BOSTON and MIAMI, Oct. 1, 2020 /PRNewswire/ -- Aegle Therapeutics Corporation today announced theU.S. Food and Drug Administration(FDA) has granted Fast Track designation to AGLE-102 for the treatment of patients with dystrophic epidermolysis bullosa ("DEB"), a rare genetic pediatric skin blistering disorder. AGLE-102 is an extracellular vesicle ("EV") therapy that delivers proteins, genetic material and regenerative healing factors to diseased and damaged tissue. AGLE-102 will be evaluated in DEB patients in a phase 1/2a trial initiating in 2021.

The Fast Track program is intended to facilitate the development and review of drug candidates that treat serious conditions and fill an unmet medical need. A drug candidate with Fast Track designation is eligible for greater access to the FDA for the purpose of expediting the drug product candidate's development, review and potential approval.

"We are pleased to have received Fast Track designation for AGLE-102. Aegle's EV therapy is unique in that it delivers collagen 7 protein, COL7A1 mRNA and regenerative healing factors to potentially address the complex nature of DEB," said Evangelos Badiavas, MD, PhD, Chief Scientific Officer atAegle Therapeutics. "This designation will expedite the development and regulatory review of AGLE-102 and highlights the importance of providing novel treatments to this patient population."

AboutAegle Therapeutics Corporation

Aegle Therapeutics (www.aegletherapeutics.com) is a privately held biotechnology company developing extracellular vesicles, including exosomes, secreted by mesenchymal stem cells as therapy for the treatment of dystrophic epidermolysis bullosa and other severe dermatological conditions. Aegle anticipates entering the clinic with AGLE-102 in early 2021.

ContactAegle Therapeutics CorporationShelley A. HartmanChief Executive Officer[emailprotected]

SOURCE Aegle Therapeutics Corporation

http://www.aegletherapeutics.com

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FDA Grants Fast Track Status to Aegle Therapeutics' AGLE-102 for the Treatment of Dystrophic Epidermolysis Bullosa - PRNewswire

Skin Stem Cells Comments Off on FDA Grants Fast Track Status to Aegle Therapeutics’ AGLE-102 for the Treatment of Dystrophic Epidermolysis Bullosa – PRNewswire | October 2nd, 2020

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Global Skin Care Cosmetic Market 2020 Global Industry Analysis by Trends, Growth, Company Overview and Forecast by 2027 Latest Research Report by...

Skin Stem Cells Comments Off on Global Skin Care Cosmetic Market 2020 Global Industry Analysis by Trends, Growth, Company Overview and Forecast by 2027 Latest Research Report by… | September 30th, 2020

Beauty lovers,listen up!AugustinusBader Skincare, afavouritewithcelebritieslikeKim Kardashian West, Courtney Cox, Demi MooreandNaomi Campbell, is now available in the region. Launched in 2018 byProfessorAugustinusBader,a world-leading expert in stem cell research,the skincare rangehas a selection of hero products that are deserving of coveted space in your over-crammed cabinet.

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It saddens me that when I tell people I have sickle cell the most common reply is what is that? sickle cell advocate Shamonica Wiggins shares with theGrio.

Sickle cell disease (SCD) is a group of red blood cell disorders occurring when a child inherits the sickle cell gene from both parents possessing the sickle cell trait. Those with the disease are often referred to as warriors because from the moment they are born, each day is its own battle.

Living with sickle cell has been a never-ending roller coaster, explains 31-year-old sickle cell warrior Shanice Williams. Sometimes everything is looking up, but the road is still bumpy mild to moderate crises and health issues. Other times Im flying down really fast always in crises, in the hospital, etc and I just have to wait until everything is going smooth again.

A sickle cell crisis occurs when the hard, sticky, sickle-shaped red blood cells of a SCD patient block blood flow causing extreme pain, anemia, fever and fatigue.

According to 24-year-old Sabah Imani, founder of the Sabah Imani Sickle Cell Foundation, sickle cell pain is almost indescribable. The best way I can put it is like having thousands and thousands of little needles running through your veins, something similar to a body part falling asleep but times 50.

In addition to the immense pain, sickle cell crises can also lead to a variety of serious ailments such as tissue damage, infections, fatal organ failure and stroke. Sickle cell warrior Tristan Lee, 37, suffered a stroke when he was 9 years old leaving him paralyzed on the left side of his body.

I spent months in the hospital after that, he says. When I was finally released, I had to do years of physical and occupational therapy to relearn how to walk, talk, and use the bathroom. I also had to begin routine blood transfusions every 3 weeks until I was 19 years old to avoid any risk of blood clots, and more complications from sickle cell.

Advocate Wiggins also suffered from strokes her first at the age of 3 and another more recently at the age of 30.

Experiencing something so traumatic, not once but twice, could break a person but I refuse to break. I bend from time to time, but breaking is not an option, she tells theGrio. As painful as this illness is, Im actually grateful that I have it. I truly believe learning to not only live, but thrive with this illness has made me a better person. It has made me a grateful person. An understanding person. A determined person and a compassionate person.

In between pain and hospitalizations, Wiggins spends her time advocating for the 100,000 Americans living with SCD. Earlier this month, that advocacy afforded her the opportunity to present at the White Houses roundtable discussion on Improving the Lives of Americans with Sickle Cell Disease.

I see sickle cell as a silent killer because although it claims the lives of so many nationwide and around the world, theres very little talk about it, so Im grateful for this platform, adds Wiggins.

Advocates like Wiggins, Imani, Williams, Lee, and 29-year-old Teonna Woolford are determined to drive the conversation forward, not simply for awareness, but because its truly a matter of life and death.

I would be irresponsible as an advocate if I did not speak on the fact that systemic racism and medical bias has held us back for far too long, says Woolford. Families impacted by sickle cell deserve the same quality and compassionate care as families impacted by other conditions such as cancer and cystic fibrosis. Sickle cell disease is far more prevalent than cystic fibrosis, yet we have far less resources.

Although sickle cell is not technically a Black disease, it is an evolutionary condition found most prevalent among people from regions of the world where malaria is common, including sub-Saharan Africa, South and Central America, Saudi Arabia, India and the Mediterranean (Greece, Sicily and Turkey). Because of this, SCD occurs in approximately 1 out of every 365 African-American births and 1 in 13 African Americans carry the sickle cell trait.

Ive been hospitalized over a hundred times, and some doctors would think, Heres this young Black person. Theyre just drug-seeking, shares 29-year-old Epiphany Samuels. What they dont understand is that Im in so much pain, Im praying for death, not drugs.

And Samuels is not alone. The pain of SCD is often as much a mental one as it is physical. Sickle cell warrior Hugh Holcomb shares that it gets really hard sometimes the loneliness from being in the hospital. Sometimes its hard to find the will to fight.

Because of this, Imani urges anyone who may know someone with SCDto really take the time to get to know and understand them.

Were so used to getting prejudged that all we want is for someone to take the time and care about us, just like you would for someone living with cancer or AIDS. As sickle cell patients, we do not look sick most of the time and that can be very misleading, she explains. We can be in the middle of the worst pain ever yet still sit and hold a conversation with you. We push ourselves to do certain activities that arent healthy for us but we just want that sense of normalcy.

Unfortunately, during this COVID-19 pandemic, normalcy is now a foreign concept even for those without SCD. But for people with underlying health conditions, this pandemic carries an extra layer of concern.

Were used to carrying sanitizer and always watching those around us for symptoms of being sick considering even a cold can push us into a crisis, or worse, possibly wind us up in ICU, says Williams.

And for Samuels, who found herself in the middle of a crisis at the height of the pandemic, navigating my sickle cell during coronavirus has been hard. There was this one moment where I was like, Oh, Epiphany, your eyes are turning green and youre in a whole lot of pain. Youre in a crisis.

She continues, I knew it was better for me to try to handle my crisis at home than to go to the ER because I can likely live through my crisis but I dont know if I can live through COVID.

Currently, the only known cure for SCD is a bone marrow or stem cell transplant from a close relative like a brother or sister. However, these procedures are extremely risky, and can have serious side effects, including frequent infections and death.

Both Imani and Woolford have undergone bone marrow transplants. Imani is now two years post transplant, and has since developed a skin care line based on the natural moisturizers she created to treat her drastically changing skin during chemotherapy and radiation treatments.

Unfortunately for Woolford, things didnt go quite as well.

It was a grueling process physically and even more so mentally, and at the end of my four-month hospital stay, I found out that I rejected the transplant, she says. That was 10 years ago, and probably the hardest thing I had ever been through. I had to let go of the dream that I would live a life free of sickle cell.

But in the years since, Woolford like many other sickle cell warriors has managed to transform her pain into power. Today, I am thriving and the happiest I have ever been. In a full circle moment, I contributed to the first ever publication of guidelines for bone marrow transplants and sickle cell disease through the American Society of Hematology. This is an incredible time for sickle cell disease. We recently had three new FDA-approved therapies after 20 years of having only one.

Tristan Lee shares in her optimism.

I believe, in my lifetime, we will have a universal cure for sickle cell disease. As long as we can continue to spread awareness and get medical professionals and people of all walks of life to join us in that awareness, we will have our cure that we desperately need.

Follow the above-mentioned advocates journeys via social media for more information on SCD.

This article is written in loving memory of Robert L. Stevenson.

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Life as a sickle cell warrior: How advocates are changing the face of the disease - TheGrio

Skin Stem Cells Comments Off on Life as a sickle cell warrior: How advocates are changing the face of the disease – TheGrio | September 30th, 2020

The Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market is expected to exceed more than US$ 4.5 Billion by 2024 at a CAGR of 4% in the given forecast period.

The report covers detailed competitive outlook including the market share and company profiles of the key participants operating in the global market. Key players profiled in the GE Healthcare, A&D Medical, Dragerwerk, Hill-Rom, and Philips Healthcare. Company profile includes assign such as company summary, financial summary, business strategy and planning, SWOT analysis and current developments.

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Autologous stem-cell transplantation (also called autogenetic, autogenic, or autogenic stem-cell transplantation or auto-SCT) is that the autologous transplantation of stem cellswhich is, the uniform cells or stem cells (cells from which different styles of cells develop) area unit taken from someone, accumulated, and given back to an equivalent person later. Although its most frequently dead by means that of hematogenic vegetative cells (antecedent of cells that forms blood) in hematogenic stem cell transplantation, in some cases internal organ cells square measure used profitably to mend the damages because of heart attacks.

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The major driving factors of Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market are as follows:

The restraining factors of Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market are as follows:

The Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market has been segmented as below:

The Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market is Segmented on the lines of Product Analysis, Application Analysis, End-User Analysis and Regional Analysis. By Product Analysis this market is segmented on the basis of BP monitoring devices, Pulmonary pressure monitoring devices and ICP monitoring devices. By Application Analysis this market is segmented on the basis of Treating neurodegenerative, Autoimmune, Cardiovascular disorders skin transplant, Oncology and Other.

By End-User Analysis this market is segmented on the basis of Hospitals Sector, ASCs Sector and Others Sectors. By Regional Analysis this market is segmented on the basis of North America, Europe, Asia-Pacific and Rest of the World.

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1) An overview of the global market for Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market and related technologies.2) Analyses of global market trends, with data from 2015, estimates for 2016 and 2017, and projections of compound annual growth rates (CAGRs) through 2024.3) Identifications of new market opportunities and targeted promotional plans for using topical acne treatment Market.4) Discussion of research and development, and the demand for new products and new applications.5) Comprehensive company profiles of major players in the industry.

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Table of Contents

1 INTRODUCTION

2 EXECUTIVE SUMMARY

3 AUTOLOGOUS STEM CELL & NON STEM SELL THERAPY -TECHNOLOGY LANDSCAPE ANALYSIS

4 AUTOLOGOUS STEM CELL & NON STEM SELL THERAPY TECHNOLOGY INVESTMENT POTENTIAL

4.1 INVESTMENT CLIMATE ASSESSMENT4.1.1 INVESTOR NETWORKS4.1.1.1 PUBLIC FUNDING BODIES4.1.1.2 FUNDING/GRANTS FROM NGO ORGANIZATIONS4.1.1.3 PRIVATE INVESTORS AND VENTURE CAPITAL FIRMS4.1.1.4 INSIGHTS ON CURRENT AND FUTURE TECH-INVESTMENT TRENDS4.1.1.5 INVESTOR INCLINATION AND PATTERNS4.2 INVESTMENT OPPURTUNITIES4.2.1 LICENSING AND ACQUISITION4.2.2 ANALYSIS OF POTENTIAL APPLICATION AREAS FOR TECHNOLOGY INVESTMENT

5 AUTOLOGOUS STEM CELL MARKET LANDSCAPE ANALYSIS

6 AUTOLOGOUS STEM CELL & NON STEM SELL THERAPY TECHNOLOGY ADOPTION POTENTIAL AND DEVELOPMENT BY GEOGRAPHY

7 COMPETITIVE LANDSCAPE

8 PATENT ANALYSIS

9 TECHNOLOGY ANALYSIS AND ROAD MAPPING

10 ANALYST INSIGHTS AND RECOMMENDATIONS

11 COMPANY PROFILES

11.1 ANTRIA (CRO) (U.S.)

11.2 BIOHEART (U.S.)

11.3 BRAINSTORM CELL THERAPEUTICS (U.S.)

11.4 CYTORI (U.S.)

11.5 DENDREON CORPORATION (U.S.)

11.6 FIBROCELL (U.S.)

11.7 GENESIS BIOPHARMA (U.S.)

11.8 GEORGIA HEALTH SCIENCES UNIVERSITY (U.S.)

11.9 NEOSTEM (U.S.)

11.10 OPEXA THERAPEUTICS (U.S.)

11.11 ORGENESIS (U.S.)

11.12 REGENEXX (U.S.)

11.13 REGENEUS (AUSTRALIA)

11.14 TENGION (U.S.)

11.15 TIGENIX (BELGIUM)

11.16 VIRXSYS (U.S.)

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Autologous Stem Cell and Non-Stem Cell Based Therapies Market Industry Development Trends & Competitive Analysis by Leading Industry Players - The...

Skin Stem Cells Comments Off on Autologous Stem Cell and Non-Stem Cell Based Therapies Market Industry Development Trends & Competitive Analysis by Leading Industry Players – The… | September 29th, 2020

Many Americans, and indeed people all over the world, were outraged when reports surfaced this past summer that President Trump had once dismissed the dead soldiers from one of World War Is iconic battles, The Battle of Belleau Wood, as suckers and losers. Amputees should be excluded from parades because nobody wants to see them, the article also reports he had said.

The president denied these claims, but the outcry highlighted the high regard in which the American public, and most of the world, holds veterans; people are united by the pride and respect for those brave enough to risk life and limb for their country.

In the United States, the number of injured soldiers returning home alive has risen from 75% to 92% since the Vietnam War, but combat takes a toll on the survivors. Its estimated that one in every 10 veterans alive today was injured seriously while serving. And, for many, the nature of the injury makes treatment very difficult. Soldiers can find themselves returning home with severe burns, spinal cord injuries, paralysis, blindness, deafness, brain injuries and loss of limbs, as well as psychological trauma, some linked directly to physical injuries.

The most significant development in recent years for severely maimed veterans and other victims of physical injuries is the acceleration of whats known as regenerative medicine. Regenerative medicine was first defined in 1999 and it encompasses many disciplines of science. Its goal is to provide clinicians with the tools to effectively repair or replace a patients damaged tissues and organs in order to return normal function.

The technology really emerged into the public consciousness in the 2000s because of the Iraq war and, since then, great strides have been made in applying it to treating many different healthcare issues. So, what about the specifics? What are the most promising breakthroughs in recent years?

Some of the most challenging war-related injuries involve bones. Severe burns, spinal cord injuries, blast injuries, traumatic brain injuriesthese seemingly disparate traumas can each lead to a painful complication during the healing process called heterotopic ossification (HO).

A team at Michigan Medicines Department of Surgery is focusing its research on how the healing process often goes awry. The problem often emerges at limb amputation sites. Weeks after surgery or injury, abnormal bones often form within soft tissues like muscleplaces where theyre not supposed to be, causing the patient agonizing pain.

Theres no way to prevent it and once its formed, theres no way to reverse it, said Benjamin Levi, M.D, co-head of the research team at the Center for Basic and Translational Research at Michigan Medicines Department of Surgery.

There may be a solution thanks to a collaborative study between Levi and a research group led by Stephen Kunkel, Ph.D. at Michigans Department of Pathology. It had been theorized that HO could be linked to inflammation at the site of injury or surgery. The researchers built on this theory by studying the cells that are present at the early stages of HO.

Working with mice, they have been able to identify a specific protein that is responsible for sending the signals that trigger stem cells within the bone to start this process of uncontrolled tissue growth. By targeting this protein and stopping its action, it could be possible to stop the process in the first place. This would improve the quality of life for many injured veterans.

Treating HO is very much a case of prevention being better than cure. Progressing this discovery into a therapeutic setting could eventually provide doctors with a mechanism to stop HO before it has a chance to develop. It would be a game changer for many veterans who would otherwise be left with this agonizing condition.

Severe blast injuries and bullet traumas also leave many veterans needing implants or prosthetics to replace bone that has been lost to severe injury. If you break a leg, a doctor will put it in a cast and allow the natural healing process to occur. If its a severe break, you may need surgery. But when a soldiers bone is ripped apart by a gunshot or a blast, the damage to the network of cells within the bone is so severe that it often cannot heal on its own.

Regenerative medicine may provide a solution. After leaving the US Army more than 20 years ago, solider Luis Alvarez founded a firm at the Massachusetts Institute of Technology that developed a paint derived from key proteins that can trigger bone regeneration. The inspiration behind Alvarezs innovation?

During my time in Iraq, I witnessed service members who suffered traumatic injuries undergo amputations weeks or months after the initial wound, because there was no reliable method for regenerating the bone.

The technology developed by his company allows doctors to coat implants with specific proteins, allowing them to trigger regeneration, thus aiding recovery of the damaged tissue. They are making great progress and looking to have something ready for doctors to use in clinics by 2021. Its an inspiring story. The company is rolling out multiple therapies heading into clinical trials over the next two years.

The military is also starting to invest heavily in one of the most exciting avenues of regenerative medicine to help veterans replace lost tissue. Bioprinting uses human cells mixed with specially designed bioinks to 3D print tissue-like structures for the purpose of regenerating damaged body parts. Using bioprinting, scientists can build replacement grafts using a patients own stem cells, thus removing the issues associated with transplant rejection. The technology is still in its infancy but, thanks to recent military investment, scientists are now applying bioprinting to the generation of skin grafts to treat the severe burns that many veterans are afflicted with.

Treating severe burns is an incredibly difficult process and many rarely heal completely. Patients can be left with extreme scarring, tight and itchy skin and disfigurement. When the skin is severely burned the body focuses on preventing infection by closing the wound as quickly as possible. New skin is generated but the structure is vastly different to normal tissue.

A 5-year research project led by Prof Jeff Biernaskie at the University of Calgary Faculty of Veterinary Medicine has made a big step forward.

What weve shown is that you can alter the wound environment with drugs, or modify the genetics of these progenitor cells directly, and both are sufficient to change their behaviour during wound healing. And that can have really quite impressive effects on healing that includes regeneration of new hair follicles, glands and fat within the wounded skin.

This research could lead to new drugs that greatly improve the healing process.

It is clear from the number of veterans currently coping with a compromised quality of life that we need to do more to treat their injuries. It is estimated that the number of veterans currently living with these life changing injuries is in the millions and their healthcare needs come at an immense economic cost. Fortunately, there is now a much stronger horse in the race to a cure.

Regenerative medicine was estimated to draw nearly $15 billion in investments in 2017. That figure is predicted to rise to in excess of $79 billion by 2026. Those are serious resources, providing hope that our veterans will benefit in the decade ahead.

Sam Moxon has a PhD in regenerative medicine and is currently involved in dementia research. He is a freelance writer with an interest in the development of new technologies to diagnose and treat degenerative diseases. Follow him on Twitter@DrSamMoxon

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Regenerative medicine and war: The next breakthrough in treating injured veterans? - Genetic Literacy Project

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Exosome Therapeutic Market analysis report encompasses infinite knowledge and information on what the markets definition, classifications, applications, and engagements are and also explains the drivers & restraints of the market which is obtained from SWOT analysis. Gathered market data and information is denoted very neatly with the help of most appropriate graphs, charts or tables in the entire report. Utilization of well established tools and techniques in this Exosome Therapeutic Market document helps to turn complex market insights into simpler version. Competitive analysis studies of this market report provides with the ideas about the strategies of key players in the market.

A large scale Exosome Therapeutic Market report endows with the data and statistics on the current state of the industry which directs companies and investors interested in this market. By applying market intelligence for this market research report, industry expert measure strategic options, summarize successful action plans and support companies with critical bottom-line decisions. The most appropriate, unique, and creditable global market report has been brought to important customers and clients depending upon their specific business needs. Businesses can accomplish great benefits with the different & all-inclusive segments covered in the Exosome Therapeutic Market research report hence every bit of market is tackled carefully.

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Market Analysis and Insights:Global Exosome Therapeutic Market

Exosome therapeutic market is expected to gain market growth in the forecast period of 2019 to 2026. Data Bridge Market Research analyses that the market is growing with a CAGR of 21.9% in the forecast period of 2019 to 2026 and expected to reach USD 31,691.52 million by 2026 from USD 6,500.00 million in 2018. Increasing prevalence of lyme disease, chronic inflammation, autoimmune disease and other chronic degenerative diseases are the factors for the market growth.

The major players covered in theExosome Therapeutic Marketreport areevox THERAPEUTICS, EXOCOBIO, Exopharm, AEGLE Therapeutics, United Therapeutics Corporation, Codiak BioSciences, Jazz Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH, ReNeuron Group plc, Capricor Therapeutics, Avalon Globocare Corp., CREATIVE MEDICAL TECHNOLOGY HOLDINGS INC., Stem Cells Group among other players domestic and global.Exosome therapeutic market share data is available for Global, North America, Europe, Asia-Pacific, and Latin America separately. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.

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Exosomes are used to transfer RNA, DNA, and proteins to other cells in the body by making alteration in the function of the target cells. Increasing research activities in exosome therapeutic is augmenting the market growth as demand for exosome therapeutic has increased among healthcare professionals.

Increased number of exosome therapeutics as compared to the past few years will accelerate the market growth. Companies are receiving funding for exosome therapeutic research and clinical trials. For instance, In September 2018, EXOCOBIO has raised USD 27 million in its series B funding. The company has raised USD 46 million as series a funding in April 2017. The series B funding will help the company to set up GMP-compliant exosome industrial facilities to enhance production of exosomes to commercialize in cosmetics and pharmaceutical industry.

Increasing demand for anti-aging therapies will also drive the market. Unmet medical needs such as very few therapeutic are approved by the regulatory authority for the treatment in comparison to the demand in global exosome therapeutics market will hamper the market growth market. Availability of various exosome isolation and purification techniques is further creates new opportunities for exosome therapeutics as they will help company in isolation and purification of exosomes from dendritic cells, mesenchymal stem cells, blood, milk, body fluids, saliva, and urine and from others sources. Such policies support exosome therapeutic market growth in the forecast period to 2019-2026.

This exosome therapeutic market report provides details of market share, new developments, and product pipeline analysis, impact of domestic and localised market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, product approvals, strategic decisions, product launches, geographic expansions, and technological innovations in the market. To understand the analysis and the market scenario contact us for anAnalyst Brief, our team will help you create a revenue impact solution to achieve your desired goal.

Global Exosome Therapeutic Market Scope and Market Size

Global exosome therapeutic market is segmented of the basis of type, source, therapy, transporting capacity, application, route of administration and end user. The growth among segments helps you analyse niche pockets of growth and strategies to approach the market and determine your core application areas and the difference in your target markets.

Based on type, the market is segmented into natural exosomes and hybrid exosomes. Natural exosomes are dominating in the market because natural exosomes are used in various biological and pathological processes as well as natural exosomes has many advantages such as good biocompatibility and reduced clearance rate compare than hybrid exosomes.

Exosome is an extracellular vesicle which is released from cells, particularly from stem cells. Exosome functions as vehicle for particular proteins and genetic information and other cells. Exosome plays a vital role in the rejuvenation and communication of all the cells in our body while not themselves being cells at all. Research has projected that communication between cells is significant in maintenance of healthy cellular terrain. Chronic disease, age, genetic disorders and environmental factors can affect stem cells communication with other cells and can lead to distribution in the healing process. The growth of the global exosome therapeutic market reflects global and country-wide increase in prevalence of autoimmune disease, chronic inflammation, Lyme disease and chronic degenerative diseases, along with increasing demand for anti-aging therapies. Additionally major factors expected to contribute in growth of the global exosome therapeutic market in future are emerging therapeutic value of exosome, availability of various exosome isolation and purification techniques, technological advancements in exosome and rising healthcare infrastructure.

Rising demand of exosome therapeutic across the globe as exosome therapeutic is expected to be one of the most prominent therapies for autoimmune disease, chronic inflammation, Lyme disease and chronic degenerative diseases treatment, according to clinical researches exosomes help to processes regulation within the body during treatment of autoimmune disease, chronic inflammation, Lyme disease and chronic degenerative diseases. This factor has increased the research activities in exosome therapeutic development around the world for exosome therapeutic. Hence, this factor is leading the clinician and researches to shift towards exosome therapeutic. In the current scenario the exosome therapeutic are highly used in treatment of autoimmune disease, chronic inflammation, Lyme disease and chronic degenerative diseases and as anti-aging therapy as it Exosomes has proliferation of fibroblast cells which is significant in maintenance of skin elasticity and strength.

Based on source, the market is segmented into dendritic cells, mesenchymal stem cells, blood, milk, body fluids, saliva, urine and others. Mesenchymal stem cells are dominating in the market because mesenchymal stem cells (MSCs) are self-renewable, multipotent, easily manageable and customarily stretchy in vitro with exceptional genomic stability. Mesenchymal stem cells have a high capacity for genetic manipulation in vitro and also have good potential to produce. It is widely used in treatment of inflammatory and degenerative disease offspring cells encompassing the transgene after transplantation.

Based on therapy, the market is segmented into immunotherapy, gene therapy and chemotherapy. Chemotherapy is dominating in the market because chemotherapy is basically used in treatment of cancer which is major public health issues. The multidrug resistance (MDR) proteins and various tumors associated exosomes such as miRNA and IncRNA are include in in chemotherapy associated resistance.

Based on transporting capacity, the market is segmented into bio macromolecules and small molecules. Bio macromolecules are dominating in the market because bio macromolecules transmit particular biomolecular information and are basically investigated for their delicate properties such as biomarker source and delivery system.

Based on application, the market is segmented into oncology, neurology, metabolic disorders, cardiac disorders, blood disorders, inflammatory disorders, gynecology disorders, organ transplantation and others. Oncology segment is dominating in the market due to rising incidence of various cancers such as lung cancer, breast cancer, leukemia, skin cancer, lymphoma. As per the National Cancer Institute, in 2018 around 1,735,350 new cases of cancer was diagnosed in the U.S. As per the American Cancer Society Inc in 2019 approximately 268,600 new cases of breast cancer diagnosed in the U.S.

Based on route of administration, the market is segmented into oral and parenteral. Parenteral route is dominating in the market because it provides low drug concentration, free from first fast metabolism, low toxicity as compared to oral route as well as it is suitable in unconscious patients, complicated to swallow drug etc.

The exosome therapeutic market, by end user, is segmented into hospitals, diagnostic centers and research & academic institutes. Hospitals are dominating in the market because hospitals provide better treatment facilities and skilled staff as well as treatment available at affordable cost in government hospitals.

Exosome therapeutic Market Country Level Analysis

The global exosome therapeutic market is analysed and market size information is provided by country by type, source, therapy, transporting capacity, application, route of administration and end user as referenced above.

The countries covered in the exosome therapeutic market report are U.S. and Mexico in North America, Turkey in Europe, South Korea, Australia, Hong Kong in the Asia-Pacific, Argentina, Colombia, Peru, Chile, Ecuador, Venezuela, Panama, Dominican Republic, El Salvador, Paraguay, Costa Rica, Puerto Rico, Nicaragua, Uruguay as part of Latin America.

Country Level Analysis, By Type

North America dominates the exosome therapeutic market as the U.S. is leader in exosome therapeutic manufacturing as well as research activities required for exosome therapeutics. At present time Stem Cells Group holding shares around 60.00%. In addition global exosomes therapeutics manufacturers like EXOCOBIO, evox THERAPEUTICS and others are intensifying their efforts in China. The Europe region is expected to grow with the highest growth rate in the forecast period of 2019 to 2026 because of increasing research activities in exosome therapeutic by population.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points such as new sales, replacement sales, country demographics, regulatory acts and import-export tariffs are some of the major pointers used to forecast the market scenario for individual countries. Also, presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of sales channels are considered while providing forecast analysis of the country data.

Huge Investment by Automakers for Exosome Therapeutics and New Technology Penetration

Global exosome therapeutic market also provides you with detailed market analysis for every country growth in pharma industry with exosome therapeutic sales, impact of technological development in exosome therapeutic and changes in regulatory scenarios with their support for the exosome therapeutic market. The data is available for historic period 2010 to 2017.

Competitive Landscape and Exosome Therapeutic Market Share Analysis

Global exosome therapeutic market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, company strengths and weaknesses, product launch, product trials pipelines, concept cars, product approvals, patents, product width and breadth, application dominance, technology lifeline curve. The above data points provided are only related to the companys focus related to global exosome therapeutic market.

Many joint ventures and developments are also initiated by the companies worldwide which are also accelerating the global exosome therapeutic market.

For instance,

Partnership, joint ventures and other strategies enhances the company market share with increased coverage and presence. It also provides the benefit for organisation to improve their offering for exosome therapeutics through expanded model range.

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Exosome Therapeutic Market Latest Industry Size, Growth, Share, Emerging Demands, and Competitive Landscape || Major Gaints Jazz Pharmaceuticals,...

Skin Stem Cells Comments Off on Exosome Therapeutic Market Latest Industry Size, Growth, Share, Emerging Demands, and Competitive Landscape || Major Gaints Jazz Pharmaceuticals,… | September 29th, 2020

News Release

Monday, September 28, 2020

Findings show deficits in the electrical activity of cortical cells; possible targets for treatment for 22q11.2 deletion syndrome.

A genetic study has identified neuronal abnormalities in the electrical activity of cortical cells derived from people with a rare genetic disorder called 22q11.2 deletion syndrome. The overexpression of a specific gene and exposure to several antipsychotic drugs helped restore normal cellular functioning. The study, funded by the National Institutes of Health (NIH) and published in Nature Medicine, sheds light on factors that may contribute to the development of mental illnesses in 22q11.2 deletion syndrome and may help identify possible targets for treatment development.

22q11.2 deletion syndrome is a genetic disorder caused by the deletion of a piece of genetic material at location q11.2 on chromosome 22. People with 22q11.2 deletion syndrome can experience heart abnormalities, poor immune functioning, abnormal palate development, skeletal differences, and developmental delays. In addition, this deletion confers a 20-30% risk for autism spectrum disorder (ASD) and an up to 30-fold increase in risk for psychosis. 22q11.2 deletion syndrome is the most common genetic copy number variant found in those with ASD, and up to a quarter of people with this genetic syndrome develop a schizophrenia spectrum disorder.

This is the largest study of its type in terms of the number of patients who donated cells, and it is significant for its focus on a key genetic risk factor for mental illnesses, said David Panchision, Ph.D., chief of the Developmental Neurobiology Program at the NIHs National Institute of Mental Health. Importantly, this study shows consistent, specific patient-control differences in neuronal function and a potential mechanistic target for developing new therapies for treating this disorder.

While some effects of this genetic syndrome, such as cardiovascular and immune concerns, can be successfully managed, the associated psychiatric effects have been more challenging to address. This is partly because the underlying cellular deficits in the central nervous system that contribute to mental illnesses in this syndrome are not well understood. While recent studies of 22q11.2 deletion syndrome in rodent models have provided some important insights into possible brain circuit-level abnormalities associated with the syndrome, more needs to be understood about the neuronal pathways in humans.

To investigate the neural pathways associated with mental illnesses in those with 22q11.2 deletion syndrome, Sergiu Pasca, M.D., associate professor of psychiatry and behavioral sciences at Stanford University, Stanford, California, along with a team of researchers from several other universities and institutes, created induced pluripotent stems cells cells derived from adult skin cells reprogramed into an immature stem-cell-like state from 15 people with 22q11.2 deletion and 15 people without the syndrome. The researchers used these cells to create, in a dish, three-dimensional brain organoids that recapitulate key features of the developing human cerebral cortex.

What is exciting is that these 3D cellular models of the brain self-organize and, if guided to resemble the cerebral cortex, for instance, contain functional glutamatergic neurons of deep and superficial layers and non-reactive astrocytes and can be maintained for years in culture. So, there is a lot of excitement about the potential of these patient-derived models to study neuropsychiatric disease, said Dr. Pasca.

The researchers analyzed gene expression in the organoids across 100 days of development. They found changes in the expression of genes linked to neuronal excitability in the organoids that were created using cells from individuals with 22q11.2 deletion syndrome. These changes prompted the researchers to take a closer look at the properties associated with electrical signaling and communication in these neurons. One way neurons communicate is electrically, through controlled changes in the positive or negative charge of the cell membrane. This electrical charge is created when ions, such as calcium, move into or out of the cell through small channels in the cells membrane. The researchers imaged thousands of cells and recorded the electrical activity of hundreds of neurons derived from individuals with 22q11.2 deletion syndrome and found abnormalities in the way calcium was moved into and out of the cells that were related to a defect in the resting electrical potential of the cell membrane.

A gene called DGCR8 is part of the genetic material deleted in 22q11.2 deletion syndrome, and it has been previously associated with neuronal abnormalities in rodent models of this syndrome. The researchers found that heterozygous loss of this gene was sufficient to induce the changes in excitability they had observed in 22q11.2-derived neurons and that overexpression of DGCR8 led to partial restoration of normal cellular functioning. In addition, treating 22q11.2 deletion syndrome neurons with one of three antipsychotic drugs (raclopride, sulpiride, or olanzapine) restored the observed deficits in resting membrane potential of the neurons within minutes.

We were surprised to see that loss in control neurons and restoration in patient neurons of the DGCR8 gene can induce and, respectively, restore the excitability, membrane potential, and calcium defects, said Pasca. Moving forward, this gene or the downstream microRNA(s) or the ion channel/transporter they regulate may represent novel therapeutic avenues in 22q11.2 deletion syndrome.

Grants:MH107800; MH100900; MH085953; MH060233; MH094714

About the National Institute of Mental Health (NIMH):The mission of theNIMHis to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery and cure. For more information, visit theNIMH website.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

Khan, T. A., Revah, O., Gordon, A., Yoon, S., Krawisz, A. K., Goold, C., Sun, Y., Kim, C., Tian, Y., Li, M., Schaepe, J. M., Ikeda, K., Amin, N. D., Sakai, N., Yazawa, M., Kushan, L., Nishino, S., Porteus, M. H., Rapoport, J. L. Paca, S. (2020). Neuronal defects in a human cellular model of 22q11.2 deletion syndrome. Nature Medicine. doi: 10.1038/s41591-020-1043-9

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funded study sheds light on abnormal neural function in rare genetic disorder - National Institutes of Health

Skin Stem Cells Comments Off on funded study sheds light on abnormal neural function in rare genetic disorder – National Institutes of Health | September 28th, 2020

Creative minds from Yokohama National University have developed an efficient method of successfully generating hair growth. Find out more here, and what this could mean for future progress.

Published in the journal Biomaterials, the research team based in Japan focused on a research method that shows "great potential".

Led by Dr Tatsuto Kageyama and Professor Junji Fukuda, they've proposed a new approach to regenerate hair.

Previous studies have utilised a three-dimensional tissue culture called hair follicle germ (HFG).

HFG is composed of hair follicle stem cells derived from both the epithelial (outer layer of skin) and mesenchymal tissue (embryonic connective tissue).

This approach requires manually merging the stem cells derived from these different origins under a microscope.

Thus, it becomes a challenge to produce the 5,000 or more HFG needed per transplant patient.

Dr Kageyama and Professor Fukuda wanted to perform research that was scalable - something that would make hair regeneration easier.

READ MORE:Losing hair fast? Applying this natural solution to the scalp resulted in new hair growth

The team "fabricated hair beads (HBs) in U-shaped wells in a plate array using hair follicle stem cells".

The hair follicle stem cells were encapsulated in collagen - a structural protein.

In fact, collagen is believed to play an important role in hair follicle generation throughout a person's life.

"A suspension of mouse epithelial cells was then added into the wells containing the gel encapsulated hair beads," detailed the researchers.

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After 24 hours, the epithelial cells adhered to the collagen gel, which then contracted to form "a bead-based hair follicle germ".

To test the efficiency of the hair bead approach, the scientists transplanted the bead-based hair follicle germ onto the back of mice.

They also used other methods, such as the one outlined earlier, to compare the results.

The collagen-enriched hair bead approach produced a "high rate of hair generation four weeks after being transplanted onto the skin of mice".

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It was noted how this method produced more hair than the other approaches, suggesting the collagen enrichment plays a vital role in hair growth.

Professor Fukuda commented on his findings: "Using an automated spotter, this approach was scalable to prepare a large number of hair follicle germs.

"[This] is important for human treatment because thousands of tissue grafts are necessary for a single patient."

The next step is to "find a way to expand the number of hair follicle stem cells".

Fukuda explained: "In this study, we worked on how to prepare tissue grafts.

"However, to deliver this approach to hair loss patients, we need a proper approach to obtain a sufficient number of hair follicle stem cells".

The researchers believe their results "show great potential for clinical applications in hair regenerative therapy".

Until then, Minoxidil has been approved as suitable treatment to help slow down hair loss.

Read more:
Hair loss treatment: Breakthrough research links one ingredient to hair growth - Express

Skin Stem Cells Comments Off on Hair loss treatment: Breakthrough research links one ingredient to hair growth – Express | September 28th, 2020

You can print a lot of things with a 3D printer. A gun, a home, a dinner. Soon, you could even print new pieces of yourself.

While most uses of 3D printing involve extruding layers of plastic through a nozzle to create a three-dimensional structure, before too long, similar technology could let physicians print structures made of human cells -- from tiny structures like 'organs on a chip', to huge ones like whole replacement organs.

"Bioprinting has a great promise -- it has a lot of advantages and capabilities. Of course, it's not really perfect yet, but despite that, we have all these good things going on in the field," says Dr Ibrahim Ozbolat, principal investigator at Penn State University's bioprinting-focused Ozbolat Lab.

SEE: Guide to Becoming a Digital Transformation Champion (TechRepublic Premium)

One of those things is making replacement organs. The process of bioprinting human tissue is a bit more involved than, say, 3D printing a new desk toy. First, you have to get some stem cells from the person who needs the new organ, culture them in the right biochemical soup until you've got enough, then turn them into a bioink that can be extruded through a nozzle that's two microns thick (or one 80th the size of a human hair). The bioink will be pushed through the printer, usually onto a scaffold made of hydrogel. A bit more culturing, and you could have a useable tissue that can either be printed directly onto the patient in an operating theatre, or built in a lab and then implanted.

Bioprinting isn't a fast process, but it could make a substantial impact in healthcare, not least in offering a solution to the chronic shortage of donor organs. In the US, for example, there are over 112,000 people still on transplant waiting lists.

Other than there simply aren't enough of them, another problem with donated organs is that recipients' immune systems can attack them, causing the donor organ to fail. If that doesn't happen in the first few days or weeks, it will eventually -- kidneys donated from living donors tend to last around 12 to 20 years. People with transplanted organs also need to take medication to suppress their immune system long-term. While those drugs lessen the chance of organ rejection, it also leaves those taking them at risk of other diseases such as certain cancers.

Bioprinted organs made from an individuals' own tissue won't be rejected by their body, will last far longer, won't need anti-rejection meds, and can be custom made to the individual's exact measurements -- whether they're a four year old or a NFL linebacker.

That's the goal, anyway. So far, most human organs that have been made in the lab and not got as far as being implanted into people. Not all human organs are created equally -- or can be created by bioprinting, for that matter. Flat tissues, like skin, and hollow ones, like the stomach or bladder, are relatively easy to print, whereas complex solid organs -- the heart, liver, or pancreas -- would be far harder to recreate with printing due to the rich blood supply they need.

The problem, according to Dr Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine, is the blood vessels of larger bioprinted organs.

"Vascularity still remains a challenge because there's so many cells per centimetre [in large organs like the heart] that you really need a lot of vascular supply and nutrition. So to create the large structures is still a challenge, even though the printer is definitely helping in that area, but we're not yet ready."

The bigger an organ is, the more blood supply it needs to bring organs and nutrients to the tissue. Large organs need a complex web of interconnected, different-sized arteries, capillaries, and veins. The walls of the vessels need to be strong enough to withstand the normal flow of blood through them without causing clots, and need to be made of specific layers. For now, it's too much complexity for 3D bioprinters to manage.

While researchers are working on how to print full-size organs, the tiniest bioprinted structures are already helping researchers. Bioprinting can also be used to make 'organs on a chip' -- tiny samples of tissue that mimic the functions and structures of their full-grown counterparts. These mini organs allow pharmaceutical companies to test drugs on versions of human tissues, and assess their effectiveness or toxicity instead of using unreliable and ethically difficult animal models.

One day, organs on a chip could be made using individuals' own cells to test potential therapies. Rather than using the same standard treatments for every patient, by taking some cells, culturing them and printing them onto the chip, physicians can have a unique view into how their patient will react to a particular drug without having to start them on a whole course of it.

"These miniature human organs we can use for drug discovery, direct toxicity testing, and personalised medicine, BCS modelling and personalised medicine. We've taken the same strategy, and by using the same printers, we can print miniature structures that replicate the normal human response," Atala says.

SEE: Coronavirus and 3D printing: How makers are stepping up to supply vital medical kit

As well as printing healthy tissue, bioprinters can make samples of diseased tissues -- like cancers -- to investigate current and future therapies.

"We're trying to find a way to create an effective treatment for solid tumours. I work with immunologists [who] engineer immune cells and make cytotoxic cells against the cancer cells. Now we're trying the immune cells in different 3D models that we print or we build. This could be used as a pre-screening tool for immunotherapy: so rather than directly going and checking things on the patient, this will be an intermediary step to screen the effectiveness of the therapy," Penn State's Ozbolat says.

And that's not the only way that bioprinting -- or rather, BioPrinters -- could help develop new therapies for common health conditions.

While HP's printers are more associated with offices rather than labs, HP also sells printers to the life sciences industry with its D300 BioPrinter line which prints drugs instead of documents. The machines are typically used in small to medium pharmaceutical companies in secondary drug discovery, where compounds thought to be effective against a particular disease are tested to see if they have any affect against the condition, and if so, at what dose.

The life sciences printer came into being, according to Annette Friskopp, global head and general manager of Specialty Printing Systems at HP Inc, after a group of HP engineers began researching the highest value fluid in the world that could be jetted through a thermal inkjet print head or similar. Was it perfume, jet fuel, rare chemical compounds?

"One of the highest value fluids that they discovered in this exploration was drug compounds If you've ever printed a photograph on an HP printer, just think of how many small droplets of ink have to directionally be sprayed down onto that piece of paper, so when the photograph comes out of your printer, there's your friends and family. Leveraging exactly that same technology, that is [drug] dispensing using thermal inkjet technology," she says.

Viiv Healthcare's David Irlbeck has been using HP's D300 in his work to create latency reversal drugs for HIV. (Latency reversal involves changing an HIV infection from its latent phase to an active one, the body can mount an immune response against it, and is thought to be a promising avenue in the search for a cure for HIV.)

SEE: 3D printing during COVID-19 shows potential, but financial realities bite

Viiv uses HP's D300 bioprinter for measuring out very small, very accurate amounts of particular compounds to see how their effectiveness changes at different doses. The machine is, says Irlbeck, "very user friendly, very easy to program, and it can do titrations that would be extremely difficult to do manually". By having a printer print out the drugs, researchers are able to get them down to finer and finer concentrations that human researchers simply wouldn't be able to make by doing the same process by hand, and would likely be less accurate if they did. And, because printers can measure out doses of drugs at tiny and highly accurate concentrations, it allows pharmaceutical researchers to reduce any wastage of the (very expensive) compounds.

Bioprinters also enable researchers to combine two drugs in very precise concentrations to see if they might have a synergistic effect -- where the two drugs together might have a greater effect than that which both produce individually. "It's very, very technically demanding to do synergy work without an instrument like the D300," Irlbeck adds.

As well as working on HIV medications, the D300 was recently co-opted into working on treatment for SARS-CoV-2, the virus that causes COVID-19, prepping drug plates for a lab at the University of North Carolina, which was looking into their antiviral potential.

The bioprinters are also being used elsewhere in the fight against coronavirus. HP has donated four of the D300e BioPrinters to four research facilities working on COVID-19: the Spanish National Research Council, the Monoclonal Antibody Discovery Laboratory at Fondazione Toscana Life Sciences in Italy, the US Center for Nuclear Receptors and Cell Signaling (CNRCS) at University of Houston, and France's Grenoble Alpes University Hospital. Between them, the facilities are using the machines for research into the fundamental biology of COVID-19, monoclonal antibodies and other potential therapeutic candidates, and work on immunisation: the future of healthcare is likely to be 3D printed.

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3D printing is making a giant leap into health. That could change everything - ZDNet

Skin Stem Cells Comments Off on 3D printing is making a giant leap into health. That could change everything – ZDNet | September 28th, 2020

Medical skin care products are used for beautifying or to address some other skin care problems. The cosmetic industry is booming and skin care forms a very huge part of this industry. The aesthetic appearance is so important that people spend a lot on skin care products and treatment. People being more technologically aware of the various new skin care products trending in the market. In addition to the aesthetic application, the medical skin care products are also used to address issues such as acne, pimples or scars.

Medical Skin Care Products Market: Drivers and Restraints

The medical skin care products is primarily driven by the need of natural based active ingredients products which are now trending in the market. Consumers demand medical skin care products which favor health and environment. Moreover, the consumers are updated with the trends so that various companies end up providing such products to satisfy the customers. For instance, a single product face mask has thousands of different variants. This offers consumers different options to select the product depending on the skin type. Moreover, the market players catering to the medical skin care products are offering products with advanced technologies. For instance, Santinov launched the CICABEL mask using stem cell material based on advanced technologies. The stem cells used in the skin care product helps to to protect and activate the cells and promote the proliferation of skin epidermal cells and the anagenesis of skin fibrosis.

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Medical Skin Care Products Market: Segmentation

On the basis of product type the medical skin care products market can be segmented as:

On the basis of application, the medical skin care products market can be segment as:

On the basis of distribution channel, the medical skin care products market can be segment as:

Medical Skin Care Products Market: Overview

Medical skin care products are used to address basic skin problems ranging from acne to scars. There are various advancements in the ingredients used to offer skin care products to the consumers. For instance, the use of hyaluronic acid and retinoids is the latest development in the industry. The anti-aging creams are at the forefront as the help treating issues such as wrinkles, scars, acne, and sun damage. Another, product in demand is the probiotic skincare which include lactobacillus and bifidobacterium.

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Medical Skin Care Products Market: Region-wise Outlook

In terms of geography, medical skin care products market has been divided into five regions including North- America, Asia- Pacific, Middle-East & Africa, Latin America and Europe. North America dominated the global medical skin care products market as international players are acquiring domestic companies to make their hold strong in the U.S. LOral is accelerating its U.S. market by signing a definitive agreement with Valeant Pharmaceuticals International Inc. to acquire CeraVe, AcneFree and Ambi skin-care brands for US$ 1.3 billion. The acquisition is expected LOreal to get hold of the brands in the price-accessible segment. Asia Pacific is expected to be the fastest growing region owing to the increasing disposable income and rising awareness towards the skin care products.

Medical Skin Care Products Market: Key Market Participants

Some of the medical skin care products market participants are Avon Products Inc., Beiersdorf AG, Colgate-Palmolive Company, Kao Corporation, LOral S.A., Procter & Gamble, Shiseido Company, The Estee Lauder Companies Inc., Unilever PLC, Revlon, Clinique Laboratories, llc., Murad, LLC., SkinCeuticals, RMS Beauty, J.R. Watkins and 100% PURE.

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Europe to Show Consistency in the Medical Skin Care market from 2017 to 2025 - Crypto Daily

Skin Stem Cells Comments Off on Europe to Show Consistency in the Medical Skin Care market from 2017 to 2025 – Crypto Daily | September 26th, 2020

Imagine if you could print yourself a new skin. Wrinkles and wounds begone with the flick of a switch. I appreciate that this sounds farfetched, but I have been looking into bioprinting and anti-aging applications are not so far off into the future.

So what is bioprinting?

Bioprinting is a type of 3D printing that uses actual cells and other biological materials as inks to fabricate 3D biological structures. Bioprinted materials have the potential to repair damaged organs, cells, and tissues in the human body (source). All sorts of cell types are being studied for bioprinting including stem cells, muscle cells, and endothelial cells. When printed, each layer of cells will cool and stick to one another (due to the collagen), creating a solid, stable structure.

Researchers have used bioprinting to introduce cells to help repair the heart after a heart attack as well as deposit cells into wounded skin.

A couple of years ago, researchers in Singapore mimicked human skin pigmentation using a 3-D bioprinter. he pigmented skin was constructed in vitro using three types of skin cells: keratinocytes, melanocytes and fibroblasts. Apparently, this was a breakthrough for the making biometic skin because while the skin itself isnt a problem, uniform pigmentation had been a real challenge.

A review of scientific literature, covering studies that mostly used collagen and hydrosol gels as the biometric ink, found that there had been a positive impact of natural bioinks in promoting wound healing. These have all been animal tests, but some researchers think that human wound healing with bioink will happen in the next 3-5 years.

A clue that we could see cosmetic skincare applications one day came when LOreal partnered with a 3-D bioprinting company to develop 3-D printed tissue for product evaluation and research (source).

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Is Bioprinting the Future of Anti-aging Skincare? - Truth In Aging

Skin Stem Cells Comments Off on Is Bioprinting the Future of Anti-aging Skincare? – Truth In Aging | September 23rd, 2020

Later that night, Fiona was searching her godfather's books on Amazon when she came across an unusual review.

"Dr Walker was my biological father and sperm donor," it read, and the commenter was trying to find out further information about him.

Fiona, curious, emailed the reviewer, Anne: She explained how she had letters and photographs, and she'd be willing to share them.

Through back-and-forth she'd discovered Dr Walker had assisted more than 100 families by using his own sperm.

By this point, Fiona was almost certain she was the result of this.

"When I fished out his letters, I found a drivers license of his that he had given me from when he was 16. And I showed it to my husband and said, 'Who does this look like?' and he just laughed, because it looks exactly like our youngest daughter," Fionasaid on SBS Insight.

"I went and had a chat to my mum and I said, 'Look, something's going on here and I'd like you to tell me the truth.'"

Fiona's mother told her they'd used a sperm donor. She said Dr Walker was her gynaecologist, and sperm donations usually come from medical students.

Fiona, then 53, asked her mother if Dr Walker was the donor, but her mother couldn't give her a straight answer.

Fiona and her mother. Image: Supplied.

She told Insight she was devastated.

"It made a lot ofsense, but at the same timeI was really angry that I'd been lied to. It was a bit of a rollercoaster, I'd be thinking it was prettycool one moment and then prettyhorrible the next moment. It's been like that eversince," she said.

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'Who does this look like?' Fiona was scrolling online when she discovered a family secret. - Mamamia

Skin Stem Cells Comments Off on ‘Who does this look like?’ Fiona was scrolling online when she discovered a family secret. – Mamamia | September 23rd, 2020

Sciences most powerful ingredients are better together.

Every skin-care enthusiast has heard of retinol, the dermatological gold standard in anti-aging and vitamin A derivative that lessens the appearance of fine lines and wrinkles, promotes collagen production, minimizes breakouts, and resurfaces your skin. But the famed ingredient is also known for some of its less desirable side effectsnamely, irritation, redness, flaking, and photosensitivity, which can make it intolerable for sensitive skin types and unsafe for use in pregnant and nursing women.

Even as most dermatologists laud retinol for its extensive benefits, holistic aestheticians remain wary of the actives corrosive effects on the skin barrier. Because the skin barrier is key for retaining moisture and protecting the dermis from external irritants, aggressors, pollutants, and more, compromising it can sensitize skin, making it more susceptible to inflammation and irritation.

Growth factors have piqued our interest for being a sensitive-skin-friendly alternative to retinol, as these pro-healing proteins are safe for more continued use and are non-corrosive to the stratum corneumthe outermost layer of the epidermisand are gentle enough for sensitive skin types. But if youre not quite ready to let go of your retinol, it turns out that they can be used together to enhance the potency of your anti-aging regimen, even buffering the skin from some of retinols less desirable side effects.

Keep reading to get schooled on the use of growth factors in skin care according to dermatologists, and some guidance on whether the controversial ingredient could be right for you to try next.

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As we grow older, our skins natural production of collagen decreases (starting around age 25), the elastin fibers begin to stiffen, and our skin produces lower quantities of growth factors, resulting in various signs of aging, like fine lines, crepiness, thinness, and sagging. This is where adding a topical growth factor into your routine can help. Says Lily Talakoub, MD, dermatologist and owner of dermtodoor.com, A growth factor is a large protein derived from human cells that targets the crucial turnover of cells, [promoting the increase] of [structural proteins] such as collagen and elastin.

Although they were first discovered in the 1950sand the scientists who did it were awarded the Nobel Prize for their research in 1986there was still some confusion as to how growth factors worked and their efficacy. But in the last few years, there has been a flurry of new anti-aging products that use growth factors like EGF (epidermal growth factor).

As Dr. Talakoub explains, growth factors stimulate the regeneration of cells that fight various signs of aging by prompting the cells to produce the structural components of the skin that are responsible for elasticity, firmness, and bounce. Specifically, ultra-healing EGF binds to the EGF receptor in the cell, aiding with cell proliferation, survival, and promoting DNA synthesis. By fortifying the presence of the structural tissues in the skin matrix, research shows that we can expect fewer fine lines and wrinkles over time. Think of growth factors as the key that unlocks and activates the cell to produce collagen and elastinboth of which give us that youthful lookand also help promote cell turnover and fight against inflammation.

As board-certified dermatologist Dr. Hadley King points out, growth factors like EGF can also be used to increase skin thickness and to improve tone and texture, particularly for sensitive skin types. If your skin is too sensitive to tolerate retinoids, then growth factors can be a substitute to stimulate collagen, even tone, and decrease roughness with much less irritation.

Dr. King explains that these proteins are almost universally tolerable, likely due to their natural presence in the body, and through inducing the bodys own natural mechanisms for repair, which in turn promotes skin healing. When they bind to receptors on cell surfaces, King continues, they send commands to repair, rejuvenate, and replicate. This makes them an excellent option for skin concerns ranging from inflammation and acne to fading scarring and post-inflammatory hyperpigmentation.

Thanks to the Kardashians, youve undoubtedly heard of the trendy vampire facial, which uses your bodys own PRPplatelet-rich plasma that is derived from your own bloodto treat acne scars and smooth skin texture. This makes them a fantastic addition to your post-laser or post-microneedling treatment at the dermatologist. Adding a growth factor serum like PRP can also enhance the efficacy of the treatment, as well as reduce healing time.

While a PRP serum created in a centrifuge from your own blood is the ultimate way to go for an in-office encounter with growth factors, you can also follow up at home with a growth-factor-based serum to maximize your treatments effects. Just be sure to perform a patch test before applying it to the area that was treated, as that skin might still be extra sensitive and prone to inflammation.

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One of the most important things to consider when selecting a growth factor comes down to the source. When we think of epidermal growth factor (EGF), there are two common methods of sourcing: bio (i.e., human- or animal-derived) and phyto (i.e., plant-derived). The general consensus within the scientific community seems to be that human-derived growth factors, especially PRP, are the most effective. Says Dr. Talakoub, Plant-based growth factors do not stimulate the growth of in vivo cells [in] the same [way] as ones derived from human cells.

However, not everyone is comfortable using a biological source for their skin-care products, even if they might deliver superior results. In products like the wildly popular growth-factor-based serums from SkinMedica and NeoCutis, the initial cell samples were obtained from neonatal fetal foreskin and fetal fibroblast cells, respectively, before being grown in the lab for use in their products. Depending on your ethical and political views, this might be an issue to consider before you try using these types of formulas.

And while these holy grail serums do use human stem cells, keep in mind that there are no body partswe repeat, absolutely no penises!in these serums, despite what Cate Blanchett says.

If youd rather bypass the ethical controversy of a human- or animal-derived growth factor altogether, rest assured that there are plant-based options. There are some engineered options that have been well tested and shown to be effective, says Dr. King, noting that the brands BIOEFFECT and DNA Renewal have both exhibited promising results related to skin repair, rejuvenation, and enhancement via a humanlike epidermal growth factor made in bio-engineered barley seeds.

Dr. Bjrn rvar, co-founder and chief scientific officer of BIOEFFECT, the makers of the worlds first bio-engineered, plant-based EGF, strongly believes that phyto-EGF is the new frontier in terms of tolerability, efficacy, and even safety. EGF has previously been grown in bacteria, which poses a risk of endotoxins, or extracted from human or animal cells, which presents ethical, moral, and legal issues as well as safety issues.

There are also upsides to selecting a phyto-sourced, synthetic EGF that go beyond ethics and speak to precision and measurable outcomes. The advantage to plant-derived growth factors is that there is a more defined concentration of known synthetic growth factors, and so it is theoretically easier to measure and predict outcomes, says dermatologist Dr. Mamina Turegano. And now with studies pointing to phyto sources of growth factor improving epidermal thicknesswhich thins as we agethese phyto-sourced options could be the new frontier in terms of bypassing the controversy altogether.

Because these two anti-aging actives work differently, with retinol promoting the turnover of keratinocytes (the primary type of cell in your epidermis) and growth factors targeting the formation of cells that produce collagen and elastin and strengthening your skin barrier, EGF and retinol can be used together to maximize your anti-aging skin-care routine.

So what happens when you use a growth factor along with a retinol product? Most growth factors are extremely large proteins [which] have a very difficult time penetrating the outer lipid bilayer of the skin, says Talakoub. Using a retinoid in combination with a growth factor allows [it] to penetrate the outer layers of the skin. She suggests using a vitamin C product during the daytime, and then layering your EGF with your retinol at night to see the best results.

If you do choose to use an EGF serum in conjunction with your favorite retinol, rvar recommends a particular process. We recommend always applying the EGF serum first, on clean skin, and allowing 510 minutes before applying anything else on top [to] give it time to activate the skin cells and do its magic, he notes. As he explains, EGF will help to boost hydration and counter the thinning of the skins outer layer that can occur with retinol. Their synergistic effects are the perfect complement to each other and will help make your anti-aging skin-care routine even more effective.

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The Anti-aging Benefits of Using Growth Factors Plus Retinol - Coveteur

Skin Stem Cells Comments Off on The Anti-aging Benefits of Using Growth Factors Plus Retinol – Coveteur | September 22nd, 2020

The medical skin care products is primarily driven by the need of natural based active ingredients products which are now trending in the market. Consumers demand medical skin care products which favor health and environment. Moreover, the consumers are updated with the trends so that various companies end up providing such products to satisfy the customers. For instance, a single product face mask has thousands of different variants. This offers consumers different options to select the product depending on the skin type. Moreover, the market players catering to the medical skin care products are offering products with advanced technologies. For instance, Santinov launched the CICABEL mask using stem cell material based on advanced technologies. The stem cells used in the skin care product helps to to protect and activate the cells and promote the proliferation of skin epidermal cells and the anagenesis of skin fibrosis.

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The Medical Skin Care Products market to Witness an Impulse between 2017 and 2025 - Industry Today

Skin Stem Cells Comments Off on The Medical Skin Care Products market to Witness an Impulse between 2017 and 2025 – Industry Today | September 22nd, 2020

If you regularly read my beauty content (thanks and Hi mum!), you'll know that I'm a huge fan of celebrity skincare fave, iS Clinical. Their formulas are revered for combining highly active ingredients and plant-derived extracts with modern science. They're all are fragrance and paraben-free and directly tackle all major skin concerns dry, dull skin, anti-ageing, pigmentation, uneven skin tone and texture.

About three or so months ago, they finally landed an Australian stockist and I was able to get my hands on their Reparative Moisture Emulsion and Pro-Heal Serum. To say I was impressed with the results was an understatement, so I decided it was time to bench my go-to cleanser and give their cult-classic Cream Cleanser a whirl.

When it comes to ingredients, iS Clinical only use high-grade, dermatologist-recommended ingredients like plant-derived acids, vitamins A to E, stem cells and ceramides, so you know that you're going to get good results. But this, this cleanser surpassed my expectations and is perfect if, like me, you're lazy and CBF washing your face too regularly. (Naughty beauty writer, I know).

The Cream Cleanser combines bio-nutrients, antioxidants, and restorative ingredients that work to thoroughly cleanse the surface and pores of the skin while soothing the look and feel of any dry patches. One of my favourite parts about this cleanser is that post-cleanse, your skin is left feeling refreshed, hydrated and clean, rather than tight and dried out. My other favourite part (and here's where my inner lazy girl fell in love) is that you don't even have to wash it off, you can simply wipe it off with a muslin cloth and voila, you're done.

I've been using this cream cleanser for about a month now and I've already noticed a difference in my skin. And I'm not alone, Chrissy Teigen, Rosie Huntington-Whiteley, January Jones and Zoey Deutch are all huge fans, too!

Scroll to shop iS Clinical's Cream Cleanser.

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I Used to Hate Washing My Face But Now I'm Reaching for This Cult-Cleanser Constantly - POPSUGAR Beauty Austrailia

Skin Stem Cells Comments Off on I Used to Hate Washing My Face But Now I’m Reaching for This Cult-Cleanser Constantly – POPSUGAR Beauty Austrailia | September 22nd, 2020

Anti-Ageing Drugs Market Data and Acquisition Research Study with Trends and Opportunities 2019-2025The study of Anti-Ageing Drugs market is a compilation of the market of Anti-Ageing Drugs broken down into its entirety on the basis of types, application, trends and opportunities, mergers and acquisitions, drivers and restraints, and a global outreach. The detailed study also offers a board interpretation of the Anti-Ageing Drugs industry from a variety of data points that are collected through reputable and verified sources. Furthermore, the study sheds a lights on a market interpretations on a global scale which is further distributed through distribution channels, generated incomes sources and a marginalized market space where most trade occurs.

Along with a generalized market study, the report also consists of the risks that are often neglected when it comes to the Anti-Ageing Drugs industry in a comprehensive manner. The study is also divided in an analytical space where the forecast is predicted through a primary and secondary research methodologies along with an in-house model.

Request a sample of Anti-Ageing Drugs Market report @ https://hongchunresearch.com/request-a-sample/61916

The following manufacturers are covered:Nu SkinBIOTIMEElysium HealthLa Roche-PosayDermaFix

Access this report Anti-Ageing Drugs Market @ https://hongchunresearch.com/report/worldwide-anti-ageing-drugs-market-2019-61916

Segment by RegionsNorth AmericaEuropeChinaJapan

Segment by TypeHormonal TherapyAntioxidantsEnzymesStem CellsOthers

Segment by ApplicationSkinHairOthers

For a global outreach, the Anti-Ageing Drugs study also classifies the market into a global distribution where key market demographics are established based on the majority of the market share. The following markets that are often considered for establishing a global outreach are North America, Europe, Asia, and the Rest of the World. Depending on the study, the following markets are often interchanged, added, or excluded as certain markets only adhere to certain products and needs.

Here is a short glance at what the study actually encompasses:Study includes strategic developments, latest product launches, regional growth markers and mergers & acquisitionsRevenue, cost price, capacity & utilizations, import/export rates and market shareForecast predictions are generated from analytical data sources and calculated through a series of in-house processes.

However, based on requirements, this report could be customized for specific regions and countries.

To Check Discount of Anti-Ageing Drugs Market @ https://hongchunresearch.com/check-discount/61916

Major Point of TOC:

Chapter One: Anti-Ageing Drugs Market Overview

Chapter Two: Global Anti-Ageing Drugs Market Competition by Manufacturers

Chapter Three: Global Anti-Ageing Drugs Production Market Share by Regions

Chapter Four: Global Anti-Ageing Drugs Consumption by Regions

Chapter Five: Global Anti-Ageing Drugs Production, Revenue, Price Trend by Type

Chapter Six: Global Anti-Ageing Drugs Market Analysis by Applications

Chapter Seven: Company Profiles and Key Figures in Anti-Ageing Drugs Business

Chapter Eight: Anti-Ageing Drugs Manufacturing Cost Analysis

Chapter Nine: Marketing Channel, Distributors and Customers

Chapter Ten: Market Dynamics

Chapter Eleven: Global Anti-Ageing Drugs Market Forecast

Chapter Twelve: Research Findings and Conclusion

Chapter Thirteen: Methodology and Data Source 13.1 Methodology/Research Approach13.1.1 Research Programs/Design13.1.2 Market Size Estimation13.1.3 Market Breakdown and Data Triangulation13.2 Data Source13.2.1 Secondary Sources13.2.2 Primary Sources13.3 Author List13.4 Disclaimer

About HongChun Research:HongChun Research main aim is to assist our clients in order to give a detailed perspective on the current market trends and build long-lasting connections with our clientele. Our studies are designed to provide solid quantitative facts combined with strategic industrial insights that are acquired from proprietary sources and an in-house model.

Contact Details:Jennifer GrayManager Global Sales+ 852 8170 0792[emailprotected]

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Impact Of Covid-19 on Anti-Ageing Drugs Market 2020 Industry Challenges, Business Overview and Forecast Research Study 2026 - The Daily Chronicle

Skin Stem Cells Comments Off on Impact Of Covid-19 on Anti-Ageing Drugs Market 2020 Industry Challenges, Business Overview and Forecast Research Study 2026 – The Daily Chronicle | September 22nd, 2020

Jodie Turner-Smith: Breast Milk Skincare

"Ever since I had my baby, my current beauty secret is that I put breast milk in all of my face serums," Turner-Smith shared with British Vogue. "My skin is very sensitive, so I use a light cleanser, and then I put on a serum with aloe and breast milk that I literally squeeze right into my hands from my boob. I think it's the lactic acid. I've just found that the milk has been revolutionary."

Blanchett refers to this, er, unique treatment as the penis facial (which she says Sandra Bullock introduced her to) but its more officially known as the Hollywood EGF Facial. "The foreskin is collected during circumcision and the stem cells are then harvested and extracted through a centrifuge," Georgia Louise, the facialist behind the treatment toldThe Hollywood Reporter. "I am always very mindful to explain radical serums and potions that I carry in my back bar, so I always explain that EGF is derived from newborn baby foreskin, but cells were taken and from that, new cells are cloned from a laboratory."

Kardashian Wests infamous blood-covered selfie caused quite the stir back in 2013, but it seems she didnt deem the vampire facial (a treatment where your own blood is spun in a centrifuge to extract the plasma within and then re-applied to your face) worth the pain, admitting that the treatment wasnt for her understandable considering her pregnancy meant painkillers were out of the question.

Unique beauty endeavours arent anything new in Paltrows case but this one has to be the most extreme yet. "I've been stung by bees. It's a thousands of years old treatment called apitherapy. People use it to get rid of inflammation and scarring. It's actually pretty incredible if you research it," she told The New York Times.

"I'm using this amazing snail [essence], yes, snail..." Ratajkowski recently revealed via social media. But while it may sound a little freaky, it certainly isnt fruitless snail mucin is a natural source of hyaluronic acid and has the ability to soothe, repair and diminish a variety of skin issues from dryness and breakouts to pigmentation.

The face and the rear end are two areas people generally like to keep pretty separate, but Bullock says the key to fighting crows feet lies in hemorrhoid care. "My favourite beauty pageant secret: I didn't realise that putting hemorrhoid ointment on your face is acceptable in the beauty business," Bullockshared back in her Miss Congeniality days. "But apparently butt cream does help lines around the eyes."

Lopez always looks a million bucks, which is fitting considering how much she invests in her complexion. In fact, its alleged that she spends approximately $1,200 per week on a texture-refining facial treatment that involves the skin-smoothing abilities of human placenta.

It might sound a little more glamorous than Lopezs placenta-centric option but the price tag is also a lot higher; yes, indeed, Kunis shelled out $7,000 for a sole precious stone treatment that uses diamonds and rubies to enhance radiance. We hope her skin was shining just as brightly as the stones after that cash splash.

Moore relies on medical leeches to keep her complexion looking tight, firm and youthful. "I feel like I've always been someone looking for the cutting edge of things that optimise your health and healing," she toldDavid Letterman in 2008. "I was in Austria doing a cleanse and part of the treatment was leech therapy. These aren't just swamp leeches thoughwe are talking about highly trained medical leeches. These are not some low level scavengerswe're talking high level blood suckers."

Beckhams topical treatment of choice? One composed of nightingale droppings. But while experts do claim that the brightening and exfoliating abilities are impressive, were simply not sure we can stomach this one. However, Beckhams perennial glow may just be enough to get us on board...

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The Strangest Beauty Treatments Celebrities Have Tried - Marie Claire

Skin Stem Cells Comments Off on The Strangest Beauty Treatments Celebrities Have Tried – Marie Claire | September 21st, 2020

Global stem cell banking market is set to witness a substantial CAGR of 11.03% in the forecast period of 2019- 2026. The report contains data of the base year 2018 and historic year 2017. The increased market growth can be identified by the increasing procedures of hematopoietic stem cell transplantation (HSCT), emerging technologies for stem cell processing, storage and preservation. Increasing birth rates, awareness of stem cell therapies and higher treatment done viva stem cell technology.

Get Sample Report + All Related Graphs & Charts (with COVID 19 Analysis) @https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-stem-cell-banking-market&pm

Competitive Analysis:

Global stem cell banking market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of inflammatory disease drug delivery market for Global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

Key Market Competitors:

Few of the major competitors currently working in global inflammatory disease drug delivery market are: NSPERITE N.V, Caladrius, ViaCord, CBR Systems, Inc, SMART CELLS PLUS, LifeCell International, Global Cord Blood Corporation, Cryo-Cell International, Inc., StemCyte India Therapeutics Pvt. Ltd, Cordvida, ViaCord, Cryoviva India, Vita34 AG, CryoHoldco, PromoCell GmbH, Celgene Corporation, BIOTIME, Inc., BrainStorm Cell Therapeutics and others

Market Definition:Global Stem Cell Banking Market

Stem cells are cells which have self-renewing abilities and segregation into numerous cell lineages. Stem cells are found in all human beings from an early stage to the end stage. The stem cell banking process includes the storage of stem cells from different sources and they are being used for research and clinical purposes. The goal of stem cell banking is that if any persons tissue is badly damaged the stem cell therapy is the cure for that. Skin transplants, brain cell transplantations are some of the treatments which are cured by stem cell technique.

Cord Stem Cell Banking MarketDevelopment and Acquisitions in 2019

In September 2019, a notable acquisition was witnessed between CBR and Natera. This merger will develop the new chances of growth in the cord stem blood banking by empowering the Nateras Evercord branch for storing and preserving cord blood. The advancement will focus upon research and development of the therapeutic outcomes, biogenetics experiment, and their commercialization among the global pharma and health sector.

Cord Stem Cell Banking MarketScope

Cord Stem Cell Banking Marketis segmented on the basis of countries into U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.

All country based analysis of the cord stem cell banking marketis further analyzed based on maximum granularity into further segmentation. On the basis of storage type, the market is segmented into private banking, public banking. On the basis of product type, the market is bifurcated into cord blood, cord blood & cord tissue. On the basis of services type, the market is segmented into collection & transportation, processing, analysis, storage. On the basis of source, market is bifurcated into umbilical cord blood, bone marrow, peripheral blood stem, menstrual blood. On the basis of indication, the market is fragmented into cerebral palsy, thalassemia, leukemia, diabetes, autism.

Cord stem cell trading is nothing but the banking of the vinculum plasma cell enclosed in the placenta and umbilical muscle of an infant. This ligament plasma comprises the stem blocks which can be employed in the forthcoming time to tackle illnesses such as autoimmune diseases, leukemia, inherited metabolic disorders, and thalassemia and many others.

Market Drivers

Increasing rate of diseases such as cancers, skin diseases and othersPublic awareness associated to the therapeutic prospective of stem cellsGrowing number of hematopoietic stem cell transplantations (HSCTs)Increasing birth rate worldwide

Market Restraint

High operating cost for the therapy is one reason which hinders the marketIntense competition among the stem cell companiesSometimes the changes are made from government such as legal regulations

Key Pointers Covered in the Cord Stem CellBanking MarketIndustry Trends and Forecast to 2026

Market SizeMarket New Sales VolumesMarket Replacement Sales VolumesMarket Installed BaseMarket By BrandsMarket Procedure VolumesMarket Product Price AnalysisMarket Healthcare OutcomesMarket Cost of Care AnalysisMarket Regulatory Framework and ChangesMarket Prices and Reimbursement AnalysisMarket Shares in Different RegionsRecent Developments for Market CompetitorsMarket Upcoming ApplicationsMarket Innovators Study

Key Developments in the Market:

In August, 2019, Bayer bought BlueRock for USD 600 million to become the leader in stem cell therapies. Bayer is paying USD 600 million for getting full control of cell therapy developer BlueRock Therapeutics, promising new medical area to revive its drug development pipeline and evolving engineered cell therapies in the fields of immunology, cardiology and neurology, using a registered induced pluripotent stem cell (iPSC) platform.In August 2018, LifeCell acquired Fetomed Laboratories, a provider of clinical diagnostics services. The acquisition is for enhancement in mother & baby diagnostic services that strongly complements stem cell banking business. This acquisition was funded by the internal accruals which is aimed to be the Indias largest mother & baby preventive healthcare organization.

For More Insights Get FREE Detailed TOC @https://www.databridgemarketresearch.com/toc/?dbmr=global-stem-cell-banking-market&pm

Research objectives

To perceive the most influencing pivoting and hindering forces in Cord Stem Cell Banking Market and its footprint in the international market.Learn about the market policies that are being endorsed by ruling respective organizations.To gain a perceptive survey of the market and have an extensive interpretation of the Cord Stem Cell Banking Market and its materialistic landscape.To understand the structure of Cord Stem Cell Banking Market by identifying its various sub segments.Focuses on the key global Cord Stem Cell Banking Market players, to define, describe and analyze the sales volume, value, market share, market competition landscape, SWOT analysis and development plans in next few years.To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market.To share detailed information about the key factors influencing the growth of the market (growth potential, opportunities, drivers, industry-specific challenges and risks).To project the consumption of Cord Stem Cell Banking Market submarkets, with respect to key regions (along with their respective key countries).To strategically profile the key players and comprehensively analyze their growth strategiesTo analyze the Cord Stem Cell Banking Market with respect to individual growth trends, future prospects, and their contribution to the total market.

Customization of the Report:

All segmentation provided above in this report is represented at country levelAll products covered in the market, product volume and average selling prices will be included as customizable options which may incur no or minimal additional cost (depends on customization)

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An absolute way to forecast what future holds is to comprehend the trend today!Data Bridge set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process.

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Cord Stem Cell Banking Market Analysis 2020 With COVID 19 Impact Analysis| Leading Players, Business Prospects, In-depth Analysis Research Report...

Skin Stem Cells Comments Off on Cord Stem Cell Banking Market Analysis 2020 With COVID 19 Impact Analysis| Leading Players, Business Prospects, In-depth Analysis Research Report… | September 18th, 2020

With September being Sickle Cell Disease Awareness Month, Loma Linda University Childrens Health wants to help educate the community about SCD one of the most common yet overlooked genetic disorders in the world.

Each year, approximately 1,000 babies in the U.S. and 500,000 worldwide are born with the disease, according to the Sickle Cell Disease Association of America.

Akshat Jain, MD, MPH, a global sickle cell disease expert at Childrens Hospital, is passionate about establishing awareness and proper care for children suffering from SCD and Sickle Cell Trait, especially the diverse patient population in San Bernardino County.

There are many barriers to receiving care for those with SCD in our community, Jain says. One barrier specifically is lack of awareness surrounding the disease coupled with lack of awareness surrounding the treatment options available at Childrens Hospital.

In sickle cell disease, a persons red blood cells have an irregular cell shape, Jain says. Instead of round discs, theyre in a crescent or sickle shape.

Due to their shape, texture and inflexibility, the cells become clumped together. This grouping causes a blockage in a childs blood vessels, hindering blood-flow. This blockage may cause varying levels of pain and potentially organ damage long-term.

Jain says some of the signs and symptoms of SCD include:

Jain says that many children with SCD develop symptoms in their first year of life. SCD is commonly diagnosed during newborn screening tests, which check for the abnormal hemoglobin found in SCD. Additionally, if both parents of a child are known carriers of a SCD trait, their child will have a 25% chance of having the disease, Jain says.

Some of the emergent issues needing immediate medical care in kids with SCD disease include:

Treatments for SCD include pain medicines for pain management, adequate hydration, blood transfusions, vaccines and antibiotics, and some medicines. Currently, stem cell transplant from bone marrow is the recognized cure for SCD.

Childrens Hospital, with Jain working as a lead on the team, performed the institutions first stem cell transplant in 2019, curing a then 11-year-old girl who had suffered from SCD since birth. Since then, the team has successfully performed the transplant on several pediatric patients.

Patients with SCD at Childrens Hospital are placed into a treatment and care program where Jain and his team offer non-traditional services such as individualized patient treatment plans and direct access to the care team in case of an emergent event. Additionally, the program is working toward offering curative gene therapy for both sickle cell and hemophilia patients.

The bottom line is children and families suffering from this disease need to know that theyre not alone, Jain says. Here at Childrens Hospital, we are here to manage and fight this disease alongside of you.

Learn more about our treatments for sickle cell disease at our Specialty Team Centers.

See the article here:
Here's what to know about Sickle Cell Disease in kids - Loma Linda University Health

Skin Stem Cells Comments Off on Here’s what to know about Sickle Cell Disease in kids – Loma Linda University Health | September 18th, 2020