News Release

Thursday, January 28, 2021

Approach could provide new path for difficult-to-treat forms of Leber congenital amaurosis.

Scientists at the National Eye Institute (NEI) have developed a promising gene therapy strategy for a rare disease that causes severe vision loss in childhood. A form of Leber congenital amaurosis, the disease is caused by autosomal-dominant mutations in the CRX gene, which are challenging to treat with gene therapy. The scientists tested their approach using lab-made retinal tissues built from patient cells, called retinal organoids. This approach, which involved adding copies of the normal gene under its native control mechanism, partially restored CRX function. The study report appears today in Stem Cell Reports. NEI is part of the National Institutes of Health.

Our treatment approach, which adds more copies of the normal gene, could potentially treat autosomal-dominant LCA caused by a variety of mutations, said Anand Swaroop, Ph.D., chief of the NEI Neurobiology, Neurodegeneration and Repair Laboratory and senior author of the report.

The U.S. Food and Drug Administration approved Luxturna in 2017 for the treatment of LCA patients with mutations in a gene called RPE65. Although hailed as a major advance in gene therapy, Luxturna is ineffective against other forms of LCA, including those caused by autosomal-dominant mutations in CRX.

The CRX gene encodes a protein (also called CRX) that binds to DNA and instructs the retinas photoreceptors to make light-sensitive pigments called opsins. Without functional CRX protein, photoreceptors lose their ability to detect light and eventually die.

Disorders like autosomal-dominant LCA are tricky to treat with gene therapy, because adding more of the normal gene does not always restore function. People with autosomal-dominant mutations still have one normal copy of the gene, but the mutant version of the protein interferes with the normal protein. Sometimes, instead of restoring normal function, simply adding more of the normal protein can enhance the disease in unpredictable ways.

To explore how gene augmentation adding copies of the normal gene would affect autosomal-dominant LCA, Swaroops team, developed retinal organoids from two volunteers with LCA and from their unaffected family members. Led by Kamil Kruczek, Ph.D., a postdoctoral fellow in Swaroops lab, they built the complex retina-like tissues in several stages, starting with skin cells, inducing the production of mature photoreceptors and other retinal cells with the genetic profile of each volunteer. As expected, patient organoids made far less light-sensing opsin than the organoids made from unaffected family members.

To carefully control how much CRX gene would be expressed by the recipient photoreceptors, the team re-engineered the CRX promoter so it could be delivered with the CRX gene as part of the gene therapy. A promoter is a neighboring sequence of DNA that controls when and how genes are expressed. The researchers packed the gene and their engineered promoter inside a virus that shuttled them into the organoid photoreceptors.

The teams gene augmentation strategy restored some CRX protein function for organoids from both patients, driving expression of opsins in both types of photoreceptors: rods and cones.

The fact that this strategy worked for both CRX mutations was pretty exciting, said Swaroop. Gene augmentation may be a viable therapy for LCA caused by other autosomal-dominant mutations.

This proof-of-concept gene therapy study is the first step toward a potential treatment for a rare form of LCA, said Brian Brooks, M.D., NEI clinical director and co-author on the study. Its a great example of bench-to-bedside science, when researchers in basic and clinical science collaborate.

The current study was funded through the intramural programs of the NEI and the National Institute of Allergy and Infectious Diseases, both part of NIH. Patient samples were collected at the NIH Clinical Center, clinical trial number NCT01432847.

NEI has protected intellectual property around this technology which is available for licensing and or co-development. Details can be found on the NIH OTT Licensing website: Gene Therapy for Treatment of CRX-Autosomal Dominant Retinopathies | Office of Technology Transfer, NIH or by contacting NEI Office of Translational Research mala.dutta@nih.gov

Additional authors include: Zepeng Qu, James Gentry, Benjamin Fadl, Linn Gieser, Suja Hiriyanna, Zacahry Batz, Mugdha Samant, Ananya Samanta, Colin Chu, Laura Campello, and Zhijian Wu.

NEI leads the federal governments research on the visual system and eye diseases. NEI supports basic and clinical science programs to develop sight-saving treatments and address special needs of people with vision loss. For more information, visit https://www.nei.nih.gov.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

Kruczek K. Qu Z, Gentry J, Fadl BR, Gieser L, Hiriyanna S, Batz Z, Samant M, Samanta A, Chu CJ, Campello L, Brooks BP, Wu Z, and Swaroop A. Gene therapy of dominantCRX-Leber congenital amaurosis using patient stem cell-derived retinal organoids.Stem Cell Reports, January 28, 2020.https://doi.org/10.1016/j.stemcr.2020.12.018

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If you have cancer and your doctor recommends Opdivo to treat it, you may be wondering what side effects this drug might cause.

Opdivo (nivolumab) is a brand-name prescription medication used in adults to treat certain types of cancer. These include specific forms of bladder, colorectal, and esophageal cancer, as well as several other cancer types. Its also used in some children to treat colorectal cancer.

Opdivo is a biologic drug (a type of drug made from living cells). Specifically, its an immunotherapy treatment, which means it can cause side effects involving your immune system. Its given as an intravenous infusion (an injection into a vein thats given over a period of time). For more information about Opdivo, see this in-depth article.

Opdivo may be a long-term cancer treatment. Your doctor will decide the length of your treatment based on various factors, including what side effects you experience.

Read on to learn more about the possible mild and serious side effects of Opdivo.

Like all drugs, Opdivo may cause side effects in some people.

The more common side effects of Opdivo include:

For more information about rash as well as muscle, bone, and joint pain, see the Side effects explained section below.

Certain side effects may be more common if other cancer drugs, such as ipilimumab (Yervoy), are part of your treatment plan. You may have a higher risk for certain side effects depending on the type of cancer you have.

Talk with your doctor about your risk for side effects, given your specific treatment plan. Also tell them about any side effect symptoms you may have.

Learn more about Opdivos side effects in the next sections.

You may experience mild side effects with Opdivo, such as:

For more information about muscle, bone, and joint pain, see the Side effects explained section below.

Opdivo may cause mild side effects other than the ones listed above. See the Opdivo Medication Guide for details.

Opdivos mild side effects should be manageable, and theyll likely go away during your treatment. But some could also be signs of more serious side effects.

If any side effects bother you, get worse, or dont go away, talk with your doctor or pharmacist. Try to keep all of your appointments to get Opdivo unless your doctor stops your treatment.

Opdivo may cause serious side effects. While these are generally rare, some people may be at higher risk for certain serious side effects. For example, your risk for some side effects may increase if youre receiving both Opdivo and other drugs for your cancer.

Call your doctor right away if youre having any new or worsening symptoms. If your symptoms feel life threatening, call 911 or get emergency medical care right away.

Serious side effects can include:

For more information on hepatitis, type 1 diabetes, and allergic reaction, see the Side effects explained section below.

Talk with your doctor about your risk for serious side effects. Also let them know about any concerns you may have.

Get answers to some frequently asked questions about Opdivos side effects.

No, Opdivo shouldnt cause confusion. In clinical studies of Opdivo, confusion wasnt a reported side effect.

However, confusion may be a symptom of rare, serious side effects of Opdivo, such as:

Also, Opdivo can cause hyponatremia (low blood sodium levels). Confusion is a symptom of this condition, which was a common side effect in certain clinical studies of Opdivo.

If youre feeling disoriented or having trouble thinking clearly during Opdivo treatment, contact your doctor right away.

In clinical studies of Opdivo as a melanoma treatment, reported side effects were similar to those researchers found when looking at the drug to treat other cancers.

However, Opdivo isnt always used alone to treat melanoma. The risk of side effects may differ depending on your treatment plan. For more information, see the Opdivo Medication Guide.

If youre receiving Opdivo infusions to treat melanoma, ask your doctor about your side effect risks.

Side effects with Opdivo can happen at any time, including after stopping treatment.

For example, severe reactions have happened during Opdivo infusions. However, these are rare compared with mild or moderate infusion-related reactions. Some people have had reactions within 2 days after their infusion, although these are rare as well.

Opdivo may cause your immune system to attack healthy tissues or organs. This can happen anytime during or after stopping Opdivo treatment.

Symptoms of a severe reaction that may happen during an Opdivo infusion can include:

If you have these or other symptoms during an Opdivo infusion, immediately tell the healthcare provider who is giving you the infusion.

Though rare, people have had reactions up to 2 days after their infusion. You should watch for any new or bothersome symptoms on the days between your infusions, too.

If you have a severe reaction, your healthcare provider may stop your Opdivo infusion. If you have a mild or moderate reaction during your infusion, they may slow the rate of infusion or pause it to help manage your symptoms.

Yes, it can. For example, Opdivo treatment could increase your risk for pneumonia. Pneumonia is a serious infection of the air sacs in one or both of your lungs.

In clinical studies for certain cancers, pneumonia was one of the more common serious reactions when Opdivo was used alone or with the cancer drug ipilimumab (Yervoy).

In clinical studies for certain cancers, rare but fatal infections have also occurred when Opdivo was used alone or with other cancer drugs.

Upper respiratory tract infection, such as a cold, is a common side effect of Opdivo. Though upper respiratory tract infections arent usually serious, they can lead to secondary infections such as pneumonia.

See your doctor if you have any infection symptoms such as a cough, shortness of breath, or fever.

Learn more about some of the side effects Opdivo may cause.

You may have painful joints from treatment with Opdivo. Joint pain is a common side effect of the drug.

Muscle, back, and bone pain are also common side effects of Opdivo.

Opdivo can cause your immune system to attack healthy tissues, even after youve stopped the drug. This can happen to any part of your body, including your joints. Rarely, arthritis (swelling in your joints) has occurred with Opdivo treatment.

If youre experiencing pain in your joints or other areas of your body during or after Opdivo treatment, talk with your doctor. They can check your symptoms and suggest ways you can manage them.

For mild joint pain, they may recommend you take an over-the-counter pain reliever, such as ibuprofen (Advil or Motrin). They may also suggest applying ice packs or warm compresses to your joints.

Rash is a common side effect of Opdivo.

In rare cases, Opdivo may cause a severe skin reaction, such as Stevens-Johnson syndrome. It may also result in allergic reactions, which may be mild or serious. Rash can be a symptom of both of these reactions.

During and after Opdivo treatment, contact your doctor if you have a rash that bothers you, gets worse, or doesnt go away. Get emergency medical care right away if you have blisters, peeling skin, or rash accompanied by fever, swelling, or trouble breathing. These could be signs of a severe, life threatening reaction.

If your symptoms are mild to moderate, your doctor may suggest that you manage them with a topical cream or ointment, such as hydrocortisone cream.

If youre having a severe skin reaction, your healthcare provider will pause or permanently stop your Opdivo infusions. Theyll manage the reaction with corticosteroids, such as prednisone, or other immune-suppressing drugs.

Though rare, Opdivo treatment may cause your immune system to attack healthy tissues, including your liver. When this happens, it can cause inflammation (swelling and damage) of your liver known as hepatitis.

This side effect may be more likely to happen if your treatment plan includes both Opdivo and the cancer drug ipilimumab (Yervoy).

If you have hepatitis from Opdivo treatment, your healthcare provider will pause or permanently stop your infusions. Theyll manage the condition with a corticosteroid drug, such as prednisone. In some cases, you may need to take another immune-suppressing drug.

During and after stopping Opdivo treatment, tell your doctor if you have any symptoms of hepatitis, such as:

Rarely, Opdivo may cause type 1 diabetes. With type 1 diabetes, your blood glucose (sugar) level becomes too high because your pancreas isnt releasing insulin. If untreated, this can lead to serious complications. An example is diabetic ketoacidosis (high levels of blood acids called ketones), which can be fatal.

Your doctor may check your blood glucose level while youre getting Opdivo. During and after your treatment, watch for any diabetes or ketoacidosis symptoms, such as:

Remember, high blood glucose can cause severe complications. If you have any of the symptoms listed above, see your doctor or get medical care right away.

Like most drugs, Opdivo can cause an allergic reaction in some people. Symptoms can be mild or serious and can include:

For mild symptoms of an allergic reaction, such as a mild skin rash or itching, call your doctor right away. They may suggest an over-the-counter oral antihistamine, such as diphenhydramine (Benadryl), or a topical product, like hydrocortisone cream, to manage your allergic reaction.

If your doctor confirms you had a mild allergic reaction to Opdivo, theyll decide if you should continue receiving this drug.

If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care.

If your doctor confirms you had a serious allergic reaction to Opdivo, theyll stop your Opdivo treatment and decide if another cancer treatment is right for you.

During your Opdivo treatment, consider keeping notes on any side effects youre having. Then, you can share this information with your doctor. This is especially helpful to do when you first start taking new drugs or using a combination of treatments.

Your side effect notes can include things like:

Sharing such notes with your doctor will help your doctor learn more about how Opdivo affects you. Your doctor can also use this information to adjust your treatment plan if needed.

Opdivo may not be right for you if you have certain medical conditions or other factors that affect your health. Talk with your doctor about your health history before starting Opdivo. Factors to consider include those mentioned below.

Stem cell or organ transplant. Opdivo treatment before or after an allogenic hematopoietic stem cell transplant (transplant of blood-forming cells from a genetic match) could cause serious or fatal problems.

If youre planning a stem cell transplant or have had one, talk with your doctor about the safety of Opdivo treatment. Also tell your doctor if youve received an organ transplant.

Allergic reaction. If youve had an allergic reaction to Opdivo or any of its ingredients, Opdivo shouldnt be part of your cancer treatment. Ask your doctor what other medications are better options for you.

Immune system problems. With Opdivo treatment, your immune system may attack healthy tissues.

Before starting Opdivo, tell your doctor if you have an autoimmune or inflammatory condition, such as Crohns disease, ulcerative colitis, or lupus. Tell them even if your condition is in remission (times when youre symptom-free).

History of chest radiation. Opdivo may cause a serious side effect of the lungs called pneumonitis. Your risk for pneumonitis may be higher if youve had radiation treatment to your chest.

Before starting Opdivo, tell your doctor about any past chest radiation treatments youve had and if youve received other drugs similar to Opdivo.

Nervous system problems. In rare cases, Opdivo treatment may cause your immune system to attack your nervous system, including your brain, spinal cord, or nerves.

Before starting Opdivo, tell your doctor if youve had a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barr syndrome.

Opdivo doesnt interact with alcohol.

However, alcohol can harm your liver. In rare cases, Opdivo can cause inflammation (swelling and damage) of your liver known as hepatitis. Opdivo can be used to treat some liver cancers.

Ask your doctor if its safe to consume alcohol while being treated with Opdivo.

Its unsafe to be treated with Opdivo during pregnancy. If youre able to become pregnant, youll need to get a pregnancy test before starting Opdivo to make sure youre not pregnant.

Youll also need to use effective birth control during treatment and for at least 5 months after your last infusion.

Opdivos manufacturer hasnt given recommendations about contraception for people taking Opdivo who have a partner who can become pregnant. If you have questions or concerns about this, talk with your doctor.

Its unknown if Opdivo is safe to use while breastfeeding. You shouldnt breastfeed during Opdivo treatment or for at least 5 months after your last infusion.

Before starting Opdivo, talk with your doctor about safe ways to feed your child.

Opdivo may help treat your type of cancer. At the same time, it can put you at risk for rare but serious side effects. However, most common symptoms of Opdivo are mild or manageable.

If youre wondering about Opdivos side effects, talk with your doctor or pharmacist. Ask questions to get the answers you need to feel confident about your cancer treatment. Here are a few to get you started:

My doctor said thyroid problems are possible serious side effects of Opdivo. What symptoms should I watch for?

Opdivo may cause your immune system to attack your thyroid gland, resulting in thyroiditis (inflammation of the thyroid gland). Though thyroiditis isnt usually serious, it can lead to hypothyroidism (low thyroid levels) or hyperthyroidism (high thyroid levels).

Hypothyroidism may happen more often, especially when Opdivo is used with ipilimumab (Yervoy).

Symptoms of hypothyroidism include increased weight, fatigue (lack of energy), and feeling cold. They also include a slow heart rate, depression, and a puffy face.

Symptoms of hyperthyroidism include a fast heart rate, high blood pressure, shaking hands, and trouble sleeping.

Call your doctor if you have any of the above symptoms. They may pause or stop your Opdivo treatment depending on how severe the side effect is. Your doctor may also recommend that you take other medication to treat your hypothyroidism or hyperthyroidism.

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Scientists have identified a protein that can slow or stop some signs of Parkinsons disease in mice.

The team found that the bone morphogenetic proteins 5 and 7 (BMP5/7) can have these effects in a mouse model of the disease.

This research, which appears in the journal Brain, may be the first step toward developing a new treatment for Parkinsons disease.

This type of brain disorder typically affects people over the age of 60, and the symptoms worsen with time.

Common symptoms include stiffness, difficulty walking, tremors, and trouble with balance and coordination.

The disease can also affect the ability to speak and lead to mood changes, tiredness, and memory loss.

Parkinsons Foundation report that about 1 million people in the United States had the disease in 2020, with about 10 million affected globally.

Despite this prevalence, scientists are still unsure why Parkinsons disease affects some people and not others, and there is currently no cure.

The National Institute on Aging note that some cases of Parkinsons disease seem to be hereditary. In other words, the disease can emerge in different generations of a family but for many people with the disease, there appears to be no family history.

Researchers believe that multiple factors may affect a persons risk, including genetics, exposure to environmental toxins, and age.

Since there is currently no cure for Parkinsons disease, treatments typically focus on alleviating its symptoms.

Existing treatments can help alleviate of Parkinsons disease, such as stiffness. However, they may work less well, or not work, for others, such as tremors or a loss of coordination.

Though researchers are still unsure why some develop the disease and others do not, they understand what occurs in the brain of a person with Parkinsons.

The disease causes the neurons in the part of the brain that controls movement to stop working or die. The brain region, therefore, produces less of the chemical dopamine, which helps a person maintain smooth, purposeful movement, as the National Institute of Neurological Disorders and Stroke observe.

Also, Lewy bodies occur in the brains of some people with Parkinsons disease. These bodies are clumps primarily made up of misfolded forms of the protein alpha-synuclein.

In their recent study paper, the scientists refer to research suggesting that neurotrophic factors molecules that help neurons survive and thrive could, in theory, restore the function of neurons that produce dopamine. However, the clinical benefit of these factors had yet to be proven.

The team focused on bone morphogenetic proteins 5 and 7 (BMP5/7). They had previously shown that BMP5/7 has an important role in dopamine-producing neurons in mice.

In the latest study, the scientists wanted to see whether BMP5/7 could protect the neurons of mice against the damaging effects of misfolded alpha-synuclein proteins.

To do this, they injected one group of mice with a viral vector that caused misfolded alpha-synuclein proteins to form in their brains. They used other mice as a control group. The scientists then injected the mice with the BMP5/7 protein.

The researchers found that the BMP5/7 protein had a significant protective effect against the misfolded alpha-synuclein proteins.

According to senior study author Dr. Claude Brodski, of the Israel-based Ben-Gurion University of the Negevs Department of Physiology and Cell Biology, We found that BMP5/7 treatment can, in a Parkinsons disease mouse model, efficiently prevent movement impairments caused by the accumulation of alpha-synuclein and reverse the loss of dopamine-producing brain cells. He continues:

These findings are very promising, since they suggest that BMP5/7 could slow or stop Parkinsons disease progression. Currently, we are focusing all our efforts on bringing our discovery closer to clinical application.

The universitys technology transfer company, BGN Technologies, is currently looking to bring the development to the market.

Dr. Galit Mazooz-Perlmuter, the companys senior vice president of bio-pharma business development, notes that There is a vast need for new therapies to treat Parkinsons disease, especially in advanced stages of the disease.

Dr. Brodskis findings, although still in their early stages, offer a disease-modified drug target that will address this devastating condition. We are now seeking an industry partner for further development of this patent-pending invention.

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Protein identified that may help treat Parkinsons disease - Medical News Today

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Lets get into the science behind it: As hair is being formed, melanocytes inject pigment into keratinocytesthe cells containing keratinwhich is the protein making up hair, skin and nails, says Wayne, NJ plastic surgeon and hair specialist Jeffrey B. Wise, MD. Over time, melanocytes continue to inject pigment into the hairs keratin, which is where hair gets its color. In the aging process, melanocytes slow down and eventually stop secreting melanin, which causes a lack of pigment, and the hair turns gray.

According to Chicago dermatologist Dr. Quenby Erickson, going gray is programmed in our genetic code, which means we can get clues as to how extensively and when it will happen by looking at our parents. However, a 2020 study published in Science Daily shows there may also be a link between stress and gray hair. When testing on mice, researchers found that the type of nerve involved in the fight-or-flight response causes permanent damage to the pigment-regenerating stem cells in the hair follicle. The study makes perfect sense, says Dr. Wise. Stress is a huge factor in premature aging, as well as hair thinning. Naturally, it should also affect hair graying as well. There is also a lot of evidence that shows smoking cigarettes plays a role in making hair go gray earlier.

Color isnt always the only factor either; textural changes can ensue as well. Some people are blessed with gorgeous gray hair, but for most of us, the gray is accompanied with thinning and rougher texture that leave our hair finer and harder to style, Dr. Erickson says. There are no proven ways to prevent hair from turning gray, but both Drs. Erickson and Wise have seen some promising results from platelet-rich plasma (PRP) injections. Because these treatments are aimed at waking up your own stem cells, they could potentially reinvigorate melanocyte production as well, explains Dr. Wise. We have seen growth of darker, thicker hairs on some of our stem cell therapy patients, even though the original goal was to combat thinning. Treatment results are dependent on the patients individual conditions, so realistic expectations should be set by your doctor.

Celebrity colorists Chad Kenyon and Rita Hazan say none of their clients embraced their grays during quarantine, or they tried, but caved eventually. For those in camp cover them up, topical dyes and root concealers can help camouflage. The process to cover gray hair is the same on both blonds and darker shades, but my clients with lighter hair can go longer in between touch-ups because gray hairs blend with blond hairs more easily, says Kenyon. Celebrity colorist Aura Friedman often suggests adding a darker pepper tone to silver hair for people who feel more comfortable being darker, but dont want the two-, three- or four-week regrowth touch-up thats needed.

For those who want to permanently cover their grays at home, Nikki Lee, celebrity colorist and cofounder of Nine Zero One Salon, recommends Garnier Nutrisse Nourishing Color Creme ($8). There are more than 75 shades and you can easily find your match using a virtual shade selector, she says. If DIY color makes you nervous, temporary root sprays are great to use in between salon appointments.

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The International Society for Stem Cell Research (ISSCR) will present this years ISSCR Momentum Award to Valentina Greco, PhD, Carolyn Walch Slayman Professor of Genetics and member of the Yale Stem Cell Center. The prize recognizes the exceptional achievements of an investigator whose innovative research has established a major area of stem cell-related research with a strong trajectory for future success. Greco will present her science during a special lecture on June 25 during ISSCR 2021 Virtual, the worlds leading meeting of global innovators in stem cell science and regenerative medicine.

Studies from Grecos lab are redefining scientific understanding of the complex mechanisms that organize and regulate the skin stem cell niche and the behavior of normal and mutant cells in the epidermis under physiologic challenge and with aging. Her groups body of work exploring cell biology in vivo determined that the niche, rather than the stem cells, are required for tissue growth, that location in the niche dictates stem cell fate, that the niche exploits stem cell plasticity to maintain homeostasis, and that homeostatic correction battles disease emergence. These breakthroughs pave the way for new concepts in mammalian regenerative biology.

Valentina is a wonderful ambassador for the stem cell community and in particular for young, female scientists in our field, said Christine Mummery, PhD, ISSCRs president. She has a confidence and skill to pursue bold new ideas. Not only is she a pioneer in live cell imaging, but she also has made multiple important discoveries regarding the mechanisms that regulate epithelial stem cell function. We are honored to recognize Valentina for her momentous achievements.

Beyond her creativity and scientific talent, Greco has shown great leadership. She is deliberate in her commitment to career development and the training of young faculty and her lab members, and brings tremendous enthusiasm to her work. Throughout her career, Greco has sought out new ways to enhance her effectiveness as a mentor by pursuing education from others, thereby establishing a strong foundation for making fundamental scientific discoveries in partnership with her lab members. She shared her perspectives and experiences as a woman and an immigrant working in science in Stem Cell Reports, Women in Stem Cell Science, Part 1.

My lab and I are honored to be recognized with this award, Greco said. Our science is inspired by the previous insights of incredible scientists that have paved the way for our contributions including the inspiring work of Cristina Lo Celso, David Scadden, Charles Lin, and Shosei Yoshida and their pioneering live imaging of mammalian stem cells in blood regeneration and spermatogenesis.

Greco was also awarded the ISSCR Dr. Susan Lim Outstanding Young Investigator Award in 2014.

Submitted by Robert Forman on January 25, 2021

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CENTENNIAL, Colo., Jan. 26, 2021 /PRNewswire/ --Essent Biologics, a nonprofit biotechnology company emerging from two years of stealth-mode operation, today announced its launch as a new venture to meet the growing need for human-derived biomaterials and data to the regenerative medicine research community, as well as producing key inputs for further manufacturing by clinical partners.

As a new venture from AlloSource, one of the world's leading manufacturers of fresh cartilage tissue used for joint repair and skin allografts to heal severe burns, Essent Biologics will leverage its connection to human tissue donation by providing low passaged primary cell lines, origin tissue and comprehensive donor data to advance translational research from benchtop to bedside. The company also has the capability to serve as a biomanufacturing partner, creating a large inventory of custom products.

"We are proud to set a new standard in human-derived biomaterials for research," said Corey Stone, Executive Director, Essent Biologics. "Essent will motivate and empower the work researchers are doing by supporting the development of innovative therapies through quality biomaterials and powerful data."

Essent Biologics will supply highly characterized human mesenchymal stem cells (MSCs) produced under current Good Manufacturing Practices (cGMP). The company has already partnered with leading academic research and biopharmaceutical companies who excitedly await Essent Biologics' official product launch, anticipated in April.For additional information on the company's product pipeline, please visit essentbiologics.org.

"The work Essent is doing to help accelerate research through human clinical trials is remarkable," said Ethan Mann, CEO of Validus Cellular Therapeutics, Inc. "We are excited to partner with such an innovative company who will support research to develop new medical solutions, and we look forward to their future growth."

According to Allied Market Research, the Cellular Therapy and Tissue Engineering industries are some of the fastest growing in the regenerative medicine sector. The Cellular Therapy market tallied a total expenditure of $7.25 billion in 2019 and is expected to hit $48.11 billion by 2027. The Tissue Engineering market tallied a total expenditure of $2.3 billion in 2019 and is expected to hit $6.8 billion by 2027. These strong growth rates are powered by an increase in clinical trials and manufacturing throughput.

About Essent BiologicsEssent Biologics is setting a new standard in human-derived biomaterials and 3D biology data for research. The nonprofit biotechnology company provides low passaged primary cells, origin tissue and scaffolds, as well as comprehensive donor and product data to advance regenerative medicine research from benchtop to bedside. Essent Biologics supplies products in small or large volumes and serves as a manufacturing partner by creating master cell banks and an inventory of custom products within a tailored specification. In order to ensure reliable product quality, safety and efficacy, all Essent Biologics products are developed using robust design control processes and produced under current Good Manufacturing Practices (cGMP). For more information, please visit essentbiologics.org.

Media ContactCorey StoneEssent Biologics720.873.4781cstone@essentbiologics.org

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Unfortunately, there arent too many manatees that dont have a wound, says Jon (JP) Peterson, vice president of zoological operations at SeaWorld in Orlando, Fla. Peterson oversees the rescue team, a group of wildlife veterinarians and animal specialists who travel the coastal waterways of the Southeast providing emergency medicine to wild animals, including injured, cold and orphaned manatees. Boats are the most common cause of wounds: Sharp skegs and propellers scrape along the animals backs and flanks, leaving behind everything from minor scratches to much more severe lacerations like those Peterson calls sucking chest wounds.

Assess the cut and nearby tissue. Gray is bad, Peterson says. You want pink. If you see dark gray or brown, blood, pus or smell a pungent odor, there is usually infection. A manatees outer skin is tough, like an elephants hide, and prone to close up quickly. Clean, flush and scrub the wound with a sterile solution like chlorhexidine until youve removed the necrotic tissue (you may need to cut it out). To accelerate healing, Petersons team uses antibiotics, cold-laser therapy and stem cells, as well as raw, unpasteurized honey. Use a tongue depressor and pack the honey into the wound, Peterson says. With its sticky, antibacterial properties, honey stays put, even underwater.

Dont underestimate the strength of these animals. Theyre one ball of muscle, Peterson says. Dolphins and whales make less challenging patients. Release healed manatees back into the wild. Of course, unless youre trained and permitted by the U.S. Fish and Wildlife Service, you should not handle manatees at all. Mistreating them is illegal and can result in a fine and prison time. In 1967, only a few hundred manatees remained in Florida when they were listed among the first class of endangered species under the Endangered Species Act. Researchers now estimate the population at 6,300, most with crisscrossing bright white scars across their bodies. In fact, scarring is so prevalent that scientists use scar patterns to identify individual manatees during aerial surveys. You can look down from an airplane and see, Oh, look, theres so-and-so, Peterson says.

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How to Treat a Wounded Manatee - The New York Times

Skin Stem Cells Comments Off on How to Treat a Wounded Manatee – The New York Times | January 27th, 2021

There are lots of places in a skincare routine where a budget product can do the job perfectly well, but your serum often isnt one of them; an effective, affordable serum is a rare thing. Its no wonder, then, that a bottle of The Body Shops brilliant youth concentrate sells every 27 seconds.

The entire Drops of Youth range, of which youth concentrate is one of the stars, is formulated around the same quad of ingredients and, as well as the serum, includes a foaming cleanser, toner, eye cream, moisturiser, night-time mask, sheet mask, reformulated liquid peel and the new bouncy jelly mist.

As part of its launch, a trio of products from the Drops of Youth range the new mist, the reformulated peel and the cult serum have been rebranded for the lockdown age, emphasising their pollution clearing and blue light-fighting properties.

Now we are spending more time indoors than ever, you might expect that our skins exposure to environmental damage is much reduced. But indoor pollution is a problem, too. Confined to our houses, heating, ventilation, cooking, damp, dust and even the light from your phone have the potential to cause surface-level congestion (aka spots) and deep damage, leading to premature ageing and possible discolouration.

High-energy visible light (HEV light), often referred to as blue light are rays emitted from the screens of the devices phones, tablets, laptops on which we increasingly spend our days, and penetrates the skin more deeply than UV rays, in part due to how much closer its source is to our faces than the sun.

We put the new and improved range to the test to see if it lives up to expectations.

You can trust our independent reviews. We may earn commission from some of the retailers, but we never allow this to influence selections, which are formed from real-world testing and expert advice. This revenue helps to fund journalism across The Independent.

Drops of Youth Bouncy Jelly Mist

(The Body Shop)

The Drops of Youth bouncy jelly mist feels wetter and more substantial on first application than many similar hydrating sprays, and quickly absorbs and dries down to a silky, matte finish on the skin. We love it for a mid-afternoon refresh, when our skin is starting to feel dry, though we find the spritz a little too heavy to apply directly to the face, and so prefer to spray it into our hands first. If you want to spray it over make-up, make sure you hold the bottle an arms length away.

The formula contains a trio of plant stem cells: criste marine, sea holly and edelweiss, all of which are known for their resilience and regenerating powers in the wild. Edelweiss, sourced from the Italian Alps, is particularly interesting. The flower survives UV rays and extreme weather where it grows at altitude, and in skincare is a powerful antioxidant.

It contains leontopodic acid, which strengthens the skins barrier, encouraging regeneration and hydration, and reducing and soothing sensitive reactions, thus increasing your skins resistance to external pressures including blue light and indoor pollution.

It also contains fair trade moringa oil, which is itself an excellent source of vitamins and antioxidants, including quercetin and vitamins A, C and E, all of which further the protection against environmental aggressors offered by the Drops of Youth plant stem cell trio. Moringa oil is also a good source of amino acids and oleic acid, a fatty acid that helps restore the skins natural barrier and protects against moisture loss, and is a lighter weight than many other plant oils. Youll find all these ingredients throughout the Drops of Youth range, making it a strong offering for both antioxidant protection and lasting hydration.

(The Body Shop)

The cult youth concentrate serum is, of course, also a favourite. With its pipette applicator, slightly gloopy texture and excellent slip across the skin (a tiny drop goes a long way), it has the application experience of a far more expensive serum. It dries to a slightly tacky finish (which we dont mind, as its rarely the final product in our routine) and feels like a fresh drink for your skin. For those who want a hydrating, protecting serum, it makes a happy two-in-one swap for hyaluronic acid and vitamin C serums, and at a very competitive price point.

Drops of Youth Liquid Peel

(The Body Shop)

Completing the trio is the liquid peel, which has a gel-like consistency and is, curiously, massaged into dry skin. After a few seconds white peelings begin to lift away from the skin; it's quite a dramatic effect and the claim is that this is dead skin lifting away, but at least some of it will be the product itself.

The classic exfoliating ingredient in the peel is citric acid, though it's very low on the ingredients list, meaning it's included in small quantities. Skin is left soft and smooth, and it's a good option for those with sensitive skin or who are scared of the exfoliating heavyweights, but those who are after a more serious peel will find it underwhelming.

Drops Of Youth Eye Concentrate

(The Body Shop)

Another highlight from the range, this has a rolling metal ball applicator and a light, gel-like texture that is more like a serum than a traditional eye cream. It is gorgeously soothing and cooling perfect on tired, irritated eyes and to alleviate morning puffiness and leaves the skin plumped and smooth.

We also love the youth cream moisturiser (25), which again has a light, whipped gel texture and leaves skin plump and silky smooth. Its the perfect base for make-up.

Drops of Youth bouncy sleeping mask

(The Body Shop)

A final favourite is the youth bouncy sleeping mask (22), and not just for the name. We love the promise of night skincare maximum time for the product to work on its skin, minimum effort involved and this is a proper mask that requires rinsing off in the morning, unlike many night-time masks, which feel more like heavy moisturisers. It has a thick, jelly-like texture that you have to really dig into to break the surface; after each unceremonious scoop it magically settles into a smooth, level surface infinitely satisfying. Skin is left brighter, nourished and glowing in the morning.

The verdict: The Body Shop Drops of Youth range

The range is a brilliant choice for skincare addicts after protection from environmental damage and bouncy, hydrated skin without the spend demanded by luxury products. The cult serum, youth concentrate, remains the star of the extended line-up, but your face will reward you for adding the new bouncy jelly mist to your cart, too. Drops of Youth is a bold marketing claim, but the plump, fresh, glowing skin it gives certainly helps.

IndyBest product reviews are unbiased, independent advice you can trust. On some occasions, we earn revenue if you click the links and buy the products, but we never allow this to bias our coverage. The reviews are compiled through a mix of expert opinion and real-world testing.

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Skin Stem Cells Comments Off on We tried The Body Shops new Drops of Youth skincare range heres what we thought – The Independent | January 27th, 2021

Stem Cell Therapy Market: Snapshot

Of late, there has been an increasing awareness regarding the therapeutic potential of stem cells for management of diseases which is boosting the growth of the stem cell therapy market. The development of advanced genome based cell analysis techniques, identification of new stem cell lines, increasing investments in research and development as well as infrastructure development for the processing and banking of stem cell are encouraging the growth of the global stem cell therapy market.

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One of the key factors boosting the growth of this market is the limitations of traditional organ transplantation such as the risk of infection, rejection, and immunosuppression risk. Another drawback of conventional organ transplantation is that doctors have to depend on organ donors completely. All these issues can be eliminated, by the application of stem cell therapy. Another factor which is helping the growth in this market is the growing pipeline and development of drugs for emerging applications. Increased research studies aiming to widen the scope of stem cell will also fuel the growth of the market. Scientists are constantly engaged in trying to find out novel methods for creating human stem cells in response to the growing demand for stem cell production to be used for disease management.

It is estimated that the dermatology application will contribute significantly the growth of the global stem cell therapy market. This is because stem cell therapy can help decrease the after effects of general treatments for burns such as infections, scars, and adhesion. The increasing number of patients suffering from diabetes and growing cases of trauma surgery will fuel the adoption of stem cell therapy in the dermatology segment.

Global Stem Cell Therapy Market: Overview

Also called regenerative medicine, stem cell therapy encourages the reparative response of damaged, diseased, or dysfunctional tissue via the use of stem cells and their derivatives. Replacing the practice of organ transplantations, stem cell therapies have eliminated the dependence on availability of donors. Bone marrow transplant is perhaps the most commonly employed stem cell therapy.

Osteoarthritis, cerebral palsy, heart failure, multiple sclerosis and even hearing loss could be treated using stem cell therapies. Doctors have successfully performed stem cell transplants that significantly aid patients fight cancers such as leukemia and other blood-related diseases.

Global Stem Cell Therapy Market: Key Trends

The key factors influencing the growth of the global stem cell therapy market are increasing funds in the development of new stem lines, the advent of advanced genomic procedures used in stem cell analysis, and greater emphasis on human embryonic stem cells. As the traditional organ transplantations are associated with limitations such as infection, rejection, and immunosuppression along with high reliance on organ donors, the demand for stem cell therapy is likely to soar. The growing deployment of stem cells in the treatment of wounds and damaged skin, scarring, and grafts is another prominent catalyst of the market.

On the contrary, inadequate infrastructural facilities coupled with ethical issues related to embryonic stem cells might impede the growth of the market. However, the ongoing research for the manipulation of stem cells from cord blood cells, bone marrow, and skin for the treatment of ailments including cardiovascular and diabetes will open up new doors for the advancement of the market.

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Global Stem Cell Therapy Market: Market Potential

A number of new studies, research projects, and development of novel therapies have come forth in the global market for stem cell therapy. Several of these treatments are in the pipeline, while many others have received approvals by regulatory bodies.

In March 2017, Belgian biotech company TiGenix announced that its cardiac stem cell therapy, AlloCSC-01 has successfully reached its phase I/II with positive results. Subsequently, it has been approved by the U.S. FDA. If this therapy is well- received by the market, nearly 1.9 million AMI patients could be treated through this stem cell therapy.

Another significant development is the granting of a patent to Israel-based Kadimastem Ltd. for its novel stem-cell based technology to be used in the treatment of multiple sclerosis (MS) and other similar conditions of the nervous system. The companys technology used for producing supporting cells in the central nervous system, taken from human stem cells such as myelin-producing cells is also covered in the patent.

Global Stem Cell Therapy Market: Regional Outlook

The global market for stem cell therapy can be segmented into Asia Pacific, North America, Latin America, Europe, and the Middle East and Africa. North America emerged as the leading regional market, triggered by the rising incidence of chronic health conditions and government support. Europe also displays significant growth potential, as the benefits of this therapy are increasingly acknowledged.

Asia Pacific is slated for maximum growth, thanks to the massive patient pool, bulk of investments in stem cell therapy projects, and the increasing recognition of growth opportunities in countries such as China, Japan, and India by the leading market players.

Global Stem Cell Therapy Market: Competitive Analysis

Several firms are adopting strategies such as mergers and acquisitions, collaborations, and partnerships, apart from product development with a view to attain a strong foothold in the global market for stem cell therapy.

Some of the major companies operating in the global market for stem cell therapy are RTI Surgical, Inc., MEDIPOST Co., Ltd., Osiris Therapeutics, Inc., NuVasive, Inc., Pharmicell Co., Ltd., Anterogen Co., Ltd., JCR Pharmaceuticals Co., Ltd., and Holostem Terapie Avanzate S.r.l.

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Skin Stem Cells Comments Off on Stem Cell Therapy Market to Witness Increase in Revenues by 2025 NeighborWebSJ – NeighborWebSJ | January 25th, 2021

While the thought of dozens of tiny needles aimed directly at our faces sounds like a scare, microneedling may be worth it for the radiant skin it delivers. As with any trending procedure, it has its pros and consheres what four top doctors want you to know before scheduling an appointment.

It Opens Up the Skin BarrierMicroneedling creates little puncture sites in the skin, which allow for deeper product penetration, says Highland Park, IL plastic surgeon Steven P. Bloch, MD, who recommends combining the treatment with TCA peels that include hydrogen peroxide, exosomesthe healing, skin-calming growth factors derived from stem cellsor vitamins to stimulate collagen and elastin production. Applying medical-grade skin-care products after the procedure offers the best results because the skin will soak everything up much more effectively.

It Stimulates Collagen ProductionAs we age, our bodies produce less collagen (starting as early as our 20s), and therefore our skin begins to lose elasticity. However, Birmingham, AL dermatologist Corey Hartman, MD explains that microneedling promotes collagen production in our skin cells, helping it look as young as possible. Microneedling, which works on all skin types, administers small injuries to kick the bodys natural healing process into gear and rejuvenate the skin, he explains. Though there are only a few procedures in cosmetic dermatology that are truly preventive, microneedling delivers on the promise to stimulate fibroblasts, which synthesize the production of collagen.

ItCanBeEffectiveforTreatingMelasmaOne of the most common concerns women walk into our office with is melasma, says Grand Rapids, MI plastic surgeon Bradley Bengtson, MD. More often than not, melasma is not optimally treated with high-heat laser devices, so microneedling is a great tool to break up the pigment. The procedure banishes dark patches by allowing brightening creams and serums with ingredients like vitamin C to penetrate deep into the epidermal and dermal layers.

ItRequiresNoSkilltoUseAny Tom, Dick, Sally or Jane can buy a microneedling machine, set up a strip-mall shop and offer it to people, says Eagan, MN dermatologist Charles E. Crutchfield III, MD, who stresses that complications can arise if you dont visit a board-certified doctor for the treatment. Instead, he recommends an ablative laser, which also boosts collagen and tightens the skin with much more sophistication.

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4 Doctors Reveal the Pros and Cons to Microneedling Treatments - NewBeauty Magazine

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Body Shop stans, assemble! We have collated the best the brand has to offer to optimise your bathroom cabinet.

But before you start shopping, here are a few did you knows. This cruelty-free, British brand was the first international cosmetics brand to prohibit the use of ingredients tested on animals and one of the first to promote Fair Trade with third world countries. Earning its place as a household name over the past four decades plus a cult following, thanks to a diverse range of over 900 products, suitable for different skin tones and types and half of which are vegan.

For some insight, this Brighton-born beauty story dates back to 1976. It was founded by the iconic entrepreneur and human rights activist Dame Anita Roddick, pioneer to ethical consumerism, who wanted to create a high quality, revolutionary skincare range that would be a positive force in the beauty landscape. What differentiated Roddicks vision to other beauty giants was her desire to create the perfect harmony between quality, accessibility, environmental consciousness (starting out with refillable containers etc) and profit. That passion filtered through to employees - and the brand's ideology hasnt much changed along the years.

Helping disadvantaged communities is a brand priority and they have been sourcing their Community Fair Trade (CFT) shea butter from Tungteiya Womens Association in Northern Ghana since 1994. Where 640 women from 11 villages, handcraft shea butter using an 18-stage process of traditional techniques, successfully creating generational opportunities passed from mother to daughter. Their CFT handcrafted paper and gift packaging is also sustainably sourced from Kathmandu, Nepal.

A B Corp certified brand is amongst the 3,000 businesses worldwide to have the highest social and environmental standards for people and the planet. One focus is on using plant-based and recycled plastic (rather than oil-based plastics) and creating initiatives to aid consumers around the world to reuse, repurpose and recycle. In 2019, we reintroduced our pioneering refill scheme, a recycling programme and removed 21 tonnes of plastic from our gifts. says says Linda Campbell, Managing Director for the UK.

The ideals of The Body Shops founder had a direct impact on the direction of the brand. They havent shied away from supporting feminist movements, constantly raising the bar on ethical consciousness and fighting to empower girls and women across all demographics. The Body Shop have spent the last few years initiating and aligning with campaigns, most recently the Covid-19 response derived #IsolatedNotAlone campaign. With the objective of raising awareness on domestic abuse and providing potentially life-saving resources for survivors and bystanders at increased risk during lockdown measures." says Campbell.

If all this doesnt make you feel more passionate about the brand, we dont know what will. And that's before we even get the quality products at consumer friendly prices. But dont let the Body Shop name fool you though, as not only extensive bath and body sup, but skincare, haircare and vegan makeup.

If youre a lover of newness, you might want to investigate the latest drop, which includes Hemp Dry Body Oil, 14, and the Drops of Youth Bouncy Jelly Mist, 16. A gel-to-mist formula protect the skin from indoor and outdoor pollution as well as the effects of blue light from all the Zooming.

But the beauty giant is just as loved for its cult products, from the nourishing glow masks to their world famous body butters (which sell at a rate of one every three seconds). If you want to know what the hype is really about, here is a selection of the 10 bestselling products and why they deserve a spot in your bathroom cabinet.

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Here's Why The Body Shop Is A Cult Brand to Know Plus The Best-Sellers To Buy - GLAMOUR UK

Skin Stem Cells Comments Off on Here’s Why The Body Shop Is A Cult Brand to Know Plus The Best-Sellers To Buy – GLAMOUR UK | January 23rd, 2021

Led by genetic counselor Jennifer Roggenbuck, MS, LGC, a one-year grant awarded by the ALS Association is funding Ohio States formal development of national clinical guidelines for ALS genetic testing that will be used by healthcare centers nationwide. We have cared for thousands of patients since opening our ALS/MND Clinic in the mid-1990s and have extensive experience with genetic testing, says Roggenbuck. We believe its extremely important to establish national testing standards, to ensure that all persons with ALS can benefit from genetic advances, and to fuel further research.

Genetic testing and counseling directly benefits our patients, explains clinic director Stephen J. Kolb, MD, PhD. Genetic characterization of our patients also opens the door to research opportunities. In addition to formal genetic counseling, our clinic has an ALS Clinical Research Coordinator who meets with every patient to explain our basic science and clinical trial opportunities and answer any related questions. Our patient partnerships are a key factor in the size and scope of our research program. Because Ohio State is now among the largest ALS research sites in the country, were regularly asked to participate in or lead high profile National Institutes of Health (NIH) and foundation studies.

A major focus of our program is to connect the individuals that we serve in clinic to the critical research efforts that are happening in laboratories here at Ohio State as well as those throughout the world. One example of this is the development of individualized models of disease, says Dr. Kolb. We and our collaborators are able to biopsy a persons skin cells and turn them into a type of stem cell that allow us to reproduce each patients exact ALS condition in the laboratory. We can then study the models to look for causes and develop therapies on a case-by-case basis.

The ALS/MND Multidisciplinary Clinic and Research Program is part of Ohio States Neurological Institute, with one of the largest neuromuscular centers in the country, so there is an established team of multidisciplinary experts to help each patient, even those with unusual or difficult symptoms. The ALS/MND program is led by Kolb, a physician-scientist, and in addition to the full-time research coordinator, he is joined by a clinical neurologist, genetic counselor, clinical nurse practitioner, social worker and nutritionist, as well as physical, occupational, respiratory and speech therapists. The Ohio State Department of Neurology is a member of NeuroNEXT: Network for Excellence in Neuroscience Clinical Trials and a contributing member to the Northeast ALS Consortium (NEALS).

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Regenerative Medicine Market Major Players:

Players active in the global regenerative medicine market include Osiris Therapeutics, Cook Biotech, Organogenesis, Baxter International, Inc., Stryker and RTI surgical, LifeSciences, CryoLife, Advanced Cell Technology, Sanofi, BioMimetic Therapeutics, Medtronic, StemCellsInc, and LifeCell Kinetic Concepts, among others.

ALSO READ :https://sapanas.tumblr.com/post/631130245458739200/regenerative-medicine-market-competitive-analysis

Regenerative Medicine Market Outlook

Global regenerative medicine market is growing continually, witnessing a massive uptake. Market growth primarily attributes to the increasing advancement in healthcare technology and the growing prevalence of chronic diseases. Besides, improvements in the field of regenerative medicine and stem cell technology drive the growth of the market excellently.

Moreover, the rising uptake of therapeutics such as stem cell biology, cellular therapy, tissue engineering in applications, including cord blood, oncology, urology, orthopedics, neurology, dermatology, and others accelerate the market growth. According to Market Research Future (MRFR), the global regenerative medicine market is poised to grow at 25.4% CAGR throughout the forecast period (2016 2022).

ALSO READ :https://yarabook.com/read-blog/138540

Additionally, the rising uptake of stem cell & tissue engineering processes in the treatment of health issues ranging from orthopedics, musculoskeletal & spine, dental, and skin/integumentary to cancer, neurology, and cardiology substantiate the market growth. Furthermore, the increasing rate of road accidents, injuries, and trauma cases drive the market exponentially, driving the demand for transplants & surgical reconstruction procedures.

On the other hand, factors such as the lack of awareness, skilled professionals, and stringent regulatory policies are projected to act as significant impeders for market growth. Nevertheless, funding support for the development of regenerative medicines would support the growth of the market throughout the predicted period. Also, widening application areas of regenerative medicines in the field of stem cell reconstructive and skin grafting would increase the market growth.

Global Regenerative Medicine Market Segments

The analysis is segmented into four dynamics;

By Material: Synthetic Materials, Genetically Engineered Materials, Pharmaceuticals, and others.

By Therapy: Stem Cell Biology, Cellular Therapy, Tissue Engineering, and others.

By Application: Cord Blood, Oncology, Urology, Orthopedics, Neurology, Dermatology, and others.

ALSO READ :http://www.marketwatch.com/press-release/fram-market-2021-industrytrends-opportunities-market-volume-competitive-landscape-possible-challenges-and-forecast-to-2025-2021-01-06

By Regions: Americas, Europe, Asia Pacific, Middle East & Africa, and Rest-of-the-World.

Regenerative Medicine Market Regional Analysis

North America is projected to continue dominating the globalregenerative medicine marketthroughout the forecast period. In 2015, North America accounted for more than 44% of the overall market share. This huge market growth attributes to the presence of a large number of major players and pharma & biotechnology companies. Moreover, huge investments made by public & private organizations drive the regenerative medicine industry in the region.

Besides, the rising prevalence of chronic diseases and orthopedic issues and increasing clinical trials to evaluate the therapeutic potential of products foster regional market growth. Also, the well-spread awareness towards the therapeutic potency of regenerative medicines impacts the market growth positively. The North American regenerative medicine market is expected to grow at a robust CAGR of 22.3% over the review period.

Europe stands second in the global regenerative medicine market. Factors such as the increasing per capita healthcare expenses and penetration of healthcare sectors in the region boost the market growth. Additionally, the rising government support and R&D funding in the life science developments substantiate the regional market growth. Markets in the UK, Germany, and France, contribute to the regional market majorly. The European regenerative medicine market is estimated to grow at 22.5% CAGR during the assessment period.

ALSO READ :http://www.marketwatch.com/press-release/m2m-communication-market-demand-to-rise-amid-industrial-automation-industry-analysis-with-business-trends-covid19-outbreak-competitor-strategyforecast-to-2023-2021-01-05

The Asia Pacific regenerative medicine market has emerged as a rapidly growing market. Factors such as the large advances in biotechnology and increasing government support for R&D are fostering the growth of the regional market. Regenerative medicine markets in highly populated countries such as China, India, and Japan support the regional market growth excellently, heading with huge technological advances. The APAC Regenerative Medicine market is predicted to demonstrate huge growth potential.

Global Regenerative Medicine Market Competitive Analysis

The well-established regenerative medicine market appears to be highly competitive with the presence of several notable players. To gain a larger competitive advantage, market players incorporate strategic initiatives such as mergers & acquisitions, expansions, and product/technology launch. Also, they make substantial investments to drive R&D to develop their capabilities and to expand their global footprints. Simultaneously, R&D funding programs initiated by the governments to enhance regenerative medicine capabilities are offering high growth potential. This is further going to attract several new entrants to the market and intensify the market competition further.

Regenerative Medicine Industry/Innovations/Related News:

March 15, 2020 - Research team at the University of Sheffield published their study on stem cell mutations that could improve regenerative medicine in the magazine Stem Cell Reports. Their study gives new insights into the cause of mutations in pluripotent stem cells and potential ways of stopping these mutations from occurring. It also suggests ways to reduce the likelihood of variations occurring in these cells when cultured. There is considerable interest in using Pluripotent stem cells to produce cells that can replace diseased or damaged tissues in applications referred to as regenerative medicine.

ALSO READ :http://www.marketwatch.com/press-release/waste-to-energy-market-share-size-key-players-regional-study-and-forecast-2024-2020-12-30

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Global Regenerative Medicine Market Insights, Overview, Analysis and Forecast 2022 NeighborWebSJ - NeighborWebSJ

Skin Stem Cells Comments Off on Global Regenerative Medicine Market Insights, Overview, Analysis and Forecast 2022 NeighborWebSJ – NeighborWebSJ | January 23rd, 2021

There's no better time than a national lockdown to test out the coolest new skincare/makeup/hair trends and snazzy innovations in beauty tech from the comfort of your own home. That said, there's nothing more frustrating than spending upwards of 100 on a snazzy new hair treatment or at-home facial system, only to find out it doesn't *actually* work.

Enter GLAMOUR Tries: the weekly Instagram series which sees GLAMOUR editors do all of the time-consuming (and expensive) work for you.

We've been busy trying out all of the (sometimes) wacky but always wonderful beauty crazes to take the internet by storm - from the FOREO's UFO 2 Smart Mask Treatment to Sarah Chapman's 138 Meso-Melt Infusion at-home facial and Toni&Guy's Hello Day! Secret Volumising Crimper. These are the products that every veteran beauty sleuth is talking about - but that you want to do a bit of research into before buying.

Thanks to GLAMOUR Tries, you won't need to waste your hard-earned pennies on testing these innovations yourself. We're getting in their first, giving you the lowdown and making sure you invest in products that genuinely work. Like what you see? You can shop all of the products seen on GLAMOUR tries, with the click of a button, down below. Don't say we don't treat you.

On GLAMOUR Tries this week, Social Media Assistant Luca Wetherby-Matthews tried the Korean beauty technique of slugging. In short, it involves putting Vaseline on your face. Intrigued? Us too.

Vaseline, 2.99, Boots

The science behind it is that petroleum jelly acts as a moisture barrier, locking in your skin's moisture and preventing any hydration from escaping overnight. You can choose where you want to put the Vaseline... you could do it all over you face, or, if you've got oilier skin you could avoid your T-Zone and target the areas where your skin is dry. You could even target your under eyes or fine lines... the choice is yours!

You want to apply the Vaseline after you've carried out your normal skincare routine - yes, even after your face serum and moisturiser - as this is your final step. You're then going to sleep in it overnight and wake up (hopefully) with a transformed complexion.

So how did it go? "It wasn't as weird as I was expecting it to be," Luca said. "It does feel like you're putting something on that you shouldn't be putting on, but not too bad, so we're going to sleep in it and see what happens in the morning."

"There is a slight difference in my skin," Luca said when she woke up. The bits that were the most dry, like my forehead, I can feel are definitely smoother. So I think as far as skin treatments go, it's *super* cheap to buy a pot of Vaseline and despite its reputation of not being as chic as other products, I think it does the job."

Vaseline, 2.99, Boots

Would you give slugging a go? Have you already tried it? Let us know your thoughts over on Instagram @glamouruk.

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Skin Stem Cells Comments Off on I Tried The Slugging Skincare Trend & Here’s What Happened – GLAMOUR UK | January 22nd, 2021

Vancouver, British Columbia, Jan. 19, 2021 (GLOBE NEWSWIRE) -- The global industrial nitrogen market is forecast to be valued at USD 29.36 Billion by 2027growing at a CAGR of 5.7%, according to a current analysis by Emergen Research. Nitrogen gas is used in a wide range of applications and end-uses, some of which include laser cutting, food packaging, coffee production, chemicals, electronics, breweries, oil and gas industries, and laboratories. Some among the primary factors driving growth of industrial liquid nitrogen market include major improvements in industrial gas industry, surge in demand from various end-use industries such as metal cutting and fabrication, manufacturing, and food & beverages industry, and growing demand from pharmaceuticals and medical industry.

However, increasingly stringent safety regulations, and structural and regulatory restrictions are some factors expected to hamper market growth to some extent. High production cost and labor force risk driven by accidental leakage of gas are other factors to consider.

In addition, demand for nitrogen for applications in cryopreservation, cryotherapies, and in cryosurgeries for removing skin tags, moles, and treating skin cancer is expected to remain consistent over the forecast period. Wide applications in preserving blood in blood banks, food freezing, rubber and plastic deflashing and grinding, cooling, preserving of biological samples, metal treating, pulverization, and other temperature-associated applications is also expected to support demand and drive market growth.

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Companies Profiled in Industrial Nitrogen Market Report Include:Praxair, Air Products and Chemicals, Air Liquide, Linde, Taiyo Nippon Sanso, Cryotec, Bhuruka Gases Limited, Sudanese Liquid Air Company, Cross Country Infrastructure Services Inc., and Canair Nitrogen Inc.

Key Highlights of Report and Developments

Check Our Prices@ https://www.emergenresearch.com/select-license/477For the purpose of this report, Emergen Research has segmented the global industrial nitrogen market based on form, production technology, distribution and transportation, end-user and regions as follows:

Click to access the Report Study, Read key highlights of the Report and Look at Projected Trends: https://www.emergenresearch.com/industry-report/industrial-nitrogen-market

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Spherical graphite market size was valued at USD 2,435.8 Million in 2019 and is forecasted to reach USD 9,598.8 Million by 2027 at a CAGR of 18.6%. The spherical graphite market is observing a double-digit growth attributed to its increasing usage in lithium-ion battery production.

Sodium dichromate market size was valued at USD 759.2 Million in 2019 and is forecasted to reach USD 1,242.4 Million by 2027 at a CAGR of 6.3%. The sodium dichromate market is observing high demand attributed to its increasing application in pigment, metal finishing, chromium compounds preparation, leather tanning, and wood preservative.

Acoustic insulation market size was valued at USD 12.94 Billion in 2019 and is forecasted to reach USD 19.64 Billion by 2027 at a CAGR of 5.3%. The acoustic insulation market is observing high demand attributed to its increasing application in building & construction, automotive, aerospace, and manufacturing.

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Industrial Nitrogen Market to Reach Value of USD 29.36 Billion by 2027 | Global Analysis, Statistics, Revenue, Demand and Trend Analysis Research...

Skin Stem Cells Comments Off on Industrial Nitrogen Market to Reach Value of USD 29.36 Billion by 2027 | Global Analysis, Statistics, Revenue, Demand and Trend Analysis Research… | January 22nd, 2021

As the air continues to dry and temperatures drop, the yearly battle against dry hands and skin has officially begun. New research from Northwestern University has discovered new evidence deep within the skin about the mechanisms controlling skin renewal and repair.

Skins barrier function gives it the unique ability to fight winter woes and keep water for our bodies. The outer layer of the skin, the skin, is constantly turning over to replace damaged or dead cells, creating new cells to reinforce the barrier function and heal damage. The gene regulatory mechanisms that control epidermis turnover remain incompletely understood.

Every month were covered with a new layer of the epidermis, said Northwesterns Xiaomin Bao, who headed the study. The next question is what does that procedure involve?

The newspaper will be published on Jan. 19 in the journal Nature Communications.

GeneticjunkThe scientific community has developed a wide breadth of knowledge about proteins, the workhorses of various cellular activities. Many mysteries remain about the nature of introns, non-coding segments of DNA that make up 24% of the human genome.

Regardless of the general belief that introns are nothing butgenetic junk, they actually play critical roles in modulating RNA transcription throughout a tissues lifespan. RNA transcription is the first step of gene expression, in which the data from DNA is copied into RNA, which is then subsequently used as a template for synthesizing proteins to drive the specific function of a cell.

Based on where transcription terminates within an intron or at the conclusion of a gene an epidermal stem cell will either remain a stem cell or become a specified cell barrier function. Bao said while its well-known that transcription ends at the end of a gene, her labs research found conflicting data.

Future research could have implications for carcinoma research.

Technology critical to the discovery of the phenomenonSkin cells are gaining popularity with researchers in part because of their regenerative properties and readiness to grow in cultures. This allows researchers to apply an assortment of state-of-the-art technologies. By growing skin cells and regenerating skin tissue in a petri dish, the Bao Lab can experiment with this fast-growing tissue to determine molecular mechanisms and regulatory elements within DNA.

Technology development is an integral driver that enabled us to uncover this new phenomenon, Bao said.

The group used a novel genomic technique that maps where transcription stops. The integration of proteomic approaches identified RNA-binding proteins which read specific regulatory sequences in the introns.

The team further leveraged CRISPR technologies to delete genomic sequences in the intron, which provided direct evidence demonstrating that the crucial roles of introns in modulating gene expression.

Before this study, mechanisms between introns to govern the switch between a skin stem cell and a terminally differential state (for example, a cell that participates in forming a skin barrier), were unknown. Most studies ignored introns, despite them accounting for 10 to 20 times more sequences than the protein-coding regions (exons) in the human genome.

The study demonstrates that different genes may involve different sets of RNA-binding proteins to recognize the regulatory sequences in their introns. These RNA-binding proteins help to mature RNAdecide whether to cut transcription early or dismiss termination sites within an intron during differentiation due to changes in protein availability.

We are only starting to appreciate the roles of the intron in human health and diseases, Bao said.

Results of this study could have broader impacts because, according to Bao, the procedures regulating skin cells are almost definitely not restricted to skin cells. Future research on other systems, including other epithelial tissues, will likely uncover similar patterns.

We are extremely hopeful that what weve found is the first step to knowing what we have ignored in the past, Bao said. My students also wish to know more about the RNA binding proteins which provide specificity in governing which site to use to terminate transcription.

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Research finds new proof about the systems controlling skin repair and regeneration - Microbioz India

Skin Stem Cells Comments Off on Research finds new proof about the systems controlling skin repair and regeneration – Microbioz India | January 19th, 2021

This article was originally published here

Hum Gene Ther. 2021 Jan 15. doi: 10.1089/hum.2020.275. Online ahead of print.

ABSTRACT

Wound healing has been greatly challenging in different acute and chronic skin injuries. Among them, non-revascularizable critical limb ischemic ulcers, venous leg ulcers, and diabetic lower limb or extremity ulcers are well-known refractory skin injuries that are difficult to treat. Partly differentiated progenitor cell-based graft transplantation or direct injection of autologous stem cells might promote the wound healing process. Studies aiming to comprehensively analyze the effects of cell therapy on skin wound healing could provide clinical evidence for skin injury treatment. Different databases were searched for full-text publications about the comparison between cell therapy and regular therapy. Heterogeneity was detected by the I2 method, and a fixed-effect model was applied for data pooling if heterogeneity was absent. Publication bias was analyzed using a funnel plot, and 10 studies were finally included in this study. After a long-term follow-up, fewer patients underwent major amputation in the cell therapy group, compared with the standard therapy group, and those in the cell therapy group were characterized with smaller ulcer area. Moreover, there was a significant difference in the wound healing rate between the intervention and control groups. However, pain caused by skin wounds was hardly mitigated by cell therapy in patients with critical limb ischemia. In this study, cell therapy proved effective in decreasing the size of ulcer and improving wound closure rate. Additionally, major amputation rate was decreased in the cell therapy group. However, the symptoms of pain were hardly alleviated by cell therapy in patients with cutaneous ulcers caused by peripheral artery disease-related critical limb ischemia.

PMID:33446038 | DOI:10.1089/hum.2020.275

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Comprehensive analysis of cell therapy on chronic skin wound healing: a meta-analysis - DocWire News

Skin Stem Cells Comments Off on Comprehensive analysis of cell therapy on chronic skin wound healing: a meta-analysis – DocWire News | January 19th, 2021

Most of us would agree that 2020 was the shortest long year, one in which you probably lost track of your routines. Although 2021 might be off to a rocky start because of political unrest and ongoing COVID-19 shutdowns, its as good a time as any to take inventory of how you can improve your daily rituals.

Studies have shown that there is a psychological benefit to self-care. Grooming is important for human behavior because it makes us feel better and it boosts our self-esteem, said Dr. Amy Wechsler, a New York-based psychiatrist and dermatologist. When people are stressed, they stop doing their routines. Routines are important. They give us a sense of control, and right now people feel really out of control. Little ways to give you back the feeling or semblance of control are helpful.

For starters, Wechsler recommends maintaining your skincare regimen. A few minutes in the morning, she said. A few minutes in the evening. It helps ground a lot of people.

Here are tips and tricks from beauty and wellness experts:

Cassandra Grey, founder of L.A. beauty boutique Violet Grey, says that skincare as a category has been on the rise over the last four years. 70% of her business sales come from skincare while 25% of her customers are men.

(Naj Jamai)

Cassandra Grey, founder of Los Angeles beauty boutique Violet Grey, has built her business around a belief in grooming and wellness as an important form of self-care. Humans are motivated by three things sex, power and self-respect, she said. I think skincare or self-care or beauty products that enhance the way you feel or the way that you look really help you achieve self-respect because you feel like youre taking care of yourself.

One of Violet Greys bestsellers is Augustinus Baders the Cream, which has become something of a phenomenon since the German brand launched three years ago. It just works, Grey said of the cream (15 milliliters, $85), which reportedly triggers existing stem cells to repair skin. You use it, and your skin looks better. Period. Thats why its become a hero product. It is innovative in the formulation. There is not a formulation like that.

One of Violet Greys bestsellers is Augustinus Baders the Cream. Three new Augustinus Bader products a cleansing gel, body lotion and body oil were added to the brands lineup.

(Augustinus Bader)

The skincare brand, which was created by leading stem cell and biomedical scientist Augustinus Bader, has released a cleansing gel (100 milliliters, $65), body lotion (30 milliliters, $35; 100 milliliters, $95) and body oil (100 milliliters, $95), which all contain the companys proprietary technology, a combination of natural amino acids, high-grade vitamins and synthesized molecules.

There are a number of result-driven brands and products on the market.

Among them are Protocol, which packages its Complete Renewing Line (four skincare products for $262) in airless, UV-proof bottles in order to protect its products oxidized retinol and L-ascorbic acid ingredients; L.A.-based Youth to the Peoples pro-grade vegan Protect the Planet Refillable Minis Kit ($60); Goops Glowing Skin Bestsellers Kit ($79), which includes the Santa Monica-based skincare companys top three products (an exfoliator, face peel and super-powder); New Zealand-based clean beauty brand Emma Lewisham whose Skin Shield Daily Face Antioxidant Protect + Repair SPF 30 ($57) is packaged in 100% post-consumer-recycled container; the Beauty Chefs Glow Inner Beauty Essential, a powder-based vitamin whole-food supplement ($65); and Chanels La Solution 10 De Chanel moisturizer (1 ounce, $80), the latter of which Wechsler helped formulate as the luxury brands consulting dermatologist.

Beyond skincare and cosmetics, Grey said her company has seen a rise in wellness products during the last year. Weve sold a lot of vibrators, a lot of candles, she said, recommending Craves Vesper Vibrator ($69) and Heretics Dirty Grass Candle ($85). Its these rituals where youre taking care of yourself and youre getting present and in the moment and youre feeling some comfort.

However, carving out time for oneself, especially during the ongoing pandemic, can be quite a challenge, Grey said. I wish I could say I was better at practicing what I preach, she said, but I think its always been a struggle for me to find balance between work, myself, my family and particularly now with us all sleeping at our offices. Were not working from home anymore. Its like were sleeping at our office.

DRX Spectralite Faceware Pro by Dr. Dennis Gross, $435.

(Dr. Dennis Gross)

With limited time in our schedules for ourselves, Grey advises combining self-care tasks. I do a treatment while I meditate because a lot of these treatments take time, she said, adding that a few of her favorites include Dr. Dennis Gross DRX Spectralite Faceware Pro ($435), Hanacures all-in-one-facial starter kit ($29) and Leonor Greyls scalp treatment ($48).

You feel refreshed, Grey said of meditating, mentioning that she favors YouTubes various free meditation videos. I think a lot of people dont meditate because they feel like they dont know how to do it, or they try to sit still and they just cant because they have so many thoughts or distractions or whatever. Its just about sitting still. Even if you dont get into a deep unconscious meditative hypnosis, its still healthy to sit still and try to get even just a moment of being present.

Iris & Romeos 3-in-1 Power Peptide Lip Balm ($26) is available at irisandromeo.com.

(Iris & Romeo)

Keeping up a routine through this stay-at-home period is really vital, but its about connecting with yourself, said Michele Gough Baril, founder of Northern California-based beauty brand Iris & Romeo. Thats when youll feel calmer, grounded and connected. Having a modified beauty routine that makes you feel good, makes you feel connected but doesnt feel like a chore is critical. Its also important to get ready for yourself, not for others.

Gough Baril launched her brand in 2019 after a personal lesson in self-care. In 2012, she was head of marketing for Smashbox, but after she helped grow the former indie company into a global Estee Lauder-acquired brand, Gough Baril decided to step away from the beauty industry. I was completely burnt out, she said. I think this is really a common thing for a lot of women. We give so much, and we never take care of ourselves. And everything else comes first. Theres the needs of the family, the needs of the business, the needs of everything. It was really a time in my life where I hit that wall.

After a year of soul searching, Gough Barils created Iris & Romeo, which, she said, stands for all the things that I believe in sustainability, clean beauty; a brand that supports the burned-out modern woman and her mental, spiritual and emotional health.

Gough Baril launched just two skincare/makeup hybrid products in varying shades after exploring what makes [people] feel good. For me, its hydrated dewy skin and lips, she said. The brands Best Skin Days ($64) combines five products into one; its a serum, moisturizer and SPF that provides coverage and blue light/pollution protection. Women want a simplified routine, she said. What is the least you need to do to make you feel like the best version of yourself?

Chanels Rouge Allure Velvet Extreme matte lip color in Pivoine Noire ($40), left, and Rogue Allure Laque Ultrawwear shine liquid lip color ($40) are from the brands new Les Fleurs de Chanel spring/summer 2021 collection available at chanel.com.

(Chanel)

Gabrielle Coco Chanel used to say, If youre sad, add more lipstick and attack, hence the brands wide array of Rouge Allure ($40) lipsticks. However, Gough Baril said theres a time and place for a red lip versus her brands 3-in-1 Power Peptide Lip Balm ($26). For Chanel, it was about the power lip, she explained. That bold red lip has a psychological effect. I wear one when I go on VC meetings. Theres something about putting on a bold red lip that makes me feel like Im in charge. But for me, the modern woman, what shes going to use every day is a lip balm, a little hint of color.

Gough Baril acknowledged theres no need for lipstick beneath a COVID-19-era face mask but said Iris & Romeos lip balms add the perfect pop of color for video-conference meetings. You just need enough to make you feel polished and pulled together, she said. Even though youre wearing your sweatpants on the bottom; on the top, you want to have a little bit of [something]. It affects your mindset. It helps you pull yourself together and say, Im ready to face the day.

Although quarantine might seem like a good time to try new products, Wechsler warned that its important to listen to your skin as you experiment. If youre buying new product, test it out under a small area on your face for three nights or three days to make sure it doesnt bug you, she said. Dont make huge, drastic changes. If you have a reaction and you used five new things, then you dont know what its from. Just add one thing at a time if youre changing, and be weary of a lot of strong fragrance in some things. A lot of plant extracts are irritating. Just go slowly. One new thing at a time.

Also, buyer beware: adult acne has seen a rise during the pandemic. Some professionals have been quick to label it mask-ne, but Wechsler has a different theory. Stress is known to cause acne, she said. I do think certain [rougher] mask materials can irritate patients skin, and certain mask materials make people sweat more and may make them break out more. But I think its the stress more than it is the mask.

To combat the problem, she advised that people look at their sleep patterns or, as she called it, sleep hygiene. According to Wechsler, adults need 7 to 8 hours of sleep a night. We heal in our sleep, said the author of The Mind-Beauty Connection.

Wechsler suggests monitoring your bedtime habits. Theres no way you can turn off [the] news and fall asleep in 10 minutes, she said, recommending you take a break from technology two hours before heading to bed. Play a game. Read a novel. Watch a comedy. Have sex, she said, explaining that a stress-induced bad night of sleep can lead to a poor complexion.

She also recommended double checking your products. A patient will come in and say, I have not changed any of my skincare products but now Im getting this rash, she said, explaining that its often the result of noncomedogenic products. A comedo is a blackhead or a whitehead. [Noncomedogenic] essentially means it wont clog your pores and cause pimples.

Her top advice: make sure you wash your face when you come home from being outside and wash your mask after each use. Ive found a lot of people not doing that, she said.

Acne can also be treated with salicylic acid, which, Wechsler said, is a nice over-the-counter ingredient. Conversely, she doesnt recommend products with benzoyl peroxide. Its really irritating, she said.

Consider your alcohol intake to keep your skin looking fresh. A list of products from brands making sustainable wine and drink alternatives and additives includes Rescue Ros, left, Kin Euphorics Kin Spritz drink, Brighter sparkling drink and Renudes Chagaccino coffee boost.

(Rescue Ros; Kin Euphorics; Brighter; Renude)

Another consideration is alcohol intake. If you drink too much, your skin will be dehydrated, Wechsler said, adding that its not known if one type of beverage is better than another. Its theorized, but that study has not been done. She said that peoples cocktail preferences and its effects are individualized but that generally speaking, drinking too much can harm how one sleeps.

If you need a drink, opt for biodynamic, organic and sustainable wines. After all, wine is known to have healthy antioxidants in it, Wechsler said.

Our suggestions: Rescue Ros, a sustainable California ros wine from Los Angeles-based stylist and animal lover Nola Singer. The wine retails for $25 at rescuerose.com and benefits Los Angeles Love Leo Rescue, a nonprofit that aids animals in need.

Or consider swapping alcohol for a healthier beverage. Kin Euphorics Kin Spritz is a nonalcoholic spirit,made of adaptogens, nootropics and botanics, which includes a blend of fresh citrus, warm spice, hibiscus and ginger. A four pack is $27 at kineuphorics.com.

Another option is Santa Monica-based Brighter, a sparkling tonic with prebiotics, acetic acid and apple cider vinegar, which might be refreshing but also supports gut health. Sold in a 12-pack for $34.99 at brightertonic.com, Brighters flavors include lemon ginger turmeric and mlange.

Lastly, Chagaccino is a new mushroom and adaptogenic coffee additive from West Hollywood-based Renude that reportedly helps relieve stress, boost immunity and has anti-aging benefits because of its clean, plant-based, antioxidant-filled ingredients. Each box includes 10 packets for $29.99 at drinkrenude.com.

Hairstylist Ted Gibson says self-care begins by taming ones tresses. Hair can transform not only the way that you look but also the way that you feel, he says.

(Ted Gibson)

Celebrity hairstylist Ted Gibson said that for many women self-care begins with taming ones hair. Hair can transform not only the way that you look but also the way that you feel, he said, noting that many of the women who have come to Starring by TedGibson, his Los Angeles-based hair salon, were eager to make major changes to their hair during the salons pandemic reopening.

They felt like before COVID they were one woman and after COVID are another, he said, adding that theres a psychological connection between hair and ones mood. It does make you feel better when you walk past a mirror and your hair is done [even if] youre in a pair of sweats.

His clients often associate their hair with major milestones in their personal lives, he said. If you ask a woman of a certain age, What defines you?, shell definitely refer to different hairstyles, he said, and different periods of her life.

From top to bottom and left to right: Headbands and hair accessories from Lelet NY ($168), LeLe Sadoughi X Stoney Clover Lane ($195), Ulla Johnson ($65), Sarah J. Curtis ($17), Tarina Tarantino ($55) and Suryo ($71).

(Lelet NY; LeLe Sadoughi X Stoney Clover Lane; Ulla Johnson; Sarah J. Curtis; Tarina Tarantino; Suryo)

Gibson said this pandemic is no different, and there are a number of quick at-home tricks to add a bit of style without much effort. One easy option is to change your hairs part. If youre always used to having your hair down the center, change your part to the side, Gibson said. It gives a whole new kind of sophistication because a center part can be a little girl-next-door and then a side part could be just a little sexier.

Another fix? A hair accessory can always go a long way, Gibson said, adding that a headband or jeweled barrette can make a nice addition to a ponytail or messy top knot to add a little oomph to your next video call, romantic date night in the backyard or mirror selfie.

A number of fashion and accessory labels have options including LeLe Sadoughi X Stoney Clover Lane, Sarah J. Curtis, Lelet NY, Suryo, Ulla Johnson and Tarina Tarantino.

When it comes to daily hair maintenance, Gibson said that most of his clients say theyve been shampooing every other day, which he supports; however, he said that hair does need a daily styling refresher.

Starring by Ted Gibsons Shooting Star Texture Meringue, $52.

(Ted Gibson)

Whether your hair is curly or straight or you want it to be a voluminous blow dry or after you put in some really beautiful beachy waves and you want the hair to have a tasseled feel to it, Starring Shooting Star Texture Meringue is the product I go to, he said of the $52 weightless mousse he created to use as a universal styling tool. I needed something that I could pull out of my bag that I could use on Debra Messing, Gabrielle Union, Lupita Nyongo and Sandra Oh. He said he uses it on himself as well because of its provocative fig, coconut and amber scent.

For her part, Gough Baril is quick to point out that hair, skincare and beauty routines merely scratch the surface when it comes to daily wellness practices.

The emotional, the physical and the spiritual well-being of a woman is interconnected, she said. Self-care is not just a pedicure.

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COVID self-care tips for skin, hair and overall wellness - Los Angeles Times

Skin Stem Cells Comments Off on COVID self-care tips for skin, hair and overall wellness – Los Angeles Times | January 19th, 2021

Tess Daly has admitted she is now "less obsessed" with how she looks since hitting her 50th birthday and is grateful to her body for giving her healthy children and a long career.

The Strictly Come Dancing presenter and mum-of-two, now 51, says she regularly sees signs of ageing like wrinkles and grey hairs but refuses to "beat herself up" and instead thanks her body.

Speaking to Mailonline, she said: "Number one, I am grateful for a healthy body that has put me in good stead this far and given me two healthy children and a long career doing what I love."

Tess continued, "I try not to dwell on the negatives. I look in the mirror and see new lines every day, I'll see the odd grey hair but this is life. I tend to try and not dwell or beat myself up about what I can't change and rather focus on what I am grateful for."

Tess, who co-hosts Strictly alongside Claudia Winkleman, 48, insists she has her glam squad to thank for her immaculate look on the show each week. She often documents her outfits to her 762k followers on Instagram.

This content is imported from Instagram. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

The presenter also uses her Instagram account to give an insight into family life with husband Vernon Kay and daughters Phoebe, 16 and Amber 11, including photos from their Christmas together and from their wedding vow renewal ceremony.

This content is imported from Instagram. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

Last week, Tess shared how she looks after herself mentally and keeps fit during lockdown.

"Just done a quick 15 min online stretch yoga session-always helps put me in a good head space for the rest of the day; which feels all the more beneficial at the moment," she wrote on Instagram.

Strictly Come Dancing will return to the BBC later this year.

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Tess Daly opens up about being "grateful" for her body and not dwelling on the negatives - Allaboutyou

Skin Stem Cells Comments Off on Tess Daly opens up about being "grateful" for her body and not dwelling on the negatives – Allaboutyou | January 19th, 2021

Retinal cell transplants are considered to be an attractive approach for treating blindness. Question is, where do you source the cells?

An international research team of scientists from Singapores Agency for Science, Technology and Research (A*STAR), the Icahn School of Medicine at Mount Sinai in New York and Germanys Eye Clinic Sulzbach is using a type of stem cell in the eye to grow the pigmented layer of retina thats essential for vision. The approach is showing promise in monkeys.

The findingssuggest that these retinal pigment epithelium (RPE) stem cell-derived RPE, or hRPESC-RPE, may be a useful source for cell replacement therapies to treatRPE-related blindness caused by diseases such as macular degeneration, the researchers suggest. The results are published in the journal Stem Cell Reports.

RPE is a layer of tissue that supports the neurosensory retina and is critical for vision. An estimated 200 million people live with diseases associated with RPE dysfunction, including macular degeneration. Early attempts at RPE replacement used cells from the patientan approach with limitationsscientists have been searching for treatment using different populations of stem cells.

In 2012, scientists identified a type of adult cell in the RPE that's normally dormant but that can be activated to take on a stem-cell-like state with self-renewing ability. These cells have the potential to differentiate into RPE cells and could therefore be used for RPE replacement therapies, the A*STAR-led team figured.

In their study, the researchers took hRPESC-RPE from donated adult eyes and grew them into RPE monolayers. When transplanted into the eyes of monkeys on a polymer scaffold, theRPE patches stably integrated for at least three months.

The stem cell-derived RPE patchespartially took over and were able to support normal light-sensing function, the team showed. Whats more, the method didnt cause vision-blocking retinal scarring that has been seen with other experimental approaches.

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Multiple types of stem cells, includinghuman embryonic stem cells and human-induced pluripotent stem cells, have been proposed as alternative sources for retinal replacement. A team led by Mount Sinai previously used gene transfer to activate a type of retinal cells called Mller glial to adopt stem-cell-like characteristics. The team prompted the cells to divide into light-sensing rod photoreceptor cells in blind mice.

Researchers led by the National Institutes of Healths National Eye Institute used five chemicals to turn skin cells directly into rod photoreceptors.

The A*STAR-led researchers believetheir study demonstrates the potential of using hRPESC-RPE transplants as a treatment for macular degeneration. Further studies are needed to test the method in monkey models of eye disease to gauge the therapeutic effect, the researcher suggested.

If the cells succeed, they could serve as an unlimited resource for human RPE. Because the cells are harvested from human eyes, the researchers suggested establishing hRPESC-RPE donor banks to provide cells that match individual patients so there is noimmune rejection.

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Eye stem cell transplant to treat blindness bolsters retinal function in monkeys - FierceBiotech

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