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Ahead of her 60th birthday on TuesdaySarah Fergusonhas opened up about her cosmetic treatments at the hands of her friendDr.GabrielaMercik- an aesthetician who has given her everything from laser facelifts to organic fillers.

In a candid interview with the Daily Mail, Ferguson and Mercik talked about thecosmetic procedures the Duchess of York has had done over the years,with Ferguson revealing she was Mercik'sguinea pig with new treatments.

The pair spoke to The Daily Mail about their close relationship, as well as Fergusons history with both invasive and non-invasive procedures including botox, mesotherapy and even stem cell therapy - specifically for Fergusons feet.

Sarah Ferguson in October 2019 (Getty Images for BFI)

Ferguson said she was comfortable talking about her treatments, sayingIm really happy to be open about what Ive had done.

Sarah Ferguson in 2010 (Getty Images)

Ferguson revealed in the interview that she used to get Botox, however as technology has advanced shes opted to move away from it. She explained, I had Botox a long time ago when there was nothing else available.

With her aesthetician calling it passe now, Ferguson added, I really dont like the frozen look. Im so animated and I like to be myself. I dont like the thought of needles and am very glad if I look well and happy.

Botox is a cosmetic procedure which is designed to help diminish wrinkles and fine lines, by injecting a chemical solution with a micro needle into specific target areas.

Sarah Ferguson in 2019 (PA)

It was revealed in the Daily Mail that Ferguson started getting mesotherapy in 2013, though she has since moved away from it in favour of other treatments.

Ferguson said that she had chosen mesotherapy to tackle sun damage, saying, I need to repair the damage that was done on the beach when I was a child. Its why I had the mesotherapy, the vitamin cocktail to hydrate and boost the skin.

According to HealthLine, mesotherapy involvesinjecting a mixture of vitamins, enzymes, hormones, and plant extracts. Designed to tighten skin and rejuvenate it, it also removes excess fat and is used by people to do everything from reduce cellulite, diminish wrinkles and tighten loose skin.

HealthLine continues, The technique uses very fine needles to deliver a series of injections into the middle layer (mesoderm) of skin. The idea behind mesotherapy is that it corrects underlying issues like poor circulation and inflammation that cause skin damage.

(Getty Images for GFI)

Following this, Ferguson chose to move onto organic fillers.

Face fillers are designed to both fade wrinkles as well as plump up parts of your face that you want to add volume to. In the case of Fergusons, hers were organic and were described as being non-invasive injectables.

Sarah Ferguson in 2017 (Getty Images)

One of Fergusons more unusual facial procedures involved something called a thread lift. She explained, Before I had it done I thought,Oh this is going to be painful, but it wasnt bad. My skin responded well. I think if you look at photos of me after I had it done, I look much better.

However, Mercik added that Ferguson had since swapped the threads for laser because its non-invasive.

Both Ferguson and Mercik explained what a thread lift involves. Patients have medical threads inserted into the skin to create a supportive mesh that pulls the face upwards - with the threads dissolving after 6-8 months and results lasting two years.

Ferguson explained, Its like garden trellising for sweet peas. You insert the threads under the skin with a fine needle and they hold everything up. They also encourage collagen production. It takes a couple of months, then the sweet peas bloom!

Mercik went into more technical details, explaining, We inserted nano peptides (synthetic growth factors) under the skin which, with the synthetic threads, stimulate collagen production.

Sarah Ferguson at Princess Eugenie's wedding (Getty Images)

Sarah Ferguson revealed that she personally swears by Merciks 6-Dimension Ultimate Laser Treatment facelift. Revealing to the Daily Mail that she much prefers it to Botox, Ferguson explained that she had actually had it done by Mercik prior to her daughter Princess Eugenies wedding.

She explained, Above all, it was being joyful for Eugenie that made me look good. But Id had some laser treatment on my face which helped, too.

She also added that she was undergoing it at the moment, ahead of her birthday on Tuesday. She said, Ive started the laser treatment, but its not finished yet. The collagen needs to rebuild. I hope it will all be done by my birthday.

Merciks laser facelift is non-invasive, pain-free, involves no recovery time and accomplished in no more than 90 minutes. It reportedly helps promote the skins natural production of youth-restoring collagen and is said to continue the work as the weeks pass.

Following a sunscreen-averse childhood (which involved Fergusons mother thinking Nivea moisturiser was sunscreen), Ferguson revealed that she was now very careful about preventing sun damage now - especially after her father and best friend died of skin cancer. She explained, It made me realise you have to look after your skin just as much as your other organs. It isnt just about aesthetics. We have to think about our skin health.

Thats why I dont go in the sun now, she continued. The tan I have is out of a bottle. Fake.

One of Fergusons more recent procedures includes a trip off to the Bahamas, which saw her undergo stem cell therapy to improve her feet. She explained, I think my toes were ruined by all the riding I did when I was young. They shaved the bone here and implanted stem cells 20 million of them taken from my midriff into my feet to make new cartilage.

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Sarah Ferguson opens up about years of plastic surgery from Botox to fillers to stem cell therapy - Evening Standard

Skin Stem Cells Comments Off on Sarah Ferguson opens up about years of plastic surgery from Botox to fillers to stem cell therapy – Evening Standard | October 12th, 2019

(Image: Four Seasons) By Chloe Pek October 11, 2019

Need a different type of getaway? From DNA and blood testing to harvesting your own stem cells, these facilities might make you want to forgo your usual spa retreats

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With so many resorts offering customised retreats tailored to every individual, today's well-travelled spa-goers are no longer satisfied with one-size-fits-all programmes. But beyond personalising activities and treatments to your fitness goals, these destinations are taking bespoke programmes to the next levelones that look into your genetic makeup and medical health to "biohack" your way to beauty and wellness.

(Related: The Tatler 10: Asia's Top Wellness Retreats)

Surrounded by the tropical rainforest in Nusa Dua, south Bali, Revivo Wellness Resort is an intimate retreat that offers 16 Balinese-style suites within three villas. The resort offers a regular schedule of three-day immersive programmes depending on individual goals, from relaxation to weight loss, as well as bespoke retreat programmes. And if you would like to take the personalisation to the next level, Revivo offers three DNA-centric plans that you can add to your programme.

In collaboration with DNA test provider GenePlanet, the Nutrifit and Nutrifit Premium plans offer individually tailored nutritional advice and lifestyle plans, based on your unique DNA makeup. Youll also return with a comprehensive report with analysis from up to 58 different DNA tests to facilitate your wellness goals. Beauty junkies can opt for the Nutriskin plan, which advises on skincare rituals, cosmetics, and diets to achieve optimum skin health.

revivoresorts.com

Surrounded by tropical gardens and white-sand beaches on Mexicos beautiful Riviera Nayarit, the newly renovated Four Seasons Resort Punta Mita offers guest rooms and suites, as well as private beach-front retreats for travellers. Besides a breathtaking oceanside golf-course, the resort also boasts the award-winning Apuane Spa, offering everything from signature massages to holistic therapies.

It is also the only spa in Four Seasons collection that offers DNA testing. Based on results from a simple cheek swab, wellness curators at the resort will create a custom programme that is tailored to your fitness goals and optimal for your genetic makeup, with recommendations to improve your health and diet.

fourseasons.com

(Related: 5 Women's Only Retreats For The Solo Female Traveller)

A preventive health and anti-ageing clinic in Switzerland, Nescens Clinique de Genolier is a luxury destination for medical tourists, overlooking Lake Geneva and the Alps. Programmes include La Cure Nescens, targetted at weight loss; Better-Aging Program which targets lifestyle issues like weight loss, fitness, detox and stress through spa treatments; and the new Nescens Stem Cell Advanced Program, which harnesses your own stem cells to combat signs of ageing.

The programme comprises a very in-depth check-up that includes physical examination, laboratory tests, diagnostic imaging, and cardiology to detect any underlying conditions. Then, following medical consultations with the specialists, a plastic surgeon will extract lipid content via liposuction. Your own stem cells are then separated and re-injected into problem areas together with lipofilling and hydrating mask treatments, to stimulate collagen production and reduce fine lines and wrinkles.

nescens.com

Tucked in a secluded cove by the Caribbean sea, BodyHoliday Saint Lucia is an all-inclusive fitness and spa resort that offers an extensive collection of wellness amenities, including an Ayurvedic temple, wellness centre, freshwater pools, fitness studios, as well as a BodyScience Clinic.

The clinics BodyScience Plus programme offers an in-depth analysis that begins prior to your arrival, requiring guests to complete an online health survey, DNA tests, and other diagnostics recommended by the clinics doctors, such as blood and urine tests. When you arrive, you will receive a personalised plan that will include Ayurvedic meals, a schedule of activities such as yoga, personal training or meditating, and also spa treatments. The programmes are specific to various wellness goals such as digestive health, weight loss, detox, destress and more.

thebodyholiday.com

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Biohack Your Way To Beauty And Health Using Your DNA And Stem Cells At These Wellness Retreats Around The World - Singapore Tatler

Skin Stem Cells Comments Off on Biohack Your Way To Beauty And Health Using Your DNA And Stem Cells At These Wellness Retreats Around The World – Singapore Tatler | October 12th, 2019

This article, written byKatharine Sedivy-Haley, University of British Columbia, originally appeared on The Conversation and is republished here with permission:

When I was applying to graduate school in 2012, it felt like stem cells were about to revolutionize medicine.

Stem cells have the ability to renew themselves, and mature into specialized cells like heart or brain cells. This allows them to multiply and repair damage.

If stem cell genes are edited to fix defects causing diseases like anemia or immune deficiency, healthy cells can theoretically be reintroduced into a patient, thereby eliminating or preventing a disease. If these stem cells are taken or made from the patient themselves, they are a perfect genetic match for that individual, which means their body will not reject the tissue transplant.

Because of this potential, I was excited that my PhD project at the University of British Columbia gave me the opportunity to work with stem cells.

However, stem cell hype has led some to pay thousands of dollars on advertised stem cell treatments that promise to cure ailments from arthritis to Parkinsons disease. These treatments often dont help and may harm patients.

Despite the potential for stem cells to improve medicine, there are many challenges as they move from lab to clinic. In general, stem cell treatment requires we have a good understanding of stem cell types and how they mature. We also need stem cell culturing methods that will reliably produce large quantities of pure cells. And we need to figure out the correct cell dose and deliver it to the right part of the body.

Embryonic, 'induced and pluripotent

Stem cells come in multiple types. Embryonic stem cells come from embryos which makes them controversial to obtain.

A newly discovered stem cell type is the induced pluripotent stem cell. These cells are created by collecting adult cells, such as skin cells, and reprogramming them by inserting control genes which activate or induce a state similar to embryonic stem cells. This embryo-like state of having the versatile potential to turn into any adult cell type, is called being pluripotent.

However, induced pluripotent and embryonic stem cells can form tumours. Induced pluripotent stem cells carry a particularly high risk of harmful mutation and cancer because of their genetic instability and changes introduced during reprogramming.

Genetic damage could be avoided by using younger tissues such as umbilical cord blood, avoiding tissues that might contain pre-existing mutations (like sun-damaged skin cells), and using better methods for reprogramming.

Stem cells used to test drugs

For now, safety concerns mean pluripotent cells have barely made it to the clinic, but they have been used to test drugs.

For drug research, it is valuable yet often difficult to get research samples with specific disease-causing mutations; for example, brain cells from people with amyotrophic lateral sclerosis (ALS).

Researchers can, however, take a skin cell sample from a patient, create an induced pluripotent stem-cell line with their mutation and then make neurons out of those stem cells. This provides a renewable source of cells affected by the disease.

This approach could also be used for personalized medicine, testing how a particular patient will respond to different drugs for conditions like heart disease.

Vision loss from fat stem cells

Stem cells can also be found in adults. While embryonic stem cells can turn into any cell in the body, aside from rare newly discovered exceptions, adult stem cells mostly turn into a subset of mature adult cells.

For example, hematopoietic stem cells in blood and bone marrow can turn into any blood cell and are widely used in treating certain cancers and blood disorders.

A major challenge with adult stem cells is getting the right kind of stem cell in useful quantities. This is particularly difficult with eye and nerve cells. Most research is done with accessible stem cell types, like stem cells from fat.

Fat stem cells are also used in stem cell clinics without proper oversight or safety testing. Three patients experienced severe vision loss after having these cells injected into their eyes. There is little evidence that fat stem cells can turn into retinal cells.

Clinical complications

Currently, stem cell based treatments are still mostly experimental, and while some results are encouraging, several clinical trials have failed.

In the brain, despite progress in developing treatment for genetic disorders and spinal cord injury, treatments for stroke have been unsuccessful. Results might depend on method of stem cell delivery, timing of treatment and age and health of the patient. Frustratingly, older and sicker tissues may be more resistant to treatment.

For eye conditions, a treatment using adult stem cells to treat corneal injuries has recently been approved. A treatment for macular degeneration using cells derived from induced pluripotent stem cells is in progress, though it had to be redesigned due to concerns about cancer-causing mutations.

A path of cautious optimism

While scientists have good reason to be interested in stem cells, miracle cures are not right around the corner. There are many questions about how to implement treatments to provide benefit safely.

In some cases, advertised stem cell treatments may not actually use stem cells. Recent research suggests mesenchymal stem cells, which are commonly isolated from fat, are really a mixture of cells. These cells have regenerative properties, but may or may not include actual stem cells. Calling something a stem cell treatment is great marketing, but without regulation patients dont know what theyre getting.

Members of the public (and grad students) are advised to moderate their excitement in favour of cautious optimism.

Katharine Sedivy-Haley, PhD Candidate in Microbiology and Immunology, University of British Columbia

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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BEYOND LOCAL: Expert recommends 'path of cautious optimism' about the future of stem cell treatment - ElliotLakeToday.com

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New York (AFP)

Creating meat from cells is no longer the realm of science fiction: a Russian cosmonaut did it aboard the International Space Station, and it is just a matter of time before these products arrive in supermarkets.

Tests carried out in space in September led to the production of beef, rabbit and fish tissue using a 3D printer.

This new technology "could make long-term travel possible and renew space exploration," to Mars for example, said Didier Toubia, the head of the Israeli startup Aleph Farms, which provided cells for the tests.

"But our goal is to sell meat on Earth," he told AFP.

The idea "is not to replace traditional agriculture," he said. "It's about being a better alternative to factory farming."

- What's in a name? -

The first burger designed with cow stem cells was made by Mark Post, a Dutch scientist from Maastricht University, and presented in 2013. Several startups have since taken to the niche market.

The cost of production is still very high, and none of the products are available for sale.

The name for the meat products is still up for debate: laboratory, artificial, cell-based, cultivated.

But tastings have already taken place, and industry players are banking on small-scale commercialization taking place fairly quickly.

"It is likely to be this year," Josh Tetrick, the head of California's JUST company, which is growing meat from cells, said at a conference in San Francisco.

"Not on the market in four thousand Walmarts or in all McDonald's, but in a handful of restaurants," Tetrick said.

"The question is what do you want to put out at what cost," said Niya Gupta, founder and CEO of Fork & Goode, which is growing meat from cells in New York.

"As an industry, we are finally making progress on the science. The next step is really making progress on the engineering challenges."

The arrival of laboratory-grown meat on supermarket shelves at reasonable prices could happen in five to 20 years, according to estimates.

But it would need more investment, according to several observers. The sector attracted a total of only $73 million in 2018, according to The Good Food Institute, an organization promoting alternatives to meat and fish.

Another obstacle is regulation, which remains imprecise.

In the United States, for example, the government outlined a regulatory framework that shared oversight of cell-based foods between the Department of Agriculture and the Food and Drug Administration, but it is not yet finalized.

- Labeling -

For supporters, cell-based meat and fish products can transform the production system sustainably by avoiding the raising and killing of animals.

However, questions remain about the real environmental impact, particularly in terms of energy consumption, as well as about safety.

But "the market opportunity is enormous, especially for seafood," said Lou Cooperhouse, the CEO of startup BlueNalu.

"Global demand in the world is at an all-time high," he said of seafood, but "we have a supply problem" with overfishing, climate change and a very variable supply, coupled with "an issue with the supply itself" with, for example, the presence of mercury in some fish.

"What if we could add a third leg on the supply chain, wild caught, farm raised, cell-based?"

Created in 2018, BlueNalu is developing a technological platform that can be used to design various seafood products, mainly fish filets without bones or skin.

Scientific literature on stem cells, biological engineering or organic tissue printing already existed, said BlueNalu's chief technology officer Chris Dammann.

"We need to put the technology back together and optimize it," Dammann said.

The rise of cell-based proteins is not a major source of concern for traditional agriculture.

"It is something we need to monitor," said Scott Bennett, the director of congressional relations for the Farm Bureau organization, which represents farmers and ranchers.

Bennett said he feels "our energy would be much better spent in focusing (on) increasing the overall market shares for proteins, especially in developing countries."

"Some people for social reasons will want to buy this product. But there will always remain a market for conventional meat," he said.

"We feel as it should not be called meat, because we don't want to confuse the consumer as to what this really is. We want to make sure the labelling is very clear," Bennett added.

2019 AFP

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Artificial meat is now made in space, coming to a supermarket near you - FRANCE 24

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The only country that has stood out in creating companies to offer stem-cell therapies has been Japan, while the other countries across the globe have been struggling to achieve the same. It has been five years since Japan has been legally allowed to extract stem cells from different skin biopsies, using them in the injections for chronic and complex diseases such as heart diseases. More than 3,700 treatments have received green light as a result of the regulatory laws being passed. However, a majority of the treatments and therapies have not passed the randomised, controlled, double blind clinical trial a global standard to prove its safety and effectiveness. Not having passed the trial proves its unreliability on the outcome of the treatment altogether.

Although, in fast need of getting therapies and products commercialised, many entrepreneurs and scientists across the world are looking to enter Japan for a more rapid route of getting their business started. Therefore, looking at the rush that various companies are in, in order to commercialise their products, the government is looking to introduce a stringent policy framework for better regulatory changes. This also forces other countries to keep an eye on the regulations to ensure ethical work is being conducted.

The law requires high quality processed stem-cells in certified cell-processing centres and treatments that need to be passed through an independent ethical-review board. While the double-blind clinical trials are expensive in Japan, as claimed by Japans Ministry of Health, Labour and Welfare, there are many ethical issues that are involved by giving placebos to people who are suffering from illnesses. This is the reason behind the need for stringent ethical laws that do not hamper the lives of people in any way and risking their health.

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Threatening regulatory policies for the birth giver of stem-cell technology - Medical Herald

Skin Stem Cells Comments Off on Threatening regulatory policies for the birth giver of stem-cell technology – Medical Herald | October 11th, 2019

Of all the beauty brains we want to pick, Elle Macphersons tops the list. We want to know it ALL. The makeup she uses, her skin care routine, what she eats in the morning, how to make our hair look THAT good, her secret to defying time the whole shebang. So, when the WelleCo founder sat down with us to chat beauty and wellness, youre going to bet we asked her everything.

Get ready to take some notes - heres what a supermodels beauty routine looks like.

On her morning ritual

I am usually up with the sun and like to wake and practice some breathing and mediation. Its a routine that helps balance me from the start of the day. (I aim to not touch my phone).

I then have hot water and lemon.

My son Cy is up at 6am and while hes getting ready for school, I prepare his breakfast and I make myself aSUPER ELIXIR Greens. I find itessentialfor wellness from within. It helps my sense of vitality, strengthens the immune system, supports the digestive system andgivesmy skina healthyglow, plus it seems to curb any sugar cravings, so my moods are more stable, and my diet is more balanced.

Once Cy is off to school, Iexercise, either in my home gym or outside in the fresh morning air, then I have my breakfast.I like to keep it simple - fruit or raw oatmeal or chia seed pudding, before jumping into the shower and getting ready for the day.On the weekends Ill have a bulletproof coffeewith coconut oil and grass-fed butter. Making sure the brain has enough fats is essential for me.

I am obsessed with dry brushing and exfoliating. I useWelleCos Japanese Green Tea Salt Scruband its the first thing I do when showering. If Im feeling courageous, Ill take hot and cold showers to encourage circulation, and usinga great body cream, likeBeautycountersBody Butter in Citrus Mimosa.

After breakfast, I head to my office, usually with 32oz of homemade green vegetable juice including kale, cucumber, turmeric, garlic, lemon, ginger, live sprouts, and Romaine lettuce.I rotate the base of the juice every day between cucumber, celery, spinach and squash. It means I geta variety of nutrients and less chance of my body forming allergies.

On her skin care routine

Beauty-wise,Ilove usingDefenAgeSkincare, which I was introduced to while I was at 11 HotelsJust Agelessspa in New York City. Their products are formulatedusingAge-Repair Defensins, which are peptides that work with our master stem cells to help combat the visible signs of ageing. I love their1-Step Multi-Cleanse, an exfoliator that containsfruit enzymes (including papaya) that are gentler on the skin than acids - but just as effective.

Whilst in Australia this time,I discoveredRationaleat All Saints Clinic.For daywearI love usingtheir B3-T Tinted Superfluid SPF50,whichprovides greatprotectionandgives my skin abeautifulhealthy radiance. In the evening, I usetheDNA Night Creamfor its potent complex of vitamin A,withUniverskinP Serum,which has a bespoke compound ofingredientsdesigned to brighten and hydrate skin, as well as improvethe appearance of pigmentation.

On her go-to makeup brands

I tend to gravitate towards makeup thats subtle and good for my skin. I am enjoying theOxygenetixline that is created and used bydoctors. TheirBreathable Second Skinfoundation is beautiful to wear and great for sensitive skin. I also like theTintSkin Hydrating FoundationbyBeautycounteras it is super hydrating.Gucci Westmans new lineWestman Atelieris fantastic,too.HerVital Skin FoundationSticksare easy to use and look beautifully natural. They are formulated with plant-based actives andfeel supernatural and glowing to wear. I always have my four favourites on standby:foundation,highlighter,blushandcontour. Their packaging is amazing.

On what drives her to launch new products for WelleCo

Through my personal wellness journey, I have discovered that nothing has an impact on my wellbeing like how I nourish my body,which ishowWelleCoreally all began six years ago.We wanted tosharewith the worldthe unique combination of plant-based and Chinese herb supplements I had been taking and experiencing incredible results with.

As an Australian-based company, WelleCo believes in empowering people to positively influence their health. We call it Wellness the Australian way. All of the ingredients were chosen for their ability to work well, as team players, creating a synergistic, amplified effect when combined.

Our constant motivatoris ourloyal, progressive and curious globalcommunity. It isalwaysWelleCos aimto accompanyeach customeron theirwellness journey.No matter what their stage of life, we wantto provide the most premium solutions that areeasy for people to incorporateinto their daily regimes.

Eachof ourproductstargetspecific personalrequirements and providesolutions that benefit all stages of wellbeing, be it our range of plant-based elixirs, our organic vegetable wash orgreen tea salt body scrub.

Our most recent launch, the WelleCo SUPER BOOSTER range,isformulated with botanical extracts and nutrients for targeted support where you need it be it immune system health, liver support or stronger hair, skin and nails. Importantly, it is designed to beeasyto use and an integral step of a simple daily wellness routine. Along with The SUPER ELIXIR and NOURISHING PROTEIN range for men, women and children, our elixirsare formulated toprovidebenefits for the whole family.All you need to do is add water.

I now know, understanding the value of a plant-based diet to feed the mitochondria of the cells isvital andwe wondered if people would value the importance ofgreens andplant-basedproteins.Luckily,our customerstell us theyexperience the same beauty, health and wellness benefitsthat I do,and we are soprivilegedthey choose toincludeWelleCo intheirdailywellnessregimes.

It is this positive feedback,andthe foundation on which we built WelleCo, thatdrivesus to continue toconstantlyinnovateto ensureweareevolvingand supporting our customersindividualwellness journeys.

On her favourite WelleCo products

The SUPER ELIXIR Greens.Its our essential daily greens anda cleanfoundation for cellular and systemic support.Each of ourelixirs are an imperative part of a simple and effective three-step daily wellness routine. The first step is The SUPER ELIXIR. I have two teaspoons every morning with filtered water without fail, and I am loving our new Ginger and Lemon flavour at the moment!

AfterTheSUPER ELIXIR, I recommend our NOURISHING PROTEIN, which isa clean, complete, powdered plant protein designed by nutritional doctors for nourishing and maintaining a lean and strong body. It is the perfect mid-morning or afternoon nourishing snack. I am obsessed with thechocolate;it tastes naughty without any of the bad stuff.

My third stepis our SLEEP WELLE Calming Tea. I have always had quite a lot oftrouble sleeping, so thistea hasnow become my nightly ritual.It is blended with natural herbs including valerian, hops and skullcap to calm the mind and help the body rest, rejuvenate and recover.Be prepared for a very deep and restorative sleep! Its truly amazing.

On her all-time favourite beauty indulgence

I am more a wellness girl to be honest. For me its not about beautifying, but more about wellness, being toned and moisturisedwith soft skin.

I was lucky to experience the most amazing wellness experience this year at Kamalaya, Koh Samui. It is a stunning Wellness Sanctuary and Holistic Spa where you can completely reset the mind and body in a beautiful and calming environment. I love their personalised approach and the focus on restorative and healing treatments, body movement and nutrition. The treatments and philosophy, food and environment were some of the best I have ever experienced. It was a wonderful combination between eastern and western treatments and I although I was there for a week, I could easily have stayed three! I was never bored and felt better as the days went on.

My biggest weekly indulgence is Sheila Perez coming to my house to do the Sheila Perez Method lymphatic drainage and sculpting. I would have her two to three times a week if I could, but for now we have a standing once a week appointment.

I lovemyTherasageThera360Portable Infrared Saunatoo.It assists the detox process, strengthens the immune system and encourages circulation and glowing skin.

On the beauty essentials she packs when travelling overseas

I love myRimowacabin bag. It fits a weeks worth of essentials,which is perfect becauseI love not packing too much stuff its so liberating.

Most importantly for travel is doubling up on my SUPER ELIXIR Greens. I always travel with Immune System Support with Kakadu Plum SUPER BOOSTERS, which I have on their own with water, or combined with my SUPER ELIXIR. Formulated with vitamin C from Kakadu plum and acerola cherry as well as medicinal herbs, they provide immune defence for fighting inflammation and supporting immune system health.

Our NOURISHING PROTEIN is always a must when I am on the road, as often I cant find quality quick and easy food and snacks. NOURISHING PROTEIN is formulated using a combination of organic pea and organic brown rice proteins, as well as herbal extracts, vitamins, minerals and pre and probiotics. It is fantastic for helping energy levels and I find it really fills me up. Its easy to take too, which of course is essential when you are travelling. Just add water, shake and sip.

I stick to my usual skin care routine. I love David de Rothschilds Lost Explorer skin careproducts. It is a super-efficient range and packaged in a travel size so it fits in my suitcase perfectly. And for something more robust the Rationale collection of serums and face creams are the right size for traveling, plus extra efficient and truly work.

My beauty style is always very natural. I dont like to wear a lot of makeup, so my beauty routine is very pared-back and simple. My favourite beauty look is one that starts with a dewy, healthy complexion. I dont tend to wear foundation, but if I need a little coverage, I apply (with my fingers) a touch of Westman AtelierVital Skin Foundation, but only where I need it. For a touch of colour, I smooth onRMS Rose Lip2CheekandPat McGrath Skin Fetishcheek shine for just the right amount of definition.They all come in travel-friendly packaging and are super easy to stow in my bag.

On the kind of beauty and wellness products we would find in her suitcase

For me, beauty comes from the inside out -so first things first -SUPER ELIXIR Greens. Our ultimate ingestible beauty formula is just the right blendof premiumplant-based nutrients that work together to address acidity in the body and nourish right down to cellular level, which really helps the body recover from thestressof travel andI really find helpsreduce jet lag.Ineverfly without mySUPER ELIXIR travel sachetstucked safely in my makeup bag for quick pick-me-ups. I have a SUPER ELIXIRbefore I board, whilst Im in the air, and another as Im landing.

I always pack a NOURISHING PROTEIN TravelSet. I have one daily, blended with water. It helpsensure Ieat as cleanly as possibleandassistswith energy levels and adjusting to a new time zone.It also ensures I always have a healthy snack on hand when options are limited.

I also try to remember to wear broad-spectrum SPF sunscreen every day, especially when out on the reflective ocean sun. Rationale make a great one and I love Dr Barbara Sturm products, particularly her Sun Drops and serums as well as sunblock.

Oh,and Ialways have a tube of LucasPapaw Ointmentstashed away to puton my lips and cuticles. Its very moisturising and very Aussie!

On her favourite career highlight

WelleCo is the combination of wanting to create a business and wanting to enable inner and outer beauty for everyone. I think its fair to say that we all aspire to having a successful business and to make money. But I believe there is also a sort of Holy Grail of business which consists of doing what you love with purpose, making a difference, and making a profit doing it. Its very fulfilling. Andso,this is what we are seeking to achieve with WelleCo creating quality products that are simple to integrate into peoples lives, and that helpthembalancetheir inner and outer beauty. The most exciting thing iswe are reallyonly just getting started!

Being a co-founder, director and shareholder of WelleCo has been very fulfilling but the most joy comes from supporting our team in making the highest quality sustainable plant-based products that help people in their daily life.

On whats next

We have so many exciting things on the horizon for WelleCo,andIm so grateful for where I am, and what Im doing in my life. It is a privilege to be in a position to be able to impact and share with people some of the things Ive learned. And the major one has been the understanding that our bodies areincredible,and they can heal and thrive if given the right environment.

Want more celebrity beauty secrets? Check out the beauty products Phoebe Burgess cant live without, and Shelley Crafts biggest skin sin.

Main image credit: @ellemacpherson

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DUBLIN--(BUSINESS WIRE)--The "3D Bioprinting Market by Component (3D Bioprinters (Microextrusion, Inkjet, Laser), Bioink (Natural, Synthetic, Hybrid)), Material (Hydrogel, Living Cells), Application (Skin, Drug Research), End user (Biopharma, Academia) - Global Forecast to 2024" report has been added to ResearchAndMarkets.com's offering.

The 3D bioprinting market is projected to reach USD 1,647 million by 2024 from USD 651 million in 2019, at a CAGR of 20.4% from 2019 to 2024.

The growth in this market is mainly driven by technological advancements in 3D bioprinters and biomaterials, increasing the use of 3D bioprinting in the pharmaceutical and cosmetology industries, and rising public and private funding to support bioprinting research activities. On the other hand, a shortage of skilled professionals and high development and production costs are hampering the growth of this market.

The major players in the market include Organovo Holdings Inc. (US), CELLINK (Sweden), Allevi Inc. (US), Aspect Biosystems Ltd. (Canada), EnvisionTEC GmbH (Germany), Cyfuse Biomedical K.K. (Japan), Poietis (France), TeVido BioDevices (US), Nano3D Biosciences, Inc. (US), ROKIT Healthcare (South Korea), Digilab Inc. (US), regenHU (Switzerland), GeSiM (Germany), Advanced Solutions Life Sciences (US), and Regenovo Biotechnology Co., Ltd. (China) among others.

Microextrusion technology commanded the largest share of 3D bioprinters segment owing to technological advancements

The component segment of the 3D bioprinting market is segmented into 3D bioprinters and bioinks. The 3D bioprinters market is further sub-segmented on the basis of technology into magnetic 3D bioprinting, laser-assisted bioprinting, inkjet 3D bioprinting, microextrusion bioprinting, and other technologies; whereas bioinks segment is further sub-segmented into natural, synthetic, and hybrid bioinks. The microextrusion bioprinting technology has commanded the largest share of the market in 2019 due to technological advancements in the segment and the increasing research activities.

The drug discovery research application segment accounted for the largest share of the 3D bioprinting market in 2019

In terms of applications, the 3D bioprinting market is segmented into research applications and clinical applications. The demand for research applications is further sub-segmented into drug research, regenerative medicine, and 3D cell culture. Among these, the drug research segment accounted for the largest share of the market in 2019, owing to the growing adoption of 3D bioprinting technology by biopharmaceutical companies. While, in terms of clinical applications, the market is segmented into skin, bone & cartilage, blood vessels, and other clinical applications.

Based on material, living cells segment commanded the leading market share in 2019

Based on material, the 3D bioprinting market is broadly segmented into hydrogels, extracellular matrices, living cells, and other biomaterials. Increasing R&D activities for the use of living cells in 3D bioprinting is driving the growth of the living cells segment. Living cells have the ability to fabricate patient-specific tissues in a defined manner. With advances in 3D bioprinting, scientists and researchers are making use of living cells as a biomaterial in 3D bioprinting. These cells can be used to print living tissues as well as organ structures for surgical implantations. However, ethical issues associated with the use of stem cells in 3D bioprinting might hamper the growth of the segment.

The US 3D bioprinting market to hold prominent market share over the forecast period

On the basis of region, the 3D bioprinting market is segmented into North America, Europe, Asia Pacific, and Rest of the World (Latin America, and the Middle East and Africa). The US held a significant share of the global 3D bioprinting market in 2019. Factors such as new product launches and technological advancements in 3D bioprinting technology and the presence of key players in the region are driving the growth of the 3D bioprinting market in the US. Moreover, extensive research activities and funding for 3D bioprinting will further fuel the market growth in the US.

Market Dynamics

Drivers

Restraints

Opportunities

Challenges

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/y3b5p7

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Global 3D Bioprinting Market Outlook, 2019-2024 - Market Anticipated to Reach $1.64 Billion by 2024 - ResearchAndMarkets.com - Business Wire

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Jenni Murray is spot on staying slim can take its toll on your features, says Christa DSouza

I do love Jenni Murray. For telling it like it is. For those of you not aware of the comments she made at the Henley literary festival, let me recap for you. She recalled the advice given to her by Barbara Cartland Jenni, you know, when you get older you sacrifice your face or your figure. Dont sacrifice your face, just sit down a lot. Murray went on to explain how, despite having gone through a gastrectomy to lose weight, she had, at the age of 69, decided to follow Babss advice because she didnt want to end up looking like Nigel Lawson. And thats no insult to Nigel Lawson, she went on to say in her mellifluous, unbitchy way, but you know, when he

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Want to get rid of a keloid? Here we are with easyand simple keloid removal home remedies that you must try. Keloid is a type of raised scar which appears where the skin had an injury. Skin burn, cut or severe acne cause a scar and some of keloids continue to grow for years.

Baking soda helps to shed the damaged and dead cells. Prepare a mixture of baking soda and diluted hydrogen peroxide. Apply the paste on the keloid affected area with the help of cotton balls and leave it for 30 minutes. Later, wash it off with water and apply any night cream moisturizer. For best results, repeat this process 2-3 times a day for a fewweeks.

ALSO READ:Hair Care: Here Are Four Essential And Simple Grooming Tips For Men

Aspirin, usually used for headache, is also used to get rid of keloids. Due to its anti-inflammatory properties, aspirin is beneficial in the treatment of keloids. Crush 3-4 aspirin tablets and add water to prepare a smooth and thick paste. Apply the paste on a scar and wait until it gets dry. Rinse off by water and apply some olive oil or tea tree oil. Use this method once a day or every alternate day.

Extract the juice from the lemon and apply on the affected area. Leave it for about 30 minutes and later wash it with warm water. For better results follow this process every day. Because of its antioxidant property, lemon helps in quick healing of keloids.

ALSO READ:Google Ban Ads For 'unproven' Medical Treatments, Including Stem Cells

Prepare a paste of sandalwood in rosewater and apply it on the affected area before bedtime. Let it rest for the whole night and rinse off with warm water the next morning. Sandalwood, which is rich in regenerating property when mixed with rosewater, gives the best result to get rid of keloids. Repeat this process every night for one week and observe changes by yourself.

Honey, one of the best-used substances, in several skin treatments, helps in getting rid of keloids. Directly apply fresh honey on scars. Massage lightly and leave it for 30-40 minutes. Rinse it off with water and use this method for some weeks to get rid of keloids.

The above-mentioned home remedies give the best results when followed religiously. As we know keloids are difficult to treat, and hence doctors suggest to take steps soon after injury or piercing. So, whenever you notice scars, follow these steps to get rid of them.

ALSO READ:Nandita Das On Discrimination: 'Wear Your Skin Colour With Confidence'

ALSO READ:Millie Bobby Brown Slammed By Internet For Faking Skin Care Tutorial

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Skincare: Five natural remedies to get rid of keloids overnight - Republic World - Republic World

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This article, written byKatharine Sedivy-Haley, University of British Columbia, originally appeared on The Conversation and is republished here with permission:

When I was applying to graduate school in 2012, it felt like stem cells were about to revolutionize medicine.

Stem cells have the ability to renew themselves, and mature into specialized cells like heart or brain cells. This allows them to multiply and repair damage.

If stem cell genes are edited to fix defects causing diseases like anemia or immune deficiency, healthy cells can theoretically be reintroduced into a patient, thereby eliminating or preventing a disease. If these stem cells are taken or made from the patient themselves, they are a perfect genetic match for that individual, which means their body will not reject the tissue transplant.

Because of this potential, I was excited that my PhD project at the University of British Columbia gave me the opportunity to work with stem cells.

However, stem cell hype has led some to pay thousands of dollars on advertised stem cell treatments that promise to cure ailments from arthritis to Parkinsons disease. These treatments often dont help and may harm patients.

Despite the potential for stem cells to improve medicine, there are many challenges as they move from lab to clinic. In general, stem cell treatment requires we have a good understanding of stem cell types and how they mature. We also need stem cell culturing methods that will reliably produce large quantities of pure cells. And we need to figure out the correct cell dose and deliver it to the right part of the body.

Embryonic, 'induced and pluripotent

Stem cells come in multiple types. Embryonic stem cells come from embryos which makes them controversial to obtain.

A newly discovered stem cell type is the induced pluripotent stem cell. These cells are created by collecting adult cells, such as skin cells, and reprogramming them by inserting control genes which activate or induce a state similar to embryonic stem cells. This embryo-like state of having the versatile potential to turn into any adult cell type, is called being pluripotent.

However, induced pluripotent and embryonic stem cells can form tumours. Induced pluripotent stem cells carry a particularly high risk of harmful mutation and cancer because of their genetic instability and changes introduced during reprogramming.

Genetic damage could be avoided by using younger tissues such as umbilical cord blood, avoiding tissues that might contain pre-existing mutations (like sun-damaged skin cells), and using better methods for reprogramming.

Stem cells used to test drugs

For now, safety concerns mean pluripotent cells have barely made it to the clinic, but they have been used to test drugs.

For drug research, it is valuable yet often difficult to get research samples with specific disease-causing mutations; for example, brain cells from people with amyotrophic lateral sclerosis (ALS).

Researchers can, however, take a skin cell sample from a patient, create an induced pluripotent stem-cell line with their mutation and then make neurons out of those stem cells. This provides a renewable source of cells affected by the disease.

This approach could also be used for personalized medicine, testing how a particular patient will respond to different drugs for conditions like heart disease.

Vision loss from fat stem cells

Stem cells can also be found in adults. While embryonic stem cells can turn into any cell in the body, aside from rare newly discovered exceptions, adult stem cells mostly turn into a subset of mature adult cells.

For example, hematopoietic stem cells in blood and bone marrow can turn into any blood cell and are widely used in treating certain cancers and blood disorders.

A major challenge with adult stem cells is getting the right kind of stem cell in useful quantities. This is particularly difficult with eye and nerve cells. Most research is done with accessible stem cell types, like stem cells from fat.

Fat stem cells are also used in stem cell clinics without proper oversight or safety testing. Three patients experienced severe vision loss after having these cells injected into their eyes. There is little evidence that fat stem cells can turn into retinal cells.

Clinical complications

Currently, stem cell based treatments are still mostly experimental, and while some results are encouraging, several clinical trials have failed.

In the brain, despite progress in developing treatment for genetic disorders and spinal cord injury, treatments for stroke have been unsuccessful. Results might depend on method of stem cell delivery, timing of treatment and age and health of the patient. Frustratingly, older and sicker tissues may be more resistant to treatment.

For eye conditions, a treatment using adult stem cells to treat corneal injuries has recently been approved. A treatment for macular degeneration using cells derived from induced pluripotent stem cells is in progress, though it had to be redesigned due to concerns about cancer-causing mutations.

A path of cautious optimism

While scientists have good reason to be interested in stem cells, miracle cures are not right around the corner. There are many questions about how to implement treatments to provide benefit safely.

In some cases, advertised stem cell treatments may not actually use stem cells. Recent research suggests mesenchymal stem cells, which are commonly isolated from fat, are really a mixture of cells. These cells have regenerative properties, but may or may not include actual stem cells. Calling something a stem cell treatment is great marketing, but without regulation patients dont know what theyre getting.

Members of the public (and grad students) are advised to moderate their excitement in favour of cautious optimism.

Katharine Sedivy-Haley, PhD Candidate in Microbiology and Immunology, University of British Columbia

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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BEYOND LOCAL: Expert recommends 'path of cautious optimism' about the future of stem cell treatment - ThoroldNews.com

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PITTSBURGH (KDKA) In a dish sits a human liver.

Not removed from a person, but created from scratch.

Its not like wahoo and the next morning you think, ah, Im gonna make a human liver,' says Dr. Alejandro Soto-Gutirrez of the Pittsburgh Liver Research Center.

It took five years of trial and error but using stem cells, genetic and tissue engineering, organ cultures and a team of experts in these areas, the researchers have come up with this.

Alexandra Collin de Lhortet, Ph.D. of the University of Pittsburgh School of Medicine explains the process.

A rat liver gets stripped of its cells so that only the connective tissue remains.

From a small piece of human skin, the scientists pluck out stem cells and coax them into becoming human liver cells and the cells are collected.

Then theyre injected into the chamber, called a bioreactor, where they take up residence in the empty rat liver.

The entire process from gathering the cells to make a liver, to get to this point, where you have an actual mini human liver in a bioreactor, takes several months.

It will stay alive, or viable, for only a few days.

But in that short time, the researchers can try different medicines to treat the diseased liver.

You could test any sort of therapeutic by simply injecting this chemical through the system, says Dr. Collin.

In the past, animal livers played a role in this kind of research but human livers didnt always respond in the same way.

With this system, the cells have had genetic modification to recreate diseases, for example, fatty liver, a growing problem in the United States.

This technology has the potential for personalized medicine. From your skin cells, they could grow your own mini liver to figure out which medicines would work for you.

I believe its a very good biological tool to screen treatments that are not otherwise being tested in humans themselves because its dangerous, says Dr. Soto.

As its designed, it would be a long stretch to create livers for transplantation.

If you mean how far we are to make actual livers for people, I think we are very far away. Were probably many years away. But this is a good step, Dr. Soto says.

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After 5 Years Of Trials, Doctors Create Human Liver From Scratch - CBS Pittsburgh

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Lab-grown meat has been successfully made in space for the first time.

Cells of a cow were taken to space where they were grown into small-scale muscle tissue using a 3D bioprinter.

Israeli food technology company, Aleph Farms grew the meat on the Russian segment of the International Space Station, 248 miles away from any natural resources.

The technique could be used in the future to provide meat for people living on the space station.

Aleph Farms said that the aim of the experiment was to advance its research into meat production and prove meat can be produced without natural resources.

"In space, we don't have 10,000 or 15,000 Litres of water available to produce one Kg (2.205 Pound) of beef," Aleph Farms said.

What is lab-grown meat?

This is the world's first lab-grown beef burger in 2013 made in a Petri dish

Lab-grown meat is meat made in a laboratory without killing animals.

Animals are made up of stem cells, which form special tissue like nerve or skin cells.

Scientists worked out how to take cells from an animal - like a cow- and multiply them in a special container called a Petri dish.

Eventually from one tiny muscle cell, tens of billions of cells can be grown. These join together to form muscle tissue.

Lots of strands of muscle tissue together can form 'meat'.

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Dr Madeline Lancaster has discovered how to turn stem cells into grey matter. It could lead to treatments for autism and spinal injury

My teenage daughter asks me where Im heading. I tell her Im off to Cambridge to interview a neuroscientist who grows mini-brains in her lab. Wow, my daughter replies. That is so cool.

I recount this to Dr Madeline Lancaster, the scientist in question. She beams and says she thinks its very cool too. In her labs at the Medical Research Councils state-of-the-art Laboratory of Molecular Biology building she cant conceal her enthusiasm as she shows me the mini-brains small curd-like blobs floating in dishes of pinkish fluid. She says wow a lot.

It is these brain organoids (as in organ-like, rather than organism-like) made of living cells that have made Lancaster, 37, a big name in science since she discovered how to create

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Many of us rely on makeup as the secret to eternal youth. From covering up dark circles with concealer to adding a flush of colour with a rosy blush it's the perfect little pick-me-up.

But, of course, it's never that simple.

And if you're using the wrong products or the wrong techniques, you may not end up quite as fresh faced as you had hoped.

From using too much powder foundation to forgetting to use SPF, many of our go-to habits could actually be making us look older.

We speak to skin expert Paul Banwell to find out exactly what we should and shouldn't be doing.

To keep your skin hydrated, Paul says you can use simple methods to keep looking youthful.

He says: You can use a high intensity moisturiser, or use indigestible products like a liquid collagen drink - I recommend Skinade, the leading collagen drink which is carefully formulated, a mixture of vitamins and minerals which results in optimal skin health.

Wearing oil based products can clog pores and cause breakouts.

Paul says: The effects of clogged pores can be aided with medical facials like the photogenic facial from TBC Skin atelier, or microdermabrasion, followed by Dermalux LED treatments.

Alternatively, I'd recommend a hydroxyacid boost for pH equilibrium and chemical exfoliation - Rationale's Catalyst Range is best.

However, you can also make a difference by making small changes at home.

Paul says: Similarly, overusing fragranced and alcohol based products may dry out the skin, and in turn cause premature lines and wrinkles.

Try to use oil free products, and aim to use hydrating foundations and creams.

Pollution can be responsible for skin dryness, dullness, clogged pores and skin ageing.

Paul says: Some tips for shielding your skin from pollution are wearing sunscreen, using a good moisturiser to create a barrier between your skin and pollutants and double cleansing your skin - use a product like the Rationale Catalyst cleanser.

Sun exposure, both UV and infrared, can result in sunburn which also causes ageing issues for the skin as the years pass.

They're often credited with giving us a matte, flawless finish but powder foundations can be one of the worst culprits when it comes to ageing. Paul says: Avoid powders, as they tend to set into the fine lines of wrinkles which can make your skin look flaky.

For immune protection, and a product which can be used during a Sunday night ritual to make your skin look fresh and luminous for the week ahead which means you won't need to wear foundation, use the immunologist mask - to be performed weekly (the pot lasts 6 months).

It hydrates and reduces inflammation in problem/ sensitive skin.

While concealers are great for hiding flaws and imperfections, they can also draw attention to any unwanted lines and wrinkles.

Paul says: Concealers might be covering the dark circles, but they also accentuating fine lines, so make sure to only apply concealer to the inner half of your under eye.

Prepping the skin before wearing makeup is also key to a youthful glow. Paul says: Skin around the eyes is thinner that the rest of your face and shows age faster!

Eye creams and products that contain Retin A, a form of vitamin A, are most effective and promote the stimulation of collagen and elastin to tighten the skin.

Suncream shouldn't just be reserved for your annual holiday or trips to the beach. Rather, it should be part of your daily skincare regime.

Paul explains: UV exposure causes 90% of skin damage. Even people who already have signs of premature skin ageing can benefit from making lifestyle changes.

We should all be protecting our skin by using SPF 30 or higher which gives your skin a chance to repair some of the damage.

Fine lines and wrinkles absolutely have a part to play here too, and the best way to eradicate these is through protecting the skin against phototoxic damage and minimising loss of skin integrity.

Collagen peptides in a drink like Skinade will increase collagen turnover and are proven to minimise fine lines.

At the Banwell clinic, we offer Ultimate Sunscreen protection with Rationale B3-T, which will ensure skin is not affected as strongly when in sunlight.

After a long day, it can be tempting to just roll into bed without a second thought for your skin. But you may end up paying the price as a result.

Paul says: Sleeping in your makeup can result in the breakdown of healthy collagen which leads to premature skin ageing. Make sure to take your makeup off thoroughly, and Id recommend a Plasma Shower facial to boost cleansing of the skin, using stem cell technology.

Plasma showers alone help improve texture and quality of skin but can be boosted by various mesotherapy treatments including stem cells, hyaluronic acid and vitamins.

Essentially it encourages hydration, which is essential for optimum physiological functioning of the skin and to optimise all biological processes and immune protection.

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Make-up mistakes that make you look older - and item that should go in the bin - Mirror Online

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DetailsCategory: DNA RNA and CellsPublished on Tuesday, 08 October 2019 19:53Hits: 337

Investigational Therapy Designed to Engineer Patients Own Stem Cells to Produce Essential Protein

CAMBRIDGE, MA, USA I October 08, 2019 IAVROBIO, Inc. (NASDAQ: AVRO) (the Company) today announced that the first patient has been dosed in the Companys AVR-RD-04 investigational gene therapy program for cystinosis, a devastating lysosomal storage disease, in an ongoing Phase 1/2 clinical trial sponsored by academic collaborators at the University of California San Diego. The gene therapy is derived from the patients own hematopoietic stem cells, which are genetically modified to produce functional cystinosin, a crucial protein that patients with cystinosis lack.

The trial will enroll up to six patients with cystinosis, a rare inherited disease caused by a defect in the gene that encodes for cystinosin. The cystinosin protein enables transport of the amino acid cystine out of lysosomes. When it is absent, cystine accumulates and crystalizes, causing progressive damage to the kidneys, liver, muscles, eyes and other organs and tissues. Cystinosis affects both children and adults; they face shortened life spans and often painful symptoms, including muscle wasting, difficulty breathing, blindness and kidney failure.

Cystinosis is a debilitating and progressive disease, and new treatment options are sorely needed. The current standard of care does not avert deterioration; at best, it can attenuate symptoms. Thats why gene therapy is particularly exciting: It has the potential to change the course of disease -- and the lives of patients -- by addressing the underlying cause of cystinosis, said Birgitte Volck, MD, PhD, President of Research and Development at AVROBIO. We believe we can engineer patients own stem cells so they sustainably produce the functional protein that is needed to prevent a toxic buildup of cystine and halt progression of the disease. We are so pleased that this investigational gene therapy is now in the clinic in collaboration with Dr. Stephanie Cherqui at UC San Diego.

The single-arm trial will enroll four adults and a potential follow-on cohort of two adults or adolescents at least 14 years of age who are currently being treated with cysteamine, the standard of care for cystinosis. If started at an early age and taken on a strict dosing schedule, cysteamine can delay kidney failure. However, the treatment regimen is highly burdensome, with side effects that can be severe and unpleasant, and many patients find it difficult to adhere to this treatment regimen. Even if compliance is high, cysteamine therapy cannot prevent kidney failure or avert other complications.

For people with cystinosis, there are no healthy days. They must take dozens of pills a day, around the clock, just to stay alive. It is a relentless disease and we urgently need new treatments, said Nancy J. Stack, President of the Cystinosis Research Foundation, which supported development of the gene therapy with more than $5.4 million in grants to Dr. Cherquis lab at UC San Diego. We believe that we are now an important step closer to the potential cure that our community has been working toward for many years.

The trials primary endpoints are safety and tolerability, assessed for up to two years after treatment, as well as efficacy, as assessed by cystine levels in white blood cells. Secondary endpoints to assess efficacy include changes in cystine levels in the blood, intestinal mucosa and skin and cystine crystal counts in the eye and skin. Efficacy will also be evaluated through clinical tests of kidney function, vision, muscle strength, pulmonary function and neurological and psychometric function, as well as through assessments of participants quality of life after treatment. The trial is funded by grants to UC San Diego from the California Institute for Regenerative Medicine (CIRM) as well as the Cystinosis Research Foundation.

This investigational gene therapy starts with the patients own stem cells, which are genetically modified so that their daughter cells can produce and deliver functional cystinosin to cells throughout the body. With this approach we aim to prevent the abnormal accumulation of cystine that causes so many devastating complications, said Stephanie Cherqui, PhD, an Associate Professor of Pediatrics at UC San Diego School of Medicine, and consultant to AVROBIO. We have been working toward this trial for years and we are grateful for all the support that brought us to this moment.

About AVR-RD-04

AVR-RD-04 is a lentiviral-based gene therapy designed to potentially halt the progression of cystinosis with a single dose of the patients own hematopoietic stem cells. The stem cells are genetically modified so they can produce functional cystinosin with the aim of substantially reducing levels of cystine in cells throughout the patients body. Before the infusion of the cells, patients undergo personalized conditioning with busulfan to enable the cells to permanently engraft. The Phase 1/2 clinical trial is being conducted under the name CTNS-RD-04 by AVROBIOs academic collaborators at the University of California, San Diego.

About Cystinosis

Cystinosis is a rare, inherited lysosomal storage disorder characterized by the accumulation of cystine in all the cells of the body, resulting in serious and potentially fatal damage to multiple organs and tissues and the shortening of patients life spans. The kidneys and eyes are especially vulnerable; more than 90% of untreated patients require a kidney transplant before age 20. An estimated 1 in 170,000 people are diagnosed with cystinosis.

About AVROBIO, Inc.

AVROBIO, Inc. is a leading, Phase 2 gene therapy company focused on the development of its investigational gene therapy, AVR-RD-01, in Fabry disease, as well as additional gene therapy programs in other lysosomal storage disorders including Gaucher disease, cystinosis and Pompe disease. The Companys plato platform includes a proprietary vector system, automated cell manufacturing solution and a personalized conditioning regimen deploying state-of-the-art precision dosing. AVROBIO is headquartered in Cambridge, MA and has offices in Toronto, ON. For additional information, visit http://www.avrobio.com.

SOURCE: AVROBIO

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AVROBIO Announces First Patient Dosed in Phase 1/2 Trial of Gene Therapy for Cystinosis | DNA RNA and Cells | News Channels - PipelineReview.com

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Josh LeVine and Oliver Walsh wanted to create a brand for men that wasnt just targeting the french male model on a motorbike. So, to bolster inclusivity and diversity for mens health, the duo built ASYSTEM, a startup which sells skincare and supplement products.

No one is really building in an aspirational, modern, diverse and inclusive way, which is the way we feel that brands should be built, Walsh said from the ASYSTEM beach house in Venice.

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ASYSTEM just raised a $4 million seed round from a crop of investors, including Firstminute Capital, S8 Capital, PLG Ventures. Board members include Kevin Datoo, former COO of Dollar Shave Club.

The betterment startup offers a subscription-based daily vitamin supplement package for $75 a month and a 3-step skincare package for $45 a month. While ASYSTEM wants to redefine mens wellness its hard to forget about the obvious, also venture-backed competition that has risen up recently.

Another company in the direct to consumer male wellness space is Hims, a San Francisco startup that works on men wellness and has raised $197 million in known venture capital to date, according to its Crunchbase profile.

LeVine said that Hims mainly focuses on Rogaine and Viagra through telemedicine. He pointed to two other brands, Roman, which sports healthy hair starting at $0.53 a day and Keeps, that also offers hair loss treatment and said they are not building products for traditional uses.

When you build a proper brand, you put the sticker on your car, he said. I dont know how many men would put a Hims sticker on their car; Id wear an Asystems on a t-shirt.

ASYSTEMs superhuman supplements promise optimization in focus, stamina, energy, mood, and sex drive, according to a press release. As a WIRED story pointed out this year, the blurry line between pharmaceuticals and supplements can be vague and potentially dangerous.

That said, Walsh said ASYSTEM worked with a range of individualsscientists and a qualified nutritionistto formulate the line.

The skincare uses fruit stem cells, avocado oils, and other ingredients, LeVine said. The entrepreneur started another fruit-based skin care product almost 15 years ago, which made its way into hotels and business airlines and used grape extracts from vineyards.

Along with building new products, the company will use the new funding to build out its experiential hub. Two weeks ago, along with the launch, ASYSTEM had a party in its beach house on Venice beach in California. Roughly 50 men from all ages showed up for a dinner, a beach workout, and guided meditation.

Walsh says the biggest surprise was that everyone was able to stay quiet for more than 10 minutes. Its proof, he says, that dialogue and camaraderie can come from this.

Illustration:Li-Anne Dias

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ASYSTEM Launches With $4M In Seed Funding To 'Redefine Male Wellness' - Crunchbase News

Skin Stem Cells Comments Off on ASYSTEM Launches With $4M In Seed Funding To ‘Redefine Male Wellness’ – Crunchbase News | October 9th, 2019

New York, Oct. 08, 2019 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "3D Bioprinting Market by Component, Material, Application, End user - Global Forecast to 2024" - https://www.reportlinker.com/p04680742/?utm_source=GNW The 3D bioprinting market is projected to reach USD 1,647 million by 2024 from USD 651 million in 2019, at a CAGR of 20.4% from 2019 to 2024. The growth in this market is mainly driven by technological advancements in 3D bioprinters and biomaterials, increasing use of 3D bioprinting in the pharmaceutical and cosmetology industries, and rising public and private funding to support bioprinting research activities. On the other hand, a shortage of skilled professionals and high development and production costs are hampering the growth of this market.

Microextrusion technology commanded the largest share of 3D bioprinters segment owing to technological advancements.The component segment of 3D bioprinting market is segmented into 3D bioprinters and bioinks.The 3D bioprinters market is further sub-segmented on the basis of technology into magnetic 3D bioprinting, laser-assisted bioprinting, inkjet 3D bioprinting, microextrusion bioprinting, and other technologies; whereas bioinks segment is further sub-segmented into natural, synthetic, and hybrid bioinks.

The microextrusion bioprinting technology has commanded the largest share of the market in 2019 due to technological advancements in the segment and the increasing research activities.

The drug discovery research application segment accounted for the largest share of the 3D bioprinting market in 2019.In terms of applications, the 3D bioprinting market is segmented into research applications and clinical applications.The demand for research applications is further sub-segmented into drug research, regenerative medicine, and 3D cell culture.

Among these, the drug research segment accounted for the largest share of the market in 2019, owing to the growing adoption of the 3D bioprinting technology by biopharmaceutical companies. While, in terms of clinical applications, the market is segmented into skin, bone & cartilage, blood vessels, and other clinical applications.

Based on material, living cells segment commanded the leading market share in 2019Based on material, the 3D bioprinting market is broadly segmented into hydrogels, extracellular matrices, living cells, and other biomaterials.Increasing R&D activities for the use of living cells in 3D bioprinting is driving the growth of the living cells segment.

Living cells have the ability to fabricate patient-specific tissues in a defined manner.With advances in 3D bioprinting, scientists and researchers are making use of living cells as a biomaterial in 3D bioprinting.

These cells can be used to print living tissues as well as organ structures for surgical implantations. However, ethical issues associated with the use of stem cells in 3D bioprinting might hamper growth of the segment.

The US 3D bioprinting market to hold prominent market share over the forecast period.On the basis of region, the 3D bioprinting market is segmented into North America, Europe, Asia Pacific, and Rest of the World (Latin America, and the Middle East and Africa).The US held the significant share of the global 3D bioprinting market in 2019.

Factors such as new product launches and technological advancements in 3D bioprinting technology and the presence of key players in the region are driving the growth of the 3D bioprinting market in the US. Moreover, extensive research activities and funding for 3D bioprinting will further fuel the market growth in the US.

Breakdown of supply-side primary interviews: By Company Type: Tier 1 - 45%, Tier 2 - 35%, and Tier 3 - 20% By Designation: C-level - 26%, Director-level - 30%, and Others - 44% By Region: North America- 34%, Europe - 26%, APAC - 23%, and RoW - 17%

The major players in the market include Organovo Holdings Inc. (US), CELLINK (Sweden), Allevi Inc. (US), Aspect Biosystems Ltd. (Canada), EnvisionTEC GmbH (Germany), Cyfuse Biomedical K.K. (Japan), Poietis (France), TeVido BioDevices (US), Nano3D Biosciences, Inc. (US), ROKIT Healthcare (South Korea), Digilab Inc. (US), regenHU (Switzerland), GeSiM (Germany), Advanced Solutions Life Sciences (US), and Regenovo Biotechnology Co., Ltd. (China) among others.

Research CoverageThis report studies the 3D bioprinting market based on component, application, material, end-user, and region.The report also studies factors such as drivers, restraints, opportunities, and challenges affecting market growth.

It also provides details of the competitive landscape for market leaders. Furthermore, the report analyzes micro markets concerning individual growth trends, and it also forecasts the revenue of the market segments for four main region.

Key Benefits of Buying the ReportThis report focuses on various levels of analysisindustry trends, market shares of top players, and company profiles, which together form basic views.It also analyzes the competitive landscape; and high-growth countries along with their respective drivers, restraints, challenges, and opportunities.

The report will help both established firms as well as new entrants/smaller firms to gauge the pulse of the market and garner greater market shares.Read the full report: https://www.reportlinker.com/p04680742/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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The 3D bioprinting market is projected to reach USD 1,647 million by 2024 from USD 651 million in 2019, at a CAGR of 20.4% from 2019 to 2024 -...

Skin Stem Cells Comments Off on The 3D bioprinting market is projected to reach USD 1,647 million by 2024 from USD 651 million in 2019, at a CAGR of 20.4% from 2019 to 2024 -… | October 9th, 2019

We are thrilled to share an excerpt form Dr. Q Schulte aufm Erley's article on Plant Stem Cells. Dr. Q is an entrepreneur, scientist and founder of one of our most loved partners: Shtrands. Shtrands is a beauty industry innovator. They provide a hair care concierge service that brings you curated products and expert advice to match your hair texture, scalp condition and styling needs.

The highly competitive cosmetics industry is always looking for the next best ingredient(s) that can fight the aging process and this led to a sizable increase in the number of anti-aging products on the market. With this is coming an increased number of active ingredients developed for this category; one of these ingredients is stem cell extract.This is an ingredient that must be assessed carefully, as marketing claims often push the limits of the available science.

The concept of stem cells originated at the end of the 19th century as a theoretical postulate to account for the ability of certain tissues (blood, skin, etc.) to renew themselves for the lifetime of organisms even though they are comprised of short-lived cells. Stem cells isolation and identification happened many years later though.

Stem cells have received a fair share of attention in the public debate mostly in connection with their potential for biomedical application and therapies. While the promise of organ regeneration have captured our imagination, it has gone almost unnoticed that plant stem cells represent the ultimate origin of much of the food we eat, the oxygen we breathe, as well the fuels we burn. Thus, plant stem cells may be ranked among the most important cells for human well-being.

A stem cell is a generic cell that can make exact copies of itself (daughters) indefinitely. These daughters can remain stem cells or further undergo differentiation (2). Such that a stem cell has the ability to make specialized cells for various tissues in the body, such as heart muscle, skin tissue, and liver tissue.

Because of their self-renewal functions, stem cells are the most important cells in the skin, as they are the source for continuous regeneration of the epidermis. Stem cell cosmetics are developed based on stem cell technology, which involves using extracts or culture media of stem cells. However, cosmetics containing human stem cells or their extracts have not been released into the market due to legal, ethical, and safety concerns. Meanwhile, plant stem cells, which circumvent these problems, are highly regarded in the cosmetics industry for improving culture technology.

The EUprohibits the use of cells, tissues, or products of human origin in cosmetics; stem cell therapy for anti-aging has not been approved or been deemed safe or effective in USA by the FDA. Furthermore, its use outside of a clinical research trial (which would be listed at http://www.clinicaltrials.gov) is prohibited. Whereas the Korea Food and Drug Association has allowed the use of sources originating from stem cell media in cosmetics since 2009 (3).

So, any cosmetics marketed as containing stem cells found on US market (should) contain stem cells extracted from plants.

A major difference between animal and plant stem cells is that plant stem cells provide cells for complete organs (branches, leaves, etc.), compared with the animal stem cells, which regenerate cells restricted to one tissue type.

Plants have nowhere to run when times get tough, so they must rely on an inner body plan to generate developmental responses to environmental changes.

Research by many labs in the last decades has uncovered a set of independent stem cell systems that fulfill the specialized needs of plant development and growth in four dimensions. In some long-lived plants, such as trees, plant stem cells remain active over hundreds or even thousands of years, revealing the exquisite precision in the underlying control of proliferation, self-renewal and differentiation.

There is some confusion around the term stem cell due to the marketing verbiage used by the cosmetic companies. In topical cosmetics the formulations dont contain stem cells straight out of the plants. They are actually a range ofplant stem cell extracts, which are manufactured using a cell culture technology.This technology consists of many and complicated methods that should ensure growth of plant cells, tissues or organs in the environment with a microbe-free nutrient. The plant cell technologyallows synthesis of the biologically active substances that exist in plants, but are not commonly available in natural environment or are difficult to obtain by chemical synthesis.

The extracts obtained through this technology from the plant stem cells are currently used for production of both common or professional care cosmetics (4).

The beneficial apple properties are known for centuries. Apples are cultivated today only for their taste, but earlier the main criterion of the type selection was the shelf life of the fruits.

One of such apple-tree types isUttwiler Spatlauberwhich is growing in Switzerland. This is a type cultivated solely due to a possible long-time storage of fruits, which remain fresh even for several months.Some trees come from the plant cutting sets planted during the 18th century!!!

The stem cell extracts are made in 2 main steps: first, the tissue material is obtained from apples (collected from a cut surfaces of the apples). Secondly, the material is going through a complicated biotechnological process to make the stem cell extracts that contains certain active ingredients. These are actually the ingredients used in formulations marketed as containing stem cells (5).

Swiss biotech company Mibelle Biochemistry created the product named PhytoCellTecTMMalus Domestica, that is a liposomal formulation (extract) derived from the stem cells of the Uttwiler Spatlauber apples. The company has published in vitro experiments done with hair follicles that showed the ability of theUttwiler Spatlauberstem cell extract to delaying of the tissue atrophy process (6); this ingredient delays hair aging.

At Teadora, we chose to includeMibelle'sPhytoCellTecTM Argan Plant Stem Cells in our ButterandBrazilian Glow Oiland here are the details from Mibelle that helped to convince us this ingredient was a must have companion to the huge list of active superfruits we crafted into our products, read on, it's pretty cool:

Deep-Seated Rejuvenation of the Skin:In order to maintain the skin in a healthy condition,cutaneous tissue is being continuously regenerated.This regenerative capacity relies on adult stem cells inthe skin. While considerable research has been done onepidermal stem cells, dermal stem cells were identifiedonly in 2009. The dermis is the middle layer of the skinand gives it tensile strength and elasticity, therefore it isalso the site where wrinkles originate.

PhytoCellTec Argan was developed to improvethe regenerative capacity of dermal stem cells therebyachieving deep-seated rejuvenation of the skin.

PhytoCellTec Argan is a powder based on stem cellsof the argan tree, one of the oldest tree species in theworld.In order to evaluate which active ingredient effectivelypromotes dermal stem cell activity, a stable humandermal papilla cell line was used as a new test system:stem cell activity is assessed based on the expression ofthe Sox2 gene, which is an established stem cell marker.Furthermore, the characteristic property of stem cells togrow in three-dimensional spherical colonies serves asa second observable indicator of stem cell viability inthis assay.

Clinical studies performed on healthy volunteers showedthat PhytoCellTec Argan:

effectively stimulates the regeneration of dermalconnective tissue, thereby increasing skin density

helps the skin to regain its firmness

significantly reduces wrinkle depth in crows feet area.

PhytoCellTec Argan is the very first active ingredientthat is capable of both protecting and vitalizing humandermal stem cells. This will not only help to acceleratethe skins natural repair process but also fights skin agingright at the root. Here are some of the amazing benefits:

Vitalizes and protects dermal stem cells Reduces wrinkles Tightens and tones skin tissues Increases skin firmness and density Deep-seated rejuvenation of the skinFirst cosmetic active with proven results forprotecting and vitalizing dermal stem cells

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Benefits of Plant Stem Cells for Skin & Hair Teadora

Skin Stem Cells Comments Off on Benefits of Plant Stem Cells for Skin & Hair Teadora | September 20th, 2019

Stem cells can do a lot of things - they can heal damaged tissue, reduce inflammation and restore function to damaged tissues. Did you know that stem cells can also improve your skin's quality and reduce the signs of aging? Innovations Stem Cell Center offers fat stem cell therapy for not only a wide array of medical conditions, but also for powerful anti-aging benefits.

How Can Stem Cell Therapy Improve Skin Quality?

Stem cells can help improve skin quality by helping to heal tissues that have been damaged by:

Aging. The aging process causes the breakdown of skin cells and skin quality, leaving the skin looking dull and dirty. Skin also loses elasticity and tightness.

Genetics. Genetics plays a large part in how your skin ages, and it's hard to fight it with over-the-counter products and treatments.

Poor diet. Lack of quality nutrition can negatively impact both the body and the skin. When the skin is not supported through a healthy diet, skin becomes dull, drab and damaged.

Environment. Environmental factors that affect the skin include pollution, dirt and germs. These things clog the pores, dull your appearance and lead to blemishes, acne and breakouts. Environmental factors also include prolonged exposure to the sun, which can cause pigmentation problems and destroy collagen and elastin.

How Is Stem Cell Therapy Used for the Skin?

One of the ways stem cell therapy is used for the skin is through a stem cell face-lift procedure. During this treatment, Dr. Johnson harvests stem cells from unwanted fat taken from another area of your body, such as your lower back or abdomen.

After the cells are harvested, they are separated from the blood and other tissue and then injected into your face with tiny needles.

The stem cell face-lift can be combined with other procedures, such as the facial fat transfer. Combining the procedures increases the odds of stem cell survival and boosts the anti-aging benefits.

What Are the Benefits of Stem Cell Therapy for the Skin?

Patients who undergo stem cell therapy for anti-aging benefits see changes in their skin such as:

Are you interested in learning more about stem cell therapy and its benefits for your skin? Call Innovations Stem Cell today at 214-256-1462 to learn more.

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Stem Cells for Skin Quality - innovationsstemcellcenter.com

Skin Stem Cells Comments Off on Stem Cells for Skin Quality – innovationsstemcellcenter.com | May 27th, 2019

Did you know that around 10,000 skin cells are born from one stem cell? Skin cells are constantly regenerating and on average live for 21 days. They make their way up from the deepest layers of your skin where they then die protecting themselves from external aggressors. As the engine for the constant renewal of your skin it is important we nourish and protect precious stem cells so they can keep producing your best skin.

As you age the activity of stem cells decrease. This is when you start to notice those first signs of ageing; thinner and more delicate skin, sagging, wrinkles and lack of luminosity. After the age of 40, the skins regeneration cycle slows down. New skin cells take longer to reach the surface of the skin, and dead cells can take twice as long to disappear, affecting the youthful appearance of your skin.

Do skincare products and skin treatments with stem cells make sense before the age of 40?Yes!

Young skin regenerates more quickly, and to mimic this we suggest an aggressive treatment, such as a peel, which removes lots of dead skin cells at once, to thenhelp your stem cells to renew andactivate the production of new, healthy and strong skin cells more quickly. Then we recommend stem cell skin products and treatments.

How exactly does a stem cell treatment work? The answer seems simple, but it is the result of many years of scientific research to ensure proven results. At Skeyndor we can guarantee this thanks to our laboratories with more than 50 years of experience in cosmeceuticals. Thanks to our incredible scientists, who have been at the forefront of skin stem cell innovations and breakthroughs we have developed two lines that contain stem cells.

Eternal:Skeyndors Eternalrangecontains the regenerative power of liposomes, derived from apple origin stem cells.These act on your skin stem cells to produce a greater amount of vital dermal substances, filling wrinkles, firming the skin and bringing luminosity to the face.

Timeless Prodigy: Timeless Prodigy by Skeyndor is a technological jewel to globally and definitively fight against the signs of skin ageing. Its formulation contains the revitalizing power of 50 million Damascus rose stem cells and is combined with the power of 10 other active ingredients, including five growth factors, white truffle and kombucha to eliminate signs of ageing. Including wrinkles and sagging, hydrating the skin in depth to revitalize its appearance and create that youthful glow. Timeless Prodigy is exclusive to select Skeyndor Spas and Beauty Salons.

Find your closest Eternal and Timeless Prodigy stockists to see the results for yourself, click here.

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What Can Stem Cells Do For Your Skin? | Skeyndor Australia

Skin Stem Cells Comments Off on What Can Stem Cells Do For Your Skin? | Skeyndor Australia | May 21st, 2019