Gurugram/New Delhi, Dec 19 : In a ground-breaking procedure, Haematologists and Bone Marrow Transplant specialists successfully treated Anurag Mishra, a 47-year-old man from New Delhi, suffering from Multiple Sclerosis (MS) from the past seven years.

The most common symptoms of MS include loss of sensation and balance, restricted arm or leg movement and vision loss in one or both the eyes.

Mishra, who was bedridden earlier, is back to his normal routine life, was diagnosed with MS an autoimmune neurodegenerative disease, where the body's own defence system starts attacking its nervous system, without any specific reason

Unlike the current line of MS treatment, which mainly includes steroid therapy, physiotherapy and symptom management, doctors used Bone Marrow Transplant (BMT).

Dr Rahul Bhargava, Director, Department of Clinical Hematology iamp; Bone Marrow Transplant, Fortis Hospital in Gurugram with his team performed autologous bone marrow transplant where they used Mishra's stem cells for transplant, thereby reducing the chances of rejection and infections.

"In an autologous BMT procedure, the healthy stem cells from the patient are taken out and preserved. Chemotherapy is then administered to reset the body's immunity and then the stem cells are injected back to rescue the person from the side effects of chemotherapy," said Bhargava.

After the surgery, the patient is kept under isolation for a few months to ensure he/she does not contract any infection. In this case, when Mr Anurag approached us, he was entirely dependent on others for his basic needs. But within six months after the treatment, he is back on his legs and is carrying on with his normal life," Bhargava added.

According to the patient, the attacks are sudden and may affect any part of your body, limiting your abilities.

"Extreme pain and disabilities this disease gave, made me very scary and depressing. I think I am very lucky to get to know about Dr Rahul Bhargava and team, who cured me miraculously," Mishra said.

"Too much delay in the procedure can considerably affect the clinical outcomes. In the case of Mr Anurag, recovery is 90 per cent, which means he received the treatment within recovery time-frame," Dr Bhargava said.

See the rest here:
47-year-old successfully treated with bone marrow transplant | newkerala.com News #267197 - New Kerala

Spinal Cord Stem Cells Comments Off on 47-year-old successfully treated with bone marrow transplant | newkerala.com News #267197 – New Kerala | December 20th, 2019

Gurugram/New Delhi: In a ground-breaking procedure, Haematologists and Bone Marrow Transplant specialists successfully treated Anurag Mishra, a 47-year-old man from New Delhi, suffering from Multiple Sclerosis (MS) from the past seven years.

Multiple sclerosis (MS) is a life-long condition, known to reduce life-expectancy. MS affects the brain and spinal cord that leads to serious disabilities.

The most common symptoms of MS include loss of sensation and balance, restricted arm or leg movement and vision loss in one or both the eyes.

Mishra, who was bedridden earlier, is back to his normal routine life, was diagnosed with MS an autoimmune neurodegenerative disease, where the body's own defence system starts attacking its nervous system, without any specific reason

Dr Rahul Bhargava, Director, Department of Clinical Hematology & Bone Marrow Transplant, Fortis Hospital in Gurugram with his team performed autologous bone marrow transplant where they used Mishra's stem cells for transplant, thereby reducing the chances of rejection and infections.

"In an autologous BMT procedure, the healthy stem cells from the patient are taken out and preserved. Chemotherapy is then administered to reset the body's immunity and then the stem cells are injected back to rescue the person from the side effects of chemotherapy," said Bhargava.

After the surgery, the patient is kept under isolation for a few months to ensure he/she does not contract any infection. In this case, when Mr Anurag approached us, he was entirely dependent on others for his basic needs. But within six months after the treatment, he is back on his legs and is carrying on with his normal life," Bhargava added.

According to the patient, the attacks are sudden and may affect any part of your body, limiting your abilities.

"Extreme pain and disabilities this disease gave, made me very scary and depressing. I think I am very lucky to get to know about Dr Rahul Bhargava and team, who cured me miraculously," Mishra said.

"Too much delay in the procedure can considerably affect the clinical outcomes. In the case of Mr Anurag, recovery is 90 per cent, which means he received the treatment within recovery time-frame," Dr Bhargava said.

Here is the original post:
Delhi: 47-year-old successfully treated with bone marrow transplant - ETHealthworld.com

Spinal Cord Stem Cells Comments Off on Delhi: 47-year-old successfully treated with bone marrow transplant – ETHealthworld.com | December 19th, 2019

Stem Cell Assay Market: Snapshot

Stem cell assay refers to the procedure of measuring the potency of antineoplastic drugs, on the basis of their capability of retarding the growth of human tumor cells. The assay consists of qualitative or quantitative analysis or testing of affected tissues and tumors, wherein their toxicity, impurity, and other aspects are studied.

Download Brochure of This Market Report at https://www.tmrresearch.com/sample/sample?flag=B&rep_id=40

With the growing number of successful stem cell therapy treatment cases, the global market for stem cell assays will gain substantial momentum. A number of research and development projects are lending a hand to the growth of the market. For instance, the University of Washingtons Institute for Stem Cell and Regenerative Medicine (ISCRM) has attempted to manipulate stem cells to heal eye, kidney, and heart injuries. A number of diseases such as Alzheimers, spinal cord injury, Parkinsons, diabetes, stroke, retinal disease, cancer, rheumatoid arthritis, and neurological diseases can be successfully treated via stem cell therapy. Therefore, stem cell assays will exhibit growing demand.

Another key development in the stem cell assay market is the development of innovative stem cell therapies. In April 2017, for instance, the first participant in an innovative clinical trial at the University of Wisconsin School of Medicine and Public Health was successfully treated with stem cell therapy. CardiAMP, the investigational therapy, has been designed to direct a large dose of the patients own bone-marrow cells to the point of cardiac injury, stimulating the natural healing response of the body.

Newer areas of application in medicine are being explored constantly. Consequently, stem cell assays are likely to play a key role in the formulation of treatments of a number of diseases.

Global Stem Cell Assay Market: Overview

The increasing investment in research and development of novel therapeutics owing to the rising incidence of chronic diseases has led to immense growth in the global stem cell assay market. In the next couple of years, the market is expected to spawn into a multi-billion dollar industry as healthcare sector and governments around the world increase their research spending.

The report analyzes the prevalent opportunities for the markets growth and those that companies should capitalize in the near future to strengthen their position in the market. It presents insights into the growth drivers and lists down the major restraints. Additionally, the report gauges the effect of Porters five forces on the overall stem cell assay market.

Global Stem Cell Assay Market: Key Market Segments

For the purpose of the study, the report segments the global stem cell assay market based on various parameters. For instance, in terms of assay type, the market can be segmented into isolation and purification, viability, cell identification, differentiation, proliferation, apoptosis, and function. By kit, the market can be bifurcated into human embryonic stem cell kits and adult stem cell kits. Based on instruments, flow cytometer, cell imaging systems, automated cell counter, and micro electrode arrays could be the key market segments.

In terms of application, the market can be segmented into drug discovery and development, clinical research, and regenerative medicine and therapy. The growth witnessed across the aforementioned application segments will be influenced by the increasing incidence of chronic ailments which will translate into the rising demand for regenerative medicines. Finally, based on end users, research institutes and industry research constitute the key market segments.

The report includes a detailed assessment of the various factors influencing the markets expansion across its key segments. The ones holding the most lucrative prospects are analyzed, and the factors restraining its trajectory across key segments are also discussed at length.

Global Stem Cell Assay Market: Regional Analysis

Regionally, the market is expected to witness heightened demand in the developed countries across Europe and North America. The increasing incidence of chronic ailments and the subsequently expanding patient population are the chief drivers of the stem cell assay market in North America. Besides this, the market is also expected to witness lucrative opportunities in Asia Pacific and Rest of the World.

Global Stem Cell Assay Market: Vendor Landscape

A major inclusion in the report is the detailed assessment of the markets vendor landscape. For the purpose of the study the report therefore profiles some of the leading players having influence on the overall market dynamics. It also conducts SWOT analysis to study the strengths and weaknesses of the companies profiled and identify threats and opportunities that these enterprises are forecast to witness over the course of the reports forecast period.

Some of the most prominent enterprises operating in the global stem cell assay market are Bio-Rad Laboratories, Inc (U.S.), Thermo Fisher Scientific Inc. (U.S.), GE Healthcare (U.K.), Hemogenix Inc. (U.S.), Promega Corporation (U.S.), Bio-Techne Corporation (U.S.), Merck KGaA (Germany), STEMCELL Technologies Inc. (CA), Cell Biolabs, Inc. (U.S.), and Cellular Dynamics International, Inc. (U.S.).

Request TOC of the Report @https://www.tmrresearch.com/sample/sample?flag=T&rep_id=40

About TMR Research:

TMR Research is a premier provider of customized market research and consulting services to business entities keen on succeeding in todays supercharged economic climate. Armed with an experienced, dedicated, and dynamic team of analysts, we are redefining the way our clients conduct business by providing them with authoritative and trusted research studies in tune with the latest methodologies and market trends.

Contact:

TMR Research,3739 Balboa St # 1097,San Francisco, CA 94121United StatesTel: +1-415-520-1050

This post was originally published on Industry Mirror

See the article here:
Stem Cell Assay Market Predicted to Accelerate the Growth by 2017-2025 - Industry Mirror

Spinal Cord Stem Cells Comments Off on Stem Cell Assay Market Predicted to Accelerate the Growth by 2017-2025 – Industry Mirror | December 19th, 2019

Cell Processing Technologies Market: Introduction

Cell processing involves a series of activities ranging from cells collection from donor, cell extraction till the storage, and cells distribution to receiver for cell therapy. Cell processing includes various processes of cell collection, cell isolation, cell analysis, cell expansion, washing and concentration, preservation, and distribution.

Cell therapy refers to administering of living whole cells in a patient for treating a disease. Cells origin can be from the same individual, known as autologous source or from another individual, known as allogeneic source. For cell therapy, different types of cells can be used, including hematopoietic stem cells, skeletal muscle cells, embryonic stem cells, neural cells, and mesenchymal cells. Cell therapy is used for the treatment of autoimmune diseases, cancers, infectious and urinary diseases, repairmen of spinal cord injuries, rebuilding damaged cartilage in joints, improvement of a weakened immune system, and aiding patients with neurological disorders.

Request a Brochure of Cell Processing Technologies Market Report

https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=73602

Key Drivers of Global Cell Processing Technologies MarketIncrease in demand for cell therapy, as it is the only curative treatment for several diseases, such as autoimmune disease, cancer, and neural disease. This factor is responsible for growth of the global cell processing technologies market.

There is a rise in prevalence of various diseases, such as cancer, immune diseases, neurological disorders, cardiovascular disease, etc. According to the National Cancer Institute, in 2016, there were an estimated 15.5 million cancer survivors in the U.S. The number of cancer survivors is anticipated to increase to 20.3 million by 2026.

Personalized medicines or precision medicines with advanced treatments such as gene therapy and cell therapy are witnessing a surge in their adoption, as most of the key biotechnology and pharmaceutical players are heavily investing in these technologies

Government investments in cell-based researches, rise in the number of GMP-certified production facilities, and increase in clinical trials of various diseases are key factors propelling the growth of the global cell processing technologies market

For More Actionable Insights into The Competitive Landscape of Cell Processing Technologies Market , Pre Book This Report

https://www.transparencymarketresearch.com/checkout.php?rep_id=73602&ltype=S

Key Restraints of Global Cell Processing Technologies Market

Cell processing is a complex procedure with high probabilities of failure. Thus, its complexity and accuracy demand technologically advanced and high-tech infrastructure, along with a skilled operating staff. These incur high infrastructural and operating costs, which limit its adoption on a large scale.

High operating cost also leads to high cell therapy cost to patients. However, at present, the cell therapy is approved for a limited number of conditions, which further limits the usage of cell processing technologies and services

Equipment Segment of Cell Processing Technologies Market to Witness Strong Growth

Complexity in cell processing steps and accuracy required for procedure has led to the development of advanced automated cell processing systems. Key players have been heavily investing in the development of advanced cell processing systems. Advancements in software for managing these systems are projected to expand the application areas for cell processing units.

In May 2018, GE Healthcare introduced the Sefia S-2000 cell processing system, which is advanced than its predecessor Sefia S-1000 cell processing system. This advanced system was developed with focus on chimeric antigen receptor (CAR) T-cell therapy.

Investments in CAR-T and other cell and gene therapy products are projected to drive the adoption of cell processing equipment. As the installed base for cell processing systems is projected to surge, the demand for consumables is likely to grow during the forecast period.

Oncology is projected to be the most promising application area of cell processing technology, considering high investments and ongoing research in cell therapies for cancer treatment and high investment made by key biotechnology and pharmaceutical companies in this area.

About Us

Transparency Market Research is a next-generation market intelligence provider, offering fact-based solutions to business leaders, consultants, and strategy professionals.

Our reports are single-point solutions for businesses to grow, evolve, and mature. Our real-time data collection methods along with ability to track more than one million high growth niche products are aligned with your aims. The detailed and proprietary statistical models used by our analysts offer insights for making right decision in the shortest span of time. For organizations that require specific but comprehensive information we offer customized solutions through adhoc reports. These requests are delivered with the perfect combination of right sense of fact-oriented problem solving methodologies and leveraging existing data repositories.

TMR believes that unison of solutions for clients-specific problems with right methodology of research is the key to help enterprises reach right decision.

ContactTransparency Market ResearchState Tower,90 State Street,Suite 700,Albany NY 12207United StatesTel:+1-518-618-1030USA Canada Toll Free:866-552-3453Email:[emailprotected]Website:http://www.transparencymarketresearch.com

Go here to read the rest:
Cell Processing Technologies Market Segmentation and Forecast Analysis up to 2027 - 101Newsindustry

Spinal Cord Stem Cells Comments Off on Cell Processing Technologies Market Segmentation and Forecast Analysis up to 2027 – 101Newsindustry | December 18th, 2019

Gary L. Dunbar, executive director of the Field Neurosciences Institute, part of Ascension St. Mary's, was recently presented with the Gusi Peace Prize International Award.

Dr. Dunbar recently traveled to Manila, Philippines to accept this honor at the Gusi Peace Prize International 20th Annual Awards Night.

The Gusi Peace Prize award is given by the Gusi Peace Prize Foundation to recognize individuals and organizations who contribute to global peace and progress through a wide variety of fields. Dunbar was one of 18 international recipients selected for the award and chosen because of his global contributions in both the educational and the research domains of neuroscience. Similarly, his contributions in research, especially for developing new strategies for treating damage to the nervous system, including transplantation of genetically altered adult stem cells as a potential therapy for injury to the brain and spinal cord as well as neurological deficits in Huntington's, Parkinson's and Alzheimer's diseases, has earned international recognition and a prominent leadership role in the American Society for Neural Therapy and Repair.

"I felt both honored and humbled to be selected for the Gusi Peace Prize, especially after meeting and hearing, first-hand, what the other 2019 Gusi Laureates have accomplished in the context of helping others, which was humbling to me," shared Dunbar. "The prize is given to those whose efforts have provided significant improvements to the lives of others through education, research, politics, and/or the arts, along with a strong commitment to humanitarian commitments, so I felt deeply honored to be included in this group of people."

Dunbar has been the executive director for the Field Neurosciences Institute since 2008. Martha Ann Joseph, Chair of the institute's board of directors, was thrilled to hear that Dunbar was a recipient of the Gusi Peace Prize International Award.

"(Field Neurosciences Institute) is blessed to have Dr. Dunbar as our executive director for the past 11 years as he has always embraced the mission of the organization, to help others in terms of preventing brain injury and searching for cures for neurological problems emanating from trauma and disease to the nervous system," Joseph said.

"Dr. Dunbar embodies the very premise of the Gusi award in attaining peace and dignity for fellow humans by his tireless devotion to finding new ways to treat a variety of neurological disorders and for his dedicated efforts in educating the next generation of neuroscientists, physicians, and health-care providers at the highest level," added E. Malcolm Field, Field Neurosciences Institute director.

Presently, Dunbar holds the John G. Kulhavi Professorship in Neuroscience, as well as the E. Malcolm Field Endowed Chair in Neuroscience at CMU.

The Gusi Peace Prize was founded by the Honorable Ambassador Barry Gusi, to honor and continue the work of his late father, Captain Gemeniano Javier Gusi, who fought against Japanese oppression during World War II and later championed human rights in the Philippines. For 20 years, the Gusi Peace Prize Award has been awarded to prominent individuals from all over the world who have made significant contributions to the betterment of humankind.

Here is the original post:
International Peace Prize awarded to Ascension St. Mary's executive director - Midland Daily News

Spinal Cord Stem Cells Comments Off on International Peace Prize awarded to Ascension St. Mary’s executive director – Midland Daily News | December 16th, 2019

Sometimes when hes asleep, Nick Hernandez has this dream.

The 54-year-old Homer Glen man is playing baseball for a professional team. He hits a ball down the line. He smells the grass. Everything is normal, vividly normal.

And then

Hernandez wakes up in a body that had a C-6 spinal injury 37 years ago.

Before the accident, Hernandez played basketball and baseball for the former Joliet Catholic High School (now Joliet Catholic Academy). He was a college prospect for both sports and was to serve as team captain for both sports his senior year.

Hernandez also was a scholar, ranking 30th out of 205 students. His grade-point average was 4.03

I loved Joliet Catholic, Hernandez said, even though I felt like a fish out of water freshman year because all my friends went to Lockport.

Hernandez has remained close to his Catholic High family through the years. And like a good family, this close group of his friends is raising $75,000 to buy Hernandez a new special needs van, which will keep him mobile and independent.

His current van is 19 years old, and Hernandezs mechanic said it soon will be unsafe to drive, Hernandez said.

Hernandez appreciates their friendship and expressed it more than once.

Im the luckiest guy on the face of the earth, he said, despite the injury.

The injury that changed his life happened Aug. 4, 1982.

It was 9:30 p.m. and Hernandez was driving home from a friends house. He was on 143rd Street, less than a mile from home, when two horses jumped out. He remembers the impact, the horses coming down on top of my vehicle before slipping into unconsciousness.

I woke up a few minutes later in the vehicle, Hernandez said. My rearview mirror was bent and facing me, and I had blood streaming down my face. I could not move, and I was in a great deal of pain, neck pain Id never felt before. I kind of knew immediately. I just knew I had a spinal cord injury.

Oddly enough, he said, a friend of the family recently had a neck injury while swimming, an incident Hernandez had only vaguely noted at the time, but something he recalled in that moment, with his vehicle on the opposite side of the road and the nice cut in the top of my head, which would leave a permanent scar.

But a scar was not Hernandezs concern at the time.

My job was just to fight, to try to stay alive, quite honestly, Hernandez said.

His parents, Nick Sr. and Madeleine, soon arrived on the scene; a priest gave last rites on the spot. Hernandez recalled thinking, Well, this is how it ends.

Hernandez said he was taken to Silver Cross to be stabilized and was transferred to Northwestern Memorial Hospital that night, his home until December. He spent three days in the intensive care unit, where he was given morphine to help him sleep, Hernandez said.

He wore a brace that was drilled into his temples to stabilize his spine You feel like Frankenstein, Hernandez said, and he was periodically rotated every two hours, as if he was on a rotisserie, he said.

It was a do-or-die situation, Hernandez said. I guess something inside me said, Youre still alive. You have to. Too many people just cared about me, I guess this was long before Christopher Reeve. I was just a kid who fought to stay alive.

Hernandezs weight dropped from 180 to 130 pounds as his muscles atrophied, he said. He learned to breathe through his diaphragm.

The experience forced him to grow up fast, he said, which he did, with the help of family, friends, teammates and coaches (Mike Gillespie coached Hernandez for basketball ,and Jack Schimanski coached Hernandez for baseball) who visited him.

I never wrapped my arms around how it could be so emotional for someone else, Hernandez said. Its the ripple effect I didnt understand at the time.

When physical therapy was completed, Hernandez returned to Catholic High to complete his senior year and graduated with honors. While there, he attended school events prom, as well as baseball and basketball games.

He eventually relearned to drive, using hand controls in a modified van. It was frightening at first, until Hernandez moved past that fear.

I wanted to be on the road again, Hernandez said. Thats the one thing about driving; it gives you that freedom.

He worked for medical supply companies until he wound up with pressure ulcers in 2010 that led to a bone infection and a flap surgery to correct it.

It was not a good time in my life, Hernandez said.

But it gave him time to reevaluate his life. He moved back to his parents house, where he now lives in a basement apartment. He now focuses his energy on taking better care of himself and spending time with loved ones, including going to movies with his girlfriend.

He still deals with nerve pain, although some days are better than others, he said.

Hernandez exercises at home with the use of a standing table (which puts pressure on his bones and reminds people just how tall he is at 6-foot-4) and swims using a modified butterfly stroke all summer in the family pool.

I just drag my legs behind me, Hernandez said. I may do 30 to 40 laps in the pool. Its really, really helpful for one with a spinal cord injury, or anybody really, when rehabbing. The water is a good way to exercise without putting too much pressure on the body.

Watching athletes, especially his nieces and nephews who play sports, from the sidelines has given Hernandez an appreciation of the capabilities of the human body when all parts work in unison.

And he thinks, I used to do that

But Hernandez has learned to deal with it, he said.

Because the other options arent pretty, Hernandez said. So if not for my family and friends, and obviously my belief in God you have doubts here and there, but I still have my faith I can hang in there if you can laugh with this injury, you can make it another day. As long as the good Lord wants you around, youll still be there. Im not preaching to anybody, but this is how I choose to live.

Hernandez still clings to his dream, his dream of walking one day.

Hes extremely excited about a Nov. 27 report from Mayo Clinic about how STEM cells from a patients fat can improve sensory motor function in people with spinal cord injuries.

If I just keep myself in shape, maybe, if Im here in another five years, maybe I can still walk, Hernandez said. It kind of keeps you motivated.

HOW TO HELP

Visit gofundme.com/f/new-wheels-for-nick-in-2020 or make checks payable to Nick Hernandez and mail to Al Petro, 4712 Galway Road, Joliet, IL 60431.

Visit link:
'I was just a kid trying to stay alive' - The Herald-News

Spinal Cord Stem Cells Comments Off on ‘I was just a kid trying to stay alive’ – The Herald-News | December 16th, 2019

Cell processing involves a series of activities ranging from cells collection from donor, cell extraction till the storage, and cells distribution to receiver for cell therapy. Cell processing includes various processes of cell collection, cell isolation, cell analysis, cell expansion, washing and concentration, preservation, and distribution.

Cell therapy refers to administering of living whole cells in a patient for treating a disease. Cells origin can be from the same individual, known as autologous source or from another individual, known as allogeneic source. For cell therapy, different types of cells can be used, including hematopoietic stem cells, skeletal muscle cells, embryonic stem cells, neural cells, and mesenchymal cells. Cell therapy is used for the treatment of autoimmune diseases, cancers, infectious and urinary diseases, repairmen of spinal cord injuries, rebuilding damaged cartilage in joints, improvement of a weakened immune system, and aiding patients with neurological disorders.

Key Drivers of Global Cell Processing Technologies Market

Increase in demand for cell therapy, as it is the only curative treatment for several diseases, such as autoimmune disease, cancer, and neural disease. This factor is responsible for growth of the global cell processing technologies market.

There is a rise in prevalence of various diseases, such as cancer, immune diseases, neurological disorders, cardiovascular disease, etc. According to the National Cancer Institute, in 2016, there were an estimated 15.5 million cancer survivors in the U.S. The number of cancer survivors is anticipated to increase to 20.3 million by 2026.

Request a PDF Sample on Cell Processing Technologies Market Report

https://www.transparencymarketresearch.com/sample/sample.php?flag=S&rep_id=73602

Personalized medicines or precision medicines with advanced treatments such as gene therapy and cell therapy are witnessing a surge in their adoption, as most of the key biotechnology and pharmaceutical players are heavily investing in these technologies

Government investments in cell-based researches, rise in the number of GMP-certified production facilities, and increase in clinical trials of various diseases are key factors propelling the growth of the global cell processing technologies market

Key Restraints of Global Cell Processing Technologies Market

Cell processing is a complex procedure with high probabilities of failure. Thus, its complexity and accuracy demand technologically advanced and high-tech infrastructure, along with a skilled operating staff. These incur high infrastructural and operating costs, which limit its adoption on a large scale.

High operating cost also leads to high cell therapy cost to patients. However, at present, the cell therapy is approved for a limited number of conditions, which further limits the usage of cell processing technologies and services

Equipment Segment of Cell Processing Technologies Market to Witness Strong Growth

Complexity in cell processing steps and accuracy required for procedure has led to the development of advanced automated cell processing systems. Key players have been heavily investing in the development of advanced cell processing systems. Advancements in software for managing these systems are projected to expand the application areas for cell processing units.

In May 2018, GE Healthcare introduced the Sefia S-2000 cell processing system, which is advanced than its predecessor Sefia S-1000 cell processing system. This advanced system was developed with focus on chimeric antigen receptor (CAR) T-cell therapy.

Investments in CAR-T and other cell and gene therapy products are projected to drive the adoption of cell processing equipment. As the installed base for cell processing systems is projected to surge, the demand for consumables is likely to grow during the forecast period.

Pre Book this Report

https://www.transparencymarketresearch.com/checkout.php?rep_id=73602&ltype=S

Oncology is projected to be the most promising application area of cell processing technology, considering high investments and ongoing research in cell therapies for cancer treatment and high investment made by key biotechnology and pharmaceutical companies in this area.

About Us

Transparency Market Research is a next-generation market intelligence provider, offering fact-based solutions to business leaders, consultants, and strategy professionals.

Our reports are single-point solutions for businesses to grow, evolve, and mature. Our real-time data collection methods along with ability to track more than one million high growth niche products are aligned with your aims. The detailed and proprietary statistical models used by our analysts offer insights for making right decision in the shortest span of time. For organizations that require specific but comprehensive information we offer customized solutions through adhoc reports. These requests are delivered with the perfect combination of right sense of fact-oriented problem solving method-ologies and leveraging existing data repositories.

TMR believes that unison of solutions for clients-specific problems with right methodology of re-search is the key to help enterprises reach right decision.

ContactMr. Rohit BhiseyTransparency Market ResearchState Tower,90 State Street,Suite 700,Albany NY 12207United StatesTel: +1-518-618-1030USA Canada Toll Free: 866-552-3453Email: sales@transparencymarketresearch.comWebsite: http://www.transparencymarketresearch.comBlog: https://theglobalhealthnews.com/

Read the original here:
Cell Processing Technologies Market Segments, Leading Player, Application and Forecast Analysis - Techi Labs

Spinal Cord Stem Cells Comments Off on Cell Processing Technologies Market Segments, Leading Player, Application and Forecast Analysis – Techi Labs | December 16th, 2019

Article courtesy of : Dr. Brent Wells, D.C.

While it is very important to be sure the whole body is healthy and maintains that good health, its also important to understand key factors regarding why the health of the spine in particular; is important. Not only is a healthy spine important for the back area, obviously, but its also beneficial in terms of the body as a whole.

Because the spine and back must be kept healthy, its understanding how it affects the rest of the body that helps one to strive to reach that level of health. Some patients dont always understand the way a healthy spine assists in maintaining a healthy immune system within. However, as an Anchorage chiropractor, I am constantly showing my patients the importance of this health aspect.

To maintain a healthy and active life requires one to have a healthy spine. Maintaining a consistent good posture is one key factor that assists the body in terms of that.

Its important to keep in mind that the spine is responsible for supporting the body along with providing structure to the body. Without support or structure, the body will eventually fail and wont be able to perform daily functions.

The spinal cord alone is responsible for certain reflexes where the body is responding quickly to outside stimulants (ex. Your hand touching a hot stove and quickly and immediately removing the hand from the heat and pain). Therefore, anytime the spine is misaligned, the body is at risk of losing those necessary functions.

Anytime the spine is imbalanced, some other aspect of the body runs the risk of being compromised. Typically, the immune system is hindered because of an imbalance in the spine. A compromised spine means that the Central Nervous System is compromised, and when the CNS is compromised, the necessary responses regarding the immune system of the body are challenged.

The spinal cord houses very important nerves that directly communicate with the brain, being sure the rest of the body understands what to do and how to move.

Balance can also be affected when the spine is in a vulnerable position. Every movement that the body makes is coming from the connection of the spinal cord and the brain, minus those reflexes solely stemming from the spinal cord.

First, let's define posture. Posture is defined as the way you hold your body not only when standing but lying down and sitting also. In every position, it's very important to learn how to practice good posture.

When practicing good posture, you place less of a strain upon your back due to focusing on maintaining the position that keeps everything within its proper alignment.

A neutral spinal position is the only position that is beneficial to the health of the spine. Any other position brings more strain, causes further back issues and can create future issues with the curvature of the spine.

Good posture is important because it leads to healthy spines and long-term success overall in terms of the body.

There are signs you can be mindful of that will help you in knowing whether an adjustment is what you need. When the spine is out of alignment there are cases where once adjustment is all a patient may need, and in average situations, a few visits usually do the trick.

A chiropractor can help you on your journey to a healthy spine whether its a massage you desire, spinal manipulation, spinal mobilization, or physical therapy; the main goal and the desire that we have for you is that you leave pain free and enjoy living with a healthy back.

In terms of the head, neck, shoulders, and hips, if you are unable to move your head and neck without a struggle and pain; it may be time for an adjustment.

The hips along with the neck are central points that can generally aid in helping you better know whats going on with your spine. A loss of mobility and an increase of stiffness and unaddressed pains and aches can symbolize a need for an adjustment.

Because the CNS is made up of the spinal cord and the brain, when the spine is out of its proper position, the functioning it provides for the rest of the body is altered.

The immune system responses lack when the spine is being challenged, seeing that the nerves that are being housed are unable to receive the proper commands from the brain to then go throughout the body. (Ex. The body requires certain signaling of blood cells to respond and fight against the common cold, but because those nerves are compromised, the body won't receive the warnings and signals, therefore disabling the immune system to fully operate and function as highly as it should).

The level of tiredness we experience from day to day can stem from the pain our bodies sometimes deal with. It takes work for the body to fight off the pain it experiences especially pain that affects the whole body.

In some cases, the reason behind fatigue is indeed the need for an adjustment to the spine. If youre feeling rather fatigued and youre also experiencing specifically pain in the neck, back or shoulder area; it could be beneficial for you to visit your local chiropractor and talk business.

Remember that visiting your local chiropractor can and will assist you in better living a life free of abnormal curvatures within the spine. Further enabling your health to improve, and your body will experience more flexibility, coordination, better responses, and your balance will be sure to improve.

Originally posted here:
The Importance Of Good Posture And Spinal Health - Anti Aging News

Spinal Cord Stem Cells Comments Off on The Importance Of Good Posture And Spinal Health – Anti Aging News | December 16th, 2019

SAN DIEGO, Dec. 12, 2019 /PRNewswire/ -- Aspen Neuroscience, Inc. today announced its launch following a $6.5 million seed round led by Domain Associates and Axon Ventures and including Alexandria Venture Investments,Arch Venture Partners,OrbiMedand Section 32 to develop the first autologous cell therapies for Parkinson's disease. Aspen's proprietary approach was developed by the company's co-founders, Jeanne F. Loring, Ph.D., Professor Emeritus and founding director of the Center for Regenerative Medicine at The Scripps Research Institute, and Andres Bratt-Leal, Ph.D., a former post-doctoral researcher in Dr. Loring's lab. The company was initially supported by Summit for Stem Cell, a founding partner and non-profit organization which provides a variety of services for people with Parkinson's disease. Aspen is led by industry veteran Howard J. Federoff, M.D., Ph.D., as Chief Executive Officer.

Parkinson's disease is characterized by the loss of specific brain cells that make the chemical dopamine. Without dopamine, nerve cells cannot communicate with muscles and people are left with debilitating motor problems. Aspen is focusing on human pluripotent stem cells, cultured cells that can become any cell type in the human body. The company's research is specific to induced pluripotent stem cells (iPSCs), which it develops by taking a skin biopsy from a person with Parkinson's disease and turning the tissue into pluripotent stem cells using genetic engineering. Aspen then differentiates the pluripotent stem cells into dopamine-releasing neurons that can be transplanted into that same person (autologous), thereby restoring the types of neurons lost in Parkinson's disease.

As an autologous cell therapy for Parkinson's disease, Aspen's treatment would eliminate the need for immunosuppression because the neurons are transplanted back into the same patient from which they were generated. The use of immunosuppression is necessary with currently available cell therapies for Parkinson's disease and when transplanting cells from one patient to another (allogeneic) to prevent rejection but can pre-dispose the patient to life-threatening complications including infection and add cost to the patient and health system. Aspen is the only company in the world offering an autologous neuron replacement therapy for Parkinson's disease.

Aspen encompasses a powerful executive leadership team including Dr. Federoff who, in addition to his leadership roles at the UC Irvine Health System, was the Executive Vice President for Health Sciences and the Executive Dean of Medicine at Georgetown University. Dr. Federoff also has significant biotech industry experience including co-founding MedGenesis Therapeutix and Brain Neurotherapy Bio, as well as leading the U.S. Parkinson's Disease Gene Therapy Study Group. The company is also proud to announce the addition of several experienced and well-known members to its leadership team including Edward Wirth, M.D., Ph.D., as Chief Medical Officer.

Dr. Wirth currently serves as the Chief Medical Ofcer for Lineage Cell Therapeutics where he oversees clinical development of its two therapeutic programs for spinal cord injuries and lung cancer. He received his M.D. and Ph.D. from the University of Florida in 1994 and remained to conduct postdoctoral research including leading the University of Florida team that performed the rst human embryonic spinal cord transplant in the U.S. Dr. Wirth went on to serve as the Medical Director for Regenerative Medicine at Geron Corporation where the world's rst clinical trial of human embryonic stem cell (hESC)-derived product occurred which demonstrated initial clinical safety.

Drs. Federoff and Wirth are joined by Dr. Loring, as Chief Scientific Officer; Jay Sial, as Chief Financial Officer; Andres Bratt-Leal, Ph.D., as Vice President of Research and Development; Thorsten Gorba, Ph.D., as Senior Director of Manufacturing and Naveen M. Krishnan, M.D., M.Phil., as Senior Director of Corporate Development.

"Aspen is developing a restorative, disease modifying autologous neuron therapy for people suffering from Parkinson's disease," said Dr. Federoff. "We are fortunate to have such a high-caliber scientific and medical leadership team to make our treatments a reality. Our cell replacement therapy, which originated in the laboratory of Dr. Jeanne Loring and was later supported by Summit for Stem Cell and its President, Ms. Jenifer Raub, has the potential to release dopamine and reconstruct neural networks where no disease-modifying therapies exist."

Aspen's lead product (ANPD001) is currently undergoing investigational new drug (IND)-enabling studies for the treatment of sporadic Parkinson's disease. Aspen is also developing a gene-edited autologous neuron therapy (ANPD002) that is in the research stage and targeted toward familial forms of Parkinson's disease beginning with the most common genetic variant in the gene encoding glucocerebrosidase (GBA). Aspen leverages proprietary machine-learning tools and artificial intelligence to ensure quality control during manufacturing and to deliver a safe and reproducible product for each cell line.

"Aspen's financial backing, combined with its experienced and proven leadership team, positions it well for future success," said Kim P. Kamdar, Ph.D., Partner at Domain Associates, one of Aspen's seed investors. "Domain prides itself on investing in companies that can translate scientific research into innovative medicines and therapies that make a difference in people's lives. We clearly see Aspen as fitting into that category, as it is the only company using a patient's own cells for replacement therapy in Parkinson's disease."

About Aspen Neuroscience

Aspen Neuroscience Inc. is a development stage, private biotechnology company that uses innovative genomic approaches combined with stem cell biology to deliver patient-specific, restorative cell therapies that modify the course of Parkinson's disease. Aspen's therapies are based upon the scientific work of world-renowned stem cell scientist, Dr. Jeanne Loring, who has developed a novel method for autologous neuron replacement. For more information and important updates, please visithttp://www.aspenneuroscience.com.

CONTACT: Jennifer Viera, AspenNeuroscience@TeamSeismic.com

SOURCE Aspen Neuroscience

http://www.aspenneuroscience.com

Read the rest here:
Aspen Neuroscience Launches With $6.5 Million Seed Funding to Advance First-of-its-Kind Personalized Cell Therapy for Parkinson's Disease - PRNewswire

Spinal Cord Stem Cells Comments Off on Aspen Neuroscience Launches With $6.5 Million Seed Funding to Advance First-of-its-Kind Personalized Cell Therapy for Parkinson’s Disease – PRNewswire | December 14th, 2019

A hockey player paralyzed in the Humboldt Broncos bus crash says it feels good to be home after spending five weeks in Thailand, where he underwent spinal surgery.

It feels good. I mean I felt that cold, cold wind hit my legs, so Im feeling good. Its good to be back, Ryan Straschnitzki said Sunday night as he wheeled himself into the Calgary airport.

The 20-year-old from Airdrie, Alta., who is paralyzed from the chest down, had an epidural stimulator implanted in his spine while he was in Bangkok. A week later, doctors also injected stem cells above and below his spinal injury to try to reverse some of the damage.

Videos posted by Straschnitzki and his father in Thailand show him straightening a leg. In another, Straschnitzki kicks a ball.

In another clip, while hes strapped into a harness, physiotherapists slowly help him walk with a wheeled machine.

It was incredible. I mean the last time I walked beside my dad was before the accident and before I moved away, said Straschnitzki. So doing that again and just seeing the look in his eyes is motivating to me.

Straschnitzki was one of 13 players injured when a semi truck blew through a stop sign and into the path of his junior hockey teams bus at a rural intersection in Saskatchewan in April 2018.

Sixteen others on the bus were killed.

READ MORE: Paralyzed Humboldt Broncos player to get spinal surgery in Thailand

Tom Straschnitzki said hes not an emotional guy, but watching the progress his son made in Thailand has given him hope.

When I actually saw him move his leg, it just took me back to imagining his last steps going onto that bus on that fateful day. And I was just thinking maybe he can go back on the bus one day, he said.

The surgery can cost up to $100,000 but isnt covered by public health care or insurance, because it has not been approved by Health Canada. The Straschnitzkis say theyre frustrated the treatment isnt available here.

Ryan Straschnitzki hopes his experience might at least get the conversation going.

Our health-care system is kind of lacking in this area for spinal cord injuries and I think its huge that Thailand and some other places are getting this started, he said.

I think if Canada can step in and advance this program, I think itll help a lot of people out.

Tom and Michelle Straschnitzki said they have been flooded with comments and questions about their sons procedure.

They want to try it and ask why doesnt Canada do it? I dont have the answer about Canada but they do it in Thailand and it is not experimental, said Tom Straschnitzki.

Health Canada has said it provides licensed spinal cord stimulators but only for pain relief. A spokesman said it has not received an application to have stimulators used to regain motor skills.

READ MORE: Loss for words Injured Bronco shocked, excited over effect of spinal surgery

Ryan Straschnitzki said he isnt expecting a cure but hopes his implant will restore some muscle movement.

Just getting that feeling of being able to move something that I wasnt able to move before and I know core is a huge part of my disability, so anything below my chest is crucial. And after the programming it really helped, he said.

Straschnitzki is hoping to make the Canadian sledge hockey team and compete in the Olympics. He even took his sled with him to Thailand and sat in it as part of his rehabilitation there.

He said he plans to take a few days off before returning to physiotherapy and hitting the ice again back home.

Bill Graveland, The Canadian Press

Like us on Facebook and follow us on Twitter

Continued here:
Kind of lacking: Injured Bronco wonders why Canada wont fund spinal surgery - Houston Today

Spinal Cord Stem Cells Comments Off on Kind of lacking: Injured Bronco wonders why Canada wont fund spinal surgery – Houston Today | December 14th, 2019

Biomedical engineers at Duke University have developed a system that allows for real-time observations of individual cells in the colon of a living mouse.

Researchers expect the procedure to allow new investigations into the digestive systems microbiome as well as the causes of diseases such as inflammatory bowel disease and colon cancer and their treatments.

The procedure described online on December 11 in Nature Communications involves surgically implanting a transparent window into a mouses abdominal skin above the colon. Similar setups are already being used to allow live looks into the detailed inner workings of the brain, spinal cord, liver, lungs and other organs. Imaging a live colon, however, is a slipperier proposition.

A brain doesnt move around a lot, but the colon does, which makes it difficult to get detailed images down to a single cell, said Xiling Shen, the Hawkins Family Associate Professor of Biomedical Engineering at Duke University. Weve developed a magnetic system that is strong enough to stabilize the colon in place during imaging to obtain this level of resolution, but can quickly be turned off to allow the colon to move freely.

Immobilizing the colon for imaging is a tricky task for traditional methods such as glue or stitches. At best they can cause inflammation that would ruin most experiments. At worst they can cause obstructions, which can quickly kill the mouse being studied.

To skirt this issue, Shen developed a magnetic device that looks much like a tiny metal nasal strip and can be safely attached to the colon. A magnetic field snaps the colon into place and keeps it stable during imaging, but once turned off, leaves the colon free to move and function as normal.

A vital organ that houses much of the digestive systems microbiome, the colon can be afflicted by diseases such as inflammatory bowel disease, functional gastrointestinal disorders and cancer. It also plays a key role in regulating the immune system, and can communicate directly with the brain through sacral nerves.

There is a great need to better understand the colon, because it can suffer from so many diseases and plays so many roles with significant health implications, Shen said.

In the study, Shen and his colleagues conducted several proof-of-principle experiments that provide starting points for future lines of research.

The researchers first colonized a living mouse colon with E. coli bacteria, derived from Crohns disease patients, that had been tagged with fluorescent proteins. The researchers then showed they could track the migration, growth and decline of the bacteria for more than three days. This ability could help researchers understand not only how antagonistic bacteria afflict the colon, Shen says, but the positive roles probiotics can play and which strains can best help people with gastrointestinal disorders.

In the next experiment, mice were bred with several types of fluorescent immune cells. The researchers then induced inflammation in the colon and carefully watched the activation of these immune cells. Shen says, this approach could be used with various types of immune cells and diseases to gain a better understanding of how the immune system responds to challenges.

Shen and his colleagues then showed that they could tag and track colon epithelial stem cells associated with colorectal cancer throughout radiation treatment. They also demonstrated that they could watch nerves throughout the colon respond to sacral nerve stimulation, an emerging therapy for treating motility and immune disorders such as functional gastrointestinal disorders and irritable bowel disorder.

While we know electrically stimulating the sacral nerves can alleviate the symptoms of these gastrointestinal disorders, we currently have no idea why or any way to optimize these treatments, Shen said. Being able to see how the colons neurons respond to different waveforms, frequencies and amplitudes of stimulation will be invaluable in making this approach a better option for more patients.

This work was supported by National Institutes of Health (R35GM122465, OT2OD023849), the Defense Advanced Research Projects Agency (N66001-15-2-4059) and the National Cancer Institutes (R35CA197616).

An Intravital Window to Image the Colon in Real Time, Nikolai Rakhilin, Aliesha Garrett, Chi-Yong Eom, Katherine Ramos C., David M. Small, Andrea R. Daniel, Melanie M. Kaelberer, Menansili A. Mejooli, Qiang Huang, Shengli Ding, David G. Kirsch, Diego V. Bohrquez, Nozomi Nishimura, Bradley B. Barth, and Xiling Shen. Nature Communications, 2019. DOI: 10.1038/s41467-019-13699-w

# # #

Read the original post:
A Window into the Hidden World of Colons - Duke Today

Spinal Cord Stem Cells Comments Off on A Window into the Hidden World of Colons – Duke Today | December 14th, 2019

A recent report published by Infinium Global Research on cell therapy market provides in-depth analysis of segments and sub-segments in the global as well as regional cell therapy market.

This press release was orginally distributed by SBWire

Pune, India -- (SBWIRE) -- 12/13/2019 -- The Infinium Global Research analyzes the "Cell Therapy Market (Cell Type - Stem Cell, and Differentiated Cell; Therapy Type - Allogenic Therapies, and Autologous Therapies; Application - Autoimmune Diseases, Oncology, Dermatology, Musculoskeletal Therapies, and Other Applications; End-users - Hospitals and Clinics, Biotechnology and Pharmaceutical Companies, and Research Institutes): Global Industry Analysis, Trends, Size, Share and Forecasts to 2025."

For More Details Get FREE Sample Pages of this Research Report@ https://www.infiniumglobalresearch.com/reports/sample-request/12810

Cell therapy is the transplantation of human cells to replace or repair damaged tissue or cells. With new technologies, products, innovative, and limitless imagination. Cells used for cell therapy often stem cells, cells that can mature into different types of specialized cells. The most common type of cell therapy has been the replacement of mature, functioning cells through blood and platelet transfusions. Cell therapies treat cancer, improving a weakened immune system, autoimmune disease, rebuilding damaged cartilage in joints, urinary problems, and infectious disease, repairing spinal cord injuries, and helping patients with neurological disorders.

Automation in Cell Therapy Manufacturing Providing Intensive Opportunities in the Cell Therapy Market

The rising occurrence of chronic diseases across the globe is the major driver for the growth of the global cell therapy market. Moreover, increasing the geriatric population, increase in cell therapy transplantation rate, and replacement of animal testing model are some of the key factors fueling the market growth. Furthermore, increasing awareness of stem cell therapy and the development of cell banking facilities contributing to the growth of the global cell therapy market.

Moreover, technological advancements and improvements in the regulatory framework continuously provide to the growing market. However, challenges in research and development, lack of proper and advanced healthcare in developing regions may hinder market growth. Furthermore, automation in cell therapy manufacturing providing intensive opportunities in the cell therapy market in the coming years.

Request a Discount on Standard Prices of this Premium Report @ https://www.infiniumglobalresearch.com/reports/request-discount/12810

Stem Cell Therapy is Expected to Hold Maximum Share in the Cell Therapy Market

The global cell therapy market is segmented on the basis of type, therapy, application, and end-user. Types are further segmented into stem cells and differentiated cells. Stem cell therapy is expected to hold maximum share in the cell therapy market. Stem cell therapies having several advantages like regenerating the body organisms and other cells, which contributes to the growth of the stem cell therapies market.

By therapy, the cell therapy market is segmented into allogeneic therapies and autologous therapies. On the basis of application, the market is further divided into autoimmune diseases, oncology, dermatology, musculoskeletal therapies, and other applications. Based on end-users, the market is hospitals and clinics, biotechnology and pharmaceutical companies, and Research Institutes.

North America is Leading the Market Share in the Cell Therapy Market

The cell therapy market is segmented regionally into North America, Europe, Asia-Pacific, and the Rest of the World. North America is leading the market share in the cell therapy market due to the high rate of cancer and blood-related disorders coupled with high investments in the research and development of novel technologies. North America has a firm healthcare organization that acts as an added advantage for the growth of the market in this region.

Asia-Pacific region is anticipated to stimulate the growth of the cell therapy market due to a large number of surgeries performed in this region. Rising awareness about advanced medicinal therapies contributes to the growth of the market in the Asia-Pacific region.

Browse Detailed TOC and Description of this Exclusive Report@ https://www.infiniumglobalresearch.com/healthcare-medical-devices/global-cell-therapy-market

Cell Therapy Market: Competitive Analysis

The leading players in the cell therapy market are NuVasive, Inc., Kolon TissueGene, Inc., JCR Pharmaceuticals Co., Ltd., Osiris Therapeutics, Inc., Stemedica Cell Technologies, Inc., MEDIPOST, Stemedica Cell Technologies, Inc., Celgene Corporation, ANTEROGEN.CO., LTD, Vericel Corporation. These companies are adopting strategic partnerships to enhance their product portfolio.

Reasons to Buy this Report:

=> Comprehensive analysis of global as well as regional markets of the cell therapy.

=> Complete coverage of all the product type and application segments to analyze the trends, developments, and forecast of market size up to 2025.

=> Comprehensive analysis of the companies operating in this market. The company profile includes analysis of product portfolio, revenue, SWOT analysis and the latest developments of the company.

=> Infinium Global Research- Growth Matrix presents an analysis of the product segments and geographies that market players should focus to invest, consolidate, expand and/or diversify.

For more information on this press release visit: http://www.sbwire.com/press-releases/automation-in-cell-therapy-manufacturing-is-driving-the-growth-of-the-cell-therapy-market-over-the-forecast-period-2019-2025-1267918.htm

See more here:
Automation in Cell Therapy Manufacturing Is Driving the Growth of the Cell Therapy Market over the Forecast Period (2019-2025) - Press Release -...

Spinal Cord Stem Cells Comments Off on Automation in Cell Therapy Manufacturing Is Driving the Growth of the Cell Therapy Market over the Forecast Period (2019-2025) – Press Release -… | December 14th, 2019

Co-founded by World-Renowned Stem Cell Scientist Jeanne F. Loring, Ph.D. and Andres Bratt-Leal, Ph.D.

Led by Chief Executive Officer Howard Federoff, M.D., Ph.D., Former Vice Chancellor for Health Affairs and Chief Executive Officer of the University of California Irvine Health System

SAN DIEGO, Dec. 12, 2019 /PRNewswire/ -- Aspen Neuroscience, Inc. today announced its launch following a $6.5 million seed round led by Domain Associates and Axon Ventures and including Alexandria Venture Investments,Arch Venture Partners,OrbiMedand Section 32 to develop the first autologous cell therapies for Parkinson's disease. Aspen's proprietary approach was developed by the company's co-founders, Jeanne F. Loring, Ph.D., Professor Emeritus and founding director of the Center for Regenerative Medicine at The Scripps Research Institute, and Andres Bratt-Leal, Ph.D., a former post-doctoral researcher in Dr. Loring's lab. The company was initially supported by Summit for Stem Cell, a founding partner and non-profit organization which provides a variety of services for people with Parkinson's disease. Aspen is led by industry veteran Howard J. Federoff, M.D., Ph.D., as Chief Executive Officer.

Aspen Neuroscience Inc. is a development stage, private biotechnology company that uses innovative genomic approaches combined with stem cell biology to deliver patient-specific, restorative cell therapies that modify the course of Parkinsons disease. Aspens therapies are based upon the scientific work of world-renowned stem cell scientist, Dr. Jeanne Loring, who has developed a novel method for autologous neuron replacement.

Parkinson's disease is characterized by the loss of specific brain cells that make the chemical dopamine. Without dopamine, nerve cells cannot communicate with muscles and people are left with debilitating motor problems. Aspen is focusing on human pluripotent stem cells, cultured cells that can become any cell type in the human body. The company's research is specific to induced pluripotent stem cells (iPSCs), which it develops by taking a skin biopsy from a person with Parkinson's disease and turning the tissue into pluripotent stem cells using genetic engineering. Aspen then differentiates the pluripotent stem cells into dopamine-releasing neurons that can be transplanted into that same person (autologous), thereby restoring the types of neurons lost in Parkinson's disease.

As an autologous cell therapy for Parkinson's disease, Aspen's treatment would eliminate the need for immunosuppression because the neurons are transplanted back into the same patient from which they were generated. The use of immunosuppression is necessary with currently available cell therapies for Parkinson's disease and when transplanting cells from one patient to another (allogeneic) to prevent rejection but can pre-dispose the patient to life-threatening complications including infection and add cost to the patient and health system. Aspen is the only company in the world offering an autologous neuron replacement therapy for Parkinson's disease.

Aspen encompasses a powerful executive leadership team including Dr. Federoff who, in addition to his leadership roles at the UC Irvine Health System, was the Executive Vice President for Health Sciences and the Executive Dean of Medicine at Georgetown University. Dr. Federoff also has significant biotech industry experience including co-founding MedGenesis Therapeutix and Brain Neurotherapy Bio, as well as leading the U.S. Parkinson's Disease Gene Therapy Study Group. The company is also proud to announce the addition of several experienced and well-known members to its leadership team including Edward Wirth, M.D., Ph.D., as Chief Medical Officer.

Story continues

Dr. Wirth currently serves as the Chief Medical Ofcer for Lineage Cell Therapeutics where he oversees clinical development of its two therapeutic programs for spinal cord injuries and lung cancer. He received his M.D. and Ph.D. from the University of Florida in 1994 and remained to conduct postdoctoral research including leading the University of Florida team that performed the rst human embryonic spinal cord transplant in the U.S. Dr. Wirth went on to serve as the Medical Director for Regenerative Medicine at Geron Corporation where the world's rst clinical trial of human embryonic stem cell (hESC)-derived product occurred which demonstrated initial clinical safety.

Drs. Federoff and Wirth are joined by Dr. Loring, as Chief Scientific Officer; Jay Sial, as Chief Financial Officer; Andres Bratt-Leal, Ph.D., as Vice President of Research and Development; Thorsten Gorba, Ph.D., as Senior Director of Manufacturing and Naveen M. Krishnan, M.D., M.Phil., as Senior Director of Corporate Development.

"Aspen is developing a restorative, disease modifying autologous neuron therapy for people suffering from Parkinson's disease," said Dr. Federoff. "We are fortunate to have such a high-caliber scientific and medical leadership team to make our treatments a reality. Our cell replacement therapy, which originated in the laboratory of Dr. Jeanne Loring and was later supported by Summit for Stem Cell and its President, Ms. Jenifer Raub, has the potential to release dopamine and reconstruct neural networks where no disease-modifying therapies exist."

Aspen's lead product (ANPD001) is currently undergoing investigational new drug (IND)-enabling studies for the treatment of sporadic Parkinson's disease. Aspen is also developing a gene-edited autologous neuron therapy (ANPD002) that is in the research stage and targeted toward familial forms of Parkinson's disease beginning with the most common genetic variant in the gene encoding glucocerebrosidase (GBA). Aspen leverages proprietary machine-learning tools and artificial intelligence to ensure quality control during manufacturing and to deliver a safe and reproducible product for each cell line.

"Aspen's financial backing, combined with its experienced and proven leadership team, positions it well for future success," said Kim P. Kamdar, Ph.D., Partner at Domain Associates, one of Aspen's seed investors. "Domain prides itself on investing in companies that can translate scientific research into innovative medicines and therapies that make a difference in people's lives. We clearly see Aspen as fitting into that category, as it is the only company using a patient's own cells for replacement therapy in Parkinson's disease."

About Aspen Neuroscience

Aspen Neuroscience Inc. is a development stage, private biotechnology company that uses innovative genomic approaches combined with stem cell biology to deliver patient-specific, restorative cell therapies that modify the course of Parkinson's disease. Aspen's therapies are based upon the scientific work of world-renowned stem cell scientist, Dr. Jeanne Loring, who has developed a novel method for autologous neuron replacement. For more information and important updates, please visithttp://www.aspenneuroscience.com.

View original content to download multimedia:http://www.prnewswire.com/news-releases/aspen-neuroscience-launches-with-6-5-million-seed-funding-to-advance-first-of-its-kind-personalized-cell-therapy-for-parkinsons-disease-300973830.html

SOURCE Aspen Neuroscience

Read the original here:
Aspen Neuroscience Launches With $6.5 Million Seed Funding to Advance First-of-its-Kind Personalized Cell Therapy for Parkinson's Disease - Yahoo...

Spinal Cord Stem Cells Comments Off on Aspen Neuroscience Launches With $6.5 Million Seed Funding to Advance First-of-its-Kind Personalized Cell Therapy for Parkinson’s Disease – Yahoo… | December 14th, 2019

JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page.Highlights

Transplantation of iPSC-derived neural precursor cells (NPCs) shows beneficial effects for spinal cord injury (SCI).

Because unsafe iPSC-NPC lines can form tumors after grafting, provisions to attenuate this risk are substantially important.

Clinical application for SCI patients using iPSCs will be conducted in the near future.

For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the treatment candidates, transplantation of neural precursor cells has gained remarkable attention as a reasonable therapeutic intervention to replace the damaged central nervous system cells and promote functional recovery. Here, we highlight transplantation therapy techniques using induced pluripotent stem cells to treat SCI and review the recent research giving consideration to future clinical applications.

Spinal cord injury

Neural precursor cells

Induced pluripotent stem cells

Clinical application

neural precursor cells

induced pluripotent stem cells

high mobility group box-1

swine leukocyte antigen

mixed lymphocyte reaction

human leukocyte antigen

peripheral blood mononuclear cells

directly reprogrammed neural precursor cells

-secretase inhibitor

herpes simplex virus type I thymidine kinase

oligodendrocyte progenitor cells

the Center for iPS Cell Research and Application

American Spinal Injury Association

chondroitin sulfate proteoglycans

Recommended articlesCiting articles (0)

2019 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.

Here is the original post:
Cell therapy for spinal cord injury using induced ...

Spinal Cord Stem Cells Comments Off on Cell therapy for spinal cord injury using induced … | December 12th, 2019

ESPCs derived from pig provide important implications for developmental biology, organ transplantation, regenerative medicine, disease modeling, and screening for drugs.

FREMONT, CA: Stem cell therapy, usually applied to humans, is now extended to animals too. It is a regenerative treatment applied to cats, dogs, pigs, and other animals. It includes removing cells from bone marrow, blood or fat, umbilical cords, and the cell can grow into any kind of cell and can repair damaged tissues. The regenerative therapy has been successful in animals. It can be used mainly for the treatment of spinal cord and bone injuries along with the problems with tendons, ligaments, and joints. One of the breakthroughs is the embryonic stem cell lines obtained from the pig.

Scientists have derived Expanded Potential Stem Cells (EPSCs) from pig embryos for the first time. They offer the groundbreaking potential to study embryonic development and produce translational research in genomics and regenerative medicine. Embryonic stem cells (ESC) are derived from the inner cells of early embryos called blastocysts. They are pluripotent cells as they can develop into various cell types of the body in the culture dish. The newly derived porcine EPSCs isolated from pig embryos are the first well-characterized cell lines worldwide. Their pluripotent ability provides important implications for developmental biology, organ transplantation, regenerative medicine, disease modeling, and screening for drugs.

The stem cells can renew themselves, showing that they can be kept in culture indefinitely while showing the typical morphology and gene expression patterns of embryonic stem cells. Because somatic cells have a limited lifespan, they cannot be used for such applications, and therefore the new stem cells are better suited for the lengthy selection process. These porcine stem cell lines can easily be edited with new genome editing techniques like CRISPR/Cas, and are currently the simplest, most versatile and precise method of genetic manipulation.

The EPSCs have a greater capacity to develop into numerous cell types of the organism as well as into extraembryonic tissue, the trophoblasts, rending them very unique and, thus, their name. This capacity is valuable for the future promising organoid technology where organ-like small cell aggregations are grown in 3D aggregates and used for research into early embryo development, various disease models, and testing of new drugs in Petri dishes. Also, they offer a unique possibility to investigate functions or diseases of the placenta in vitro.

More:
How Will Animals Get Benefitted by Stem Cell Therapy? - Medical Tech Outlook

Spinal Cord Stem Cells Comments Off on How Will Animals Get Benefitted by Stem Cell Therapy? – Medical Tech Outlook | December 12th, 2019

SAN DIEGO, Dec. 12, 2019 /PRNewswire/ -- Aspen Neuroscience, Inc. today announced its launch following a $6.5 million seed round led by Domain Associates and Axon Ventures and including Alexandria Venture Investments,Arch Venture Partners,OrbiMedand Section 32 to develop the first autologous cell therapies for Parkinson's disease. Aspen's proprietary approach was developed by the company's co-founders, Jeanne F. Loring, Ph.D., Professor Emeritus and founding director of the Center for Regenerative Medicine at The Scripps Research Institute, and Andres Bratt-Leal, Ph.D., a former post-doctoral researcher in Dr. Loring's lab. The company was initially supported by Summit for Stem Cell, a founding partner and non-profit organization which provides a variety of services for people with Parkinson's disease. Aspen is led by industry veteran Howard J. Federoff, M.D., Ph.D., as Chief Executive Officer.

Parkinson's disease is characterized by the loss of specific brain cells that make the chemical dopamine. Without dopamine, nerve cells cannot communicate with muscles and people are left with debilitating motor problems. Aspen is focusing on human pluripotent stem cells, cultured cells that can become any cell type in the human body. The company's research is specific to induced pluripotent stem cells (iPSCs), which it develops by taking a skin biopsy from a person with Parkinson's disease and turning the tissue into pluripotent stem cells using genetic engineering. Aspen then differentiates the pluripotent stem cells into dopamine-releasing neurons that can be transplanted into that same person (autologous), thereby restoring the types of neurons lost in Parkinson's disease.

As an autologous cell therapy for Parkinson's disease, Aspen's treatment would eliminate the need for immunosuppression because the neurons are transplanted back into the same patient from which they were generated. The use of immunosuppression is necessary with currently available cell therapies for Parkinson's disease and when transplanting cells from one patient to another (allogeneic) to prevent rejection but can pre-dispose the patient to life-threatening complications including infection and add cost to the patient and health system. Aspen is the only company in the world offering an autologous neuron replacement therapy for Parkinson's disease.

Aspen encompasses a powerful executive leadership team including Dr. Federoff who, in addition to his leadership roles at the UC Irvine Health System, was the Executive Vice President for Health Sciences and the Executive Dean of Medicine at Georgetown University. Dr. Federoff also has significant biotech industry experience including co-founding MedGenesis Therapeutix and Brain Neurotherapy Bio, as well as leading the U.S. Parkinson's Disease Gene Therapy Study Group. The company is also proud to announce the addition of several experienced and well-known members to its leadership team including Edward Wirth, M.D., Ph.D., as Chief Medical Officer.

Dr. Wirth currently serves as the Chief Medical Ofcer for Lineage Cell Therapeutics where he oversees clinical development of its two therapeutic programs for spinal cord injuries and lung cancer. He received his M.D. and Ph.D. from the University of Florida in 1994 and remained to conduct postdoctoral research including leading the University of Florida team that performed the rst human embryonic spinal cord transplant in the U.S. Dr. Wirth went on to serve as the Medical Director for Regenerative Medicine at Geron Corporation where the world's rst clinical trial of human embryonic stem cell (hESC)-derived product occurred which demonstrated initial clinical safety.

Drs. Federoff and Wirth are joined by Dr. Loring, as Chief Scientific Officer; Jay Sial, as Chief Financial Officer; Andres Bratt-Leal, Ph.D., as Vice President of Research and Development; Thorsten Gorba, Ph.D., as Senior Director of Manufacturing and Naveen M. Krishnan, M.D., M.Phil., as Senior Director of Corporate Development.

"Aspen is developing a restorative, disease modifying autologous neuron therapy for people suffering from Parkinson's disease," said Dr. Federoff. "We are fortunate to have such a high-caliber scientific and medical leadership team to make our treatments a reality. Our cell replacement therapy, which originated in the laboratory of Dr. Jeanne Loring and was later supported by Summit for Stem Cell and its President, Ms. Jenifer Raub, has the potential to release dopamine and reconstruct neural networks where no disease-modifying therapies exist."

Aspen's lead product (ANPD001) is currently undergoing investigational new drug (IND)-enabling studies for the treatment of sporadic Parkinson's disease. Aspen is also developing a gene-edited autologous neuron therapy (ANPD002) that is in the research stage and targeted toward familial forms of Parkinson's disease beginning with the most common genetic variant in the gene encoding glucocerebrosidase (GBA). Aspen leverages proprietary machine-learning tools and artificial intelligence to ensure quality control during manufacturing and to deliver a safe and reproducible product for each cell line.

"Aspen's financial backing, combined with its experienced and proven leadership team, positions it well for future success," said Kim P. Kamdar, Ph.D., Partner at Domain Associates, one of Aspen's seed investors. "Domain prides itself on investing in companies that can translate scientific research into innovative medicines and therapies that make a difference in people's lives. We clearly see Aspen as fitting into that category, as it is the only company using a patient's own cells for replacement therapy in Parkinson's disease."

About Aspen Neuroscience

Aspen Neuroscience Inc. is a development stage, private biotechnology company that uses innovative genomic approaches combined with stem cell biology to deliver patient-specific, restorative cell therapies that modify the course of Parkinson's disease. Aspen's therapies are based upon the scientific work of world-renowned stem cell scientist, Dr. Jeanne Loring, who has developed a novel method for autologous neuron replacement. For more information and important updates, please visithttp://www.aspenneuroscience.com.

View original content to download multimedia:http://www.prnewswire.com/news-releases/aspen-neuroscience-launches-with-6-5-million-seed-funding-to-advance-first-of-its-kind-personalized-cell-therapy-for-parkinsons-disease-300973830.html

SOURCE Aspen Neuroscience

Read the rest here:
Aspen Neuroscience Launches With $6.5 Million Seed Funding to Advance First-of-its-Kind Personalized Cell Therapy for Parkinson's Disease - P&T...

Spinal Cord Stem Cells Comments Off on Aspen Neuroscience Launches With $6.5 Million Seed Funding to Advance First-of-its-Kind Personalized Cell Therapy for Parkinson’s Disease – P&T… | December 12th, 2019

Parkinsons disease is characterized by the loss of specific brain cells that make the chemical dopamine. Without dopamine, nerve cells cannot communicate with muscles and people are left with debilitating motor problems. Aspen is focusing on human pluripotent stem cells, cultured cells that can become any cell type in the human body. Many health technology startups are on the raise to cure this disease. At the forefront is Aspen Neuroscience, a healthtech startup developing first-of-its-kind personalized cell therapy for Parkinsons disease.

Aspen Neuroscience is a development stage, private biotechnology company that uses innovative genomic approaches combined with stem cell biology to deliver patient-specific, restorative cell therapies that modify the course of Parkinsons disease.

Today,Aspen Neuroscience announced its official launch with $6.5 million seed financingto develop the first autologous cell therapies for Parkinsons disease.The round was led by Domain Associates and Axon Ventures and including Alexandria Venture Investments, Arch Venture Partners, OrbiMed and others.

Aspens proprietary approach was developed by the companys co-founders, Jeanne F. Loring, Ph.D., Professor Emeritus and founding director of the Center for Regenerative Medicine at The Scripps Research Institute, and Andres Bratt-Leal, Ph.D., a former post-doctoral researcher in Dr. Lorings lab. The company was initially supported by Summit for Stem Cell, a founding partner and non-profit organization which provides a variety of services for people with Parkinsons disease. Aspen is led by industry veteran Howard J. Federoff, M.D., Ph.D., as Chief Executive Officer.

The companys research is specific to induced pluripotent stem cells (iPSCs), which it develops by taking a skin biopsy from a person with Parkinsons disease and turning the tissue into pluripotent stem cells using genetic engineering. Aspen then differentiates the pluripotent stem cells into dopamine-releasing neurons that can be transplanted into that same person (autologous), thereby restoring the types of neurons lost in Parkinsons disease.

As an autologous cell therapy for Parkinsons disease, Aspens treatment would eliminate the need for immunosuppression because the neurons are transplanted back into the same patient from which they were generated. The use of immunosuppression is necessary with currently available cell therapies for Parkinsons disease and when transplanting cells from one patient to another (allogeneic) to prevent rejection but can pre-dispose the patient to life-threatening complications including infection and add cost to the patient and health system. Aspen is the only company in the world offering an autologous neuron replacement therapy for Parkinsons disease.

Aspen encompasses a powerful executive leadership team including Dr. Federoff who, in addition to his leadership roles at the UC Irvine Health System, was the Executive Vice President for Health Sciences and the Executive Dean of Medicine at Georgetown University. Dr. Federoff also has significant biotech industry experience including co-founding MedGenesis Therapeutix and Brain Neurotherapy Bio, as well as leading the U.S. Parkinsons Disease Gene Therapy Study Group. The company is also proud to announce the addition of several experienced and well-known members to its leadership team including Edward Wirth, M.D., Ph.D., as Chief Medical Officer.

Dr. Wirth currently serves as the Chief Medical Ofcer for Lineage Cell Therapeutics where he oversees clinical development of its two therapeutic programs for spinal cord injuries and lung cancer. He received his M.D. and Ph.D. from the University of Florida in 1994 and remained to conduct postdoctoral research including leading the University of Florida team that performed the rst human embryonic spinal cord transplant in the U.S. Dr. Wirth went on to serve as the Medical Director for Regenerative Medicine at Geron Corporation where the worlds rst clinical trial of human embryonic stem cell (hESC)-derived product occurred which demonstrated initial clinical safety.

Drs. Federoff and Wirth are joined by Dr. Loring, as Chief Scientific Officer; Jay Sial, as Chief Financial Officer; Andres Bratt-Leal, Ph.D., as Vice President of Research and Development; Thorsten Gorba, Ph.D., as Senior Director of Manufacturing and Naveen M. Krishnan, M.D., M.Phil., as Senior Director of Corporate Development.

Aspen is developing a restorative, disease modifying autologous neuron therapy for people suffering from Parkinsons disease, said Dr. Federoff. We are fortunate to have such a high-caliber scientific and medical leadership team to make our treatments a reality. Our cell replacement therapy, which originated in the laboratory of Dr. Jeanne Loring and was later supported by Summit for Stem Cell and its President, Ms. Jenifer Raub, has the potential to release dopamine and reconstruct neural networks where no disease-modifying therapies exist.

Continue reading here:
Aspen Neuroscience launches with $6.5M seed funding to develop personalized and autologous cell therapy for Parkinson's disease - TechStartups.com

Spinal Cord Stem Cells Comments Off on Aspen Neuroscience launches with $6.5M seed funding to develop personalized and autologous cell therapy for Parkinson’s disease – TechStartups.com | December 12th, 2019

When embryonic Stem Cell therapy was first discovered in 1998, it changed the face of medicine. The idea of being able to regenerate and replace damaged cells seemed futuristic at the time, yet today such treatments are commonplace. Now, science has taken another quantum leap this time into the nano-sized world of exosomes, tiny bubbles that grow out of cell walls and contain much of the information contained within the cell including Growth factors, microRNA and messenger RNA. Mesenchymal stem cell (MSC) exosome therapy is currently one of the hottest trends in regenerative medicine, one that patients at AM Medical in Yelm can now experience.

Everyone has heard of stem cell therapy, but it turns out that its not the stem cells that are doing the work, says Dr. Ana Mihalcea, President of AM Medical. Its the exosomes that carry the information of regeneration. Infused stem cells, attach to blood vessel walls, and then give off exosomes.

Exosomes have several key differences from stem cells; they do not get removed from the circulation like stem cells, which are in the body for less than 72 hours before they get destroyed by the immune system; they do not produce a rejection reaction because they are not a cell and contain no DNA, and they pass the blood brain barrier, Mihalcea notes. In a study on stroke scientists fluorescently tagged exosomes, and the infused exosomes went exactly to the region where the stroke had occurred, she adds. The same was not true of stem cells as they do not cross the blood brain barrier.

As a result of their powerful cargo, exosomes can be used to address a multitude of conditions, including arthritis, autoimmune disorders, cardiovascular and neurogenerative diseases like Parkinsons and Alzheimers. Old cells can be reprogrammed by MSC exosomes as the target cells can transcribe the microRNA into functional proteins. Just like a virus, the exosome information of the young stem cells can infect the old cells with Youth, explains Mihalcea.

Spinal cord injuries are an area in which exosomes have produced dramatic results. Mihalcea cites the example of Dr. Douglas J. Spiels Interventional Pain Specialty Practice in NJ. Dr. Spiel has been able to rehabilitate spinal cord injuries with Exosome infusions into the spine and intravenously, she says. After several weeks, hes had patients regain muscle strength and sensation. These are prolonged, ongoing regenerative effects that continued to improve for months after the infusion.

When it comes to autoimmune diseases, inflammation plays a key role. Again, exosomes are able to reduce the problem by downregulating inflammation. TGF Beta 3 [Transforming growth factor beta-3] is the most important anti-inflammatory protein in the body and is abundant in MSC exosomes says Mihalcea. Many more Growth factors for blood vessel growth, neuronal and other tissue growth are present, allowing regenerative effects in all organ systems including skin wounds and burns.

The exosomes at AM Medical come from a laboratory in Florida that conducted pioneering research in the field. They come from perinatal mesenchymal stem cells and are scanned for any possible viruses to ensure their safety. Once harvested, the exosomes are concentrated so they can be infused in large doses.

For patients who qualify, the infusion process takes 10 to 15 minutes. Already, its been producing results for AM Medical patients. Weve had people with arthritis and chronic pain who had great responses, Mihalcea notes. There is an overall increase in wellbeing and sense of rejuvenation that is definitely noticeable.

Perhaps one of the largest sources of excitement over exosomes has to do with their anti-aging effects. Recently, ideas about the root causes of aging have been evolving, according to Mihalcea. Its been thought that aging occurs due to multiple different reasons like stem cell exhaustion, epigenetic changes, telomere shortening and others, she explains. It turns out that exosomes can modify almost all the hallmarks of aging. Theyre changing epigenetic expression to youthful function, and there are many potential applications. This is a new frontier in regenerative medicine that can help many people.

Learn more by watching Dr. Ana Mihalceas video on Exosomes The New Frontier Part 1: Longevity and Age reversal or reading further on the AM Medical website.

Sponsored

See the rest here:
Cutting Edge Exosome Regenerative Therapy Comes to Yelm's AM Medical - ThurstonTalk

Spinal Cord Stem Cells Comments Off on Cutting Edge Exosome Regenerative Therapy Comes to Yelm’s AM Medical – ThurstonTalk | December 12th, 2019

Biomedical engineers at Duke University have developed a system that allows for real-time observations of individual cells in the colon of a living mouse.

Researchers expect the procedure to allow new investigations into the digestive systems microbiome as well as the causes of diseases such as inflammatory bowel disease and colon cancer and their treatments.

The procedure described online today (December 11, 2019) in Nature Communications involves surgically implanting a transparent window into a mouses abdominal skin above the colon. Similar setups are already being used to allow live looks into the detailed inner workings of the brain, spinal cord, liver, lungs and other organs. Imaging a live colon, however, is a slipperier proposition.

A brain doesnt move around a lot, but the colon does, which makes it difficult to get detailed images down to a single cell, said Xiling Shen, the Hawkins Family Associate Professor of Biomedical Engineering at Duke University. Weve developed a magnetic system that is strong enough to stabilize the colon in place during imaging to obtain this level of resolution, but can quickly be turned off to allow the colon to move freely.

This video shows green fluorescent colon neurons activated by neurostimulation in real-time. This is the first time that sacral nerve stimulation, an FDA approved therapy for colon motility disorders, has definitively been shown to activate neurons in the colon in live animals, explaining why the therapy might work.

Credit: Xiling Shen, Duke University

Immobilizing the colon for imaging is a tricky task for traditional methods such as glue or stitches. At best they can cause inflammation that would ruin most experiments. At worst they can cause obstructions, which can quickly kill the mouse being studied.

To skirt this issue, Shen developed a magnetic device that looks much like a tiny metal nasal strip and can be safely attached to the colon. A magnetic field snaps the colon into place and keeps it stable during imaging, but once turned off, leaves the colon free to move and function as normal.

A vital organ that houses much of the digestive systems microbiome, the colon can be afflicted by diseases such as inflammatory bowel disease, functional gastrointestinal disorders, and cancer. It also plays a key role in regulating the immune system, and can communicate directly with the brain through sacral nerves.

There is a great need to better understand the colon, because it can suffer from so many diseases and plays so many roles with significant health implications, Shen said. In the study, Shen and his colleagues conducted several proof-of-principle experiments that provide starting points for future lines of research.

The researchers first colonized a living mouse colon with E. coli bacteria, derived from Crohns disease patients, that had been tagged with fluorescent proteins. The researchers then showed they could track the migration, growth and decline of the bacteria for more than three days. This ability could help researchers understand not only how antagonistic bacteria afflict the colon, Shen says, but the positive roles probiotics can play and which strains can best help people with gastrointestinal disorders.

In the next experiment, mice were bred with several types of fluorescent immune cells. The researchers then induced inflammation in the colon and carefully watched the activation of these immune cells. Shen says, this approach could be used with various types of immune cells and diseases to gain a better understanding of how the immune system responds to challenges.

Shen and his colleagues then showed that they could tag and track colon epithelial stem cells associated with colorectal cancer throughout radiation treatment. They also demonstrated that they could watch nerves throughout the colon respond to sacral nerve stimulation, an emerging therapy for treating motility and immune disorders such as functional gastrointestinal disorders and irritable bowel disorder.

While we know electrically stimulating the sacral nerves can alleviate the symptoms of these gastrointestinal disorders, we currently have no idea why or any way to optimize these treatments, Shen said. Being able to see how the colons neurons respond to different waveforms, frequencies and amplitudes of stimulation will be invaluable in making this approach a better option for more patients.

###

Reference: An intravital window to image the colon in real time by Nikolai Rakhilin, Aliesha Garrett, Chi-Yong Eom, Katherine Ramos Chavez, David M. Small, Andrea R. Daniel, Melanie M. Kaelberer, Menansili A. Mejooli, Qiang Huang, Shengli Ding, David G. Kirsch, Diego V. Bohrquez, Nozomi Nishimura, Bradley B. Barth and Xiling Shen, 11 December 2019, Nature Communications.DOI: 10.1038/s41467-019-13699-w

This work was supported by National Institutes of Health (R35GM122465, OT2OD023849), the Defense Advanced Research Projects Agency (N66001-15-2-4059) and the National Cancer Institutes (R35CA197616).

Read the rest here:
A Real-Time Window Into the Hidden World of the Colon of a Living Animal - SciTechDaily

Spinal Cord Stem Cells Comments Off on A Real-Time Window Into the Hidden World of the Colon of a Living Animal – SciTechDaily | December 12th, 2019

PATIENTS with life-changing injuries could walk again thanks to a pioneering electrical spinal implant. The device has proven effective in trials on macaque monkeys and researchers in Canada are hopeful it will be available for use on human patients in as little as a decade.

Lead researcher Dr Vivian Mushahwar, of the University of Albertas Neuroscience and Mental Health Institute, said: We think that intraspinal stimulation itself will get people to start walking longer and longer, and maybe even faster.

That in itself becomes their therapy. Theres been an explosion of knowledge in neuroscience over the last 20 years.

Were at the edge of merging the human and the machine.

The device features hair-like electrical wires that plunge deep into the spinal grey matter, sending electrical signals to trigger the networks that already know how to do the hard graft.

To work alongside the implant, the team created a map to identify which parts of the spinal cord trigger the hip, knees, ankles and toes, and the areas that put movements together.

People tend to think the brain does all the thinking, but the spinal cord has built-in intelligence, said Dr Mushahwar.

A complex chain of motor and sensory networks regulate everything from breathing to bowels, while the brain stems contribution is basically go! and faster!

Your spinal cord isnt just moving muscles, its giving you your natural gait. Being able to control standing and walking would improve bone health, improve bowel and bladder function, and reduce pressure ulcers, the researchers say.

For those with less severe spinal injuries, an implant could be therapeutic, removing the need for months of gruelling physical therapy regimes that have limited success, they add. The team are now focused on refining the hardware further by miniaturising an implantable stimulator and getting approval for human trials.

The first generation of the implants will require a patient to control walking and movement through physical means, but longer term, the implants could potentially include a direct connection to the brain, they say.

Dr Mushahwar said it has the power to transform lives.

Imagine the future, a person just thinks and commands are transmitted to the spinal cord. People stand up and walk. This is the dream, she said.

23million The number of lives saved globally by vaccines between 2000 and 2018, as estimated by the US Centers for Disease Control and Prevention

WHILE they may not be as talkative as Jungle Books King Louie, it turns out wild orangutans have some serious communication skills.

Researchers at the University of Exeter in Devon have identified 11 vocal signals and 21 physical gesture types that the apes use to communicate with one another.

The findings reveal orangutans are highly responsive to communication, reacting either before gesturing ended or in less than a second in 90 per cent of communications.

The team studied video footage of 16 orangutans consisting of seven mother-child pairs and a pair of siblings, noting a total of 1,299 communicative signals 858 vocal signals and 441 gestures.

The sounds included the kiss squeak a sharp kiss noise created while inhaling the grumph (a low sound lasting one or two seconds made on the inhale), the gorkum (a kiss squeak followed by a series of multiple grumphs) and the self-explanatory raspberry.

Gestures included beckoning, stamping, pushing out a lower lip, shaking objects and presenting a body part.

The eight identified goals or requests of their communications are acquire object, climb on me, climb on you, climb over, move away, decrease intensity, resume play and stop that.

Orangutans are the most solitary of all the apes, which is why most studies have been done on African apes, and not much is known about wild orangutan gestures, said University of Exeter scientist Dr Helen Morrogh-Bernard. We spent two years filming more than 600 hours of footage of orangutans in the Sabangau peat swamp forest in Borneo, Indonesia.

While some of our findings support what has been discovered by zoo-based studies, other aspects are new and these highlight the importance of studying communication in its natural context.

More signals are likely to be identified in the future, the researchers say.

1/2million The number of hermit crabs estimated to have been killed by plastic waste, according to a study by the Natural History Museum

WE MAY like to put our feet up at Christmas but for older people, even a short period of reduced physical activity could lead to significant loss of muscle mass and gains in body fat.

Just a fortnight of walking fewer than 1,500 steps a day could have a severe impact making daily tasks harder and kick-starting chronic health conditions a University of Liverpool study found.

The team measured the effect of two weeks inactivity on 47 participants, around half of whom were elderly. All lost muscle size, strength and bone mass. But the older volunteers also experienced a big drop in cardio fitness and mitochondrial function the way cells produce energy.

If the gym is hard to get to, people should be encouraged to just meet 10,000 steps, said researcher Juliette Norman. Even this can guard against reductions in muscle and bone health as well as maintaining healthy levels of body fat.

EXPERIENCING stress at a young age could help you live longer. Juvenile Caenorhabditis elegans worms that produce more oxidants and free radicals, which are associated with stress and ageing, last longer, US researchers at the University of Michigan found. Study leader Daphne Bazopoulou said early exposure may make you better able to fight stress later in life.

AGE can be predicted by protein levels in the blood. Using blood samples from more than 4,000 18- to 95-year-olds, scientists at Stanford University, California, found 373 proteins that peak and trough across a lifespan. The blood test can also show how physiological and real ages compare, which could flag those more at risk of ageing-related illnesses or reveal the ageing effect of drugs and treatments.

To brag flagrantly is, most of us realise, unbecoming, and so a favoured mitigation tactic has emerged: the humblebrag. This is a way of masking a boast, either in a feigned complaint or as fake modesty, such as its so exhausting staying in touch with all my friends or if someone told me Id pass with first-class honours, Id never have believed them. Unfortunately for humblebraggers, the tactic is too transparent to work. Last year, researchers at the University of North Carolina and Harvard Business School found humblebraggers are less liked, and perceived as less competent, because they appear insincere.

Astronomers have found magnetic field strengths near supermassive black holes can be as strong as their intense gravitational fields. These fields are able to expel material from the vicinity of the black hole to form highly energetic outflows called jets. However, this process is not acting on material that has already passed beyond the black holes event horizon, where not even light can escape. Such material would need to be accelerated to the speed of light to escape, which would require an infinite amount of energy. No magnet, however powerful, could provide this.

The ethics of Nazi research dissected

What really happens in near-death experiences

Having babies in space

Read more:
Lab: Electric implant could allow people with crippling injuries to walk again - Metro Newspaper UK

Spinal Cord Stem Cells Comments Off on Lab: Electric implant could allow people with crippling injuries to walk again – Metro Newspaper UK | December 12th, 2019