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Kelvin K Huiet al. Bioessays. 2024 Dec.

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This year marks the tenth anniversary of the world's first transplantation of tissue generated from induced pluripotent stem cells (iPSCs). There is now a growing number of clinical trials worldwide examining the efficacy and safety of autologous and allogeneic iPSC-derived products for treating various pathologic conditions. As we patiently wait for the results from these and future clinical trials, it is imperative to strategize for the next generation of iPSC-based therapies. This review examines the lessons learned from the development of another advanced cell therapy, chimeric antigen receptor (CAR) T cells, and the possibility of incorporating various new bioengineering technologies in development, from RNA engineering to tissue fabrication, to apply iPSCs not only as a means to achieve personalized medicine but also as designer medical applications.

Keywords: bioengineering; cell therapy; clinical trials; iPS cells; regenerative medicine; transplantation.

2024 Wiley Periodicals LLC.

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iPS cell therapy 2.0: Preparing for next-generation regenerative ...