Washington: A recent study has suggested that adding a drug once commonly used to treat schizophrenia to traditional radiation therapy helped improve overall survival in mice with glioblastoma, one of the deadliest and most difficult-to-treat brain tumours.

The findings of the study conducted by researchers at the UCLA Jonsson Comprehensive Cancer Center and colleagues was published in the journal 'Proceedings of the National Academy of Sciences'.

It shows that a combination of radiation and the drug trifluoperazine not only targets glioblastoma cells but also helps overcome the resistance to treatment so common to this aggressive form of cancer. The results could prove promising for patients with the disease, for whom the median survival time is only 12 to 18 months following diagnosis.

Radiation is an integral part of therapy for people with cancer and one of the most effective treatments. In many cases, it can help cure the disease. But in glioblastoma, tumour cells often become resistant to radiation treatment because the radiation itself can induce "phenotype conversion," a process that turns certain non-tumour stem cells into tumour-producing cells, causing cancer to reoccur.

"While radiotherapy is one of the few treatments that prolong survival in glioblastoma patients, radiation alone does very little in treating the disease in our models because we are dealing with highly aggressive tumours," said the study's senior author, Dr Frank Pajonk, a professor of radiation oncology at the David Geffen School of Medicine at UCLA and a member of the Jonsson Cancer Center.

"The drug trifluoperazine by itself does not do much either, but we found when you combine them, they become highly efficient. Importantly, the drug does not sensitise cells to radiation but rather prevents the occurrence of resistant glioma stem cells," Pajonk added.

UCLA researchers have been exploring new ways to prevent glioblastoma tumour cells from becoming resistant to radiation by adding drugs to the treatment regimen that have traditionally been used for other purposes.

To find out if there were any existing drugs that could interfere with the radiation-induced phenotype conversion, the team screened more than 83,000 compounds through the shared resources at UCLA, which provides researchers access to specialised equipment and services to help them pursue cutting-edge research.

They were able to identify nearly 300 compounds, including the dopamine receptor antagonist trifluoperazine, that had the potential to block phenotype conversion and improve the efficacy of radiation therapy.

Once trifluoperazine was identified, it was tested on mice with patient-derived orthotopic tumours. The team found that when used in combination with radiation, trifluoperazine successfully delayed the growth of the tumours and significantly prolonged the overall survival of the animals.

Combining radiation treatment with trifluoperazine extended survival in 100 per cent of the mice to more than 200 days, compared to 67.7 days in the control group receiving only radiation.

"Many preclinical glioblastoma studies report fairly small increases in overall survival in mice, and that rarely translates into benefits for patients," said Pajonk, who is also a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.

"But here, we see pretty drastic effects in improved overall survival and I find that very encouraging. It gives us hope that this is all going to translate into a benefit for people," Pajonk further said.

The team plans to start a clinical trial this summer for people with recurrent glioblastoma to test using dopamine receptor antagonist with radiation therapy.

"I think we can find a combination of treatments with radiation that is very tolerable to patients and can do well," said co-author Leia Nghiemphu, an associate professor of clinical neurology at the Geffen School of Medicine and principal investigator on the upcoming clinical trial. "The next step is to see if we can stop this resistance to radiation in humans," added Nghiemphu.

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Schizophrenia drug combined with radiation shows promise in treating deadly brain tumours, says study - Free Press Journal

Skin Stem Cells Comments Off on Schizophrenia drug combined with radiation shows promise in treating deadly brain tumours, says study – Free Press Journal | May 3rd, 2020

Cytokines are the cell signaling molecules which are secreted from the different body cells. Cytokines are the proteins which play an important role of messenger between cells and regulates various physiological and metabolic activities. Cytokines regulate various inflammatory responses, stimulate blood cells production, and stimulate tissue development & maintenance. Cytokine is a large family of the small protein which includes tumors necrosis factor, interleukins, interferons, lymphokines and chemokines. Cytokines are produced by a wide range of cells includes cells like macrophages, lymphocytes, T lymphocytes, endothelial cells, mast cells, fibroblasts, stromal cells and cells. Some cytokines developed into protein therapeutics to treat bone-related disorders, anemia, cancer, infection, multiple sclerosis. Cytokine is most commonly used in the research & development activities in the field of life sciences and drug development.

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Increasing research and development activities expected to favour the growth of the cytokines market. As well as growing life science research funding boost up the growth of the cytokines market. Increasing prevalence of diseases such as cancer and skin disorders expected to drive the growth of the cytokines market. The growing demand for regenerative medicines impels the growth of the cytokines market. The growing demand for cytokines for wound management and cancer therapeutics expected to drive the growth of the market. Growing funding for cancer-based research influencing the growth of cytokines market. Growing cell culture-based research activities and increasing demand for cytokines in stem cell biology are major factors expected to drive the growth of the cytokines market. Growing manufacturers investments in cell culture media production expected to favour the growth of the growth factors market over the forecast period. Growing strategic acquisition and merger activities among market players is the major trend in the cytokines market. The high cost of research-based cytokines products is the major factor expected to restrain the growth of the cytokines market.

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The global cytokines market is segmented on basis of product type, application, end users and region:

Cytokine is the large family of cytokines includes tumour necrosis factor-TNF, interleukins (IL), interferons, chemokines and other cytokines. Interleukins (IL) is the most commonly used cytokine and have large family. IL-1 family, IL-4 family, IL-6 family, IL-10 family are mostly commonly used interleukins family in the research. Cytokines are used in various field of the research such as dermatology, cancer, orthopedics, respiratory and other fields. Cytokines are used for the research application among end users such as pharmaceutical & biotechnology companies, contract research organizations and academic & research institutes.

North America expected to dominate the global cytokines market as increasing demand for cytokines products as increasing research and development activities. Europe expected to contribute second-highest revenue share in global cytokines market as a growing number of clinical trial and drug development activities. The Asia Pacific expected to grow with the highest growth rate in the cytokines market as an increasing number of pharmaceutical manufacturers, biotechnology companies and academic institutions in the Asia Pacific region. India, South Korea & China cytokines market expected to grow with a higher growth rate as growing research and development funding from the government. The Middle East & Africa cytokines market expected to grow with the lowest growth rate due to lack of research and development activities in the region.

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Some of the players operating in the global cytokines market are ,

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Increasing Demand for Cytokines Market to Substantially Surge the Revenues Through the COVID-19 Lockdown Phase and Forecast 2019 2029 Cole Reports -...

Skin Stem Cells Comments Off on Increasing Demand for Cytokines Market to Substantially Surge the Revenues Through the COVID-19 Lockdown Phase and Forecast 2019 2029 Cole Reports -… | May 2nd, 2020

Now that your makeup layer is gone, you can proceed with washing your face. "A cleanser gets rid of dead skin, pollutants, oils, dirt, and bacteria," says Rabach. Both she and Ciraldo recommend also doing this step when you first wake up in the morning, in order to prep your skin to absorb the active ingredients in your other products.

The best cleanser for you will depend on your skin type. "It's important to pay attention to what's in your cleanser and what's not in it," says Ciraldo. She recommends avoiding sulfates, which can have a harsh, stripping effect on your faceand looking for actives that suit your needs. "For normal or dry skin, I favor a hydrating cleanser with peptides," she says. "If you're oily or acne-prone, use a mild exfoliating cleanser with salicylic acid, which dislodges the dead cells that can clog pores."

Do This Step: Morning and Night

The first product to go on your face? Eye cream. The reason is simplebecause you'll probably forget to do it otherwise. Ciraldo recommends patting eye cream on gently with your ring finger (this way you'll tug less at the delicate skin there) all the way around your eyes, not just underneath them. If you're worried about eye cream causing your concealer or eye makeup to smear, choose a more lightweight option, like a hydrating gel that sinks in quickly and stays put.

For the best results, look for ingredients like peptideswhich help tighten your skin and de-puffas well as antioxidants. Rabach recommends formulas that contain hydrating hyaluronic acid, brightening caffeine, and ceramides (these lock in moisture and help strengthen your skin barrier).

Do This Step: Morning and Night

Both toners and essences are meant to help further prime your skin to absorb active ingredients, but the one you choose will depend on your skin type. Old-school toners were meant to balance skin pH and counteract alkaline soaps, before soap-free cleansers became popular. Now, toner usually refers to liquid formulations geared toward oily skin that's in need of gentle exfoliation and resurfacing. Ciraldo says those with oily or acne-prone skin should look for toners with ingredients like glycolic or salicylic acid.

Essences, on the other hand, tend to be more hydrating. Rabach recommends looking for actives like hyaluronic acid, which will flood your skin with moisture that you can lock in during subsequent steps. To apply, soak a cotton pad in liquid and gently pat it over your face. Alternatively, you can use your hands to do the same thing.

Do This Step: Morning and Night

This is the step where you'll deliver the bulk of active ingredients to your toner/essence-primed face, and it's important to do it early on in your routine. "Serums are formulated with smaller molecular-weight actives so they penetrate into deeper skin layers," says Ciraldo. "If you apply your serum after a thicker formulation, the active ingredients may not penetrate as well."

While you should apply serum twice a day, you shouldn't be using the same formulation. "Serum actives differ for day and night," says Rabach. During the day, she likes to choose serums with antioxidants that protect skin from daytime stressors like free radicals (caused by UV rays), pollutants, and blue light. The most popular ingredient for this is vitamin C, which you will have no problem finding in serum form. (Just make sure to choose one that's properly stabilized for maximum effect.) At night, opt for a serum with peptides and growth factors to repair skin.

For both daytime and nighttime serums, Rabach also has a general list of ingredients she likes to look for across both formulations: Niacinamide to reduce redness, hyaluronic acid to pull moisture into your skin, and alpha and beta hydroxy acids (AHAs and BHAs), which help boost collagen and even out skin pigmentation. Ciraldo further splits up her preferred serum ingredients by skin type. "For acne-prone skin, look for stem cells, retinol, and green tea," she says. "For dehydrated skin, look for lipids, hyaluronic acid, and peptides. And for hyperpigmented skin, look for vitamin C."

Do This Step: At Night Only

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Best Skin Care Routine: Order of Products to Use Morning & Night - Glamour

Skin Stem Cells Comments Off on Best Skin Care Routine: Order of Products to Use Morning & Night – Glamour | May 1st, 2020

The healthcare industry has been focusing on excessive research and development in the last couple of decades to ensure that the need to address issues related to the availability of drugs and treatments for certain chronic diseases is effectively met. Healthcare researchers and scientists at the Li Ka Shing Faculty of Medicine of the Hong Kong University have successfully demonstrated the utilization of human induced pluripotent stem cells or hiPSCs from the skin cells of the patient for testing therapeutic drugs.

The success of this research suggests that scientists have crossed one more hurdle towards using stem cells in precision medicine for the treatment of patients suffering from sporadic hereditary diseases. iPSCs are the new generation approach towards the prevention and treatment of diseases that takes into account patients on an individual basis considering their genetic makeup, lifestyle, and environment. Along with the capacity to transform into different body cell types and same genetic composition of the donors, hiPSCs have surfaced as a promising cell source to screen and test drugs.

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In the present research, hiPSC was synthesized from patients suffering from a rare form of hereditary cardiomyopathy owing to the mutations in Lamin A/C related cardiomyopathy in their distinct families. The affected individuals suffer from sudden death, stroke, and heart failure at a very young age. As on date, there is no exact treatment available for this condition.

This team in Hong Kong tested a drug named PTC124 to suppress specific genetic mutations in other genetic diseases into the iPSC transformed heart muscle cells. While this technology is being considered as a breakthrough in clinical stem cell research, the team at Hong Kong University is collaborating with drug companies regarding its clinical application.

The unique properties of iPS cells provides extensive potential to several biopharmaceutical applications. iPSCs are also used in toxicology testing, high throughput, disease modeling, and target identification. This type of stem cell has the potential to transform drug discovery by offering physiologically relevant cells for tool discovery, compound identification, and target validation.

A new report by Persistence Market Research (PMR) states that the globalinduced pluripotent stem or iPS cell marketis expected to witness a strong CAGR of 7.0% from 2018 to 2026. In 2017, the market was worth US$ 1,254.0 Mn and is expected to reach US$ 2,299.5 Mn by the end of the forecast period in 2026.

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Customization to be the Key Focus of Market Players

Due to the evolving needs of the research community, the demand for specialized cell lines have increased to a certain point where most vendors offering these products cannot depend solely on sales from catalog products. The quality of the products and lead time can determine the choices while requesting custom solutions at the same time. Companies usually focus on establishing a strong distribution network for enabling products to reach customers from the manufacturing units in a short time period.

Entry of Multiple Small Players to be Witnessed in the Coming Years

Several leading players have their presence in the global market; however, many specialized products and services are provided by small and regional vendors. By targeting their marketing strategies towards research institutes and small biotechnology companies, these new players have swiftly established their presence in the market.

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Induced Pluripotent Stem Cells Market to Witness CAGR 8.7% Growth in Revenue During the Period 2026 - Cole of Duty

Skin Stem Cells Comments Off on Induced Pluripotent Stem Cells Market to Witness CAGR 8.7% Growth in Revenue During the Period 2026 – Cole of Duty | April 30th, 2020

Transparency Market Research (TMR)has published a new report on theamniotic membrane marketfor the forecast period of2019-2027. According to the report, the global amniotic membrane market was valued at ~US$ 980 Mnin2018and is projected to expand at a CAGR of ~10%from2019to2027.

GlobalAmniotic Membrane Market:Overview

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Increase in Research on Stem Cell Biology & Regenerative Medicineto Drive Market

Cryopreserved Amniotic Membrane Products to Dominate Market

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Ophthalmology to be Promising Application

Hospitals Account for Major Share of Global Market

North America to Dominate Global Amniotic Membrane Market

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Global Amniotic Membrane Market: Competitive Landscape

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Amniotic Membrane Market: Locally Available Amniotic Allografts Increasingly Meeting Needs of Patients with Joint Pain - BioSpace

Skin Stem Cells Comments Off on Amniotic Membrane Market: Locally Available Amniotic Allografts Increasingly Meeting Needs of Patients with Joint Pain – BioSpace | April 30th, 2020

Although I live in New York City, many of my friends call Seoul, South Korea, home. Through our many FaceTimes, KakaoTalk messages, and visits, they've introduced me to trendy Korean beauty brands that haven't made their way to America yet, like Hince, Sioris, and Nonfiction. They also share their picks from K-beauty brands we know and love in the U.S., such as Sulwhasoo, Dr. Jart, and Nature Republic. Every time I hear about their favorite products, I'm fascinated by how different they are from our stateside K-beauty offerings.

We're only exposed to a fraction of what is available on the other side of the world, and we are missing out on dreamy lip tints, barely-there cushion foundations, and magical moisturizers. With this in mind, I put my friends' makeup, hair, and skin-care selections in one place.

Some background on the names I'm about to mention: Daniella is my clean beauty expert. Whenever I see her, she always gives me a bag full of goodies made with natural, cruelty-free ingredients. When I want to know about the hottest brands at the moment, I go to Haylie. Joyce, founder of consulting agency Talk to Her, always has her eye out for the latest K-beauty innovations. Tattoo artist Young, on the other hand, mixes classic imports, like SK-II and Urban Decay, with unexpected K-beauty finds.

Consider this a list of K-beauty products Koreans actually use.

All products featured on Allure are independently selected by our editors. However, when you buy something through our retail links, we may earn an affiliate commission.

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23 Best Korean Beauty Products, According to Koreans Hair, Makeup, Skin-Care Reviews - Allure Magazine

Skin Stem Cells Comments Off on 23 Best Korean Beauty Products, According to Koreans Hair, Makeup, Skin-Care Reviews – Allure Magazine | April 28th, 2020

By Sarah Parsons 28-Apr-2020

Hair Care | Ingredients | Skin Care

The Swiss-led speciality chemicals manufacturer Clariant Active Ingredients has developed two new plant-based ingredients

Speciality chemicals giant Clariant has unveiled its latest beauty ingredients.

This week, the Swiss-led company launched two new plant-based ingredients for skin and hair.

Clariant Active Ingredients, Clariant's beauty business unit, released Rootness Energize, an extract of Luffa cylindrica, otherwise known as Egyptian cucumber, and can also be used as a natural cleaning sponge.

Developed for the skin, Claraint claims that sustainably-sourced Rootness Energize is rich in bryonolic acid, and can increase energy production in skin cells and stimulate ATP production.

"In turn, Rootness Energize visibly increases skin elasticity and reduces age-related lack of tonicity and firmness appealing factors for products such as firming creams, skin elasticity boosters and revitalising care products for well-aging skin care," explained the company.

Reported visible results include more than a 20% increase in firmness, tonicity and elasticity with 1% Rootness Energize.

For the hair, Clariant Active Ingredients has developed EquiScalp to target tightness, extreme dryness, itchiness and redness.

Based on stem cells from the Central Asian Malus domestica apple tree, according to the firm, the ingredient protects the scalp as it maintains the level of healthy bacteria.

Malus domestica is said to contain concentrated phloridzin, which can control inflammation as well as sebum overproduction.

Clariant Active Ingredients recommends EquiScalp for oily scalp treatments, sensitive scalp formulas and scalp itch erasers.

Alexandre Lapeyre, Global Head of Marketing, Clariant Active Ingredients, described EquiScalp and Rootness Energize as examples of using technology to develop sustainable ingredients.

"We apply science to nature to create potent actives effective at addressing very specific beauty needs, each one underpinned by plant resources preservation, traceability, no exploitation of cultural land and ecological cultivation," Lapeyre said.

"In doing so, we help cosmetic formulators support consumers requests for scientifically-proven and sustainably-sourced plant derived ingredients.

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Clariant taps natural sponges and apple trees for new beauty ingredients - Cosmetics Business

Skin Stem Cells Comments Off on Clariant taps natural sponges and apple trees for new beauty ingredients – Cosmetics Business | April 28th, 2020

Mathais Fleury, Givaudans global category manager of biotech actives, told CosmeticsDesign-Asia that leveraging on green biotechnology would allow companies to find solutions to consumers desire for products that are natural, sustainable and high-performing.

Green Biotech truly is a key pillar of the future. Consumers are looking for more naturality while protecting nature a difficult challenge, made possible by biotech along with a high level of innovation, said Fleury.

Most recently, the Swiss company collaborated with South Korean biotech company BIO-FD&C to tackle two frustrating beauty concerns by leveraging on green biotechnology.

It recently unveiled two actives, K-phyto [SC] Camellia and K-phyto [PP] GHK, which were developed to address dry scalp and oily skin respectively.

This exclusive partnership with Bio FD&C leverages the untapped power of plants through stem cell cultures and unique phytopeptides. It allows our experts to offer innovative natural and reliable solutions for hair and skin care issues such as dry scalp and oily skin, while protecting our planet, said Fleury.

K-phyto [SC] Camellia is an ingredient obtained from camellia phytoplacenta cells culture.

According to the company, the active can increase the scalp moisture content by 13.8%. This reinforces the epidermal cohesion of the scalp keratinocytes and reduces dry flakes and dandruff down by 33.6%.

It also was observed soothe the scalp by being able to reduce erythema down 6.6%.

According to Givaudan, having botanical claims with popular ingredients such as camellia, more commonly known as Tsubaki in the region, can drive hair care product launches by 70% in APAC.

The second ingredient, K-phyto [PP] GHK, is a molecule that combines botanicals and peptides to act on the mechanisms of sebum production.

Clinical studies have shown facial sebum production reduction by 35.5% in two weeks and 67.5% in one month.

Oily skin is a major claim requested by the market, specifically in APAC. Clinical results with the phytopeptide we've chosen to bring to market are outstanding and we definitely believe this could be a game changer, said Fluery.

The Swiss firm believes that the two actives showed a lot of promise for the global market.

Our partner was already doing a very good job in its local market, but we want to leverage our access to different places over the world to highlight its expertise and know-how. This collaboration is a real opportunity to bring innovative ingredients to consumers globally, and that's why we'll offer these products to our partners all over the world, said Fleury.

Additionally, these ingredients are aligned with the ideals of clean beauty, one of the most talked-about trends in the beauty market right now.

The two technologies that we've identified in Bio FD&C portfolio are a perfect answer to this need of clean beauty combined with performance, said Fluery.

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'A key pillar of the future': Givaudan tips growth for ingredients developed with green biotech - CosmeticsDesign-Asia.com

Skin Stem Cells Comments Off on ‘A key pillar of the future’: Givaudan tips growth for ingredients developed with green biotech – CosmeticsDesign-Asia.com | April 28th, 2020

CRANFORD, N.J., April 27, 2020 /PRNewswire/ --Citius Pharmaceuticals, Inc.. ("Citius" or the "Company") (Nasdaq: CTXR), a specialty pharmaceutical company focused on developing and commercializing critical care drug products, today announced that it submitted a pre-IND meeting request and supporting briefing documents to the Center for Biologics Evaluation and Research ("CBER") of the FDA under the Coronavirus Treatment Acceleration Program (CTAP) on April 24. The Company has requested the Division's feedback to support the most expeditious pathway into the clinic to evaluate a novel cell therapy in patients suffering from COVID-19-related ARDS.

The cells, called NoveCite Cells or NC-MSCs, are made by Novellus, Inc. ("Novellus"), a Cambridge-based biotechnology company, using its patented mRNA-based cell-reprogramming process. NC-MSCs are mesenchymal stem cells derived from a single donor's fibroblasts that have been dedifferentiated into an induced pluripotent stem cell (iPSC) master cell bank, thereby avoiding the need to source additional donor cells. The iPSCs are then further differentiated into a mesenchymal stem cell (MSC) therapy. Citius and Novellus plan to develop NC-MSCs for the treatment of ARDS, and last month the companies signed an exclusive option agreement.

The Company plans a multi-center randomized placebo-controlled dose-finding study followed by an expansion phase to assess the safety, tolerability, and efficacy of NC-MSCs in patients with moderate to severe ARDS due to COVID-19. The proposed trial, a Phase 1b/2 clinical trial, is titled "A Randomized Placebo-Controlled Dose-Finding Study Followed by a Dose Level Expansion to Assess the Safety and Efficacy of NoveCite MSCs in Subjects with Acute Respiratory Distress Syndrome (ARDS) Due to SARS-CoV-2 Disease (COVID-19)," or "MARCO". The primary objectives of this study are to evaluate the safety and efficacy of NoveCite cells as a treatment for subjects with moderate-to-severe ARDS due to COVID-19 and to identify therapeutic doses.

"MSCs have an established track-record of clinical safety, and have shown promise in the treatment of inflammatory lung disease," said Matt Angel, PhD, co-founder and Chief Science Officer at Novellus, Inc. "Our research has shown that the NoveCite cells, being derived from mRNA-reprogrammed iPSCs, secrete higher levels of immunomodulatory proteins than donor-derived MSCs, and have unique manufacturing advantages."

"We believe we have the key elements in place from a clinical design and manufacturing point of view to evaluate this novel cell therapy approach to deal with the current pandemic," said Myron Holubiak, Chief Executive Officer of Citius. "ARDS is a very serious complication for many patients suffering from COVID-19, and is believed to account for about 80% of the deaths in ventilated patients. There is no proven or FDA-approved treatment for it, other than oxygen therapy, including use of mechanical ventilation, and fluid management. Literature from previous investigational studies with MSCs in the treatment of lung injuries support the idea that MSCs could prove effective in treating COVID-19-related ARDS. We look forward to our FDA discussions and are excited to be at the cusp of what could be a novel and effective therapy for ARDS."

About Acute Respiratory Distress Syndrome (ARDS)ARDS is a type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs. ARDS is a rapidly progressive disease that occurs in critically ill patients most notably now in those diagnosed with COVID-19. ARDS affects approximately 200,000 patients per year in the U.S., exclusive of the current COVID-19 pandemic, and has a 30% to 50% mortality rate. ARDS is sometimes initially diagnosed as pneumonia or pulmonary edema (fluid in the lungs from heart disease). Symptoms of ARDS include shortness of breath, rapid breathing and heart rate, chest pain (particularly while inhaling), and bluish skin coloration. Among those who survive ARDS, a decreased quality of life is relatively common.

About Coronavirus Treatment Acceleration Program (CTAP)In response to the pandemic, the FDA has created an emergency program called the Coronavirus Treatment Acceleration Program (CTAP) to accelerate the development of treatments for COVID-19. By redeploying staff, the FDA is responding to COVID-19-related requests and reviewing protocols within 24 hours of receipt. The FDA said CTAP "uses every available method to move new treatments to patients as quickly as possible, while at the same time finding out whether they are helpful or harmful." In practice, that means developers of potential treatments for COVID-19 will benefit from an unusually faster track at the FDA to shorten wait times at multiple steps of the process.

About Citius Pharmaceuticals, Inc.Citius is a late-stage specialty pharmaceutical company dedicated to the development and commercialization of critical care products, with a focus on anti-infectives and cancer care. For more information, please visit http://www.citiuspharma.com.

About Novellus, Inc.Novellus is a pre-clinical stage biotechnology company developing engineered cellular medicines using its non-immunogenic mRNA, nucleic-acid delivery, gene editing, and cell reprogramming technologies. Novellus is privately held and is headquartered in Cambridge, MA. For more information, please visit http://www.novellus-inc.com.

Safe HarborThis press release may contain "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements are made based on our expectations and beliefs concerning future events impacting Citius. You can identify these statements by the fact that they use words such as "will," "anticipate," "estimate," "expect," "should," and "may" and other words and terms of similar meaning or use of future dates. Forward-looking statements are based on management's current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition, and stock price. Factors that could cause actual results to differ materially from those currently anticipated are: the risk of successfully negotiating a license agreement with Novellus within the option period; our need for substantial additional funds; the ability to access the FDA's CTAP program for the MARCO trial; the estimated markets for our product candidates, including those for ARDS, and the acceptance thereof by any market; risks associated with conducting trials for our product candidates, including those expected to be required for any treatment for ARDS and our Phase III trial for Mino-Lok; risks relating to the results of research and development activities; risks associated with developing our product candidates, including any licensed from Novellus, including that preclinical results may not be predictive of clinical results and our ability to file an IND for such candidates; uncertainties relating to preclinical and clinical testing; the early stage of products under development; risks related to our growth strategy; our ability to obtain, perform under, and maintain financing and strategic agreements and relationships; our ability to identify, acquire, close, and integrate product candidates and companies successfully and on a timely basis; our ability to attract, integrate, and retain key personnel; government regulation; patent and intellectual property matters; competition; as well as other risks described in our SEC filings. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions, or circumstances on which any such statement is based, except as required by law.

Contact:Andrew ScottVice President, Corporate Development(O) 908-967-6677 x105ascott@citiuspharma.com

View original content:http://www.prnewswire.com/news-releases/citius-announces-pre-ind-submission-to-fda-under-the-coronavirus-treatment-acceleration-program-for-a-novel-stem-cell-therapy-for-acute-respiratory-distress-syndrome-ards-in-covid-19-301047150.html

SOURCE Citius Pharmaceuticals, Inc.

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Citius Announces Pre-IND Submission to FDA Under the Coronavirus Treatment Acceleration Program for a Novel Stem Cell Therapy for Acute Respiratory...

Skin Stem Cells Comments Off on Citius Announces Pre-IND Submission to FDA Under the Coronavirus Treatment Acceleration Program for a Novel Stem Cell Therapy for Acute Respiratory… | April 27th, 2020

Stem Cell Restore is a formula that works toward improving your health on a cellular level to decrease age-related weakness and fatigue. This product employs natural ingredients for reaching its goals such as resveratrol, black current cocktail, icariin, and grape seed.

Multiple research works from renowned universities back the approach that this product takes. The best part is that it makes you feel stronger, younger, more refreshed, and more energetic without requiring you to get injected with needles. A simple and convenient solution. Another anti-aging plus weight loss supplement that you can opt for is Resurge. This is a new formula by John Barban. Interested folks can learn more about Resurge customer reviews on USAToday.

Stem Cell Restore Review

Aging is the only thing in your life that is bound to happen. Unfortunately, it is not the best experience. Sure, it gives you wisdom, but those wrinkles, that weakness, declining energy levels all these negative factors completely loot the good things. After all, no one likes to wake up in the morning to feel down and weak. No one likes it when it their joints ache or when they look in the mirror to see a dull reflection.

This brings us to possible solutions that you can go for. One of these is Stem Cell Restore. This is a potent dietary supplement that has been made using natural ingredients. The product is backed by science which is what marks it as reliable. Since it comes in the form of capsules, it can be a convenient addition to your routine. Hence, if you are on the lookout for an age-reversing formula, this is one that you can invest in.

Why Choose This Product?

Around the globe, women and men alike are waiting for a magical solution for saving themselves from accelerated aging. There certainly are many options available out there. However, most of these are not worth it. Why? Because they come with negative side effects. Not to mention, these so-called techniques for erasing the effects of aging are all supremely painful. They involve countless injections or an elaborate surgery.

Would you like to still go for these youth preserving tactics? Surely, youre at the very least hesitant. If you decide to go ahead nevertheless, know that the procedures are expensive. They cost hundreds of dollars and still, they are unnatural and eventually make your skin sag. This is where Stem Cell Restore comes into the picture and steals the limelight. The dietary supplement is based on the concept of stem cell surgery.

However, it has three favorable points that win over any surgery. First of all, it doesnt cost as much. In fact, you get to become youthful, energetic, and strong all with a solution that is less than $100. Secondly, the product happens to be completely natural. It doesnt contain any harmful components such as chemicals, additives, preservatives, and the like. This translates to safe usage. Lastly, theres no needles involved; you are just supposed to take the pills regularly.

Working Of This Product

Stem Cell Restore taps into the idea of repairing cells and rejuvenating them. By doing so, it is able to refresh your health completely. All your parts from tendons and joints to your heart and kidneys are able to function better as a result. Old cells are repaired at a fast rate and new ones are created. This makes you feel fresher, and more active. Its not uncommon of people to experience bodily aches and fatigue after crossing 30 years of age.

This product is a suitable solution for everyone. It gets to the core of preserving youth and improves health. Moreover, it also tackles the issue of inflammation which is what disturbs health in numerous ways. Unlike mainstream products, your skin is not the only organ that benefits. In fact, your entire body experiences the effects. To reach its goals, the formula employs only natural ingredients which are effective at their job. As mentioned above, Resurge is another formula for deep sleep and anti-aging. It comes with a money-back guarantee. You can check out more Resurge reviews on Yahoo Finance before deciding which one to buy among the two.

Ingredients Of This Product

Stem Cell Restore has an entirely natural composition. It doesnt comprise of any such ingredients which can have damaging effects in the short- or long-run. The product is a winner mainly because of this. No additives, fillers or other such harmful components are present in the formula. Since all the ingredients are completely organic you dont have to worry about any negative side effects of use. Lets take a look at the ingredients:

Pricing Of The Product

Did you know that you can get this product for absolutely free? Yes, thats true. For a trial period, the dietary supplement is entirely free of cost. You just have to pay for shipping and handling which just requires $9.95 from your wallet. The trail period lasts for 30 days.

If the product satisfies you, its yours and automatically charges are deducted from your account or card. Thats simple and gives you a chance to see whether or not this supplement actually works. There are also three bonus products that tag along with this supplement. These come for free as well. Heres a list of the bonus product that accompany:

Verdict

Stem Cell Restore is a great product for maintaining youthful energy and strength. The product is great for recovering from the pain and fatigue that usually occurs after the age of 30. This formula repairs and encourages the production of cells through the body. In this way, it improves each organs functionality and hence, overall health. You can know more about this dietary supplement by visiting its website online.

Related

Read more from the original source:
Stem Cell Restore Helps Regain Youthful Strength And Energy - ZOBUZ - Zobuz

Skin Stem Cells Comments Off on Stem Cell Restore Helps Regain Youthful Strength And Energy – ZOBUZ – Zobuz | April 27th, 2020

As the number of confirmed cases of COVID-19 surges past 2.5 million globally with deaths at 177,115 (as of April 22), clinicians and pathologists are struggling to understand the damage its wrought. They realize that although the lungs are ground zero, its reach can extend to many organs: Its viciousness is breathtaking and humbling.

When an infected person expels virus-laden droplets and someone else inhales them, this coronavirus enters the nose and throat. It finds a welcome home in the lining inside the nose. Cells there are rich in a surface receptor (pandikit) called angiotensin-converting enzyme 2 (ACE2), which the virus requires to enter the cell. Once inside, the virus hijacks the cells reproductive machinery, making myriad copies of itself and invading new cells.

A virus can copy anything it wants and can even make itself comfortably adapt to the environment where it chooses to stay while killing the normal cells of your body.

As it multiplies, an infected person may shed copious amounts of it, especially during the first week or so. Symptoms may be absent or the infected may develop fever, dry cough, sore throat, loss of smell and taste, or head and body aches.

Photo from dermatologyadvisor.com

If the immune system does not fight back, the virus then marches down the windpipe to attack the lungs, where it can turn deadly. This is because the thinner, distant branches of the lungs respiratory tree end in tiny air sacs called alveoli, which are also rich in ACE2 receptors. The virus can attach itself again and wreak havoc.

Normally, oxygen crosses the air sacs into the capillaries, tiny blood vessels that lie beside them. The oxygen is then carried to the rest of the body. COVID infection disrupts this healthy oxygen transfer. The front liners of our immune system, white blood cells, release inflammatory molecules called chemokines that summon more immune cells to target and kill virus-infected cells, leaving a stew of fluid and dead cells pus behind. This results in pneumonia: coughing, fever and rapid, shallow breathing.

Some COVID-19 patients recover, sometimes with no support other than oxygen. But others deteriorate, often suddenly, developing a condition called acute respiratory distress syndrome (ARDS). The oxygen levels in their blood plummet and they struggle even harder to breathe. On X-rays and computed tomography scans, their lungs are riddled with white opacities (areas without air). Commonly, these patients end up on ventilators. Many die. Autopsies show their alveoli became stuffed with fluid, white blood cells, mucus and the detritus of destroyed lung cells.

The invaders impact does not end there. The bodys response to destroy it can injure even more organs. Clinicians suspect that the driving force in many gravely ill patients downhill trajectories is a disastrous overreaction of the immune system, or cytokine storm.

Cytokines are chemical signaling molecules that guide a healthy immune response, but in a cytokine storm, levels of certain cytokines soar far beyond whats needed, and immune cells start to attack healthy tissues. Blood vessels leak, blood pressure drops, clots form and catastrophic organ failure can ensue.

Cardiovascular damage occurs.Kidneys, liver, blood vessels, the skin and brain are affected as well.Blood clots can break apart and land in the lungs, blocking vital arteries a condition known as pulmonary embolism that can kill COVID-19 patients.

Brain incursion via the nose can reach the olfactory bulb, inducing loss of smell. Clots from arteries can also lodge in the brain, causing a stroke.

Some people with COVID-19 briefly lose consciousness. Doctors wonder whether in some cases, infection depresses the brain stem reflex that senses oxygen starvation, which explains why some patients are not gasping for air, despite dangerously low blood oxygen levels.

COVID-19 can also infect the lining of the lower digestive tract, where ACE2 receptors are abundant. Viral RNA has been found in as many as 53 percent of patients stool samples, raising the unsettling possibility that it could be passed on through feces. As of this writing, theres no evidence that fecal transmission can occur.

Others develop conjunctivitis pink, watery eyes, others had elevated levels of enzymes indicating injury to the liver or bile ducts.But this may also be due to drugs or an over-driven immune system.

Lastly, cutaneous or skin manifestations have been reported in COVID-19 patients:

Generalized sporadic red rasherupting along the trunk or extremities that are typically transient and resolve on their own. They may be very itchy. Sometimes this can be confused with dengue.

Petechiae.Pinpoint bleeding underneath the skin that does not disappear when pressure is applied.

Generalized urticaria are wheal-like rashes that can coalesce together to form large plaques.

Vesicular eruptionmimicking varicella (chicken pox) blisters.

Vasculopathic presentations. Frostbite-like lesions on the feet and hands multifocal, often asymmetric patches manifest in two to three days. It then evolves to the formation of blisters, to bruises or necrosis (black, dead skin).Sometimes they appear as red, purplish bumps on the feet and hands that evolve into hemorrhagic bullae, or develop a blackish crust due to damage to the lining of the blood vessels, leading to clots that block blood vessels. These can lead to ulcer or gangrene formation, and death.

Acute hemorrhagic edema in infants.Sudden swelling of limbs with patches of bruises in a well-appearing child, before the rash dissipates in 48 hours along with the swelling.

Erythematouslarge patches scattered all over the body that may be slightly itchy.

Localized extreme pruritus,like in the wrist or ankle areas only.

This map of the devastation that COVID-19 can inflict on the body is still just a sketch. It will take years of painstaking research to sharpen the picture of its reach.

* * *

For inquiries, call 8401-8411 or 0917-497-6261, 0999-883-4802 or email gc_beltran@yahoo.com. Follow me on facebook@dragracebeltran.

Continued here:
COVIDs devastation on the body includes the skin - Philippine Star

Skin Stem Cells Comments Off on COVIDs devastation on the body includes the skin – Philippine Star | April 27th, 2020

Cosmetic Skin CareMarketBusiness Insights and Updates:

The latest Marketreport by a Data Bridge Market Researchwith the title[Global Cosmetic Skin CareMarket Industry Trends and Forecast to 2026].The new report on the worldwide Cosmetic Skin CareMarketis committed to fulfilling the necessities of the clients by giving them thorough insights into the Market. The various providers involved in the value chain of the product include manufacturers, suppliers, distributors, intermediaries, and customers.The reports provide Insightful information to the clients enhancing their basic leadership capacity identified.Exclusive information offered in this report is collected by analysis and trade consultants.

Global cosmetic skin care market is set to witness a substantial CAGR of 5.5% in the forecast period of 2019- 2026.

Cosmetic skin care is a variety of products which are used to improve the skins appearance and alleviate skin conditions. It consists different products such as anti- aging cosmetic products, sensitive skin care products, anti- scar solution products, warts removal products, infant skin care products and other. They contain various ingredients which are beneficial for the skin such as phytochemicals, vitamins, essential oils, and other. Their main function is to make the skin healthy and repair the skin damages.Get PDF Samplecopy(including TOC, Tables, and Figures) @https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-cosmetic-skin-care-market

Thestudy considers the Cosmetic Skin CareMarketvalue and volume generated from the sales of the following segments:Major Marketmanufacturerscovered in the Cosmetic Skin CareMarketare:LOral, Unilever, New Avon Company, Este Lauder Companies, Espa, Kao Corporation, Johnson & Johnson Services, Inc., Procter & Gamble, Beiersdorf, THE BODY SHOP INTERNATIONAL LIMITED, Shiseido Co.,Ltd., Coty Inc., Bo International, A One Cosmetics Products, Lancme, Clinique Laboratories, llc., Galderma Laboratories, L.P., AVON Beauty Products India Pvt Ltd, Nutriglow Cosmetics Pvt. Ltd, Shree Cosmetics Ltd

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Based on regions, the Cosmetic Skin CareMarketis classified into North America, Europe, Asia- Pacific, Middle East & Africa, and Latin AmericaMiddle East and Africa (GCC Countries and Egypt)North America (United States, Mexico, and Canada)South America(Brazil, Argentina etc.)Europe(Turkey, Germany, Russia UK, Italy, France, etc.)Asia-Pacific(Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

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Cosmetic Skin Care Market to see impressive Growth by 2027| Leading Companies- L'Oral, Unilever, Espa, Kao, Johnson & Johnson - Cole of Duty

Skin Stem Cells Comments Off on Cosmetic Skin Care Market to see impressive Growth by 2027| Leading Companies- L’Oral, Unilever, Espa, Kao, Johnson & Johnson – Cole of Duty | April 27th, 2020

(L-R) Professor Geoff Lindeman and Professor Jane Visvader

are joint heads of the Institutes ACRF Stem Cells and Cancer

Division.

Using advanced three-dimensional (3D) imaging techniques, the team observed how the immune cells monitor for threats in the mammary ducts and help to maintain tissue health by eating up dying milk-producing cells needing to be cleared away once lactation stops.

The preclinical research was led by Walter and Eliza Hall Institute researchers Dr Caleb Dawson, Professor Geoff Lindeman and Professor Jane Visvader, along with Dr Anne Rios who is now based at the Princess Mxima Center for Pediatric Oncology, Netherlands. It was published today in the journal Nature Cell Biology.

Institute breast cancer researcher Dr Caleb Dawson.

The mammary gland is a dynamic organ that undergoes dramatic remodelling throughout life. The branching ducts bloom to form milk-producing factories in lactation, which must be eliminated once lactation stops. Mammary ducts are of particular interest to breast cancer researchers because this site is prone to cancer development.

While exploring mammary ducts using high-resolution imaging techniques, Dr Dawson said the researchers were surprised to discover a new immune cell type, and its specific role in maintaining healthy, intact breast tissue.

We discovered an entirely new population of specialised immune cells, which we named ductal macrophages, squeezed in between two layers of the mammary duct wall.

We were excited to find that these cells play an essential role at a pivotal point in mammary gland function called involution when lactation stops, milk-producing cells die and breast tissue needs to remodel back to its original state, he said.

We watched incredulously as the star-shaped ductal macrophages probed with their arms and ate away at dying cells. The clearing action performed by ductal macrophages helps redundant milk-producing structures to collapse, allowing them to successfully return to a resting state, Dr Dawson said.

When the researchers later removed ductal macrophages from the mammary ducts they discovered that no other immune cells were able to swiftly carry out this essential process.

Most organs in the body including the brain, liver, lung, skin and intestine have their own population of macrophages a name of Greek origin that means big eater. These cells play important roles in regulating infection, inflammation and organ function within their sites of residence.

Professor Visvader said discovering mammary duct-specific macrophages was a remarkable step forward in understanding how the immune system interacted with the ductal network and impacted upon mammary gland development.

As breast cancer researchers, there is a need to understand which cells are doing what, so that we can identify how these intricate cellular processes become dysregulated, such as in the case of breast cancers, she said.

More than 19,000 Australians are diagnosed with breast cancer every year. It is the most common cancer in Australian women.

Dr Dawson said that going forward, the team hoped to explore the function of ductal macrophages at different stages of mammary gland development, such as the transitions into adulthood and pregnancy.

We also want investigate the role that these duct-specific immune cells play in helping cancer to grow and spread.

Ductal macrophages are spread throughout the mammary ducts. As cancer grows, these macrophages also increase in number. We suspect that theres the potential for ductal macrophages to inadvertently dampen the bodys immune response, which would have dangerous implications for the growth and spread of cancer in these already prone sites, Dr Dawson said.

Professor Visvader said the teams ultimate goal was to understand these cells enough to manipulate them.

Given that tumour macrophages likely promote growth of the tumour, blocking their activity could serve as a treatment strategy for breast cancer, she said.

The research was supported by the National Health and Medical Research Council, the National Breast Cancer Foundation, the Australian Cancer Research Foundation, The Qualtrough Cancer Research Fund, Cure Cancer Australia and the Victorian Government.

Read more:
New type of immune cell discovered in breast ducts - Mirage News

Skin Stem Cells Comments Off on New type of immune cell discovered in breast ducts – Mirage News | April 27th, 2020

In his book 21 Lessons for The 21st Century, historian Yuval Noah Harari begins by writing, In a world deluged by irrelevant information, clarity is power. Before the Internet, access to information was relatively limited, and media was concentrated in the hands of a few corporations, which had its problems.

When it comes to supposed facts about COVID-19 posted on the internet, its best to check first with those doing the real checking: scientists. Photo: AFP

Today, with YouTubers, bloggers, and social media at our fingertips, the world is filled with more information than ever. The problem is that much of it is fake news and rumours. Too many voices are clamouring for our attention, but few are fact-checked for accuracy.

Since the spread of COVID-19 began, weve seen snake oil salesmen hawking cures and prophylaxis, and the spread of conspiracy theories about the viruss origins.

In a world where breathing the same air as someone else can kill you, misinformation can be as deadly as the virus. Now more than ever we need to be mindful of what we say, what we post, and how we behave. So, we need to understand and trust in science.

Why Should We Believe in Science?

According to Harvard Professor Naomi Oreskes, author of Why Trust Science?, for several decades there has been an organised campaign to undermine the publics trust in science funded mainly by industries whose financial interests are threatened by its findings.

At its core, science is the study of how the natural world works.

It has a long history of success, and when done correctly it is the single best method of inquiry we have for the pursuit of truth. Because of science, we have aeroplanes, cars, GPS, the Internet, smartphones and modern medicine. The only reason we know that COVID-19 exists is because of science. More importantly, science is a self-policing system of checks and balances that exists to reveal problems and correct inaccuracies.

It begins with the scientific method, something we all learned in school:

Once a scientist has drawn a conclusion, it undergoes rigorous scrutiny by colleagues who are working in the same discipline. This process of scrutiny can lead to rejecting or accepting the hypothesis, redesigning the experiment or finding additional data to support the conclusion. If the claim is valid, the scientist then publishes their work in a reputable scientific journal such as Nature or Science.

Submission of a paper begins the rigorous peer-review process where experts in the same field deliberately challenge the scientists arguments, inspect their data and look for errors in their methodology. So, before a claim is made and the general media gets a hold of it, a study is peer-reviewed and subjected to scrutiny by dozens, if not hundreds of other experts in the same field.

In areas where there is a scientific consensus, such as the relative safety and efficacy of vaccines, or that climate change is anthropogenic, thousands of studies on these topics have been published over decades and reviewed by thousands of scientists in dozens of countries.

Professor Oreskes notes that a critical aspect of scientific judgment is that it is done collectively and not individually. This weeds out personal biases or someone who might have a specific agenda.

Scientific claims are put through a process much like a trial. Questions are posed, data is analysed, and facts are debated before the community comes to a consensus. This process can take years, even decades. So, when your beliefs are founded on scientific consensus, you are relying on the knowledge of dozens if not hundreds, or thousands of experts in their fields.

Because COVID-19 is still so new, there are lots of unknowns. It will take time to review the data and draw definitive conclusions. There remains speculation about how the virus transmits, whether recovered patients acquire sustained immunity, the effect of heat and humidity have on infection rates and the viability of various treatments, among other things. Nevertheless, our reaction to COVID-19 should be grounded in facts, evidence and empirical data rather than, unfounded opinions, suppositions and fears.

Science Makes Mistakes

Like any other human discipline, science has its failures. For example, in 2014, Japanese biologist Haruko Obokata knowingly falsified data regarding the creation of stimulus acquired pluripotent (STAP) cells in mice. If her claim had been valid, it would have revolutionised the production of embryonic stem cells, which are blank cells that can be programmed to become any of 200 different cell types in the human body, including bone, hair, skin or muscle.

However, due to the self-policing nature of science, within days, other biologists in her field refuted her claims after failing to replicate her experiments. Within months, her paper was retracted, and her career ended in disgrace.

Knowing that science sometimes makes mistakes and admits and corrects for them shouldnt make us trust it any less if anything it should make us believe in it more. Especially when compared to other methods of inquiry, which have no process of scrutiny.

The Problem with Intuition

In his book Thinking Fast Thinking Slow, Nobel Prize-winning behavioural economist Daniel Kahneman defined intuition as, Thinking that you know something without knowing why you do. As an example, he poses this problem:

A bat and ball cost $1.10.

The bat costs one dollar more than the ball.

How much does the ball cost?

If you answered 10 cents, you are incorrect. This question confounds 50% of students from some of the best universities in the world.

The correct answer is 5 cents.

Kahneman identifies two methods for problem-solving. System 1 is quick, intuitive, spontaneous and effortless. It instantly helps us to recognise faces, to act when confronted with dangers and to solve simple questions. System 2 is slow, rational, reflective and effortful. It gets into the drivers seat when you focus and concentrate on a complicated problem.

The problems occur when we try to use System 1 to make complex decisions that require System 2. People will often make judgements based on intuition when a given situation is easy to imagine. For example, when asked what the most dangerous method of generating energy is, public opinion is usually most negative toward nuclear. However, on a per terawatt-hour basis, atomic energy has killed far fewer people than oil, coal and even solar. But because most people conflate nuclear power with war, they tend to answer incorrectly.

When our perception of reality is based on stories that people tell us, rather than science, facts and evidence, it leads to poor decisions. In the modern world, we need to learn to think in terms of data as it is a far too complicated a place to always reason by intuition.

Linear Vs. Exponential Thinking

Part of the reason many governments didnt foresee the problems COVID-19 would create is that their leaders are linear thinkers.

As an example, if you take 30 linear steps, you move 30 standard paces from where you started, or about 30 metres. However, if you take 30 exponential steps, one, two, four, eight, sixteen by the time you get to the last step, you end up a billion metres from where your started thats about 26 times around the planet!

Its the reason why at the beginning of March the United States only had 65 infections and by April 14 it had over 500,000.

We are In This Together

Whether we like it or not, we are in this together. The virus doesnt distinguish between race, social class, tourist, expat or Thai.

We must be careful about what we say or post in social media. The virus kills quickly, but misinformation can also kill by influencing people to do foolish things.

For sources of science that have been peer-reviewed or vetted by experts, you can go to the following websites:

PubMed

The Lancet

Nature Medicine

The New England Journal Of Medicine

The British Medical Journal

WebMD

Healthline

When we depend on intuition, gossip, fake news and conspiracy theories to make decisions, we get leaders who make demonstrably poor decisions that lead to disastrous consequences. In this regard many people think of Donald Trump.

To quote John F. Kennedy, We are not here to curse the darkness, but to light the candle that can guide us through that darkness to a safe and sane future.

Science, both literally and figuratively, is that light; to disregard it is to remain in the dark.

See the article here:
Sustainably Yours: The importance of understanding and trusting in Science - The Phuket News

Skin Stem Cells Comments Off on Sustainably Yours: The importance of understanding and trusting in Science – The Phuket News | April 26th, 2020

Insulin injections cancontrol diabetes, but patients still experience serious complications such as kidney disease and skin infections. Transplanting pancreatic tissues containing functional insulin-producing beta cells is of limited use, because donors are scarce and patients must take immunosuppressant drugs afterward.

Now, scientists atWashington University in St. Louis havedeveloped a way to use gene editing system CRISPR-Cas9 to edit a mutation in human-induced pluripotent stem cells (iPSCs) and then turnthem into beta cells. When transplanted into mice, the cells reversed preexisting diabetes in a lasting way, according to results published in the journal Science Translational Medicine.

While the researchers used cells from patients with Wolfram syndromea rare childhood diabetes caused by mutations in the WFS1 genethey argue that the combination of a gene therapy with stem cells could potentially treat other forms of diabetes as well.

Virtual Clinical Trials Online

This virtual event will bring together industry experts to discuss the increasing pace of pharmaceutical innovation, the need to maintain data quality and integrity as new technologies are implemented and understand regulatory challenges to ensure compliance.

One of the biggest challenges we faced was differentiating our patient cells into beta cells. Previous approaches do not allow for this robust differentiation. We use our new differentiation protocol targeting different development and signaling pathways to generate our cells, the studys lead author, Kristina Maxwell, explained in a video statement.

Making pancreatic beta cells from patient-derived stem cells requires precise activation and repression of specific pathways, and atthe right times, to guide the development process. In a recent Nature Biotechnology study, the team described a successful method that leverages the link between a complex known as actin cytoskeleton and the expression of transcription factors that drive pancreatic cell differentiation.

This time, the researchers applied the technology to iPSCs from two patients with Wolfram syndrome. They used CRISPR to correct the mutated WFS1 gene in the cells and differentiated the edited iPSCs into fully functional beta cells.

After transplanting the corrected beta cells into diabetic mice, the animals saw their blood glucose drop quickly, suggesting the disease had been reversed. The effect lasted for the entire six-month observation period, the scientists reported. By comparison, those receiving unedited cells from patients were unable to achieve glycemic control.

RELATED:CRISPR Therapeutics, ViaCyte team up on gene-edited diabetes treatment

The idea of editing stem cells with CRISPR has already attracted interest in the biopharma industry. Back in 2018, CRISPR Therapeutics penned a deal with ViaCyte to develop off-the-shelf, gene-editing stem cell therapies for diabetes. Rather than editing iPSCs from particular patients themselves to correct a faulty gene, the pairs lead project used CRISPR to edit healthy cells so that they lackedthe B2M gene and expressed PD-L1 to protect against immune attack. The two companies unveiled positive preclinical data inSeptember.

Other research groups working on gene therapy or stem cells for diabetes include a Harvard University scientist and his startup Semma Therapeutics, whichdeveloped a method for selecting beta cells out of a mixture of cells developed from PSCs. Scientists at the University of Wisconsin-Madison recently proposed that removing the IRE1-alpha gene in beta cells could prevent immune T cells from attacking them in mice with Type 1 diabetes.

The Washington University team hopes its technology may help Type 1 diabetes patients whose disease is caused by multiple genetic and environmental factors as well as the Type 2 form linked to obesity and insulin resistance.

We can generate a virtually unlimited number of beta cells from patients with diabetes to test and discover new drugs to hopefully stop or even reverse this disease, Jeffrey Millman, the studys co-senior author, said in the video statement. Perhaps most importantly, this technology now allows for the potential use of gene therapy in combination with the patients own cells to treat their own diabetes by transplantation of lab-grown beta cells.

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Reversing diabetes with CRISPR and patient-derived stem cells - FierceBiotech

Skin Stem Cells Comments Off on Reversing diabetes with CRISPR and patient-derived stem cells – FierceBiotech | April 25th, 2020

Whether youre blasting the heat or AC (or both, because, April), staying inside all day puts you on the fast track to dry skin. Unless youve got a humidifier decorating your WFH space, the air in your home is ripe for sucking the moisture straight out of your face. And while diligently slathering on moisturizer every hour on the hour is certainly one way to hold in the hydration, the easiest method to hydrate skin at home is actually by repurposing your hydrating sleep mask for use during waking hours.

No, were not talking sleeping eye masks. Think of sleep masks, which came to us by way of K-beauty and popularized over the last few years, as a sort of jacket for your skin. Unlike regular masks, they dont need to be washed off, and they create a protective boundary between your skin and environment thats even tougher to permeate than your usual skin products. We recommend using a concentrated mask during the day when working from home, because your skin is so susceptible to losing moisture if you dont adequately hydrate it, says Glow Recipe founder Sarah Lee. Because overnight masks are usually very hydrating with nourishing properties, it really helps to keep that moisture retained throughout the hours. Because of this, its also a great way to maximize the ingredients youre getting from the products youre applying underneath it.

A sleep mask should be the final layer after your usual skin-care routine, and can go on either on top of your moisturizer or in place of it. Scroll through for our favorite picks worth dedicating a spot to in your routine.

This influencer-approved mask is chock full of vitamins (C and E, to be specific) and amino acids that give dull, sleepy skin an instant boost. Its got antioxidants to help protect from free-radical damage, and ceramides to really lock in the moisture it provides.

A combination of watermelon and hyaluronic acid helps to infuse moisture in the skin, and a mixture of AHAs (including glycloic and lactic acids) clear away the top layer of dead skin cells to help moisture penetrate more deeply. The jelly texture is ultra light so that you wont feel like youve got some goopy mask on your face all day long, and can you beat the packaging?

This drugstore beauty buy is not only immensely hydrating (and under $20), but it also leaves behind a pearlescent finish that will make you look luminous while you work. Its formulated with skin-soothing niacinamide and moisture-drawing humectants to hydrate and brighten as it absorbs.

Thanks to its barely-there, water-based formula, this jelly mask absorbs almost immediately into your skin. In addition to highly concentrated mineral water, its also packed with calming and brightening ingredients like orange flower, rose, sandalwood, apricot, and evening primrose. Thirsty pores will drink it right up.

With this mask, youll be waking up, spending your day,and going to sleep beautiful. Its got all kinds of nourishing, natural ingredients like quinoa, mushrooms, and floral stem cells, and is infused with aromatherapy elements to help keep you calm throughout the work day.

Originally posted here:
Repurpose your sleep masks to keep WFH skin fresh and hydrated all day - Well+Good

Skin Stem Cells Comments Off on Repurpose your sleep masks to keep WFH skin fresh and hydrated all day – Well+Good | April 25th, 2020

The global Cosmetic Skin Care market reached ~US$ xx Mn in 2019and is anticipated grow at a CAGR of xx% over the forecast period 2019-2029. In this Cosmetic Skin Care market study, the following years are considered to predict the market footprint:

The business intelligence study of the Cosmetic Skin Care market covers the estimation size of the market both in terms of value (Mn/Bn USD) and volume (x units). In a bid to recognize the growth prospects in the Cosmetic Skin Care market, the market study has been geographically fragmented into important regions that are progressing faster than the overall market. Each segment of the Cosmetic Skin Care market has been individually analyzed on the basis of pricing, distribution, and demand prospect for the Global region.

Request Sample Report @https://www.mrrse.com/sample/6559?source=atm

below:

Global Cosmetic Skin Care Market, Product Analysis

Global Cosmetic Skin Care Market, Application Analysis

In addition the report provides cross-sectional analysis of all the above segments with respect to the following geographical markets:

Global Cosmetic Skin Care Market, by Geography

Each market player encompassed in the Cosmetic Skin Care market study is assessed according to its market share, production footprint, current launches, agreements, ongoing R&D projects, and business tactics. In addition, the Cosmetic Skin Care market study scrutinizes the strengths, weaknesses, opportunities and threats (SWOT) analysis.

COVID-19 Impact on Cosmetic Skin Care Market

Adapting to the recent novel COVID-19 pandemic, the impact of the COVID-19 pandemic on the global Cosmetic Skin Care market is included in the present report. The influence of the novel coronavirus pandemic on the growth of the Cosmetic Skin Care market is analyzed and depicted in the report.

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Potential Impact of COVID-19 on Cosmetic Skin Care Market to Show Outstanding Growth by 2025 Profiling Global Players Industry Developments, Outlook,...

Skin Stem Cells Comments Off on Potential Impact of COVID-19 on Cosmetic Skin Care Market to Show Outstanding Growth by 2025 Profiling Global Players Industry Developments, Outlook,… | April 25th, 2020

The coronavirus crisis is affecting every aspect of our lives, including the condition of our skin. Have you noticed that your skin is particularly spotty, irritated and angry lately? That's another thing you can blame on COVID-19.

Express.co.ukspoke to Dr. Luca Russo, Dermatologist at Urban Retreat, to find out why.Dr. Russo says there are several reasons for your unexpected breakouts.He said: "There might be several reasons for noticing a tendency to break out during this national emergency."It's probably to do with what's going on inside, and what you're putting in your body, says Dr. Russo.

READ MORE- Coronavirus symptoms: Man reveals skin-related warning sign

Are you up all night worrying about the virus?Dr. Russo says: "The most likely cause of your breakout is stress."During such uncertain and stressful times, our system copes with increased production of Cortisol."Cortisol is an androgen hormone that is released when we are facing unusual challenges and prepare us to "fight'."However, it will also increase the sugar level in the bloodstream and production of sebum that might be a cause of the breakout."

In order to prevent breakouts that stem from high levels of stress, you'll need to calm yourself down.Dr Russo recommends doing activities that allow you to relax and unwind, such as yoga.He also suggests exercising regularly, so it's time to start making use of that daily government-approved walk, cycle, or run.

If you hate exercising, don't worry, the antidote to high cortisol levels doesn't have to be physical.Laughing, a solid night of sleep, or practising your favourite hobby are all effective options.

Having a soak in the bath and doing a face-mask may help you feel more in control of your skin.

This relief may cause a decrease in oil production and pimples.

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Can you honestly say you have been eating well throughout the lockdown?Most people have stocked up on sugary treats and salty snacks in order to cheer themselves up in the face of COVID-19.And what about the good-old "support local businesses" excuse you use every time you order a greasy takeaway?Dr Russo says: "During isolation food becomes one of the few focal points of the day with more consumption of comfort food."Just like any other organ in your body, a poor diet affects your skin negatively.The body breaks down our food into tiny particles of proteins, fats, and carbs, and circulates it to the organs that need them.These nutrients make their way to your skin too, impacting its condition.It makes sense that inflammatory foods, such as sweets, some dairy, processed meat, and refined carbohydrates, will cause a flare-up in your complexion.

Dr. Russo says: "To improve your skin, you must eat well."Eat foods that are packed with vitamins and proteins and snack on fruit and veg."Drinking lots of water will replace the moisture that is lost through sweat and other processes, keeping your skin hydrated.If you fill up on foods rich in healthy oils and omega-3 fatty acids, you will improve the collagen production in your skin.This makes your skin smoother, suppler, and will help you in the longterm by preventing premature ageing.These oils and fats are found in fish, nuts, olive oil, and many more commonly found items.

During the lockdown, we're stuck inside all day and often don't get a chance to let our skin feel the sun.Dr. Russo says: "At the moment, skin isn't being exposed to natural light much at all."When your skin is exposed to natural light, the production of Vitamin D is increased."Endorphins are also produced, and this boosts your immune system and well-being."Make sure you get some fresh air every day, in order to reap these benefits of the sun.The sun is a great natural resource to improve your skin, but make sure you protect yourself with sun protection before you go out.You should wear an SPF of at least 30 on your face whenever you leave the house or are in front of a window for a prolonged amount of time.

Most people are shunning makeup in favour of the natural look since no one other than our household is going to see our faces.This means you may be tempted to skip your cleansing routine and go straight to bed once the day is over.

If you normally get facials and now can't, this may also be why you are breaking out or seeing changes.Dr. Russo explains: "You have probably been unable to receive professional treatments over this time, and this will contribute towards your breakouts."Dr. Russo recommends continuing with your normal skincare routine.He says: "Carry on as normal, but add an exfoliating cleanser to your routine."Exfoliating cleansers make your skincare routine shorter, by combining exfoliating and cleansing in one step.They remove dead skin cells and any build-up of dirt and oil in one go.There are hundreds of physical exfoliating cleansers on the market, as well as chemical exfoliating cleansers, so take your pick!

While surgical masks are thought to protect us against coronavirus, they're not great for our skin, said Dr. Russo.Wearing a mask over your face for many hours is damaging to your skin, especially when it's hot outside.The mask offers the perfect spot for bacteria and germs to harbour.Try double cleansing on the lower half of your face if you've worn a surgical mask for a prolonged period of time.

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Breakouts: Why is my skin worse during the coronavirus pandemic? - Express

Skin Stem Cells Comments Off on Breakouts: Why is my skin worse during the coronavirus pandemic? – Express | April 25th, 2020

Dispositiu per a realitzar registres electrofisiolgics amb les llums LED incorporades per lus doptogentica.

Equip investigador.

Researchers from Lund University (Sweeden) and the Institute of Neurosciences of the University of Barcelona (UBNeuro) have recovered, through cell therapy, the mobility and sensibility of mice that suffered a cardiovascular accident. The results of this study were published in the journal Proceedings of the National Academy of Sciences (PNAS).

Researchers used an ischemic model of ictus in mice to which they transferred stem cells obtained from the skin of a healthy human donor. The cells were reprogramed to become neuronal progenitors of the damaged area of the brain, specifically the brain cortex. Six months after the transplant, researchers could observe how the new cells had repaired the damage that was caused by the cerebrovascular injury. In addition, the sensor and motor problems resulting from the stroke had been reversed as well.

We observed that the fibers of the cells that were put in the cortical area grew and created connections in brain areas that are far from the transplant area, notes Daniel Tornero, researcher in the Laboratory of Stem Cells and Regenerative Medicine in UBNeuro. To identify the transplanted cells, researches used different techniques that enable the monitoring so as to prove the connection in damaged circuits is right. Although there is a lot of work to do -the researcher adds-, the study sheds light on the possibility of replacing the damaged cells for new healthy cells in patients with ictus.

This is the last study of a series of three articles in which the researchers used cell therapy to work on brain healing. Previous studies showed it is possible to transplant nervous cells derived from human stem cells or reprogrammed cells in the brain of mice affected by cardiovascular injuries. However, researchers did not know whether the transformed cells could create new connections in the mice brains and restore the movement and feelings of touch.

The next step is to understand how the transplant affects intellectual functions such as memory, and the potential adverse effects, concludes Tornero.

Article reference:

S. Palma-Tortosa, D. l Tornero, M. Grnning Hansen, E. Monni, M. Hajy, S. Kartsivadze, S. Aktay, O. Tsupykov, M. Parmar, K. Deisseroth, G. Skibo, O. Lindvall, y Z. Kokaia. Activity in grafted human iPS cellderived corticalneurons integrated in stroke-injured rat brain regulatesmotor behavior. Proceedings of the National Academy of Sciences (PNAS). Doi: doi: 10.1073/pnas.2000690117

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Researchers use cell therapy to recover damaged brain areas in mice that suffered - Mirage News

Skin Stem Cells Comments Off on Researchers use cell therapy to recover damaged brain areas in mice that suffered – Mirage News | April 25th, 2020

Using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes calledWolfram syndrome, researchers transformed the human stem cells into insulin-producing cells and used the gene-editing tool CRISPR-Cas9 to correct a genetic defect that had caused the syndrome. They then implanted the cells into lab mice and cured the unrelenting diabetes in those mice.

The findings, from researchers at Washington University School of Medicine in St. Louis, suggest the CRISPR-Cas9 technique may hold promise as a treatment for diabetes, particularly the forms caused by a single gene mutation, and it also may be useful one day in some patients with the more common forms of diabetes, such as type 1 and type 2.

The study is published online April 22 in the journal Science Translational Medicine.

Patients with Wolfram syndrome develop diabetes during childhood or adolescence and quickly require insulin-replacement therapy, requiring insulin injections multiple times each day. Most go on to develop problems with vision and balance, as well as other issues, and in many patients, the syndrome contributes to an early death.

This is the first time CRISPR has been used to fix a patients diabetes-causing genetic defect and successfully reverse diabetes, said co-senior investigatorJeffrey R. Millman, PhD, an assistant professor of medicine and of biomedical engineering at Washington University. For this study, we used cells from a patient with Wolfram syndrome because, conceptually, we knew it would be easier to correct a defect caused by a single gene. But we see this as a stepping stone toward applying gene therapy to a broader population of patients with diabetes.

Wolfram syndrome is caused by mutations to a single gene, providing the researchers an opportunity to determine whether combining stem cell technology with CRISPR to correct the genetic error also might correct the diabetes caused by the mutation.

A few years ago, Millman and his colleagues discovered how to convert human stem cells into pancreatic beta cells. When such cells encounter blood sugar, they secrete insulin. Recently, those same researchers developed a new technique to more efficiently convert human stem cells into beta cells that are considerably better at controlling blood sugar.

In this study, they took the additional steps of deriving these cells from patients and using the CRISPR-Cas9 gene-editing tool on those cells to correct a mutation to the gene that causes Wolfram syndrome (WFS1). Then, the researchers compared the gene-edited cells to insulin-secreting beta cells from the same batch of stem cells that had not undergone editing with CRISPR.

In the test tube and in mice with a severe form of diabetes, the newly grown beta cells that were edited with CRISPR more efficiently secreted insulin in response to glucose. Diabetes disappeared quickly in mice with the CRISPR-edited cells implanted beneath the skin, and the animals blood sugar levels remained in normal range for the entire six months they were monitored. Animals receiving unedited beta cells remained diabetic. Their newly implanted beta cells could produce insulin, just not enough to reverse their diabetes.

We basically were able to use these cells to cure the problem, making normal beta cells by correcting this mutation, said co-senior investigatorFumihiko Urano, MD, PhD, the Samuel E. Schechter Professor of Medicine and a professor of pathology and immunology. Its a proof of concept demonstrating that correcting gene defects that cause or contribute to diabetes in this case, in the Wolfram syndrome gene we can make beta cells that more effectively control blood sugar. Its also possible that by correcting the genetic defects in these cells, we may correct other problems Wolfram syndrome patients experience, such as visual impairment and neurodegeneration.

In the future, using CRISPR to correct certain mutations in beta cells may help patients whose diabetes is the result of multiple genetic and environmental factors, such as type 1, caused by an autoimmune process that destroys beta cells, and type 2, which is closely linked to obesity and a systemic process called insulin resistance.

Were excited about the fact that we were able to combine these two technologies growing beta cells from induced pluripotent stem cells and using CRISPR to correct genetic defects, Millman said. In fact, we found that corrected beta cells were indistinguishable from beta cells made from the stem cells of healthy people without diabetes.

Moving forward, the process of making beta cells from stem cells should get easier, the researchers said. For example, the scientists have developed less intrusive methods, making induced pluripotent stem cells from blood and they are working on developing stem cells from urine samples.

In the future, Urano said, we may be able to take a few milliliters of urine from a patient, make stem cells that we then can grow into beta cells, correct mutations in those cells with CRISPR, transplant them back into the patient, and cure their diabetes in our clinic. Genetic testing in patients with diabetes will guide us to identify genes that should be corrected, which will lead to a personalized regenerative gene therapy.

Reference:

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Diabetes Reversed in Mice With CRISPR-Edited Stem Cells From Patients - Technology Networks

Skin Stem Cells Comments Off on Diabetes Reversed in Mice With CRISPR-Edited Stem Cells From Patients – Technology Networks | April 24th, 2020