

CAS PubMed Article PubMed Central Google Scholar

Vahter, M. E. et al. Demethylation of methyl mercury in different brain sites of Macaca fascicularis monkeys during long-term subclinical methyl mercury exposure. Toxicol. Appl. Pharmacol. 134, 273284 (1995).

CAS PubMed Article PubMed Central Google Scholar

Teixeira, F. B. et al. Exposure to inorganic mercury causes oxidative stress, cell death, and functional deficits in the motor cortex. Front. Mol. Neurosci. 11, 125 (2018).

PubMed PubMed Central Article CAS Google Scholar

Danscher, G. & Moller-Madsen, B. Silver amplification of mercury sulfide and selenide: A histochemical method for light and electron microscopic localization of mercury in tissue. J. Histochem. Cytochem. 33, 219228 (1985).

CAS PubMed Article PubMed Central Google Scholar

Pamphlett, R., Bishop, D. P., Kum Jew, S. & Doble, P. A. Age-related accumulation of toxic metals in the human locus ceruleus. PLoSOne 13, e0203627 (2018).

PubMed PubMed Central Article CAS Google Scholar

Pamphlett, R., Kum Jew, S., Doble, P. A. & Bishop, D. P. Elemental analysis of aging human pituitary glands implicates mercury as a contributor to the somatopause. Front. Endocrinol. (Lausanne) 10, 419 (2019).

Article Google Scholar

Pamphlett, R., Doble, P. A. & Bishop, D. P. Mercury in the human thyroid gland: Potential implications for thyroid cancer, autoimmune thyroiditis, and hypothyroidism. PLoSOne 16, e0246748 (2021).

CAS PubMed PubMed Central Article Google Scholar

Pamphlett, R., Doble, P. A. & Bishop, D. P. The prevalence of inorganic mercury in human kidneys suggests a role for toxic metals in essential hypertension. Toxics 9, 67 (2021).

PubMed PubMed Central Article Google Scholar

Pamphlett, R., Kum Jew, S., Doble, P. A. & Bishop, D. P. Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging. Sci. Rep. 11, 2961 (2021).

ADS CAS PubMed PubMed Central Article Google Scholar

Pamphlett, R. & Png, F. Y. Shrinkage of motor axons following systemic exposure to inorganic mercury. J. Neuropathol. Exp. Neurol. 57, 360366 (1998).

CAS PubMed Article Google Scholar

Pamphlett, R., Colebatch, A. J., Doble, P. A. & Bishop, D. P. Mercury in pancreatic cells of people with and without pancreatic cancer. Int. J. Environ. Res. Public Health 17, 8990 (2020).

CAS PubMed Central Article PubMed Google Scholar

Chang, A. Y., Skirbekk, V. F., Tyrovolas, S., Kassebaum, N. J. & Dieleman, J. L. Measuring population ageing: An analysis of the Global Burden of Disease Study 2017. Lancet Public Health 4, e159e167 (2019).

PubMed PubMed Central Article Google Scholar

Benarroch, E. E. Locus coeruleus. Cell Tissue Res. 373, 221232 (2018).

PubMed Article Google Scholar

Pamphlett, R. et al. Concentrations of toxic metals and essential trace elements vary among individual neurons in the human locus ceruleus. PLoSOne 15, e0233300 (2020).

CAS PubMed PubMed Central Article Google Scholar

Rudman, D. et al. Effects of human growth hormone in men over 60 years old. N. Engl. J. Med. 323, 16 (1990).

CAS PubMed Article Google Scholar

Seravalle, G. & Grassi, G. Sympathetic nervous system, hypertension, obesity and metabolic syndrome. High Blood Press. Cardiovasc. Prev. 23, 175179 (2016).

CAS PubMed Article Google Scholar

Barbi, E., Lagona, F., Marsili, M., Vaupel, J. W. & Wachter, K. W. The plateau of human mortality: Demography of longevity pioneers. Science 360, 14591461 (2018).

ADS MathSciNet CAS PubMed PubMed Central MATH Article Google Scholar

Gampe, J. Mortality of Supercentenarians: Estimates from the Updated IDL. In Exceptional Lifespans (eds Maier, H., Jeune, B., & Vaupel, J. W.) Ch. 3, 2935 (Springer, 2021).

Holland, D., Desikan, R. S., Dale, A. M. & McEvoy, L. K. Rates of decline in Alzheimer disease decrease with age. PLoSOne 7, e42325 (2012).

ADS CAS PubMed PubMed Central Article Google Scholar

Hirsch, L., Jette, N., Frolkis, A., Steeves, T. & Pringsheim, T. The incidence of Parkinsons disease: A systematic review and meta-analysis. Neuroepidemiology 46, 292300 (2016).

PubMed Article PubMed Central Google Scholar

Logroscino, G. et al. Incidence of amyotrophic lateral sclerosis in Europe. J. Neurol. Neurosurg. Psychiatry 81, 385390 (2010).

PubMed Article PubMed Central Google Scholar

Monnet-Tschudi, F., Zurich, M. G., Boschat, C., Corbaz, A. & Honegger, P. Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases. Rev. Environ. Health 21, 105117 (2006).

CAS PubMed Article PubMed Central Google Scholar

Smith, D. W. Cancer mortality at very old ages. Cancer 77, 13671372 (1996).

CAS PubMed Article PubMed Central Google Scholar

Harding, C., Pompei, F., Lee, E. E. & Wilson, R. Cancer suppression at old age. Cancer Res. 68, 44654478 (2008).

CAS PubMed Article PubMed Central Google Scholar

International Agency for Research on Cancer. Mercury and mercury compounds. IARC Monogr. Eval. Carcinog. Risks Hum. 58, 239345 (1993).

Google Scholar

Nersesyan, A. et al. Results of micronucleus assays with individuals who are occupationally and environmentally exposed to mercury, lead and cadmium. Mutat. Res. 770, 119139 (2016).

CAS Article Google Scholar

Noureldine, S. I. & Tufano, R. P. Association of Hashimotos thyroiditis and thyroid cancer. Curr. Opin. Oncol. 27, 2125 (2015).

PubMed Article PubMed Central Google Scholar

Kim, C. S. et al. Association of hypertension and blood pressure with kidney cancer risk: A nationwide population-based cohort study. Hypertension 75, 14391446 (2020).

CAS PubMed Article PubMed Central Google Scholar

Danscher, G. Light and electron microscopic localization of silver in biological tissue. Histochemistry 71, 177186 (1981).

CAS PubMed Article PubMed Central Google Scholar

Pamphlett, R. & Kum Jew, S. Age-related uptake of heavy metals in human spinal interneurons. PLoSOne 11, e0162260 (2016).

PubMed PubMed Central Article CAS Google Scholar

Pamphlett, R. & Kum Jew, S. Inorganic mercury in human astrocytes, oligodendrocytes, corticomotoneurons and the locus ceruleus: Implications for multiple sclerosis, neurodegenerative disorders and gliomas. Biometals 31, 807819 (2018).

CAS PubMed PubMed Central Article Google Scholar

Pamphlett, R. et al. The distribution of toxic metals in the human retina and optic nerve head: Implications for age-related macular degeneration. PLoSOne 15, e0241054 (2020).

CAS PubMed PubMed Central Article Google Scholar

Pamphlett, R., Kum Jew, S. & Cherepanoff, S. Mercury in the retina and optic nerve following prenatal exposure to mercury vapor. PLoSOne 14, e0220859 (2019).

CAS PubMed PubMed Central Article Google Scholar

Pamphlett, R., Satgunaseelan, L., Kum Jew, S., Doble, P. A. & Bishop, D. P. Elemental bioimaging shows mercury and other toxic metals in normal breast tissue and in breast cancers. PLoSOne 15, e0228226 (2020).

CAS PubMed PubMed Central Article Google Scholar

Pamphlett, R. & Kum Jew, S. Mercury is taken up selectively by cells involved in joint, bone, and connective tissue disorders. Front. Med. (Lausanne) 6, 168 (2019).

Article Google Scholar

Danscher, G., Horsted-Bindslev, P. & Rungby, J. Traces of mercury in organs from primates with amalgam fillings. Exp. Mol. Pathol. 52, 291299 (1990).

CAS PubMed Article PubMed Central Google Scholar

Warfvinge, K. & Bruun, A. Mercury distribution in the squirrel monkey retina after in Utero exposure to mercury vapor. Environ. Res. 83, 102109 (2000).

CAS PubMed Article PubMed Central Google Scholar

Parkin Kullmann, J. A. & Pamphlett, R. A comparison of mercury exposure from seafood consumption and dental amalgam fillings in people with and without amyotrophic lateral sclerosis (ALS): An international online case-control study. Int. J. Environ. Res. Public Health 15, 2874 (2018).

CAS PubMed Central Article Google Scholar

The rest is here:
The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old | Scientific Reports - Nature.com

Related Post


categoriaSpinal Cord Stem Cells commentoComments Off on The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old | Scientific Reports – Nature.com | dataAugust 19th, 2021

About...

This author published 4793 posts in this site.

Share

FacebookTwitterEmailWindows LiveTechnoratiDeliciousDiggStumbleponMyspaceLikedin

Comments are closed.





Personalized Gene Medicine | Mesenchymal Stem Cells | Stem Cell Treatment for Multiple Sclerosis | Stem Cell Treatments | Board Certified Stem Cell Doctors | Stem Cell Medicine | Personalized Stem Cells Therapy | Stem Cell Therapy TV | Individual Stem Cell Therapy | Stem Cell Therapy Updates | MD Supervised Stem Cell Therapy | IPS Stem Cell Org | IPS Stem Cell Net | Genetic Medicine | Gene Medicine | Longevity Medicine | Immortality Medicine | Nano Medicine | Gene Therapy MD | Individual Gene Therapy | Affordable Stem Cell Therapy | Affordable Stem Cells | Stem Cells Research | Stem Cell Breaking Research

Copyright :: 2024