Pune, May 27, 2020 (GLOBE NEWSWIRE) -- The global regenerative medicine market size is expected to reach USD 151,949.5 billion by 2026, exhibiting a CAGR of 26.1% during the forecast period. The growing R&D investment by key players for the development of innovative regenerative therapies can be a vital factor enabling the growth of the market during the forecast period, states Fortune Business Insights in a report, titled Regenerative Medicine Market Size, Share and Industry Analysis By Product (Cell Therapy, Gene Therapy, Tissue Engineering, Platelet Rich Plasma), By Application (Orthopaedics, Wound Care, Oncology), By Distribution Channel (Hospitals, Clinics) & Regional Forecast, 2019 2026 the market size stood at USD 23,841.5 Million in 2018. The growing organ transplantation surgeries will spur opportunities for the market during the forecast period.

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Market Driver:

Escalating Cases of Genetic Disorders to Augment Growth

The increasing prevalence of chronic disorders can be an essential factor enabling the growth of the market. Similarly, the growing incidence of genetic disorders will fuel demand for the market. The growing investment in R&D activities by major market players will have a positive impact on the regenerative medicine market growth during the forecast period. For instance, in March 2018, SanBio Group, a leader in regenerative medicine and therapies for neurological disorders announced that it has made a deal with Hitachi Chemical Advanced Therapeutics Solutions, LLC, a cell manufacturing company for the development and manufacturing of innovative regenerative medicines.

Furthermore, the rising cases of neurological disorders will influence the healthy growth of the market. The growing healthcare expenditure in developed and developing countries will boost the market in the forthcoming years. The ongoing clinical trials and robust pipeline products in stem cell andgene therapy will contribute tremendously to the growth of the market. The rising utilization of skin substitutes, grafts, bone matrix, and other tissue-engineered regenerative medicine in orthopedic and neurosurgical applications will augment the growth of the market.

An Overview of the Impact of COVID-19 on this Market:

The emergence of COVID-19 has brought the world to a standstill. We understand that this health crisis has brought an unprecedented impact on businesses across industries. However, this too shall pass. Rising support from governments and several companies can help in the fight against this highly contagious disease. There are some industries that are struggling and some are thriving. Overall, almost every sector is anticipated to be impacted by the pandemic.

We are taking continuous efforts to help your business sustain and grow during COVID-19 pandemics. Based on our experience and expertise, we will offer you an impact analysis of coronavirus outbreak across industries to help you prepare for the future.

To get the short-term and long-term impact of COVID-19 on this Market.

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Regional Analysis:

Development of Novel Therapies to Favor Growth in North America

The market in North America generated a revenue of USD 9,128.2 million in 2018 and is predicted to grow rapidly during the forecast period owing to the presence of major pharmaceutical companies. The growing launch of novel therapeutics and the availability of advanced technologies along with clinical trials will support growth in North America. Asia Pacific is expected to witness a high growth rate during the forecast period owing to the

developing healthcare infrastructure and facilities. The increasing stem cell research in developing countries such as India, Japan China will contribute positively to the growth of the market. For instance, In April 2013, the Japan Ministry of Health, Labor, and Welfare approved Regenerative Medicine law. The growing number of clinical developments of regenerative and cell-based therapies will drive the market in the region. The increasing government initiatives for human embryonic stem cell research and development will further encourage growth in the region. The surge in geriatric patients, the evolving lifestyle of people, and the growing need for novel therapies are factors likely to aid the expansion of the market in Asia Pacific.

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Key Development:

2018: Novartis announced that it has received EUs approval for one-time gene therapy Luxturna, to restore vision in people with rare and genetically-associated retinal disease.

List of the Key Companies Operating in the Regenerative Medicine Market are:

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Induced Pluripotent Stem Cells Market Size, Share and Global Trend By Derived Cell Type (Amniotic cells, Fibroblasts, Keratinocytes, Hepatocytes, Others), By Application (Regenerative medicines, Drug development, Toxicity testing, Reprogramming technology, Academic research, Others), By End-user (Hospitals, Education & research institutes, Biotechnological companies) and Geography Forecast till 2026

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Regenerative Medicine Market to Exhibit a CAGR of 26.1% by 2026; Rising Prevalence of Genetic Disorders to Fuel Demand, states Fortune Business...

Skin Stem Cells Comments Off on Regenerative Medicine Market to Exhibit a CAGR of 26.1% by 2026; Rising Prevalence of Genetic Disorders to Fuel Demand, states Fortune Business… | May 27th, 2020

The Faculty of Health and Medical Sciences at the University of Copenhagen recently discovered how a particular protein, Phosphoprotein phosphatase 2A (PP2A), inhibits tumor development in mice.

Proteins are complex molecules in cells that are necessary for the function, structure, and regulation of the body's organs and tissues. Proteins have five primary functions: antibodies, enzymes, messengers, structural components, and transport or storage of atoms or small molecules.

Professor Jakob Nilsson, from the Novo Nordisk Foundation Center for Protein Research, explained that PP2A is called a household protein as it can be commonly found in most places. Everything that lives with simple cells or complex cells contain PP2A.

The PP2A Protein is also being studied by pharmaceutical companies as it is known to show unique patterns of kinase opposition, or simply, it is a tumor suppressor. Protein kinases are enzymes that induce change, switching active proteins into an inactive form.

While there is still insufficient research on which specific types of proteins PP2A regulates to prevent cancer, results from the new data do gain more insight.

Other tumor suppressor proteins include the retinoblastoma protein (pRb) and the p53 gene. Both regulate the cycling behavior of cells in a process called cell proliferation and growth are known as cell cycle progression.

Rb has a vital part in regulation G1/S transition, which is the 'start' checkpoint which controls the production of starter kinase proteins. What follows is Rb's 'role in the functioning of normal andcancer stem cells,' as well as its effect on the 'energy metabolism of cancer cells.'

According to a study called Nanostructures for Cancer Therapy, P53 is a protein that can 'respond to hypoxia, DNA damage, and loss of normal cell contacts when activated,' as it mediates the growth and death of cells.

The same study notes, 'targeting p53-MDM2 interaction would be attractive in cancer therapy.'

Read Also: Metformin, a Drug for Diabetes, is Investigated for Cancer-Causing Contaminant

Associate Professor Marie Kveiborg from the Biotech Research and Innovation Centre notes that what is new about their study is that they can show how the specific PP2AB56 'selects the phosphate groups that shall be removed from other proteins,' while it turns off the enzyme ADAM17. ADAM17 being switched off resulted in 'inhibition of tumor growth in mice.'

A disintegrin and metalloprotease domain 17 (ADAM17) is a protein-coding gene associated with diseases including inflammatory skin (psoriasis), inflammatory bowel disease (Crohn's disease), and breast cancer. The test mice were all injected with three variations of ADAM17 cells.

On the day of injection, '4T1 A17wt, I762A, and LEE cells,' all ADAM17 variants, were given and the scientists monitored tumor growth through time.

When they began observing how PP2A-B56 interacted with ADAM17, 'none of the mice injected with ADAM17 LEE cells reached tumor endpoint criteria, as opposed to ADAM17 wt or I762A injected mice, which exhibited only 50% survival by the end of the experiment.'

The newly discovered data on cancer research will hopefully develop into studies with human tumors, expressed by the researchers. The scientists concluded, 'the B56 inhibitor displays excellent specificity toward the PP2AB56 holoenzyme family.' As a result, scientists also want to make additional research to determine if PP2A also can regulate other proteins with its tumor suppressor function.

Read Also:Will COVID-19 End Scientific Breakthroughs?

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BREAKTHROUGH! Scientists Discover Particular Protein that Could Block Cancer Growth - Science Times

Skin Stem Cells Comments Off on BREAKTHROUGH! Scientists Discover Particular Protein that Could Block Cancer Growth – Science Times | May 27th, 2020

By Matthew Tontonoz Tuesday, May 26, 2020

Starving skin cancer tumors of serine increases cancer stem cell differentiation in mice. In this image, skin stem cells undergoing differentiation are magenta and those remaining as stem cells are green.

Summary

A team of scientists at the Sloan Kettering Institute and The Rockefeller University has discovered that cancer stem cells rely on a steady external supply of the amino acid serine. This dependency makes them vulnerable to restrictions on this supply, a discovery that could potentially be exploited therapeutically.

In recent years, cancer biologists have come to understand that metabolism the way that cells acquire and use nutrients can directly affect their tendency to become cancerous.

SKI cell biologist Lydia Finley and colleagues in the Elaine Fuchs lab at The Rockefeller University have now deepened knowledge of this relationship in the context of squamous cell carcinoma, a cancer that arises from stem cells in the skin. Using mouse models and cells growing in tissue culture, they found that the amount of the amino acid serine present in a stem cells environment influences its decision to keep dividing or to grow up (differentiate). Differentiated cells generally do not form cancer.

The stem cells that give rise to squamous cell carcinoma seem to be highly dependent on extracellular serine for their growth, Dr. Finley says. Trying to starve these cells of this source of serine could be a strategy to try to curb their growth by forcing them to differentiate.

A normal stem cell will respond to a shortage of extracellular serine by synthesizing more. Atthe same time, they will begin differentiating: The biochemical pathways involved with serine synthesis interact with proteins called histones that wrap DNA like a spool of thread and allow specific genes to be turned on. Stem cells with cancer-predisposing mutations, on the other hand, seem intent onavoiding new serine synthesis.

Cancer stem cells heightened reliance on extracellular serine reflects what Dr. Finley calls metabolic rewiring: By relying on extracellular serine, the cancer stem cells can avoid serine synthesis, with the happy side effect (for the cancer cell) that the path toward differentiation is blocked.

Our findings link the nutrients that a skin stem cell consumes to their identity and their ability to initiate a tumor, says Sanjeethan Baksh, a Tri-Institutional MD/PhD student in the Fuchs lab and the papers first author. Not only do nutrients allow stem cells and cancer cells to grow, but our study also shows that metabolism directly regulates gene expression programs important for cancer stem cell identity.

Although restricting serine in the diet is not feasible in humans, the team is currently looking for ways that they might be able to interfere with cancer stem cells ability to take up serine in the hope of curbing cancer growth.

The findings were reported on May 25 in the journal Nature Cell Biology.

This study received financial support from the Howard Hughes Medical Institute, the National Institutes of Health (grants R01-AR31737, F31CA236465, F30CA236239-01, and 1F32AR073105), the Human Frontiers Science Program, the European Molecular Biology Organization, NYSTEM (CO29559), The Starr Foundation, the Damon Runyon Cancer Research Foundation, the Concern Foundation, the Anna Fuller Fund, The Edward Mallinckrodt, Jr. Foundation, and the Memorial Sloan Kettering Cancer Center Support Grant P30 CA008748. The study authors declare no competing interests.

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Cancer Stem Cells Reliance on a Key Amino Acid Could Be an Exploitable Weakness - On Cancer - Memorial Sloan Kettering

Skin Stem Cells Comments Off on Cancer Stem Cells Reliance on a Key Amino Acid Could Be an Exploitable Weakness – On Cancer – Memorial Sloan Kettering | May 26th, 2020

Science has fascinated Ainissa Ramirez ever since she watched her very first episode of the PBS kids science show 3-2-1 Contact. It changed the way she looked at the world and put her on a career path.

Today Ramirez is a materials scientist. Shes done research at Bell Labs and has taught at Yale and MIT. Shes also on a quest to transform our understanding of inventions: how they came to be and how they've changed our lives. In her new book, The Alchemy of Us, she writes, In order to create the finest version of ourselves we need to think critically about the tools that surround us.

WSHUs Morning Edition Host Tom Kuser recently spoke to Ainissa Ramirez. Below is a transcript of their conversation.

I understand you were inspired to write this book after a particularly challenging glass blowing class.What happened during that class?

Well theres a wonderful studio not far from me, in Branford. I live in New Haven, and I wanted to take some glass blowing classes, just on my bucket list. It was fun but I was also very scared. Usually I would take a small amount of glass and make a small vase.

But one day I came in in a very bad mood and actually took a lot of glass on the end of my pipe. As I was making this piece, all I had to do was one last step.But I wasnt really paying attention because I was talking to a friend.And the glass piece fell on the floor.My instructor came by and he fixed it, he reattached it to my pipe.And we were able to put it back together, although it now had a flattened side.

But as it was cooling and as I was calming down, I thought a little bit about what had happened. I was shaping the glass but the glass was actually shaping me.I came to the class in a bad mood and I was leaving in a better mood.It might feel a little existential, but I just said, I wonder how materials and humans have been shaping each other over the eons.So thats what compelled me to write my book, The Alchemy of Us.

Its clear in reading your book that this is not a dry scientific tome.You tell some very compelling stories about fascinating characters who played very significant roles in innovations that changed and are still changing our culture for better and for worse.

The eight chapters highlightspecific innovations. The chapter called CONVEY explores the development of the telegraph.SEE is all about the invention of artificial light and in CAPTURE, you focus on photography.With so many inventions over the millennia, how did you focus on just eight?

[Laugh] Yeah.It could have been much, much longer. In the architecture of the book, I was looking for stories and they had to show how humans changed.And as you mentioned the chapters are given titles that are verbs. So when I was hunting for various stories, I found eight very compelling stories to do that.There are other materials that I could have focused on but these seem to sing the loudest.So thats how I selected it.Each material had to show how it impacted culture by changing the human experience.

In your first chapter INTERACT, you take on time itself through clocks and how they now control our sleep.How did that happen?

INTERACT is one of my favorite chapters because it starts off with a woman who sold time.

Yes. I never heard that story before and I found it fascinating.

In the 19th century, when we became more and more obsessed with time, someone actually had a job where they would walk around with a watch that was certified from the Royal Observatory and show it to different businesses.Now before Ruth Bellville had her business, people slept differently.We used to sleep in two different segments.We would go to bed at 9:00. Go to sleep for about 3 1/2 hours, wake up for about an hour, do something around the house, read, talk to our neighbors who were also up, and then go back to sleep for another 3 1/2 hours.

These segments were called first and second sleep, and everyone slept that way. And if you read old books, youll see words like first sleep and second sleep and thats what they mean. As we became more obsessed with time, we had to wake up earlier so one of those segments got truncated and also with the development of electrical lights the first segment got truncated and they consolidated and that type of sleep is how we sleep today.

And that, you point out, has an impact on health.

Oh absolutely.A lot of people say they have a form of insomnia, and historians actually think its harkening back to this old way of sleeping. And also in terms of our health, the artificial light also seems to be also impacting our health because our bodies actually have two modes.We have a daytime mode and a nighttime mode.

How the body knows which mode to be in is based on blue light.Now when our ancestors were alive they lived by sunlight, which has a lot of blue in it, and candlelight which has less. But we live under artificial lights all the time.And when we're in daytime mode our bodies are actually in growth mode and thats actually impacting us because our cells will respond to that growth mode in ways that we dont necessarily want.

You bring up the chapter about the electric light or artificial light, and of course you include Thomas Edison in the chapter which is called SEE. But it seems that your protagonist, I guess I can call him that, is really an inventor named William Wallace of Ansonia, Connecticut.Why is he a player in this story?

Well, I really loved William Wallace because if you read books about Edison, very thick books, youll always see William Wallace as a footnote. And I said, Who is this guy? I found out that Edison actually came to Ansonia and he met William Wallace.Wallace had created an early version of the electric light, it was an arc light so it was very, very bright, it was like a searchlight, so it wasnt really useful for the home, but Edison saw this and said, Hey, I think Ill start working on electric lights.And then he went back to Menlo Park in New Jersey and created his incandescent bulb. But he wouldnt have had that idea if he didnt come to Connecticut. And most people in Connecticut dont know this. That Edison came up here. So thats why I highlighted William Wallace. I wanted this little known inventor to get his moment in the sun.

You mention the day Thomas Edison came to meet Wallace in Ansonia was really the beginning of a period of darkness for Wallace because he was cut out of the invention process from beyond that time.

That is absolutely right.Wallace thought his moment had come.The great Wizard of Menlo Park came to visit him to see what he had created.And Wallace had created not only this fantastic light, he created a special generator which transmitted the water power from the Naugatuck River into electricity because there wasnt any electricity in the homes yet. And so Edison said well I want one of these electrical systems.He brought it back to his place in Menlo Park and he cut Wallace out of the deal.He just bought the units from Wallace and never included Wallace in his inventions moving forward.

You also talk about the things that weve lost along with what we gained through these innovations. For example with the light bulb, we lost darkness.Tell us about that down side.

Well our ancestors used to look and see thousands of stars.Now if you and I look up, well see about fifty. Recently I went on a trip and I went to a place that was very, very dark.And the starred sky is amazing.You feel very small and you feel connected to nature.So I do talk about how that has happened.As a result of having all these lights, this abundance of lights, it really disconnects us from really seeing how beautiful the night sky is.

And one of the illustrations you use, when talking about the effect on the environment is the life cycle of the lighting bug or the firefly.

Yeah, well on the East Coast were very lucky.We have this wonderful bug, the lightning bug or firefly. But it ends up on the West Coast the fireflies dont make it that far. And the number of fireflies has been decreasing and the reason is because of the lights. Fireflies speak to each other through a Morse code of flashes but its really important that they see each other in a dark sky. They can see each other, connect, and make future fireflies.But when theres a street light overhead, the female firefly doesnt know to flash back to the male firefly so they dont meet. So thats why their numbers are decreasing.Even though artificial lights are convenient for us, for humans, theyre really making things difficult for fireflies.

Since you mentioned the Morse Code that the fireflies use,Id like to jump over to CONVEY, the third chapter in the book about telegraph wires and the invention of the telegraph with Samuel B. Morse.You connect Morse with a number of things in culture that have changed over the years, including the way we write and also, a lack of personal social interaction due to things like texting and emails.Could you connect those dots for us?

Sure.When Morse was first making his telegraph he would work with his assistant (Alfred Vail). And he would chide him and say, condense your language, which was harsh language back in those days.And what he was trying to tell Vail is to not write so much when sending a message.

What Vail would do or what Morse would do, is they would write their letters by longhand and then convertall the letters in the alphabet in the word to dots and dashes, and type in those dots and dashes, figure out what those dots and dashes mean and then write out the word. That took a lot of time.

And so Morse would get a message from Vail and it would be dash, four dots and another dot and youd convert it and youd seek the word the. Thats a lot of work for a word that doesnt do very much.So he was telling Vail to shorten what youre saying in the message that youre transmitting.

It ends up that telegraphs become very popular in society and telegraph officers would tell customers to be brief because the telegraph was great at sending information long distances but it couldnt handle a lot of messages. And so the officers wanted customers to just send very short messages so they could keep it available for the next set of customers.

Telegraphs became popular in newsrooms and editors would tell their reporters to be succinct, again one of the limitation of their prose was because of the telegraph. Now there was one reporter that really loved this style of writing with short declarative sentences. His name was Earnest Hemingway.So the way that he writes is a style that was designed by the use of the telegraph. So this is how one technology, this technology of the telegraph has changed language.

Now the other thing that you mention is about how the telegraph has squeezed out the human part. Morse use to write very, very long letters and used wonderful prose that described everything around him. But when you use the telegraph, you dont have that luxury.

And so the progeny of the telegraph is text messages.

And again when we as humans communicate, we use a lot of different ways of getting a message across besides words.We can look at body language, we can look at peoples eyes.And as a result of communicating in this one-dimensional way, what historians, linguists and scholars are concerned with is that were reducing our ability to empathize.

So thats one of the things that I also point to in The Alchemy of Us, is that this technology is useful in getting information across but its deteriorating our ability to be human with each other, that is to empathize and relate to one another.

Your chapter about photography, called CAPTURE explores several stories and several dimensions of how photography affected culture in the years following its invention and development.One Id like to talk about, you explaining how the development of film actually contributed to the stereotyping of African Americans. Can you please connect those dots for us.

Well it ends up that the most photographed person in the world at one point was Frederick Douglass.Not Lincoln, not Twain. Frederick Douglass. Now why was he so crazy about getting selfies of himself? Well he was trying to use his image as a way to combat the negative stereotypes about African Americans. here were a lot of characters that were hand-drawn and they would show people with exaggerated expressions, with eyes that were white and were bugging out and wide smiles.And if youve ever seen a photograph of Frederick Douglass he looks so regal, hes a handsome looking guy he wanted to combat that image.And so thats the reason why every time he went by a portraiture place for pictures, he would go in to take his pictures because those pictures would also be sold.And so he wanted to use this as a way to combat that stereotype.

Maybe you could talk a bit more about the technical issue that resulted in film really all the way into the later part of the 20th century resulting in film that did not expose correctly darker skin.

Ok thats a very good question.In the 1950s, 1960s, African American mothers were looking at class photos of their children and they saw something that didnt look right. The black children did not come out as well as the white children.And African American mothers they asked manufactures of film to fix this. What they had seen is that actually there was a bias in the film. The film was tailormade or was optimized for people with lighter skin because the main customer were people of lighter complexion.Initially camera film was egalitarian because it was homemade chemistry that you could do in your kitchen. Whoever took a picture, their likeness would be depicted.But as it became manufactured by companies, they tailored the process so that it was optimized for a certain population.And this is what these African American mothers saw in the 1950s.

And so after some chiding, not from these African American mothers, even though they wrote letters. It was only when two businesses, furniture manufacturers and confectioners that made chocolate, when they told this manufacturer that they had to change their film, that changes happened.

Because they wanted their chocolates of different flavors, you know, white chocolate, milk chocolate, dark chocolate.They wanted people to be able to discern those different types of chocolate and in the current form of the film.That wasnt happening. So eventually the formulation was changed so that the film was democratic and could pick up different hues of chocolate as well as different hues of skin.

And I cant let you go without asking for your perspective on the COVID-19 pandemic.Im wondering if theres an innovation from our past that might have created this unfortunate situation?

I dont know if theres an innovation in our past.Weve benefited from not having pandemics because weve got tremendous medicines.And weve got new technologies that can do things that couldnt happen as quickly in the past.We can trace. We can test.So weve got things to combat it a little bit better. Were not actually using them as well as we could, but technologies can definitely help.

From your vantage point as a scientist and a science communicator, how do you see this pandemictransforming perhaps science and our culture looking forward?

This pandemic is also because people feel disconnected from science.I think if people were a little bit more informed about how things work, they would adhere, they would comply a little bit more.Because weve had a little bit of a breakdown with how we teach science, STEM in particular, we dont see how were part of a global system, that what you do affects me.As scientists we forgot to teach that and so as a result, people dont see that their actions actually have some ripple effect outward.

So thats kind of what I see as the impact.And I hope that going forward science, science communicators and also society in general will just realize that theres an ecology, that what you do affects other people although you may not be able to see them.

My ignorance is showing here now.You are a materials scientist.Can you explain just what that is?

I tell people Im an atom whisperer. Materials science sits where chemistry and physics overlap. So chemistry is interested in how things bond and physicists are interested in how materials behave in different situations and I want to show how one thing is linked to the other.So that is what materials science is. Its not very well-known but a lot of the things you take for granted like the cell phone and the fact that this phone call being made by microphone, thats all materials science.

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'The Alchemy Of Us' Examines Inventions And How They've Shaped Human Life - WSHU

Skin Stem Cells Comments Off on ‘The Alchemy Of Us’ Examines Inventions And How They’ve Shaped Human Life – WSHU | May 26th, 2020

New York City, United States The change during the COVID-19 pandemic has overhauled our dependence on pattern setting developments, for instance, expanded reality, computer generated reality, and the Healthcare web of things. The unfulfilled cash related targets are persuading the relationship to grasp robotization and forefront advancements to stay ahead in the market competition. Associations are utilizing this open entryway by recognizing step by step operational needs and showing robotization in it to make an automated structure as far as might be feasible

Medical skin care products are used for beautifying or to address some other skin care problems. The cosmetic industry is booming and skin care forms a very huge part of this industry. The aesthetic appearance is so important that people spend a lot on skin care products and treatment. People being more technologically aware of the various new skin care products trending in the market. In addition to the aesthetic application, the medical skin care products are also used to address issues such as acne, pimples or scars.

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Medical Skin Care Products Market: Drivers and Restraints

The medical skin care products is primarily driven by the need of natural based active ingredients products which are now trending in the market. Consumers demand medical skin care products which favor health and environment. Moreover, the consumers are updated with the trends so that various companies end up providing such products to satisfy the customers. For instance, a single product face mask has thousands of different variants. This offers consumers different options to select the product depending on the skin type. Moreover, the market players catering to the medical skin care products are offering products with advanced technologies. For instance, Santinov launched the CICABEL mask using stem cell material based on advanced technologies. The stem cells used in the skin care product helps to to protect and activate the cells and promote the proliferation of skin epidermal cells and the anagenesis of skin fibrosis.

Medical Skin Care Products Market: Segmentation

On the basis of product type the medical skin care products market can be segmented as:

On the basis of application, the medical skin care products market can be segment as:

On the basis of distribution channel, the medical skin care products market can be segment as:

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Medical Skin Care Products Market: Overview

Medical skin care products are used to address basic skin problems ranging from acne to scars. There are various advancements in the ingredients used to offer skin care products to the consumers. For instance, the use of hyaluronic acid and retinoids is the latest development in the industry. The anti-aging creams are at the forefront as the help treating issues such as wrinkles, scars, acne, and sun damage. Another, product in demand is the probiotic skincare which include lactobacillus and bifidobacterium.

Medical Skin Care Products Market: Region-wise Outlook

In terms of geography, medical skin care products market has been divided into five regions including North- America, Asia- Pacific, Middle-East & Africa, Latin America and Europe. North America dominated the global medical skin care products market as international players are acquiring domestic companies to make their hold strong in the U.S. LOral is accelerating its U.S. market by signing a definitive agreement with Valeant Pharmaceuticals International Inc. to acquire CeraVe, AcneFree and Ambi skin-care brands for US$ 1.3 billion. The acquisition is expected LOreal to get hold of the brands in the price-accessible segment. Asia Pacific is expected to be the fastest growing region owing to the increasing disposable income and rising awareness towards the skin care products.

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Medical Skin Care Products Market: Key Market Participants

Some of the medical skin care products market participants are ,

Report Highlights:

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Advancements in Medical Skin Care Products Market to boost Revenues Through COVID-19 Crisis Phase and Forecast 2017 2025 - WaterCloud News

Skin Stem Cells Comments Off on Advancements in Medical Skin Care Products Market to boost Revenues Through COVID-19 Crisis Phase and Forecast 2017 2025 – WaterCloud News | May 25th, 2020

The health focus today is squarely on the bodys natural defense system. Until there is a vaccination, preventative measures are all we can turn to. Ayurveda can help, experts believe, especially a technique thats been gaining popularity. It's called Photo Bio Modulation (PBM). Availableat Indus Valley AyurvedicCentre (IVAC) in Mysore, itsan emerging medical practicein which exposure to low-level laser light or light-emitting diodes stimulates cellular function. This results in beneficial clinical outcomes for various conditions and diseases, primarily low immunity, in addition to lung disorders, respiratory disorders, joint problems, skin issues, and stress.

How does it work?Also known as Low-Level Laser Therapy (LLLT), it increases the production of Adenosine Triphosphate (ATP) in the mitochondria of the cells, which scavenges the free radicals. By doing so, it stimulates stem cell proliferation, lymph nodes associated with respiratory tract, the immune system and stimulates local tissues to support lung function leading to protection from asthma, bronchitis, pneumonia and Chronic Obstructive Pulmonary Disease, says Dr Talavane Krishna, Founder,President, IVAC.

Nasal ApplicationWhile PBM is gaining prominence now, processes such as nasal application, part of Panchakarma (five actions) treatment, have been a standard Ayurvedic antidote to viruses for aeons. One has to apply different herbal powders, liquid extracts, medicated ghee or oil inside the nostrils. Medications like Anu Taila, sesame or coconut oil, Brahmi ghrutha etc are antimicrobial and act as a protective filter inside the nose and throatthe primary entry point for the viruses. This simple procedure could be a daily practice for both adults and children.

Oil pulling Likewise, oil pulling with sesame or coconut oil as a daily oral health practice is useful. It involves swishing a teaspoon of oil in the mouth for three-five minutes and then spitting the oil, followed by washing/brushing the mouth. This kills bacteria that may lead to tooth decay, bad breath, and gum disease.

Rasayana This is one of the eight major branches of Ayurveda. Popularly known as a form of rejuvenation therapy, not only does it focus on anti-aging, but also immunity. This is accomplished by taking certain Ayurvedic preparations, food based on body constitution, and following an Ayurvedic way of life. This increases Ojas, the very essence of the bodys immunity. Medicines include single herbs like Ashwagandha, Shatavari, Amrita, and formulations like Chyavanaprash, Triphala, Makaradhwaja, notto mention regular body-mind detoxifications like Panchakarma and Rejuvenation.

Balance is keyKeeping the body alignedwith its natural rhythms is a prerequisite to the success of your health. For this, Ayurvedic principles namely Dhincharya (daily regime) and Rithucharya (seasonal regime) are crucial. Dhinacharya looks at aspects such as oral hygiene, yoga, pranayama, meditation, diet, bowel movements and more. Ritucharya describes the various changes in our body during the different seasonsand its effect on health. Italso teaches us how to keepa good balance.

The importance of dietcannot be negated, therefore ensure you add ginger, garlic, pepper, turmeric, clove, cumin, fenugreek and cinnamon in your food as all these ingredients build the immunesystem and bring aboutperfect balance, says Gita Ramesh, Joint MD, Kairali Ayurvedic Group.Dont forget to take warm showers and apply sesame oil on the entire body before the morning bath. Allow nostrils to be lubricated by application of cow ghee or oil, and do warm turmeric water gargles regularly, says Dr Aruna Bhide, Senior Ayurveda Doctor and Consultant, Mercure Goa Devaaya Retreat. Breathing exerciseslike Anulom vilom pranayama (alternate breathing), Kapal bhati (forceful exhalation) and Nadi shuddhi pranayama are beneficial too. Keep in mind to exercise until you sweat as this is the best way to excrete toxins.

Potions for healing(Do consult an Ayurvedic doctor)

Indukantha Kashyam Prevents the recurrence of debilitating diseases and keeps the body healthyVilwadi GulikaA tablet used as a treatment for insect bites, rodent bites, gastroenteritis etc.

Chyawanprash High in Vitamin C, it aids in the production of haemoglobinand white blood cells

Kushmandarasayana Comes in a herbal jam form and is used in respiratory conditions

TriphalaGhritam Support bowel health and aids digestion. As an antioxidant, its also thought to detoxify the body and support immunity.

AshwagandhaIt has demonstrated excellent immune-boosting effects, and has also shown to encourage anti-inflammatory and disease-fighting immune cells, thatkeep illnesses at bay

Amrita Used as a blood purifierMakaradhwaja A mineral-based preparation used for its aphrodisiac characteristics, it enhances the effectiveness of several medicines

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COVID-19: The Prevention Prescription - The New Indian Express

Skin Stem Cells Comments Off on COVID-19: The Prevention Prescription – The New Indian Express | May 24th, 2020

New research has identified two actives that can prevent stem cell decline as we age and increase collagen 17 levels in cells. It was published in Nature last year and has just been covered in Scientific American. The study was described as elegant by a prominent dermatologist, not involved in the project. As I am always on the look out for next big thing in antiaging skincare, I pounced.

Ill cut straight to the car chase. The two actives are Y27632 and apocynin and I was curious to see if they could be tracked down outside of a lab and, perhaps, in our potions and lotions. The first is a chemical that I havent been able to track down. Happily, I had better luck with apocynin.

Apocynin has been identified in a specific strain of cannabis, but also in cloudberry. And rubus chamaemorus (AKA cloudberry) seed oil is in a facial oil by Keracell. Ill post a link at the end of this article.

So, how do Y27632 and apocynin work? Emi Nishimura, a professor of stem cell biology at Tokyo Medical and Dental University in Japan, revealed that aging and UV exposure deplete stem cells of a crucial collagen protein. Heres what happens.

As part of normal skin health, the top layer of the epidermis is constantly being sloughed off and replaced from a self-replenishing pool of stem cells in the basal layer. These stem cells have roots that anchor them to a thin piece of tissue called the basement membrane that connects the epidermis and the dermis. Only when tethered can they replicate and mature into another type of cell.

This is where collagen 17 comes in. This collagen protein does the tethering (see the "adhesive molecule" in the illustration above), rooting the stem cell to the basement membrane. As stem cells become damaged, they lose precious amounts of collagen 17. The more protein they lose, the weaker their bond to the basement membrane, until eventually they are forced out by neighboring healthy cells.

Thats why this study is potentially a breakthrough. It has identified the process, the key protein that needs to be replenished and the chemicals that might just be able to do that.

You can find rubus chamaemorus (AKA cloudberry) seed oil and a potential source of apocynin in KERACELL Liquid Gold Enriching Elixir ($160 in the shop).

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New research could be a breakthough in collagen and stem cell research - Truth In Aging

Skin Stem Cells Comments Off on New research could be a breakthough in collagen and stem cell research – Truth In Aging | May 23rd, 2020

Are you hallucinating or are you seeing the same face everywhere? You know the one. Highly sculpted. Quasi-"exotic." Suggestively cyborgian with equidistant almond eyes, '90s-supermodel high cheekbones and a poufy cupid pout. Dubbed "Instagram Face" in a New Yorker article by writer Jia Tolentino, it's an exactingly symmetrical look facilitated over the last decade by high-tech advancements in digital facial-tuning filters and injectable facial fillers, aka tweakments, aka the minimally invasive cosmetic procedures that have made Botox and Juvderm household names. Filters and fillers.

Though this chiseled face devoid of smiles, frowns, furrowed brows of worry or concentration and wrinkles is primarily found on women, it was, in many ways, a face forged by men. As of 2018, 85% percent of board-certified plastic surgeons in the US were male, while 92% of their patients were female. Meanwhile, Facebook, which owns Instagram, home to some of the most popular filters behind these trends, has a tech workforce that was, as of 2019, 77% male.

Historically, this "Oz behind the curtain" dynamic when it comes to "ideal femininity" is not new. From 1950s advertising executives brainstorming buxom, button-nosed visions of domesticity to 1980s filmmakers placing a prepubescent Brooke Shields in The Blue Lagoon's thinly veiled mainstream erotica, men in positions of power have consistently manufactured the American beauty construct.

And, like any functioning ideology, that construct has mutated to mirror its moment. The face of the 2010s indeed, the supposedly ideal face at the core of the beauty paradigm for eons has often relied on an essential recipe that Dr. Andrew Jacono, a prominent New York plastic surgeon and author of 2019's bestseller The Park Avenue Face, likens to the perfectly balanced proportions reflected in the wings of a butterfly or the gothic cathedrals of France. But remember in the early '90s when we sea-changed seemingly overnight from the flawless buoyancy of Cindy Crawford to the fucked-up teeth and waifish "heroin chic" of Kate Moss? Apart from the golden ratio, there is another beauty truth we could probably all agree upon: The trend pendulum eventually swings. Does that mean that we're in for a face envisioned by women? And, if so, what would that face look like? Could we imagine it might appear not less but more emotive?

In sharp contrast to the tacit perfectionism of filter/ filler plasticity, Doniella Davy, the makeup artist for HBO's aesthetic bombshell Euphoria, said in an interview with Allure that she, herself, leaves the house every day in a different color of glitter or eyeliner because she's presenting herself to the world in a way that feels authentic. "I don't need anyone's approval," she put it. Similarly, rather than using makeup to convey a character's stereotypical core identity in keeping with traditional Hollywood sets, Davy applies a Technicolor palette to the show's stars as a way to signal their changing and changeable emotional states. It's a vibe makeup artists like Pat McGrath, who rhinestoned eyebrows and gilded undereyes for Marc Jacobs' Spring 2020 New York Fashion Week show not to mention drag queens and the LGBTQIA communities have been experimenting with since the dawn of time. Lady Gaga and Lizzo clearly got the memo. But the crayon box sensibility does seem to hold a new grip on our collective cultural imagination. According to Google Trends, the search term "glitter eye" spiked in September in the wake of NYFW Spring 2020, then again in February on the night of the Oscars, when Janelle Monae showed up in a hooded dress dripping with thousands of crystals part Little Red Riding Hood, part disco ball matched by glittery silver eyeliner and cherry red lips.

One potentially telling facet of these new trends' appeal is the fact that they leave much more room for experimentation and customization. Because if beauty is based not just on symmetry but also on value and rarity, and if a glut of influencers have all bought the same injectable features and nearly anyone can go out and mimic them by following one of thousands of rote YouTube tutorials with a highlighter stick and some concealer, does that face even look special anymore? What, then, will we all be fixating on in the decade ahead? Look a little closer at Euphoria. There is a common denominator: Across moods and characters, the skin beneath operates like a clean canvas. It looks raw, fresh, tween. And its desirability isn't limited to the show, to 20-somethings or to Hollywood. It's already attracted a cultish, worldwide following.

The Korean beauty world calls it "glass skin." The basic properties are pristine porelessness and crystalline clarity. We can supposedly achieve glass skin by slathering ourselves daily with several kinds of moisturizers, toners, hydrophilics and exfoliants following a bajillion-step K-beauty routine. Or, in certain states where it is legal, we could have semi-permanent BB Glow pigment microneedled into our skin. But one downside to tattooing fake skin into actual skin is that BB Glow needling is not FDA approved and runs the risk of severe allergic reaction, among other untested, uncharted waters. Artificial intelligence could help. As though to underscore our oncoming skin-tone mania, at CES, the tech expo in Las Vegas this January, the two main beauty attractions were Procter & Gamble's Opt wand and L'Oral's Perso, both AI gadgets that purport to scan and analyze skin in order to optimize the camouflaging of spots, sunspots and hyperpigmentation over time.

Plastic surgeons, whose procedures, injections and treatments have proffered permanent (or semi-permanent) versions of the contouring and highlighting that ruled the 2010s, are also thinking about how this pendulum shift could affect their practices. "When times are harder and people have to work harder, more chiseled, masculine features become more desirable. Because of this, in the last decade, you saw a lot of chiseled features come into play," Dr. Simon Ourian, a cosmetic dermatologist, tells me, in the glitzy waiting room of his Rodeo Drive enclave, Epione, an aesthetic surgery center in Beverly Hills. Referring to the economic challenges of the Great Recession and its recovery over the last decade, he goes on to say, "Women who were trying to show their strength and independence came to fruition by showing very strong features." But, he adds, for centuries, when the economy is strong, as it seems to be now, society has appreciated a softer, "more feminine look."

Ourian invented the Coolaser, a cosmetic dermatology office mainstay that evens skin tone. He is also the A-list's go-to expert in Hollywood, counting among his openly vocal celebrity clients Miley Cyrus, Iggy Azalea, Lady Gaga and the entire Jenner-Kardashian clan, including Kylie and Kim.

We talk about what, specifically, that new softer look might be led by, now that the chiseled cheekbones, chins and jawlines Ourian pioneered have become a worldwide phenomenon. Given his inside line, I'm hoping he'll share what the starlet subset is starting to request that they weren't requesting a year ago. He defers, not wanting to dictate trends from his "little office in Beverly Hills," but he admits he derives all of his trend intel from Facebook and Instagram, casually mentioning, on the subject of the platforms' instantaneity, the summer boob job. "Temporary breast augmentation started a few years ago because now we can inject fillers into the breasts and they go away after a few months," he explains. "So if you don't want to commit the rest of your life to being one or two sizes bigger, you can try it for a summer and fit better into your bathing suit." (And, judging by the rash of articles about the surge of temporary, non-invasive "Botox brow lifts" among the same cohort of stars and influencers who personify "Instagram Face," it's not just lips and breasts that are getting these temporary enhancements.)

And does this mean a person could theoretically "try on" Ourian's signature cheekbones too? Will party prep soon include the prosthetic cheekbones that paraded down Balenciaga's controversial Spring 2020 runway? According to Ourian, yes. "You can do the same thing with your face," he says. "You can get a filler in your face that lasts a month or two and if you don't like it, it goes away ... It's like trying something on in a dressing room. That appeals to the concept of the Instagram generation who want to change a filter and see how they look."

Whatever strange, weird extremes the fashion world might pursue, however, Ourian maintains that neither of those two adjectives should be confused with beauty. "One definition of beauty has been average," he notes. "You take a thousand people in a society and you superimpose that face. The average of those faces is what's considered to be beautiful by the people of that society, because they are not very strange." But one thing, he admits, has changed: "Now that instead of seeing a thousand people, our eyes are used to seeing millions of people because of the internet, our average has expanded."

In keeping with our ocular intake's exponential widening, Ourian concedes that the spectrum for what could be considered beautiful has expanded. Noses, he says, are no longer really a thing. "Ten years ago if you showed someone with a larger behind or a larger nose or a different skin color, few people would jump at it and say that's beautiful," he says, citing the model Winnie Harlow, who's rendered the skin condition vitiligo no less a beauty disqualifier than blue eyes or blond hair. But symmetry, he emphasizes sternly, will never go away. Rather than a cathedral, he points to the sleek sofa I'm sitting on and says pointedly, "Even furniture looks better when it's symmetrical."

After a decade of the Ourian-Kardashian beauty dynasty, however, LA's young, rising beauty vanguard seem to be ready for a look that's less kittenish, more renegade. When I meet up with 26-year-old photographer Kelia Anne MacCluskey, who's shot for PAPER, Playboy and The New York Times, and her boyfriend Lucky Pettersen, 27, a casting director who's cast campaigns for Gucci, Levi's and Calvin Klein, for drinks at a tapas spot in Highland Park, both suggest in their own way that they're constantly searching for models and talent with gap teeth or a unibrow, the sort of authentic, identifying mark that makes an instant, unforgettable impact. Pettersen, for example, philosophizes on Gen Z's desire for honesty as exemplified by 22-year-old model Salem Mitchell. After trolls compared her freckled skin to overripe fruit, Mitchell launched herself on Instagram by posting a photo in response, hashtag #bananaface.

Yet as empowering as a swing toward this aesthetic individualism might sound, it would be nave to assume that any new trend would outright eschew the inherent pressures of the beauty paradigm. New standards will be set, new expensive treatments spawned. At the moment, unibrows and sequin brows aside, all overarching signs point to a standard centered on pristine skin.

In Perfect Me, a book about the perils of our current global beauty ethic, British academic Heather Widdows attributes this growing preoccupation to a "forensic gaze" fueled by visual culture and the omnipresence of hi-def screens and cameras that require us to look smooth and luminous "not just when our picture is likely to be taken (on holidays or at weddings), but increasingly all the time ... given that we can imagine ourselves (or our failings) being photographed in almost any context." In an interview with PAPER, she cautions that the "forensic gaze of HD TV and selfie culture is something we need to take much more seriously as shaping who we think we are and putting pressure on us to perfect our faces in ways that really aren't possible for living, breathing, sweating, aging human beings." She also argues that the widening of the beauty spectrum under the auspices of the internet might actually be just the opposite: a contraction. Whereas, pre-internet, beauty norms were decided by the more localized scopes of one's cultural community into micro-ranges, these ranges are converging into a more singular worldwide beauty window with less room for divergence: "thin and slim, with breasts and butt curves, smooth, luminous, glowing skin, and large eyes and lips ... White women are just as unable to attain the beauty ideal without intervention as Asian and Black women are," she says.

But what if we could regrow our own genuine genetic skin the way it looked before sun damage, cigarettes, sleeplessness, acne and other little scars set in?

What if we rolled out of bed in the morning and didn't have to waste a single second thinking about makeup, let alone fueling the industrial beauty complex and its ecological fallout with our hard-earned third-wave feminist salaries because we'd woken up in our own living, breathing, sweating childhood skin? "That is truly the holy grail of cosmetic dermatology," according to Ourian. "What makes a kid's skin perfect aside from the fact that they haven't been exposed to the environment their skin repairs itself much faster," he explains. Up until now, there was no way to unlock the skin's reparative memory. Ourian gets enthused again. Declaratively, he pronounces: "Stem cells are going to be the biggest thing." And he's not talking about the Vampire Facial craze. He does not think having one's skin needle-scratched raw and bloody before pouring stem cell serum derived from placentas onto it is of any use. No, if you ask Ourian, the holy grail, the next Botox, is injectable skin.

In his office, he already performs a version of it with stem cells derived from the patient, but it's expensive and not as efficient or effective as Ourian believes it will soon become. "First I have to get rid of all the old junk, Coolaser to get rid of the sun damage," he explains. "To get this baby skin we have to retrain it to keep itself healthy, and that's where the stem cells come in ... but in the next five or ten years we will achieve a level of age reversal that will mimic the way your skin was in your 20s or pre-teens." He's hoping it becomes as mainstream as Botox: "For a few hundred dollars, you can get it done."

Then and now, there will always be the non-conformists who consciously push back against the ever-tightening beauty construct, whether it's dictated by Kim-face, Glass-face or any face in between. The artists, activists, intellectuals and outsiders: Alicia Keys, Salem Mitchell, Frances McDormand, Heather Widdows, maybe your daughter or son or nonbinary child, maybe mine. For her part, Widdows has this advice for anyone who wants to help broaden beauty norms: "Call out 'lookism.' We need to name it (as we once named sexism) and make body shaming not and never okay." In the meantime, Simon Ourian will be chasing his white whale. As we age, the extraorbital fat pads that cushion our eyeballs in our ocular sockets erode, and the eyes sink into the face. "We can put a fat pad in the back of the eyes surgically, but not in a quick procedure," he explains. "So that keeps me up at night. How do I put fat pads back behind the eyes without cutting faces?"

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What's the Next '"nstagram Face"? - Papermag

Skin Stem Cells Comments Off on What’s the Next ‘"nstagram Face"? – Papermag | May 21st, 2020

Surveys consistently report that people fear total blindness more than any other disability, and currently the major cause of untreatable blindness is retinal disease. The retina, a part of the brain that extends into the eye during development, initiates vision by first detecting light with the rod and cone photoreceptors. Four classes of retinal neurons then begin the analysis of visual images. Defects in the optical media that transmit and focus light rays onto the retina (lens and cornea) can usually be dealt with surgically, although such treatments are not available in some parts of the world, resulting in as many as 20 to 30 million legally blind individuals worldwide. Untreatable retinal disease potentially causes legal or total blindness in more than 11 million people in the United States alone, but progress in treatments raises the possibility of restoring vision in several types of retinal blindness (1).

Retinal neurons comprise bipolar and horizontal cells, which are second-order neurons that receive signals from the photoreceptors in the outer retina. Third-order amacrine and retinal ganglion cells are activated in the inner retina by bipolar cells. Axons from the ganglion cells form the optic nerve and carry the visual message to the rest of the brain (see the figure). The cells most susceptible to blinding retinal disease are the photoreceptors and ganglion cells. Whereas progress has been made in combating blindness caused by photoreceptor degeneration, little can be done currently to address ganglion cell loss, such as occurs in glaucoma.

The approach that has been most successful in restoring photoreceptor loss that results in complete blindness is the use of retinal prosthetic devices, with two now approved for clinical use (2). These devices electrically stimulate either bipolar or ganglion cells. They require goggles that have a camera that converts visual stimuli into electrical stimuli that activate the device, which in turn stimulates the retinal cells. Several hundred of these devices have been implanted in blind or virtually blind individuals, 70 to 80% of whom report improvement in quality of life. For those who are completely blind, the ability to experience again at least some visual function is viewed as a miracle.

There are substantial limitations to the devices, however. The best visual acuity attained so far is poor (20/500) and visual field size is limited, but many improvements, mainly technical, are being developed and tested, including the potential use of electronic low-vision devices to increase visual field size and acuity (3). Retinal prostheses are not useful for patients who are blind because of loss of ganglion cells and/or the optic nerve, but prostheses that bypass the retina and stimulate more central visual structures, including the lateral geniculate nucleus (the intermediary between retina and cortex) and visual cortex, are being developed and tested in humans (4). There remain considerable technical issues, but preliminary data indicate that such devices are feasible.

A second approach to treat photoreceptor degeneration and potential blindness, now in the clinic, is gene therapy (5). This involves injecting a viral construct into the eye that contains a normal gene to replace an abnormal one. Success so far has been limited to the treatment of Leber congenital amaurosis (LCA) type 2, a rare form of retinitis pigmentosa in which the gene whose product is required to form the correct isomer of vitamin A aldehyde, the chromophore of the visual pigments, is mutated. Little of the correct isomer is made in LCA patients, resulting in substantial loss of photoreceptor light sensitivity. This is reversed when viral constructs encoding the normal gene are injected deep into the eye between the photoreceptors and pigment epithelium.

Two factors make this approach feasible in LCA: The genetic defect is monogenic, and many of the photoreceptors in the patients remain alive, although compromised. Thus, how broadly feasible gene therapy will be for treating the enormous range of inherited retinal diseases now known to exist (300) remains to be seen. But at least a dozen other gene therapy trials on monogenic inherited eye diseases similar to LCA are under way (6). Other methods to manipulate genes are now available, including CRISPR-mediated editing of retinal genes. So far, the experiments have been mainly on isolated cells or retinas, but these powerful techniques are likely to have eventual clinical applications.

A variation on the use of gene therapy techniques is optogenetics, in which light-sensitive molecules are introduced into non-photosensitive retinal cells. This approach holds much promise for restoring vision to totally blind individuals whose photoreceptors have been lost. Using viruses to insert genes encoding light-sensitive molecules into bipolar and ganglion cells, as well as surviving photoreceptor cells that are no longer photosensitive, has been accomplished in animals and shown to restore some vision (7). Again, technical issues remain: The cells made light-sensitive require bright light stimuli, and the light-sensitive cells do not adapt. That is, whereas photoreceptors normally allow vision over as much as 10 log units of light intensity, the cells made light-sensitive respond only to a range of 2 to 3 log units. Various methods to overcome these limitations are now being developed, and at least one clinical trial is under way. Experiments to make cortical neurons sensitive to light or other stimuli that better penetrate the skullmagnetic fields or ultrasound, for exampleare also being developed and tested in animals.

Other promising approaches to restore vision are being explored. In cold-blooded vertebrates, retinal cells (in fish) and even the entire retina (in amphibians) can regenerate endogenously after damage. Regeneration of retinal cells in zebrafish is now quite well understood (8). The regenerated neurons come from the major glial cell in the retina, the Mller cell. After retinal damage, Mller cells reenter the cell cycle and divide asymmetrically to self-renew and produce a progenitor cell that proliferates to produce a pool of cells capable of differentiating into new retinal cells that repair the retina.

A number of transcription factors and other factors identified as being involved in retinal regeneration in zebrafish have been shown to stimulate some Mller cell proliferation and neuronal regeneration in mice. Regenerated bipolar and amacrine cells, as well as rod photoreceptors, have so far been identified in mouse retinas, and these cells are responsive to light stimuli (9, 10). Further, cells postsynaptic to the regenerated neurons are activated by light stimuli, indicating that the regenerated neurons have been incorporated into the retinal neural circuitry. So far, the regenerative capacity of mammalian Mller cells is limited, but directed differentiation of specific types of neurons with a mix of factors appears to be a possibility. Regrowth of ganglion cell axons after the optic nerve is disrupted is also under active investigation, and although the number of axons regrowing is low (10%), those that do regrow establish synaptic connections with their correct targets (11). Therefore, endogenous regeneration is still far from clinical testing, but substantial progress has occurred.

The retina lines the back of the eye and consists of rod and cone photoreceptors, as well as four types of neuron: second-order bipolar and horizontal cells and third-order retinal ganglion cells (RGCs) and amacrine cells. Mller glial cells fill the spaces between the neurons. The pigment epithelium, critical for photoreceptor function, underlies the retina. Photoreceptors and RGCs are most susceptible to blinding retinal disease. Progress in combating photoreceptor degeneration has been made, but there are few strategies to address RGC loss.

A long-studied area of research is transplantation of retinal cells, particularly photoreceptors, into diseased retinas. In experiments with mice, transplanted postmitotic rod photoreceptor precursor cells derived from embryonic retinas or from stem cells appeared to integrate into diseased retinas in reasonable numbers and to be functional. A surprising and unexpected complication in the interpretation of these experiments was recently discovered. Rather than integrating into diseased retinas, the donor cells appear to pass material (RNA or protein) into remaining host photoreceptor cells, rejuvenating them, and these appear to be most of the functional cells (12). The current evidence suggests that only a small proportion of the donor cells integrate, but progress in overcoming this setback is being made.

More success has been reported with stem cells induced to become pigment epithelial (PE) cells, which provide essential support for photoreceptors. A number of blinding retinal diseases relate to the degeneration of the PE cells, and replacement using such cellsin a suspension or on a scaffoldis being actively pursued. PE cells do not need to integrate synaptically with retinal cells; they simply need to contact the photoreceptor cells. This is achieved when PE cells are placed between the retina and the back of the eye. Early clinical trials suggest that the transplants are safe, but retinal detachment, a serious complication, can occur and efficacy has yet to be shown (13).

The finding that donor photoreceptor cells can help diseased host retinal cells to recover function suggests that certain substances can provide neuroprotection. Indeed, a substantial number of such neuroprotective molecules have been shown to affect retinal disease progression, especially degeneration of photoreceptor cells. No one factor has been shown to be effective generally, but two have received much attention. One, ciliary neurotrophic factor (CNTF), promotes photoreceptor survival in light-induced photoreceptor degeneration and in several other models of retinal degeneration (14). Some evidence suggests that CNTF acts primarily on Mller cells, but how it works, and on what cells, is still unclear. The other factor, rod-derived cone viability (RDCV) factor, has received less research attention, but with recent industrial support, it is now being advanced to the clinic. Current evidence indicates that RCDV factor protects cones after rod degeneration.

Two of the most common retinal diseases in developed countriesage-related macular degeneration (AMD), the leading cause of legal blindness (visual acuity of less than 20/200), and glaucoma, the leading cause of total blindnessare not monogenic diseases, and so genetic treatments for them are not obvious. Attempts to understand the etiology of these diseases are under way, but currently their underlying causes are still unclear. A difficulty presented by AMD is that no animal model is readily available, because it is a disease of the fovea, which mediates high-acuity vision. Except for primates, other mammals do not possess this small critical retinal area. Whereas large primates are not feasible for extensive cellular or molecular studies, small primates such as marmosets that have a fovea are potential models but have not been used much to date.

Other approaches for restoring vision have been suggested and have even yielded some progress. From both normal humans and those with an inherited retinal disease, skin biopsy cells can be induced to form tiny retinal eyecups called organoids (15). Containing all retinal cell types, these structures could be a source of retinal cells for studying retinal disease development and possible therapies, as well as for cell transplantation. A fovea has not been observed in any organoid so far, but this is not beyond the realm of possibility. Another suggested approach is to surgically transplant whole eyes into blind individuals. This appears feasible, but whether there is sufficient optic nerve regrowth remains an open question.

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Restoring vision to the blind - Science Magazine

Skin Stem Cells Comments Off on Restoring vision to the blind – Science Magazine | May 21st, 2020

Cosmetic Skin CareMarketBusiness Insights and Updates:

The latest Marketreport by a Data Bridge Market Researchwith the title[Global Cosmetic Skin CareMarket Industry Trends and Forecast to 2026].The new report on the worldwide Cosmetic Skin CareMarketis committed to fulfilling the necessities of the clients by giving them thorough insights into the Market. The various providers involved in the value chain of the product include manufacturers, suppliers, distributors, intermediaries, and customers.The reports provide Insightful information to the clients enhancing their basic leadership capacity identified.Exclusive information offered in this report is collected by analysis and trade consultants.

Global cosmetic skin care market is set to witness a substantial CAGR of 5.5% in the forecast period of 2019- 2026.

Cosmetic skin care is a variety of products which are used to improve the skins appearance and alleviate skin conditions. It consists different products such as anti- aging cosmetic products, sensitive skin care products, anti- scar solution products, warts removal products, infant skin care products and other. They contain various ingredients which are beneficial for the skin such as phytochemicals, vitamins, essential oils, and other. Their main function is to make the skin healthy and repair the skin damages.Get PDF Samplecopy(including TOC, Tables, and Figures) @https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-cosmetic-skin-care-market

Thestudy considers the Cosmetic Skin CareMarketvalue and volume generated from the sales of the following segments:Major Marketmanufacturerscovered in the Cosmetic Skin CareMarketare:LOral, Unilever, New Avon Company, Este Lauder Companies, Espa, Kao Corporation, Johnson & Johnson Services, Inc., Procter & Gamble, Beiersdorf, THE BODY SHOP INTERNATIONAL LIMITED, Shiseido Co.,Ltd., Coty Inc., Bo International, A One Cosmetics Products, Lancme, Clinique Laboratories, llc., Galderma Laboratories, L.P., AVON Beauty Products India Pvt Ltd, Nutriglow Cosmetics Pvt. Ltd, Shree Cosmetics Ltd

Segmentation:Global Cosmetic Skin Care Market

By Product

By Application

By Gender

By Distribution Channel

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Based on regions, the Cosmetic Skin CareMarketis classified into North America, Europe, Asia- Pacific, Middle East & Africa, and Latin AmericaMiddle East and Africa (GCC Countries and Egypt)North America (United States, Mexico, and Canada)South America(Brazil, Argentina etc.)Europe(Turkey, Germany, Russia UK, Italy, France, etc.)Asia-Pacific(Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

Market Drivers:

Market Restraints:

Key Developments in the Market:

Key Benefits for Cosmetic Skin CareMarket:

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About Us:Data Bridge Marketresearch endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process Data Bridge set forth itself as an unconventional and neoteric Marketresearch and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best Marketopportunities and foster efficient information for your business to thrive in the Market.We ponder into the heterogeneous Markets in accord with our clients needs and scoop out the best possible solutions and detailed information about the Markettrends. Data Bridge delves into the Markets across Asia, North America, South America, Africa to name few.

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Cosmetic Skin Care Market is Thriving with Rising Latest Trends by 2026 | Top Players- L'Oreal, Unilever, New Avon, Estee Lauder Companies, Espa, Kao,...

Skin Stem Cells Comments Off on Cosmetic Skin Care Market is Thriving with Rising Latest Trends by 2026 | Top Players- L’Oreal, Unilever, New Avon, Estee Lauder Companies, Espa, Kao,… | May 21st, 2020

Last week, she was given the all-clear to start re-entering the lab after it closed in March due to COVID-19 restrictions.

"We fired up the lab and turned everything back on. It felt fantastic to be back working towards research goals," she said.

Professor Sharon Ricardo's lab was closed under COVID-19 restrictions.Credit:Jason South

Over the last few months, she has been churning through grant writing and Zoom meetings.

She said her days spent video-conferencing and doing administrative work were "tiring but productive".

Professor Ricardo said a healthy balance between laboratory work and paperwork was important to her and her team as they "became researchers because we get excited about what we do".

They produce three-dimensional miniature kidneys from skin cells useful for disease modelling, called organoids.

The organoids are made by collecting patients' skin cells, developing them into stem cells, and "adding factors to the cell cultures to form mini kidneys," she said.

According to Professor Ricardo, the closure of the laboratories has seriously impeded some of her students' research.

One of her PhD students had one organoid experiment left to go when the restrictions came in to play and labs were closed.

"We had to freeze the lines and turn off all the incubators," she said.

The Universitys labs are reopening gradually. Hygiene and social distancing measures were being taken to ensure the safety of staff and students, she said.

"You go to the lab, perform what you need to do, and go home," said Professor Ricardo. Shes received strict instructions not to hang around the office.

Even with the new social distancing measures, she is very excited to be back with her colleagues.

"Every time I see somebody at work, I feel like I am seeing my best friend," she said.

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Universities Australia Chief Executive Catriona Jackson said COVID-19 has "upended almost every area of endeavour" across the university research sector.

"Australias researchers have pivoted their work to join the community in fighting the virus, from world-leading vaccine and treatment research to work on all aspects of the deep social and economic impact of the crisis," she said.

The pandemic has been devastating for the university research community. "The loss to university R&D [research and development] is estimated at $2.5 billion in 2020, placing at risk at least 38 per cent of research salaries," said Ms Jackson.

While specific regulations around reopening physical research facilities differ for each state and university, Ms Jackson said they are closely following guidance from medical authorities and government.

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Research frozen by COVID-19 begins to thaw - The Age

Skin Stem Cells Comments Off on Research frozen by COVID-19 begins to thaw – The Age | May 21st, 2020

The recently published market study by MRRSE highlights the current trends that are expected to influence the dynamics of the Cosmetic Skin Care market in the upcoming years. The report introspects the supply chain, cost structure, and recent developments pertaining to the Cosmetic Skin Care market in the report and the impact of the COVID-19 on these facets of the market. Further, the micro and macro-economic factors that are likely to impact the growth of the Cosmetic Skin Care market are thoroughly studied in the presented market study.

According to the report, the Cosmetic Skin Care market is expected to grow at a CAGR of ~XX% during the forecast period, 20XX-20XX and attain a value of ~US$ XX by the end of 20XX. The report is a valuable source of information for investors, stakeholders, established and current market players who are vying to improve their footprint in the current Cosmetic Skin Care market landscape amidst the global pandemic.

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Reasons to Trust Our Business Insights

Critical Data in the Cosmetic Skin Care Market Report

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Regional Assessment

The regional assessment chapter in the report offers an out and out understanding of the potential growth of the Cosmetic Skin Care market across various geographies such as:

Application Assessment

The presented study ponders over the numerous applications of the Cosmetic Skin Care and offers a fair assessment of the supply-demand ratio of each application including:

below:

Global Cosmetic Skin Care Market, Product Analysis

Global Cosmetic Skin Care Market, Application Analysis

In addition the report provides cross-sectional analysis of all the above segments with respect to the following geographical markets:

Global Cosmetic Skin Care Market, by Geography

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The report resolves the following doubts related to the Cosmetic Skin Care market:

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Weekly Update: Global Coronavirus Impact and Implications on Cosmetic Skin Care Market Forecast Report Offers Key Insights, Key Drivers, Technology -...

Skin Stem Cells Comments Off on Weekly Update: Global Coronavirus Impact and Implications on Cosmetic Skin Care Market Forecast Report Offers Key Insights, Key Drivers, Technology -… | May 21st, 2020

On Monday, it was announced thatNSW public schools will return to the classroom full time from next Monday, two months after COVID-19 restrictions forced around 800,000 children to study remotely.

Its a normal school week from next week and they need to be attending. Rolls will be marked as normal and unexplained absences will be followed up, NSW Education Minister Sarah Mitchell said on Tuesday.

However, many teachers are not pleased with how they discovered the return to full-time schooling, withNSW Teachers Federation president Angelo Gavrielatos saying the union had not been consulted before the governments decision.

He said teachers had already planned for the previously announced staggered return to school, with face-to-face learning gradually scaled up throughout term two.

This caused a lot of concern, frustration and anger among teachers and principals across the state. They turned themselves inside out not once, not twice, but repeatedly, trying to come to terms with this crisis, Gavrielatos told ABC television.

This is a pandemic that we find ourselves in thats what makes what happened last night even more important and more disrespectful.

Listen: The risk And reality of a COVID19 second wave in Australia. Post continues below audio.

Mamamiaspoke to five teachers about how they discovered the news of the return to full-time schooling, and how they feel about it. Heres what they had to say.

I went on Facebook last night and saw an article and was shocked! I checked my staff emails and there was no information. I messaged every other teacher I knew and no one had any idea except for seeing it on Facebook.

We all found this out through Facebook, except for those who dont seem to have social media, who found out when Gladys Berejeklian announced it this morning. The principals were not informed so they were unable to inform us!

There has still been no official communication from the department or our union. It was infuriating to find out on Facebook! But I dont blame any principals or teachers or the Department of Education, as they all found out at the same time as I did, in the same way. Which is disgusting!

I think its been a really hard time to navigate. I have been frustrated by the way weve been treated, but I dont blame anyone.

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'I found out on Facebook.' 5 teachers share how they feel about returning to school full-time. - Mamamia

Skin Stem Cells Comments Off on ‘I found out on Facebook.’ 5 teachers share how they feel about returning to school full-time. – Mamamia | May 21st, 2020

Coronavirus and Mesenchymal Stem Cells

Therapy for Pneumonia Patients infected by 2019 Novel Coronavirus

Treatment With Mesenchymal Stem Cells for Severe Corona Virus Disease 2019(COVID-19)

Mesenchymal Stem Cell Treatment for Pneumonia Patients Infected With 2019 Novel Coronavirus

On the website of the Harvard Stem Cell Institute you will find the following news release about the ongoing clinical trial conducted by our daughter company RHEACELLin patients suffering from limbal stem cell deficiency: Restoring vision: A stem cell therapy for cornea regeneration reaches the clinical-trial stage.

The international phase I/IIa clinical trial has been approved by the U.S. Food and Drug Administration (FDA) and several European competent national regulatory authorities. The medicinal drug product tested in this trial has recently been granted Orphan Drug designation from the FDA and the European Medicines Agency (EMA) for the treatment of EB.

The international phase I/IIa clinical trial has been approved by the U.S. Food and Drug Administration (FDA) and the German regulatory authority (Paul Ehrlich Institute). The medicinal drug product tested in this trial has recently been granted Orphan Drug designation from the FDA and the European Medicines Agency (EMA) and Fast Track designation from the FDA for the treatment of LSCD.

In a comprehensive preclinical study program, safety and local tolerability of ABCB5+ MSCs following subcutaneous, intramuscular and intravenous application has been demonstrated (Tappenbeck et al., 2019).

Link:
TICEBA >< Advantages of Skin Stem Cells

Skin Stem Cells Comments Off on TICEBA >< Advantages of Skin Stem Cells | May 19th, 2020

New treatment for baldness has shown its effectiveness: for its realization has been applied proteins derived from stem cells of adipose tissue means. The experiment was carried out by scientists from South Korea.

The scientific staff of the Busan University as part of the experience tested the ability to cure the most familiar type of baldness androgenic alopecia, utilizing extract of stem cells of adipose tissue. This disease can not be attributed to the most hazardous to health, but it negatively affects the psychological status and life of the people. Highest quality drugs against the disease have side effects, including erectile dysfunction, therefore physicians continue to look for safe assets.

For the experiment, scientists from South Korea has invited nine women and 29 men of middle age who had suffered from androgenic alopecia. They were divided into two groups, representatives of one of them they rubbed my skin with the extract of stem cells, and the second placebo. Four months later, the experience of those volunteers, to whom was applied the protein to stem cells, the researchers found a significant increase in hair volume and diameter of follicles. Next, the researchers intend to perform a similar experiment with a larger number of respondents from different population groups.

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In South Korea the problem of hair loss solved with the help of stem cells of adipose tissue - The Times Hub

Skin Stem Cells Comments Off on In South Korea the problem of hair loss solved with the help of stem cells of adipose tissue – The Times Hub | May 19th, 2020

Image: A scanning electron microscope image of SARS-CoV-2 (Photo courtesy of NIAID-RML)

The drug, interferon-lambda, is a manufactured form of a naturally occurring protein that has been given in previous clinical trials to more than 3,000 people infected with hepatitis viruses. Results in laboratory settings and in animals also suggest that lambda-interferon may be helpful in controlling viruses that cause respiratory illnesses such as influenza and SARS, an often fatal disease, as well as help snuff out other common viral infections. Interferon-lambda orchestrates the bodys natural defenses against infection by issuing a call in the troops order to constituent cells of the immune system. Receptors for interferon-lambda are restricted to the linings of the lungs, intestine and liver, thus producing fewer side effects.

The clinical trial is underway at Stanford Medicine will determine whether the drug can keep people who have just tested positive for the coronavirus out of the hospital, help them recover faster and make them safer to be around in the meantime. The researchers will also investigate whether the drug stems viral shedding, which would reduce transmission to family members and the community. The investigators are recruiting 120 participants who have just been diagnosed with cases of mild COVID-19 at Stanford Health Care and other local hospitals, emergency rooms, clinics and drive-through testing sites. Trial participants, randomly sorted into two groups, will be given single injections under the skin of either a placebo or interferon-lambda. Then they will be monitored for 28 days for symptoms, disease severity, rates of hospitalization, and duration and quantity of viral shedding.

Even though these individuals may not need hospitalization, infection with COVID-19 results in respiratory symptoms and lost productivity, said Upinder Singh, MD, professor of infectious diseases and of microbiology and immunology at the school, who is co-leading the study. Plus and this is important patients with mild disease contribute to community disease transmission. Limiting viral shedding from this group would reduce transmission to family members and others, which is crucial to controlling epidemic disease spread.

Related Links:Stanford Medicine

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Stanford Researchers Investigate New Drug that Can Treat Mild COVID-19 Cases and Stem Viral Shedding - HospiMedica

Skin Stem Cells Comments Off on Stanford Researchers Investigate New Drug that Can Treat Mild COVID-19 Cases and Stem Viral Shedding – HospiMedica | May 19th, 2020

I didnt have any mum friends to give me the heads up on this a few years ago, and I vowed to never let someone else walk into that battlefield unprepared.

I know poo talk isnt very graceful, but knowledge is power, and absolutely no one had given me the much-needed secret poo power prep talk.

So, heres yours, with all the learnings that made my second time around much more bearable.

LISTEN: We take a look at the final month of pregnancy, including what to pack in your hospital bag. Post continues after audio.

Soften those bad boys up with stool softeners. If you ignore them, theyll go away only works for door-knockers. The longer you leave these guys, the harder theyll knock. With each passing day, your poo will join forces and create a solid army. A rock-solid army of pain.

Pushing can be a scary feeling. Everything down there is vulnerable, and I was worried I might give birth to my entire uterus mid poo. I didnt (phew). I found the stool softeners helped with this and I didnt need to use so much scary force the second time round.

So to sum it up? Prunes and prune juice are your friends, drink loads of water, and dont be afraid to ask for laxatives if you need them.

Hold your fragile stitched (or unstitched) front if that makes you feel more comfortable and secure. It may still be an uncomfortable experience, but it doesnt have to feel like the ass apocalypse I experienced. NO ONE PREPARED ME FOR IT.

Dont be scared though, Id still do it all again for my kids. Just be prepared so you can crap like a queen on the porcelain throne.

If you didnt struggle with a post-birth poo, I have only one question How does it feel to be one of Gods favourites?

This post originially appeared on Living My Family Life and has been edited and republished with full permission.

Katie Bowman is a mum to a 4-year-old girl and two-year-old twin girls. A part-time hairdresser, she spends her time blogging about her days of chaos on her Facebook page,Living My Family Life.

Feature Image: Supplied.

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'I need to talk about the 'third birth' no one prepares you for: The post-baby poo.' - Mamamia

Skin Stem Cells Comments Off on ‘I need to talk about the ‘third birth’ no one prepares you for: The post-baby poo.’ – Mamamia | May 19th, 2020

This story appeared in the June 2020 issue as "Out of His Mind."Subscribeto Discover magazine for more stories like this.

It isnt every day that writer Philip Ball is asked to contribute to scientific experiments typically, hes reporting on them instead. But in 2015, scientists from a London-based project called Created Out of Mind asked Ball and a few other creatives if theyd participate in their work and then reflect on the experience. He agreed.

Ball first gave a sample, made up of cells from his skin, which was reprogrammed into stem cells that were subsequently grown into a brain organoid or, as the research team called it, a miniature brain in a dish. These futuristic-sounding specimens arent literal brains, and they dont look it, either. The round, cream-colored clusters of neurons simply resemble little blobs. Theyre not conscious. But they can be studied to better understand brain development such as where and when certain proteins misfold, which can signal whether a person will develop dementia.

This stained microscope image shows cells growing in a cross-section of a brain organoid, with neurons visible in red. (Credit: Chris Lovejoy and Selina Wray)

The researchers then asked Ball to reflect on his experience through writing. What started as a few blogs for Created Out of Mind eventually bloomed into a book, How to Grow a Human. Here, Ball recounts his time spent with his mini brain, and how the process gave him new insight into the future of lab-grown life.

Id pop into the lab from time to time and see how things were going. At one point, I stopped by and one of the researchers told me that the organoids werent looking great for some reason, they werent growing as they thought they might. We werent sure quite how they were going to turn out, and in the end many of them died before they could fully form.

Philip Ball (Credit: Richard Houghton)

But one day, out of the blue, one of the project leaders dropped me an email with photos and said, Look, heres your mini brain. And there it was ... I wish there was some drama to it, but the researchers were pretty casual about it because they grow these things all the time. And I wish I could say that I remember thinking, Oh my God, this is my second brain, but I think I was more relieved than anything that it actually grew into an organoid. The fact that they actually got one that had these really clear, discernible structures in it was pretty remarkable. If anything, I felt a little bit proud of myself that we actually created something in the end.

For me, one of the really interesting things I gleaned from the project was that the stuff we are made from is incredibly versatile. The technology of transforming cells from virtually any other tissue in the body is relatively new, and its leading to all sorts of directions in medicine and research. I was fascinated to see firsthand what extraordinary things cells even mature, adult cells are capable of.

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What It's Like to Grow a 'Mini-Brain' From Your Own Cells - Discover Magazine

Skin Stem Cells Comments Off on What It’s Like to Grow a ‘Mini-Brain’ From Your Own Cells – Discover Magazine | May 18th, 2020

DUBLIN--(BUSINESS WIRE)--The "Cell Therapy - Technologies, Markets and Companies" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering.

The cell-based markets was analyzed for 2018, and projected to 2028. The markets are analyzed according to therapeutic categories, technologies and geographical areas. The largest expansion will be in diseases of the central nervous system, cancer and cardiovascular disorders. Skin and soft tissue repair as well as diabetes mellitus will be other major markets.

The number of companies involved in cell therapy has increased remarkably during the past few years. More than 500 companies have been identified to be involved in cell therapy and 309 of these are profiled in part II of the report along with tabulation of 302 alliances. Of these companies, 170 are involved in stem cells.

Profiles of 72 academic institutions in the US involved in cell therapy are also included in part II along with their commercial collaborations. The text is supplemented with 67 Tables and 25 Figures. The bibliography contains 1,200 selected references, which are cited in the text.

This report contains information on the following:

The report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. Role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice.

Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation.

Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. Methods of delivery of cell therapy range from injections to surgical implantation using special devices.

Cell therapy has applications in a large number of disorders. The most important are diseases of the nervous system and cancer which are the topics for separate chapters. Other applications include cardiac disorders (myocardial infarction and heart failure), diabetes mellitus, diseases of bones and joints, genetic disorders, and wounds of the skin and soft tissues.

Regulatory and ethical issues involving cell therapy are important and are discussed. Current political debate on the use of stem cells from embryonic sources (hESCs) is also presented. Safety is an essential consideration of any new therapy and regulations for cell therapy are those for biological preparations.

Key Topics Covered

Part I: Technologies, Ethics & Regulations

Executive Summary

1. Introduction to Cell Therapy

2. Cell Therapy Technologies

3. Stem Cells

4. Clinical Applications of Cell Therapy

5. Cell Therapy for Cardiovascular Disorders

6. Cell Therapy for Cancer

7. Cell Therapy for Neurological Disorders

8. Ethical, Legal and Political Aspects of Cell therapy

9. Safety and Regulatory Aspects of Cell Therapy

Part II: Markets, Companies & Academic Institutions

10. Markets and Future Prospects for Cell Therapy

11. Companies Involved in Cell Therapy

12. Academic Institutions

13. References

For more information about this report visit https://www.researchandmarkets.com/r/7h12ne

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The Cell Therapy Industry to 2028: Global Market & Technology Analysis, Company Profiles of 309 Players (170 Involved in Stem Cells) -...

Skin Stem Cells Comments Off on The Cell Therapy Industry to 2028: Global Market & Technology Analysis, Company Profiles of 309 Players (170 Involved in Stem Cells) -… | May 14th, 2020

Dr Shikha Sharma

Coronavirus disease (COVID-19) is an unforgettable word in 2020. World health organization has declared COVID-19 as pandemic and according to the Worldometer site, it has affected 212 countries and territories and has caused approximately 2.8 lakhs deaths so far. According to the various published scientific evidences COVID-19 is an infectious disease caused by new coronavirus that can lead to lung dysfunction. There are 7 coronaviruses that are known to cause disease in humans and among these 3 can cause the severe respiratory infection. These are severe acute respiratory syndrome coronavirus (SARS-CoV) identified in 2002 in China, Middle East respiratory syndrome coronavirus (MERS-CoV) identified in 2012 in Saudi Arabia and severe acute respiratory syndrome coronavirus2 (SARS-CoV2) commonly called COVID-19 identified in late 2019 in Wuhan, China. SARS-CoV, MERS-CoV and COVID-19 are closely related but COVID-19 spread more quickly than the other two. Over 8000 people from 29 different countries were affected with SARS-CoV epidemic during 2002-2004 while 40.78 lakhs people are affected with COVID-19 so far. In most cases, immune response (bodys defence system) triggered by the COVID-19 infection is sufficient to combat its pathogenesis leads to the recovery of patient. However, in some cases, COVID-19 infection causes highly inflammatory form of lung cells death and injury as the most dangerous phase of its pathogenesis which leads to the overproduction of inflammatory cytokines by bodys own immune cells creating cytokine storm that results in damage to the lung tissues causing pneumonia, acute respiratory distress syndrome (ARDS) and sepsis. In Pneumonia and ARDS air sac of lungs fill with fluid or pus. These complications lead to severe condition such as shortness of breath that require treatment with oxygen and ventilator. Therefore controlling inflammatory response is utmost important to prevent coronavirus lethality rate and for the longer life of a patient. Currently no specific treatment is available for COVID-19 infection but several vaccines, drugs and stem cells testing in various countries has generated hope to combat its pathogenesis. Recent breakthrough has demonstrated mesenchymal stem cells (MSCs) as cell medicine therapy to reduce COVID-19 infection.What are MSCsMSCs are multipotent adult stem cells that are capable of differentiating into various cell types such as fat cells, bone cells, liver cells, pancreatic cells, brain cells, heart cells and skin cells thus can participate in the repair and regeneration of various tissues and organs of the body. Inside the body, upon injury, MSCs migrate to the injured site and participate in the regeneration and repair of the organ either by differentiation or by paracrine secretion or both. In addition MSCs possess immunomodulatory and anti-inflammatory properties that contributes to its cell medicinal properties. MSCs can be isolated from various tissues such as bone marrow, peripheral blood, body fat, muscle, placenta, umbilical cord, umbilical cord blood, teeth and hair follicles and can be expanded ex vivo and used for transplantation for treating disease and disorders after genetic stability test.How MSCs reduce COVID-19pathogenesisAs reported by various research groups that upon intravenous injection or through mist inhalation the significant population of MSCs migrate to the lung and secrete various immunomodulatory and anti-inflammatory factors to cure lung dysfunction by normalizing immune response altered by COVID-19 and stimulate lung repair. Moreover MSCs are resistant to COVID-19 infection and can be used for autologous and allogenic transplantation.Clinical trial with MSCs for COVID-19There are several clinical trials registered with MSCs for the treatment of COVID-19 from various countries such as China, USA, UK, Germany, UAE, Jordan and Iran and some reports have been published. Approximately 100 patients have been treated with MSCs therapy from moderate to critical conditions within 10-15 days of transplantation. A first case treated with MSCs showed the recovery of 65 year old critical ill patient in Baoshan Peoples Hospital, Longling County, China. Initially the patient was treated with antiviral therapy and immunomodulator thymosin alpha1 but hasnt shown any recovery. Later after 10 days patient was diagnosed with severe pneumonia, acute respiratory distress syndrome, multiorgan injury, type2 diabetes, moderate anaemia, electrolyte disturbance, immunosuppression, acute gastrointestinal bleeding and other symptom was shifted to ICU and on ventilator. They showed that after three MSCs injections along with thymosin alpha1 lead to the recovery of patient from COVID-19 infection. FDA has approved 24 patient clinical trial in USA to test safety and efficacy of MSCs from umbilical cord to prevent COVID-19 infection. Recently, in USA three critically ill patients in ICU and on ventilator recovered from COVID-19 infection with MSCs treatment. An Israeli pharmaceutical company Pluristem therapeutics have tested MSCs therapy on 7 critically ill patient and found positive results. More recently, UAE also reported the treatment of 73 COVID-19 infected patients with stem cells. They have developed the technology to isolate the stem cells from patient blood, activate them and reintroduce them by mist inhalation. These reports are indicative that MSCs hold the potential to treat the COVID-19 infection by preventing bodys own defense system from overreacting and normalise its response to fight against COVID-19 infection. Many companies from different countries are seeking approval to begin clinical trial with stem cells against COVID-19 infection.Why are we lagging behind when we have stem cell companies/labs/facility in our country? We also produce GMP grade stem cells for transplantation. China tested the stem cell therapy on first patient when all other therapies failed and stem cells was one of option left to save the life of the patient. In India also so many deaths are happening due to COVID-19 we can also check if stem cells can reduce the mortality rate. Moreover as per some reports MSCs dont stay inside the body for more than 1-3 months and they eventually die and dont result in teratoma formation. Our government along with doctors and scientist can also formulate committee on stem cells and begin such initiative to test MSCs for the treatment of COVID-19 infection. Nevertheless, MSCs has joined the army along with the other possible interventions to prevent the COVID-19 illness.(The author is (PhD and Postdoc in Stem Cells)feedbackexcelsior@gmail.com

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Stem cells therapy A prospective treatment against coronavirus? - Daily Excelsior

Skin Stem Cells Comments Off on Stem cells therapy A prospective treatment against coronavirus? – Daily Excelsior | May 14th, 2020