Stem cells found in the lungs can be redirected to the heart using a new inhaled antibody therapy to help boost healing following a heart attack.

Image credit: Jesse Orrico on Unsplash

Cardiovascular diseases are one of the leading causes of death globally. Medical advancements have lowered a persons risk of dying from an episode, but cell death and scar tissue that form afterward drastically increase the risk of eventual heart failure.

Stem cell therapy is a promising strategy used to help minimize long-term damage by regenerating new, healthy heart cells at damaged sites. However, their clinical application is hampered by poor cell engraftment, which comes with trying to grow new cells on a constantly moving organ.

Solutions to this have been proposed in the past, such as using durable patches to help the cells adhere to the heart surface, but a team of researchers from North Carolina State University propose that redirecting easy-to-access stem cells already found in the body could help spur repair in an injured heart.

Stem cells have become [] important for cardiomyocyte regeneration over the last two decades, wrote the team in their paper published in Advanced Science. In fact, as [part of] the bodys own repair mechanism, endogenous stem cells from the bone marrow are recruited into the heart. The issue, they point out, is that these stem cells lack the ability to properly target the heart, which hinders their ability to accumulate where they are needed.

In previous studies, the team demonstrated that heart attack biomarkers can be used to guide infused or endogenous stem cells to the site of cardiac injury. They also took advantage of cells called platelets, which help form blood clots and have an exceptional ability to target and accumulate in injured tissue.

By taking advantage of the injuryhoming ability of platelets, we can target stem cells to the [damaged] area, said the authors. [However], this strategy has a caveat: most of the bodys endogenous stem cells are produced in the bone marrow, and these cells are difficult to access.

The lung has recently been recognized as a site where both stem cells and navigator cells, such as platelets, are found in high concentrations. The team therefore sought to develop a strategy to link those two types of cells to provide an in-house treatment for repairing damaged cardiac tissue following a heart attack.

In this way, platelets can piggyback on stem cells found in the lungs called hematopoietic stem cells (HSCs) and bring them to the damaged site for repair, they said. To do this, they designed what is called a bispecific antibody, which is an artificial protein that can simultaneously bind to two different types of molecules. They are commonly used in treating cancers and different autoimmune diseases, but in the current study, the researchers used them to bind HSCs as well as platelets, to help the stem cells accumulate where they are needed.

An interesting and advantageous aspect of this strategy is the fact that the bispecific antibodies can be delivered through inhalation since their desired location is the lungs. Unlike previous strategies, this provides a safe, non-invansive, and convenient way of administration.

In the study, the team tested whether the inhaled antibodies could effectively link HSCs with platelets and redirect them to the injured heart, and bench-marked this route of administration against an intravenous infusion. It was found that the antibody therapy effectively conjoined HSCs and platelets, and the redirected stem cells helped promote repair and minimized inflammation at the site of injury, which led to increased cardiac function compared to controls. In addition, inhalation of the platelet-antibody therapy was found to be more efficient and specific than the intravenous route.

While there are limitations that still need to be overcome before this can move into clinical trials, this work demonstrates an innovative and easy approach to help boost heart healing and limit the long-term damage of heart attacks. The team is hopeful that this work can be used as a jumping point to help bring this type of treatment closer to clinical application.

Reference: Mengrui Liu, et al. Bispecific Antibody Inhalation Therapy for Redirecting Stem Cells from the Lungs to Repair Heart Injury. Advanced Science (2020). DOI: 10.1002/advs.202002127

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The Autologous Stem Cell Based Therapies Market was valued at US$ XX million in 2019 and is projected to reach US$ XX million by 2025, at a CAGR of XX percentage during the forecast period. In this study, 2019 has been considered as the base and 2020 to 2025 as the forecast period to estimate the market size for Autologous Stem Cell Based Therapies Market

Deep analysis about market status (2016-2019), competition pattern, advantages and disadvantages of products, industry development trends (2019-2025), regional industrial layout characteristics and macroeconomic policies, industrial policy has also been included. From raw materials to downstream buyers of this industry have been analysed scientifically. This report will help you to establish comprehensive overview of the Autologous Stem Cell Based Therapies Market

Get a Sample Copy of the Report at: https://i2iresearch.com/report/global-autologous-stem-cell-based-therapies-market-2020-market-size-share-growth-trends-forecast-2025/

The Autologous Stem Cell Based Therapies Market is analysed based on product types, major applications and key players

Key product type:Embryonic Stem CellResident Cardiac Stem CellsUmbilical Cord Blood Stem Cells

Key applications:Neurodegenerative DisordersAutoimmune DiseasesCardiovascular Diseases

Key players or companies covered are:RegeneusMesoblastPluristem Therapeutics IncU.S. STEM CELL, INC.Brainstorm Cell TherapeuticsTigenixMed cell Europe

The report provides analysis & data at a regional level (North America, Europe, Asia Pacific, Middle East & Africa , Rest of the world) & Country level (13 key countries The U.S, Canada, Germany, France, UK, Italy, China, Japan, India, Middle East, Africa, South America)

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Key questions answered in the report:1. What is the current size of the Autologous Stem Cell Based Therapies Market, at a global, regional & country level?2. How is the market segmented, who are the key end user segments?3. What are the key drivers, challenges & trends that is likely to impact businesses in the Autologous Stem Cell Based Therapies Market?4. What is the likely market forecast & how will be Autologous Stem Cell Based Therapies Market impacted?5. What is the competitive landscape, who are the key players?6. What are some of the recent M&A, PE / VC deals that have happened in the Autologous Stem Cell Based Therapies Market?

The report also analysis the impact of COVID 19 based on a scenario-based modelling. This provides a clear view of how has COVID impacted the growth cycle & when is the likely recovery of the industry is expected to pre-covid levels.

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It dawned on Eian Kantor on a Saturday in early April as he brewed a cup of tea from fresh mint leaves: he had lost his sense of smell. The tea suspiciously smelled of nothing at all. Kantor proceeded to rifle through the fridge, sniffing jars of pickles, chili sauce and garlicnothing.

Ever since New York State went into lockdownin late March,Kantor, age 30, and his girlfriend had stayed isolated in their Queens, N.Y., apartment. So he did not suspect he had COVID-19 despite running a slight fever that he chalked up to seasonal allergies. When he was finally able to get tested weeks into his loss of smell, or anosmia, he tested negative. But months later, he says, several tests showed that his antibodies to the novel coronavirus were off the charts high, which affirmed that I had had it.

An estimated 80 percent of people with COVID-19 have smell disturbances, and many also have dysgeusia or ageusia (a disruption or loss of taste, respectively) or changes in chemesthesis (the ability to sense chemical irritants such as hot chilies). Smell loss is so common in people with the disease that some researchers have recommended its use as adiagnostic testbecause it may be a more reliable marker than fever or other symptoms.

One lingering mystery is how the novel coronavirus robs its victims of these senses. Early in the pandemic, physicians and researchers worried that COVID-related anosmia might signal that the virus makes its way into the brain through the nose, where it could do severe and lasting damage. A suspected route would be via the olfactory neurons that sense odors in the air and transmit these signals to the brain. But studies have shown that this isprobably not the case, says Sandeep Robert Datta, a neuroscientist at Harvard Medical School. My gestalt read of the data to date suggests that the primary source of insult is actually in the nose, in the nasal epithelium, the skinlike layer of cells responsible for registering odors. It looks like the virus attacks, predominantly, support cells and stem cells and not neurons directly, Datta says. But that fact does not mean that neurons cannot be affected, he emphasizes.

Olfactory neurons do not have angiotensin-converting enzyme 2 (ACE2) receptors, which allow the virus entry to cells, on their surface. But sustentacular cells, which support olfactory neurons in important ways, are studded with the receptors. These cells maintain the delicate balance of salt ions in the mucus that neurons depend on to send signals to the brain. If that balance is disrupted, it could lead to a shutdown of neuronal signalingand therefore of smell.

The sustentacular cells also provide the metabolic and physical support needed to sustain the fingerlike cilia on the olfactory neurons where receptors that detect odors are concentrated. If you physically disrupt those cilia, you lose the ability to smell, Datta says.

In astudyinBrain, Behavior and Immunity, Nicolas Meunier, a neuroscientist at the Paris-Saclay University in France, infected the noses of golden Syrian hamsters with SARS-CoV-2. Just two days later, about half of the hamsters sustentacular cells were infected. But olfactory neurons were not infected even after two weeks. And strikingly, the olfactory epithelia were completely detached, which, Meunier says, resembled skin peeling after a sunburn. Although olfactory neurons were not infected, their cilia were entirely gone. If you remove the cilia, you remove the olfactory receptors and the ability to detect odorants, he says.

Disruption of the olfactory epithelium could explain the loss of smell. Yet it remains unclear whether the damage is done by the virus itself or invading immune cells, which Meunier observed after infection. Widespread reports of anosmia with COVID are not typical of other diseases caused by viruses. We think its very specific to SARS-CoV-2, Meunier says. In aprevious studywith other respiratory viruses at his lab, he foundsustentacular cells infected only rarely, whereas with SARS-CoV-2, about half of cells contained the pathogen. With other viruses, smell is usually compromised by a stuffed-up nose, but COVID doesnt usually cause nasal congestion. This is very different, Meunier says.

Researchers have found a few clues about the loss of smell, but they are less certain about how the virus causes a loss of taste. Taste receptor cells, which detect chemicals in the saliva and send signals to the brain,do not contain ACE2, so they probably do not get infected by SARS-CoV-2. But other support cells in the tongue carry the receptor, perhaps providing some indication of why taste goes away. (Although taste can seem to disappear with anosmia because odors are such a key component of flavor, many people with COVID truly develop ageusia and cannot detect even sweet or salty taste.)

The loss of chemical sensingthe burn of hot chilies or the refreshing sensation of mintalso remains unexplained and largely unexplored. These sensations are not tastes. Instead their detection is conveyed by pain-sensing nervessome of whichcontain ACE2throughout the body, including the mouth.

More clues to how the virus obliterates smell come from people recovering from anosmia. The majority of patients lose smell like a light switch going off and recover it rapidly, Datta says. Theres a fraction of patients that have much more persistent anosmia and recover on longer time scales. The olfactory epithelium regularly regenerates. Thats the bodys way of protecting against the constant onslaught of toxins in the environment, Meunier says.

Still, more than seven months after he first experienced anosmia, Kantor falls in the second group of patients: he has yet to detect any odors at all. Its hard because you dont realize how much you relate to smell until you lose it, he says. If the house were on fire, I wouldnt know it. Its very concerning. And then there is what anosmia does to the joy of eating. Foods that used to be good now taste meh, Kantor says.

Carol Yan, a rhinologist at the University of California, San Diego, says that anosmia poses a real health risk. It actually increases mortality. If you cant smell and taste food, it can predispose you to harm, like rotten food or a gas leak, she says. It can also cause social withdrawal or nutritional deficits.

The variation on sensory themes extends to another symptom called parosmia, a possible sign of recovery in people with long-lasting anosmia. Freya Sawbridge, a 27-year-old New Zealand woman, is such an individual. She got COVID-19 in March. After several weeks of anosmia and ageusia, when everything tasted of ice cubes and cardboard, she says, Sawbridge began to regain the most basic tastessweet, salty, sourbut no nuance of flavor, which comes from foods aromas. Chocolate tastes like sweet rubber, she says.

Then, after about five months, some odors returned but not as expected. For a while, all foods smelled of artificial strawberry flavor. But now everything smells hideous and distorted, Sawbridge says. Nothing is accurate, and the odors are all unpleasant. The smell of onions, she says, is unbearable, and a strange chemical flavor permeates everything. All my food tastes like it was sprayed with window cleaner, Sawbridge adds.

Parosmia may occur when newly grown stem cells that develop into neurons in the nose attempt to extend their long fibers, called axons, through tiny holes in the base of the skull and connect with a structure in the brain called the olfactory bulb. Sometimes axons connect to the wrong place, causing erratic smell, but the miswiring can potentially correct itself, given enough time.

That news is welcome for people such as Sawbridge. But the question she wants answered is: How long will her anosmia last? We dont know the final time course of recovery for those with anosmia, Yan says, but it is usually from six months to a year. With long-term postviral smell loss from the flu, after six months, there is a 30 to 50 percent chance of spontaneous recovery without any treatment, she adds. There have been case reports of recovery after two years. But after that, we think the regenerative capability may be hindered. And the chances of recovery are quite slim, unfortunately.

Kantor has tried every avenue imaginable to regain his sense of smell: a course of high-dose steroids to reduce inflammation; a smell-training program with essential oils; beta-carotene supplements for nerve regeneration; acupuncture. Nothing has made a difference. Yan recommends irrigation of the sinuses with budesonide, a topical steroid shown to improve outcomesin a Stanford Universitystudy of people with postflu smell loss for more than six months. Another promising treatment Yan and others areinvestigating is platelet-rich plasma, an anti-inflammatory concoction isolated from blood that has been used to treat some types of nerve damage. But with any treatment, Yan says, the results are not amazing. Its not like youll wake up and say, Wow, I can smell again. But if you can smell soap again or enjoy the taste of some foods, thats a big gain.

There is one final worrying note about anosmia: it has beenidentified as a risk factorfor some neurodegenerative diseases. After the flu pandemic of 1919, we saw an increase in the prevalence of Parkinsons disease, Meunier says. It would be really concerning if something similar were happening here.

But Yan thinks that fear is overblown. There is certainly a link between anosmia and diseases, but we think that viral-induced anosmia is [working by] a totally different mechanism, she says. Having postviral anosmia doesnt put you at higher risk for disease. These are two completely separate phenomena. That should reassure Sawbridge and Kantorand the millions of others worldwide affected with COVID-related smell loss.

Read more about the coronavirus outbreak fromScientific Americanhere. And read coverage from our international network of magazineshere.

This article was first published atScientificAmerican.com. ScientificAmerican.com. All rights reserved. Follow Scientific American on Twitter @SciAm and @SciamBlogs. VisitScientificAmerican.comfor the latest in science, health and technology news.

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Mysteries of COVID smell loss finally yield some answers - Livescience.com

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The new year is always a good time to 'reset' your life and implement new and improved health and fitness habits.

Maintaining new routines isnt easy, but here are four wellness retreats around the world that will help put the architecture in place that you need to live better.

Following the opening of Revivo in Bali in 2018, the brand will be launching a new wellness retreat in the Tarn region of France, in summer 2021.

Revivo Chteau de Fiac will take over a renovated castle on a three-hectare estate, and will feature 16 bedrooms, as well as a salt cave, a spa offering massages and hydrotherapy, bootcamp circuits, and the chance to eat freshly grown vegetables from the on-site garden.

Revivo is a proponent of teaching mind-body connectivity so always incorporates physical activity such as yoga with art classes and meditation, for example.

Also opening in spring/summer 2021, Qatars Zulal Wellness Resort will be the Middle Easts inaugural full-immersion wellness destination and the worlds first centre for traditional Arabic Islamic medicine.

Operated by wellness pioneer Chiva-Som, Zulal will have 120 rooms in a Family Wellness enclave, and 60 suites and villas in a separate zone for adults-only.

Just one hours drive away from Doha International airport, the extravagant hideaway will prescribe healing methods based on centuries of knowledge provided by Islamic medicinal historians and herbalists.

Situated in northern Goa, India, Kings Mansion will join Revivo and Zulal in making its debut in 2021.

Bringing together science and genomics with Ayurvedic medicine, the cutting-edge retreat will offer six wellbeing programmes, including areas such as:

Stays are a minimum of one week and both the Shodhana and Kshipra Shodhana detox programmes require a DNA test before arrival. These tests are to determine genetic pre-dispositions for certain health conditions, thereby allowing for highly personalised treatments.

Located on Lake Constance in southern Germany, Buchinger Wilhelmi is a hotel-clinic specialising in therapeutic fasting and integrative medicine.

In September it launched a new Immunity+ programme that is designed to boost wellbeing (with the specific aim of reducing the risk of getting Covid-19), and is bookable as a 110 add-on to its fasting packages.

After guests have been given a quick blood test on arrival to make sure they dont have Covid, they then get to relax in luxurious surroundings while embarking on a calorie-restricted regime (ten days costs 2,340 per person), which includes nurse checks, consultations with a doctor, daily activities, and a menu of freshly-made vegetable bouillon and pressed fruit juices.

Dr Francoise Wilhelmi de Toledo, scientific director at Buchinger Wilhelmi, explains, When you fast, all your digestive processes are in rest. Without needing the energy to digest, all stresses are diminished and you actually need less immunity.

"During this time, you change your microbiome. You stimulate the lungs, skin, kidneys, liver and the system itself triggers autophagy an extraordinary capacity of the body to eliminate damaged cellular structures. When you fast, you activate stem cells to rejuvenate immune cells.

Jenny Southan is editor and founder of travel trend forecasting agency Globetrender.

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Four life-changing wellness retreats from around the world - Euronews

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Avrobio has shared data on the first Gaucher disease patient to receive its gene therapy AVR-RD-02. The patient, who was stable on enzyme replacement therapy at baseline, experienced a 22% drop in a toxic metabolite after receiving AVR-RD-02 and stopping taking the standard of care.

Gaucher, like the Fabry disease targeted by Avrobios lead prospect, is currently treated using enzyme replacement therapies sold by Sanofi and Takeda, which entered the market through its takeover of Shire. However, a significant minority of patients experience physical limitations despite treatment. Negative outcomes include bone pain and spleen enlargement. Johnson & Johnsons Zavesca offers an oral alternative, but there remain unmet medical needs.

Avrobio is developing AVR-RD-02 to address those needs. The data shared as part of Avrobios R&D day mark the start of the effort to show AVR-RD-02 performs as hoped in the clinic.

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The first patient to receive AVR-RD-02 discontinued enzyme replacement therapy one month before taking the gene therapy. Three months after receiving the gene therapy, levels of Gaucher biomarker lyso-Gb1 had fallen 22%. The patients level of plasma chitotriosidase, a biomarker of cells associated with severe organ damage, was down 17%. Hemoglobin and platelets were in the normal range.

AVR-RD-02 triggered those changes without causing serious adverse events. The data drop offers an early indication that Avrobio may be able to improve outcomes by harvesting hematopoietic stem cells, adding a gene that encodes for glucocerebrosidase and reinfusing the cells back into the same patient. With enzyme replacement therapies costing healthcare systems up to $400,000 a year per patient, there is scope for AVR-RD-02 to cut the cost of treating Gaucher disease.

Avrobio shared the early look at clinical data on AVR-RD-02 alongside updates about other assets. There is now more than three years of data on some Fabry patients treated with Avrobios lead asset, putting the company in a position to plot a path to accelerated approval. Avrobio plans to submit its briefing book to the FDA by the end of the year to align on an accelerated approval strategy.

The update also covered cystinosis candidate AVR-RD-04. The first patient to receive the candidate is off oral and eye drop cysteamine 12 months after receiving the gene therapy. The number of crystals in the patients skin are down 56%, leading Avrobio to posit they may have gained the ability to make their own functional cystinosin protein.

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Voters in California have approved Proposition 14, which will pump billions of dollars into the state's stem cell research program. The Associated Press called the vote on Thursday, with 51 percent of ballots for and 49 percent against.

The result will allow the state to borrow $5.5 billion from investors for its stem cell agency, the California Institute for Regenerative Medicine (CIRM). The moneywhich taxpayers will repay with interest over the next 30 yearswill enable the institute to stay open, expand its research programs, and build new facilities.

Some $1.5 billion of the money will be spent researching conditions affecting the brain and central nervous system, such as Alzheimer's, Parkinson's, epilepsy, and stroke.

Unlike specialized cellssuch as blood cells or bone cellsstem cells do not have a specific job. Think of them as the raw materials of our bodies. When they divide, they can either renew and make new stem cells, or turn into specialized cells.

Despite making headlines for years, stem cell research is still in its early stages, with some treatments that have appeared to have worked in animals now going into clinical trials. These include treatments for macular degeneration, a common cause of blindness, as well as stroke, Lou Gehrig's disease, and spinal cord injuries.

It is hoped growing stem cells into specialized cells could also one day be used to replace damaged tissue and organs, for instance by helping the pancreas produce insulin in people with diabetes.

Currently, stem bone marrow transplantation is the most common form of stem cell therapy, used to treat blood cancer patients. Stem cell therapy has also been used for grafts of corneal stem cells, as well as skin grafts for burns victims.

As well as creating treatments, stem cell research can also help scientists understand diseases. Observing the cells in a lab as they turn into specialized cells, for instance, can provide clues on how we develop certain conditions.

There are a number of stem cells: embryonic stem cells, adult stem cells, adult stem cells tweaked to behave like embryonic stem cells, and stem cells found in the amniotic fluid and the umbilical cord of babies.

The controversy around stem cell research largely lies in the use of embryonic stem cells. These are taken from human embryos in their early stages of development. Opponents have likened this to abortion, although others disagree with this stance.

Embryonic stem cells used in research come from donations from IVF clinics, where an egg is fertilized with a sperm but not implanted into a patient because it is not needed. Embryonic stem cells are preferred over adult stem cells, as it may not be possible to specialize the latter and they are more likely to have abnormalities. But research suggests that it may be possible to turn adult stem cells into a wider range of specialized cells than previously thought, which may make them more useful.

In 2001, the Bush administration banned federal funding for stem cell research. This lead real estate developer Robert N. Klein II to initiate and help fund Proposition 71 in California. The aim was to enshrine the right to carry out stem cell research in the state's constitution, and establish CIRM. Klein was motivated by his son's experience with Type 1 diabetes, and his mother's Alzheimer's diagnosis. In 2004, Californians voted in favor of the proposition.

The institute has performed 64 clinical trials, and published over 3,000 scientific articles on the subject. But 16 years after Proposition 71 passed, CIRM started to run out of funds, and stopped accepting applications for new projects last year. This prompted the Californians for Stem Cell Research, Treatments and Cures political action committee (PAC) to lead the campaign for Proposition 14. Klein was among its supporters, as well as California governor Gavin Newsom, LA mayor Eric Garcetti, and the Michael J. Fox Foundation established by the Back to the Future actor and Parkison's disease patient who is its namesake.

On November 1, the foundation urged people via Twitter to vote in favor of Prop 14 to fund research on neurological disease. "Without this proposition vital research may come to a halt, delaying new treatments for people with," it said.

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As California Passes Prop 14, What Is Stem Cell Research and Why Is It Controversial? - Newsweek

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The company's active ingredient product lines meet consumer expectations of quality, performance, and sustainability

LONDON, Nov. 18, 2020 /PRNewswire/ --Based on its recent analysis of the global personal care active ingredientsmarket, Frost & Sullivan recognizes Mibelle AG Biochemistry with the 2020 Global Company of the Year Award. It has successfully introduced several breakthrough sustainable active ingredients, whose efficacy is shttps://mma.prnewswire.com/media/1337466/Mibelle_Award.jpg upported by in-vivo and in-vitro study results. Mibelle is a pioneer with regards to using senolytics to delay skin aging in cosmetic applications, which has helped the company achieve a leading positioning in the market.

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"Demonstrating its expertise in recognizing the dynamic needs of the cosmetics industry, Mibelle launched the Alpine Rose Active line of products to fight skin aging,"said Prateeksha Kaul Research Analyst. "This line of products uses a natural senolytic agent extracted from the Alpine rose leaves in the Swiss Alps to eliminate senescent cells, which are the cells responsible for aging, without affecting the neighboring cells. This halts the skin's aging process while rejuvenating it and increasing its elasticity. This product also meets the rising demand for natural and sustainable products over harsh chemicals that are harmful to both the environment and the skin."

Similarly, in response to the growing interest in phytocannabinods, Mibelle introduced an encapsulated cannabidiol (CBD) product, the Lipobelle Pino C. Other players in the market have had limited success with CBD in spite of its potential benefits for the skin because it is not soluble in water. Mibelle addressed this limitation with the Lipobelle Pino C. By encapsulating the CBD into a nanoemulsion using hemp oil, Mibelle made it water-soluble and stable in cosmetic formulations. Its combination with an extract from Swiss stone pines also helps the product fight inflammation. Lipobelle Pino C exploits the anti-inflammatory and regenerating effects of CBD for cosmetic benefits such as easing facial tension, reducing inflammation, and regenerating tissue.

Mibelle has been a pioneer in utilizing interesting biochemical concepts for its active ingredients. In 2008, it gained a first-mover advantage with the launch of its active ingredient PhytoCellTec Malus Domestica, which involved the application of stem cells in cosmetics for the very first time. In 2019, Mibelle utilized its PhytoCellTec technology to launch the PhytoCellTec Goji, which stimulates the mesenchymal stem cell (MSC) culture with goji stem cells for enhancing face shape by preventing the skin from sagging. The success of this technology and other recent innovations has allowed the company to achieve a 15 percent growth rate annually.

"Mibelle works closely with certification bodies to analyze the ingredients, raw materials, and processes to obtain the required certifications for its products. It also collaborates with personal care product manufacturers to offer premium high-quality products that benefit the end user," noted Kaul. "With its ability to introduce breakthrough active ingredients, Mibelle AG Biochemistry has carved a niche for itself in the personal care industry. It has consistently adopted a holistic innovation approach that has enabled it to consistently develop novel concepts and ingredients."

Each year, Frost & Sullivan presents a Company of the Year award to the organization that demonstrates excellence in terms of growth strategy and implementation in its field. The award recognizes a high degree of innovation with products and technologies, and the resulting leadership in terms of customer value and market penetration.

Frost & Sullivan Best Practices awards recognize companies in a variety of regional and global markets for demonstrating outstanding achievement and superior performance in areas such as leadership, technological innovation, customer service, and strategic product development. Industry analysts compare market participants and measure performance through in-depth interviews, analysis, and extensive secondary research to identify best practices in the industry.

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For over five decades, Frost & Sullivan has become world-renowned for its role in helping investors, corporate leaders, and governments navigate economic changes and identify disruptive technologies, Mega Trends, new business models, and companies to action, resulting in a continuous flow of growth opportunities to drive future success. Contact us: Start the discussion.

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Harley GadomskiP: 12104778469E: [emailprotected]

About Mibelle AG Biochemistry

Mibelle Biochemistry designs and develops innovative, high-quality actives based on naturally derived compounds and profound scientific know-how. Inspired by nature - Realized by Science.

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Mibelle Biochemistry's Ability to Introduce Breakthrough Active Ingredients for the Personal Care Market Lauded by Frost & Sullivan - PR Newswire...

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18-Nov-2020

Ingredients | Marketing

The company's active ingredient product lines meet consumer expectations of quality, performance andsustainability

Based on its recent analysis of the global personal care active ingredients market, Frost & Sullivan recognises Mibelle AG Biochemistry with the 2020 Global Company of the Year Award.

It has successfully introduced several breakthrough sustainable active ingredients, whose efficacy is supported by in-vivo and in-vitro study results. Mibelle Biochemistry is a pioneer with regards to using senolytics to delay skin aging in cosmetic applications, which has helped the company achieve a leading positioning in the market.

"Demonstrating its expertise in recognising the dynamic needs of the cosmetics industry, Mibelle Biochemistry launched the Alpine Rose Active ingredient to fight skin aging," said Prateeksha Kaul Research Analyst.

"This ingredient contains a natural senolytic agent extracted from the Alpine rose leaves in the Swiss Alps to eliminate senescent cells, which are the cells responsible for ageing, without affecting the neighboring cells.

"This halts the skins aging process while rejuvenating it and increasing its elasticity. This active also meets the rising demand fornatural and sustainable products over harsh chemicals that are harmful to both the environment and the skin."

Similarly, in response to the growing interest in phytocannabinods, Mibelle Biochemistry introduced an encapsulated cannabidiol (CBD) ingredient, the Lipobelle Pino C. Other players in the market have had limited success with CBD in spite of its potential benefits for the skin because it is not soluble in water.

Mibelle addressed this limitation with the Lipobelle Pino C. By encapsulating the CBD into a nanoemulsion using hemp oil, Mibelle made it water-soluble and stable in cosmetic formulations.

Its combination with an extract from Swiss stone pines also helps the product fight inflammation. Lipobelle Pino C exploits the anti-inflammatory and regenerating effects of CBD for cosmetic benefits such as easing facial tension, reducing inflammation, and regenerating tissue.

Mibelle Biochemistry has been a pioneer in utilising interesting biochemical concepts for its active ingredients. In 2008, it gained a first-mover advantage with the launch of its active ingredient PhytoCellTec Malus Domestica, which involved the application of stem cells in cosmetics for the very first time.

In 2019, Mibelle utilised its PhytoCellTec technology to launch the PhytoCellTec Goji, which stimulates the mesenchymal stem cell (MSC) culture with goji stem cells for enhancing face shape by preventing the skin from sagging. The success of this technology and other recent innovations has allowed the company to achieve a 15 percent growth rate annually.

Each year, Frost & Sullivan presents a Company of the Year award to the organisation that demonstrates excellence in terms of growth strategy and implementation in its field.

The award recognises a high degree of innovation with products and technologies, and the resulting leadership in terms of customer value and marketpenetration.

Frost & Sullivan Best Practices awards recognize companies in a variety of regional and global markets for demonstrating outstanding achievement and superior performance in areas such as leadership, technological innovation, customer service, and strategic product development.

Industry analysts compare market participants and measure performance through in-depth interviews, analysis, and extensive secondary research to identify best practices in the industry.

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Mibelle Biochemistry announces: Mibelle Biochemistrys Ability to Introduce Breakthrough Active Ingredients for the Personal Care Market by Frost and...

Skin Stem Cells Comments Off on Mibelle Biochemistry announces: Mibelle Biochemistrys Ability to Introduce Breakthrough Active Ingredients for the Personal Care Market by Frost and… | November 18th, 2020

A doll-obsessed couple describe themselves as human Barbie and Ken.

The Los Angeles-based pair have had futuristic stem-cell injections to achieve their looks.

Marcela Iglesias and her husband Steven Berman get the treatment in the hope of rejuvenating their bodies, skin and hair.

The former said: "Weve both had stem cell therapy through IV.

Thirty million mysenthanial cells each a total of 60 million stem cells through the drip.

The 43-year-old has also turned back the clock by getting 60,000 worth of cosmetic procedures.

As well as this, Marcela hones her sculpted figure by following a gruelling fitness regime.

She said: "I never had plastic surgery but I am not against it just a couple of cosmetic procedures like Botox and a little filler to maintain face volume, but have never completely changed or modified my appearance.

"The Barbie doll is an inspiration for becoming whoever you want to be and achieving all your life goals.

Obviously, the aesthetic of the doll is impeccable but at the same time, my approach is a more natural look and I achieve it by working out all the time on my Edgecross-X training system.

"Surgery-wise, I have been contemplating a mini facelift but with the new Morpheus 8, a non-surgical advanced needling treatment that uses radio frequency to tighten and smooth wrinkles on the face and body.

Marcela added: I am also considering a boob and booty boost, basically to make them perky and firm again.

"I admire what the doll represents more than how she looks; I am very respectful of the image of the Barbie doll as I want to encourage all men and women around the world to pursue their dreams and to achieve the look they want.

While the Barbie fan hasnt had any invasive plastic ops done, her Ken doll-loving husband has.

Steven 53, has had a chin implant, two hair transplantations and neck surgery.

The couples extreme appearance helps them to stand out on the street.

Marcela said: "When we go out together, people tell us that we look like Barbie and Ken because we are both blonde and have the doll-like aesthetic.

"I always wear vibrant colours. We break the mould I guess.

The couple, who have been together since meeting on Myspace in 2009, seem to enjoy the attention their looks bring.

Their fame has allowed them to buy McLaren 570s sports cars that cost 200,000.

The motor features an oil-slick rainbow paint job, courtesy of hit TV show Pimp My Ride's West Coast Customs in Los Angeles.

Marcela, who sometimes goes by the nickname 'Queen of Hollywood' and shares glossy lifestyle shots with 310,000 followers on Instagram page @marcelaiglesiashollywood, added: "This type of car is more like a fulfilling a fantasy and achieving one of my dreams.

"I always wanted a car where the doors open like angel wings, so this year with everything that's been going on, I decided to treat myself and my husband.

"I must admit that I had to compromise on the colour because I originally wanted something more pinky toned, but my husband has to drive the car as well and I didn't want him to feel embarrassed!

I believe this car is an extension of my personality - a reflection of myself... I dress the car like I would like to dress!

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Real life 'Barbie and Ken' achieve doll-like looks with futuristic stem-cell injections - Daily Star

Skin Stem Cells Comments Off on Real life ‘Barbie and Ken’ achieve doll-like looks with futuristic stem-cell injections – Daily Star | November 18th, 2020

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The healthcare industry has been focusing on excessive research and development in the last couple of decades to ensure that the need to address issues related to the availability of drugs and treatments for certain chronic diseases is effectively met. Healthcare researchers and scientists at the Li Ka Shing Faculty of Medicine of the Hong Kong University have successfully demonstrated the utilization of human induced pluripotent stem cells or hiPSCs from the skin cells of the patient for testing therapeutic drugs.

The success of this research suggests that scientists have crossed one more hurdle towards using stem cells in precision medicine for the treatment of patients suffering from sporadic hereditary diseases. iPSCs are the new generation approach towards the prevention and treatment of diseases that takes into account patients on an individual basis considering their genetic makeup, lifestyle, and environment. Along with the capacity to transform into different body cell types and same genetic composition of the donors, hiPSCs have surfaced as a promising cell source to screen and test drugs.

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In the present research, hiPSC was synthesized from patients suffering from a rare form of hereditary cardiomyopathy owing to the mutations in Lamin A/C related cardiomyopathy in their distinct families. The affected individuals suffer from sudden death, stroke, and heart failure at a very young age. As on date, there is no exact treatment available for this condition.

This team in Hong Kong tested a drug named PTC124 to suppress specific genetic mutations in other genetic diseases into the iPSC transformed heart muscle cells. While this technology is being considered as a breakthrough in clinical stem cell research, the team at Hong Kong University is collaborating with drug companies regarding its clinical application.

The unique properties of iPS cells provides extensive potential to several biopharmaceutical applications. iPSCs are also used in toxicology testing, high throughput, disease modeling, and target identification. This type of stem cell has the potential to transform drug discovery by offering physiologically relevant cells for tool discovery, compound identification, and target validation.

A new report by Persistence Market Research (PMR) states that the globalinduced pluripotent stem or iPS cell marketis expected to witness a strong CAGR of 7.0% from 2018 to 2026. In 2017, the market was worth US$ 1,254.0 Mn and is expected to reach US$ 2,299.5 Mn by the end of the forecast period in 2026.

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Customization to be the Key Focus of Market Players

Due to the evolving needs of the research community, the demand for specialized cell lines have increased to a certain point where most vendors offering these products cannot depend solely on sales from catalog products. The quality of the products and lead time can determine the choices while requesting custom solutions at the same time. Companies usually focus on establishing a strong distribution network for enabling products to reach customers from the manufacturing units in a short time period.

Entry of Multiple Small Players to be Witnessed in the Coming Years

Several leading players have their presence in the global market; however, many specialized products and services are provided by small and regional vendors. By targeting their marketing strategies towards research institutes and small biotechnology companies, these new players have swiftly established their presence in the market.

Explore Extensive Coverage of PMR`sLife Sciences & Transformational HealthLandscape

Persistence Market Research (PMR) is a third-platform research firm. Our research model is a unique collaboration of data analytics and market research methodology to help businesses achieve optimal performance.

To support companies in overcoming complex business challenges, we follow a multi-disciplinary approach. At PMR, we unite various data streams from multi-dimensional sources. By deploying real-time data collection, big data, and customer experience analytics, we deliver business intelligence for organizations of all sizes.

Our client success stories feature a range of clients from Fortune 500 companies to fast-growing startups. PMRs collaborative environment is committed to building industry-specific solutions by transforming data from multiple streams into a strategic asset.

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The Induced Pluripotent Stem Cells Market To Witness Fierce Competition Amongst The Key Players - KYT24

Skin Stem Cells Comments Off on The Induced Pluripotent Stem Cells Market To Witness Fierce Competition Amongst The Key Players – KYT24 | November 18th, 2020

What is the value of time? La Prairie has been pondering that question for nearly a century, since founder Dr. Paul Niehans, who earned the sobriquet father of cellular therapy, began experimenting with remedies for longevity in 1931 at the Clinique La Prairie in Montreux, Switzerland.

Over the years, the heritage Swiss luxury house has lived at the forefront of beauty innovation, producing indulgent face creams and serums that introduce science into skincare and incorporate rarefied ingredients such as caviar, gold, and now platinum. The precious metal is the anchor of new the Platinum Rare Haute-Rejuvenation collection, the brands latest fountain-of-youth formula offered in a seven product range.

Housed in an assortment of sculptural, amethyst-shaded vessels with enhanced platinum accents, the velvety creams and elixirsperfumed with La Prairies signature scentshowcase a new science dubbed Haute-Rejuvenation. At the core of it is a cellular renewal process that smooths wrinkles, improves skin moisture, restores volume, and induces a vibrant glow. By invigorating epidermal stem cells, it in effectturns back time to more youthful skin.

La Prairies Exclusive Cellular Complex is a life force for the skin. It uses biotechnological research to give new life and energy back to the very cells where beauty is born. It invigorates and nourishes epidermal stem cells to enable them to resume cellular renewal and functionality similar to that of young skin.

When we age, the skins natural rejuvenating capacity decreases, leading to the appearance of signs of aging, says Dr. Jacqueline Hill, the brands global director of strategic innovation. La Prairies Science of Haute-Rejuvenation seeks to specifically modulate and stimulate the skins natural network of interconnected rejuvenating processes to compensate for the age-related decrease of its performance.

Another pillar of the brands history is art. To celebrate the launch of Platinum RareHaute Rejuvenation, La Prairie commissioned the acclaimed British composer Max Richter and Japanese artist Nobuhiro Nakanishi to collaborate on an immersive installation set to debut at this years West Bund Art & Design in Shanghai (Nov. 12-15). Richter masterminded a score for Nakanishis layer drawing Echo of Time, a sculptural work with a sequential photography series of the Swiss Alps at twilight.

The duo was tasked to consider the essence of time and space, particularly a billion -year-long meteor shower responsible for bringing platinum to earth. For his contribution, Nakanishi traveled to Niederhorn peak in the Swiss Alps where he photographed a vibrant sunrise of blue, red, and purplethe colors that imbue Platinum Rares bottle design. The colors dyed the mountains and at the same time, the sky awakened and became amethyst, Nakanishi says of the scene. The mountainous scenery in Switzerland is the perfect place to illustrate the notion of timeless nature through the clearness of the water, the air, and the reflection of light created by nature itself.

Richters melodic composition begins with pulsating choral strings that give way to an individual acoustic figure meant to stimulate the feeling of entering a new landscape. It provokes a dynamic encounter with a new world and makes you feel alive, he says. To Richter, time is mysterious and doesnt always move at the same speed. This is the kind of thing a piece of music can trigger: it can stop time or speed it up, it can make time feel more intense.

Its a synergetic notion: Manipulating the effects of time is something La Prairie does best.

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La Prairies New Collection Is Inspired by a Platinum Meteor Shower that Lasted 200 Million Years - Surface Magazine

Skin Stem Cells Comments Off on La Prairies New Collection Is Inspired by a Platinum Meteor Shower that Lasted 200 Million Years – Surface Magazine | November 18th, 2020

PARIS, FRANCE - OCTOBER 06: A model walks the runway during the Chanel Womenswear Spring/Summer 2021 ... [+] show as part of Paris Fashion Week on October 06, 2020 in Paris, France. (Photo by Stephane Cardinale - Corbis/Corbis via Getty Images)

In 2020, a symbol of confidence is the perfect companion as the year (thankfully) comes to a close. Americans are turning over a new leaf after being quarantined and pushed forward growing accustomed to a home-hibernated lifestyle. Nowadays, breaking from the tradition has given rise to the public forefront where a socially distant meeting isnt so distant any-longer.

Nonetheless, beauty is a gesture, a symbol of self-assurance that transcends to self-care while remaining true to creating something more modern. The silver lining to 2020, is that given the endless hours spent at home, many Americans came across a new found peace and serenity. In turn, a straight path forward to curate and maintain a healthy lifestyle.

To mark the most memorable moments, home workouts did not go unnoticed. In addition, binge buying had its place to fill a chapter of satisfaction. But what about beauty regimes?Well, that continued to hold its own during this era of self-isolation and wellness. After all, strong willed optimism to return to the once dreaded daily-grind will bestow itself upon us in the near future.

Over the years, innovative treatments in skincare brought forth a fresh new set of revolutionary products and devices that have been entering the market segmentation. For example, Dr. Dennis Gross has pioneered an LED (light emitting diode) device that not only succeeds in its wrinkle reducing and acne fighting purpose, but rather transports you to a world of futuristic rejuvenation as you place this sci-fi mask on your face.

As businesses across the country begin to open their doors again, Dr. Barbara Sturm is providing extensive knowledge and intricate detail into the scientific formulation of serums such as her Anti-Pollution Drops that replenishes skin from HEV blue light, ejected from digital devices; something mankind cannot escape in modern times.

In fact, celebrity makeup artist Marie-Jose Leduc attests that using pure natural oils is the best path forward. Ms Leduc recently launched Odile, a skincare line where the products are a cocktail of active botanicals and devotedly organic. Let go of the harsh chemicals Leduc tells us. Scale it back a little and go gentle. More to the point, Gen Z advocates sustainability, a key factor to the largely lucrative industry.There is a small group of us who look at the big picture. I cant make money knowing that I am harming the environment, Leduc preaches with strength to pave an organic pathway for those that follow.

Now that the world is getting closer and closer, the next chapter is confidence and hope. Americans are rediscovering comfort and security found in beauty and wellness. As tough as 2020 has been, people are feeling refreshed and replenished to take on the next chapter. To help you begin your fresh skincare and wellness regiment, I have reviewed a handful of the best products and services developed to stand the test of time.

Armani Beauty:

Armani beauty Crema Nera Supreme Reviving Cream ($400)

Armani Beauty- Crema Nera Supreme Reviving CreamThe Supreme Revivng Cream is part of a complete Crema Nera skincare ritual that awakens the skin with luxurious, hydrating formulations. The ranges powerful fusion of nature and revolutionary technology imparts both instant results and lasting benefits to the skin. The powerful, exclusive Reviscentalis ingredient defines the Crema Nera collection, and is infused throughout the full range. Prized for its healing and medicinal powers, an extract from the Reviscentalis plant is able to uncover radiant skin and a more youthful appearance. $400

ARTIS:

Perfect for applying foundation, skincare, bronzer and contour with some glam. Its proprietary ... [+] animal-free CosmeFibre can be used with liquids, creams and powders across makeup and skincare formulas.

Artis has created elegance and glamour this holiday season with their limited- edition Elite Oval 7 brushes, each encrusted with a unique design of Swarovski Crystals!The EmeraldCrystal Elite Mirror Oval 7 Brush is adorned with 70 crystalsrichly pigmented soft-green Swarovski crystals, while theThe translucent Crystal Elite Mirror Oval 7 Brush is decorated with 362 translucent-white Swarovski crystals, and the Red Crystal Elite Mirror Oval 7 Brushis filled with 362 ravishing ruby red crystals, all options bring to life a classic holiday color choice thatshines on any bathroom counter. EmeraldCrystal Elite Mirror Oval 7 Brush-$200,Translucent Crystal Elite Mirror Oval 7 Brush$250 andRed Crystal Elite Mirror Oval 7 Brush$250

BABOR:

Babor

DOCTOR BABOR Power Serum Ampoules: This seven day intensive treatment deeply hydrates the skin with four types ofhyaluronic acids of varying weight to plump the skins surface and improve skin elasticity.The Hyaluronic acid + Booster Tripeptides work together to deliver intense hydration and effectively plump the skin. Helps improve skin elasticity with long lasting effects. $49.95

BIOEFFECT:

tk

To celebrate the 10-year anniversary of BIOEFFECT and the brands award-winning, best-selling EGF Serum, BIOEFFECT launched a 50 mL Limited Edition EGF Serum produced in their new patented black barley. Containing only seven ingredients, this serum is three times the size of the original and features double the concentration of EGF proven to reduce the appearance of wrinkles and fine lines as well as plumps skin to increase density and thickness. The unique bottle is custom-sculpted and designed by renowned Icelandic-born, Brooklyn-based artist, Shoplifter, who designed the bottle to show how the magic of nature and science can merge and influence a work of art. $495 USD

Biophile Skin:

Created by maverick creative scientist and award-winning clean beauty pioneer Alison Cutlan, along ... [+] with seasoned business executive Grace Fooden, the biophile brand synthesizes traditional ecological wisdom with modern science in an alchemical process called biofermentation

Biophile is a new generation of biologically advanced, sustainable skincare that works to balance the microbiome, activate the skins regenerative abilities and strengthen skin barrier function. Biophiles breakthrough trio of productsRoot Bionic Refining Essence, Bio-Shroom Rejuvenating Serum, and Bio Barrier Nourishing Oilfeed the skin with probiotic bacteria and botanicals, fungi and superfoods to boost skin immunity and hydration, increase cellular energy, reduce wrinkles and pigmentation, and increase smoothness. Each biophile product is designed to work synergistically to bring skin to life .First, the Root Bionic Refining Essence resurfaces and regenerates to prepare skin for the award-winning Bio-Shroom Rejuvenating Serum. Next, the Bio-Shroom Serum feeds and supports the skin with three powerful mushrooms and age-defying actives and peptides, supporting the skins barrier and microbiome. Finally, the Bio Barrier Nourishing Oil strengthens and fortifies for a plump-and-seal effect. $125

BeautyBio:

BeautyBio

Professional-grade stainless steel, dual-ended Cryo Roller harnesses the natural power of ice-cold temps to depuff, tighten and detoxify skin for a clearer, sculpted, more radiant appearance.USD: $85.00

Dr. Barbara Strum:

Courtesy of Dr. Barbara Sturm Dr. Barbara Sturm Anti-Pollution Drops ($145) strengthen and calm ... [+] skin while also providing protection from damaging HEV blue light.

Dr. Barbara Sturm HEV is a blue light thats emitted by digital devices, and it penetrates deep into the skin making it potentially more dangerous than UV rays. Over time, it can compromise skin barrier function, triggering an inflammation cascade that causes premature aging, uneven tone, loss of firmness, dryness, impaired skin healing, sensitivity and even breakouts. HEV light exposure is a growing danger for our skin. In fact, during quarantine, US-based Internet service providers reported screen time increases of up to 50% as people turn to their phones to stay connected and informed. Dr. Barbara Sturms Anti-Pollution Drops contain a Skin Protect Complex that strengthens the skins defenses, Cocoa Seed Extract that forms a shield to protect against UV rays, and the brands signature ingredient, Purslane, to help calm irritation. Dr. Barbara Sturms propriety blend of Hyaluronic Acid also provides hydration on both deep and surface levels, which is essential to maintaining healthy barrier function. To protect your skin from blue light, apply Dr. Barbara Sturms Anti-Pollution Drops after cleansing and before applying face cream, and reapply as needed throughout the day. $145 USD

Courtesy of Dr. Barbara Sturm

Dr. Barbara Sturm Anti-Pollution Drops ($145) strengthen and calm skin while also providing protection from damaging HEV blue light.

Dr. Dennis Gross Skincare:

Dr. Dennis Gross LED FaceWare Device

Dr. Dennis Gross skincare- This FDA-cleared SpectraLite FaceWare Pro mask is a LED mask offering professional light therapy at the comfort of your home. A combination of 100 light emitting diodes in red mode + 62 LED lights in blue mode work together to smooth wrinkles, diminish discoloration, and clear acne for a beautiful, youthful complexion. Red light emitting diode penetrate deep within skins dermis to boost collagen production. Blue light emitting diode destroy P. acnes bacteria to reduce redness, inflammation, and prevent future breakouts. Within days, see a reduction of acne. In 2 weeks, experience a clearing of mild to moderate acne and fading lines. Optimal skin results occur after a 10 week course of treatment. $435 USD

Dr. Loretta:

Dr. Loretta

This advanced sunscreen protects skin from the four external factors responsible for more than 85% of skin aging pollution, light, climate and irritants. Lipochroman provides antioxidant protection from free radical damage caused by pollution and UV radiation the leading causes of fine lines and age spots. Indian ginseng extract protects skin from HEV light emitted from the sun and electronic devices, while peptides hydrate and firm skin. Zinc oxide protects skin from UVA/UVB and irritants.$50

Franz Skincare USA:

Franz Skincare Premium Microcurrent Facial Dual Mask

The Franz Microcurrent Facial Dual Mask is an award-winning microcurrent facial treatment delivered in a dual-layered mask (set of 2 treatments). The first of its kind, this dual mask system is powered by water energynot batteriesto create tiny waves across skin, letting the masks essences go 6x deeper than the leading face mask* for max results. Price: $50

Garden Apothecary:

Ground facial serum, handmade fresh from our farm

Garden ApothecaryHigher Ground botanical serumis formulated by our in-house botanist, offering the ultimate nourishment with everyday use.With rich phytonutrients, powerful antioxidants, and replenishing peptides, this hydrating serum is dense with healing botanicals, straight from our organic farm. We sustainably grow the saffron that goes into each and every bottle we make here in Half Moon Bay, CA.$108.

GOOPGENES BY GOOP:

GOOPGENES All-In-One Nourishing Face Cream is a luscious treat for the skin and a clinically tested ... [+] supercream that leaves skin looking and feeling soft, smooth, firm, and moisturized for up to 48 hours.

GOOPGENES BY GOOPThis luxuriously rich, all-in-one super-cream melts into skin, leaving it deeply nourished with a unique whipped texture that makes it feel like an invisible second skin. The clinically tested formula is made with seven highly active botanicalsincluding Schisandra fruit, Illipe butter, Caviar lime, and Squalenethat work synergistically to leave skin ultra-moisturized, soft, supple, smooth, firm, and even-toned. A megadose of plant-based ceramides promotes noticeable radiance while smoothing, firming, and hydrating. After just one use, 100% of women experienced significant improvement in hydration. After four weeks of use, 100% showed significant improvement in skin firmness and 94% said their skin appeared brighter. Fragrance-free. $95 USD

iS CLINICAL:

CLINICAL Youth Body Serum

NEW iS CLINICAL Youth Body Serum-This refreshing lightweight serum mist gently absorbs into the skin providing powerful hydration and antioxidant protection against environmental aggressors. The purest form of Hyaluronic Acid, potent extracts of Watermelon, Blue-Micro Algae, Licorice Root and Holy Herb, are combined with essential Vitamin B5, and our proprietary Extremozymes to create a unique and effective formula designed specifically for the body. Much more than a moisturizer, this nourishing treatment leaves skin feeling fresh, soft, and more hydrated. USD$120

KLUR:

Organic hempseed, avocado, and grapeseed oils deliver reparative nutrients to parched areas, while ... [+] providing replenishment and protection against daily moisture loss featuring a comforting aromatic bouquet scent of Neroli Orange Blossom, Bulgarian Rose, and French Lavender.

Klur This uniquely fragrant multi-purpose botanical body oil is formulated to nourish, firm and replenish skin.A comforting aromatic bouquet of Neroli Orange Blossom, Bulgarian Rose, and French Lavender impart a delicate floral yet earthy, gender-fluid aroma. Organic hempseed, avocado, and grapeseed oils deliver reparative nutrients to parched areas, while providing replenishment and protection against daily moisture loss. Thus, transforming skin to its most radiant state. $70 USD

Lancer Skincare:

Lancer Legacy Youth Treatment revitalizes the very look of skin, engineered to promote a ... [+] healthy-looking complexion in five essential functions: supporting rejuvenation, recapturing skin vitality, and providing a moisture barrier, water saturation and antioxidant defense.

Lancer Legacy Youth TreatmentThis luxurious skin rejuvenation treatment saturates the epidermis with moisture and in combination with advanced factors, elicits a fresh, rejuvenated and healthy-looking complexion. A compound of precious saffron and sake help to promote a brighter, more even-looking skin tone. Next generation amino and hyaluronic acids enhance natural moisture retention for supremely supple and renewed skin.Lines appear softer and smoother, skin looks firmer, and the complexion glows with innate vitality. After polishing and cleansing, apply a generous amount to clean, dry skin using upward strokes sweeping onto the entire face, neck and dcollet and pat gently into the skin for one minute. Over 30 ingredients, sourced from around the world, engineered into 5 revolutionary complexes: Youth GF Complex, Firming Mesh Complex, MitoSmooth Compound, Aquadermal Complex, and SativusBright Compound. Price: $1,000

LightStim:

LightStim for Wrinkles is available at major prestige retailers including Sephora, Nordstrom, Neiman ... [+] Marcus, Revolve and more, as well as LightStim.com.

LightStim-The restorative benefits of sunlight have been known for thousands of years, but in more recent history we have become aware of the damage that can be caused by excessive exposure to UV. Often called red light therapy and generally referred to as low-level light therapy or photobiomodulation among researchers and clinicians, this treatment contains no UV and utilizes only clinically proven beneficial wavelengths (or colors) of light to treat the skin. Studies performed over many decades, including those conducted by NASA, have shown that the human body has the ability to absorb light through the skin and other body tissues and convert it into energy. This is important, because as we age our skin loses the energy needed to maintain its plump, youthful appearance. As a result, fine lines and wrinkles form, and skin appears slack. The key to LightStim for Wrinkles' effectiveness is its patented MultiWave technology which allows for a more thorough and comprehensive treatment. The device simultaneously emits 4 different wavelengths of UV-free therapeutic light energy. Amber, deep red, light red and infrared wavelengths nourish the skin from within, filling in fine lines and wrinkles, and over time reducing and even eliminating them all in an easy-to-use, portable hand-held device. $249

Luzern:

Nuit Cleaning Emulsion: Hydrates as it cleans, leaving skin glowing and revitalized

Luzern- Nuit Cleansing EmulsionNuit Cleansing Emulsion. The ultimate pampering and rejuvenating entre' into your evening regimen. Nutrient-rich Alpine extracts are suspended in this ultra-rich cleansing balm.Blended with 6 nourishing oils to help decongest skin without disrupting its delicate protective barrier. Melts on contact with the skin's warmth to dissolve away impurities, makeup, and pollution to prepare it for nighttime renewal. Nuit Cleansing Emulsion: MSRP $135.00

MARA:

MARA's limited edition Sea the Glow Radiance Duo featuring a full-size luxury Universal Face Oil ... [+] and a travel size luxury Algae Retinol Face Oil developed to work in tandem to soften signs of aging, texture and dark spots while delivering fatty acids and phytonutrients for the ultimate hydration and glow.

MaraOur two best selling luxury face oils to hydrate and treat your way to a gorgeous glow this holiday season! This limited edition Sea the Glow Radiance Duo has a full size Universal Face Oil and a travel size Algae Retinol Face Oil so you can treat yourself or someone you love to the gift of good skin this holiday. These two products were developed to work in tandem. Travel size Algae Retinol Face Oil is a nighttime treatment that softens signs of aging, texture and dark spots; Universal Face Oil is filled with fatty acids and phytonutrients for insane hydration and glow. $105 USD

NELI Naturals:

NELI Naturals Skincare Collection

NELI, meaning the truth will be revealed, is an effective, clean skincare line with an attainable price point. Created alongside dermatologists, the cruelty-free (Leaping Bunny Certified), vegan, paraben-free, all-natural ingredient product line consists of a Gentle Facial Cleanser, AHA/BHA Superfruit Hydrating Scrub, Collagen Peptide SPF Daily Moisturizer, 4.25% Retinoid Collagen Night Moisturizer and an Apple Stem Cell Hydrating Eye Cream. The glow boosting, anti-aging collection is enriched with essential ingredients such as collagen, hyaluronic acid and berry antioxidant extracts to improve your skin barrier while maintaining a healthy and hydrated complexion.$102 USD

NON GENDER SPECIFIC:

A luxurious moisturizing face cream with 23 powerful botanicals

Non Gender Specific Everything Cream is a luxurious moisturizing face cream that works to deliver phytonutrients and hydration deep into the skin, thanks to 23 powerful botanicals. This formula works to nourish the skin with natural oils that absorb quickly and are never greasy, leaving skin feeling soft withthe appearance of brighter skin, refined pores andreduced redness.USD$58

PMD Beauty:

The new Personal Microderm Elite Pro is a cordless option for effortless, on-the-go beauty featuring ... [+] an extended range of discs for all your exfoliation needs.

PMD BeuatyThe newly launched Personal Microderm Elite is the brands first microderm device that is wireless and rechargeable. Get rid of dull skin with the revolutionary microdermabrasion tool - on the go. The Elite offers a customizable treatment for your unique skin type. After just one treatment it will reveal smoother, softer skin. Now you can reduce fine lines and wrinkles, increase hydration and even out skin texture at a fraction of an in-spa treatment cost. $299

Phyto-C:

evens-out the appearance of uneven skin tone

PHYTO-CThe new HYPER-C now includes AHAs (Glycolic and Lactic Acid) for even brighter, smoother skin! Formulated with HA technology plus peptides and pure Vitamin C, Hyper-C works to rejuvenate the appearance of dull looking skin by using the highest concentration of Vitamin C (20%) clinically tested to provide the maximum amount of antioxidant benefits to the skin. The unique HA technology, which stands for HYPER absorbing hyaluronic acid delivers essential ingredients where you need them most at the perfect absorption rate. $70

SAINT JANE:

Clean botanicals are paired with rich concentrations of full-spectrum hemp to enhance its benefits, ... [+] making this powerhouse duo the ultimate skin-transforming routine for calm, nourished, and glowing skin

Saint Jane THE IDEAL DUO Layerthese two award-winning skincare powerhousesfor your bestskin days.Start with The C-Drops for 20% active Vitamin C plus soothing hemp extract to resurface and brighten. Follow with Luxury Beauty Serum on top for deepnutrients and intense moisture.They work together to deliver exactly what your skin needs for complete nutrition throughout your day. $200.00

Sunday Riley:

Pink Drink Firming Resurfacing Essence

Sunday Riley A power drink for your skin, this peptide-infused essence resurfaces, balances, and firms the look of your skin (while drenching it in advanced green tea, antioxidant support). Peptides help firm the skin, while fermented honey and botanical extracts balance the skins natural microbiome and resurface the skin. $48.00

Tata Harper:

This limited edition duo is a natural face lift in a bottle, engineered with the most lifting and ... [+] firming technology. Includes the Boosted Contouring Serum and Boosted Contouring Eye Balm.

Tata HarperBoosted Contouring SetThis hyper-potent duo including the Boosted Contouring Serum and Boosted Contouring Eye Balm transforms thelook of mature, sagging skin to restore a youthfully firm, lifted look on both the face, dcollet, and under eye area. Best used for loss of firmness/ elasticity, fine lines & wrinkles, and dryness.$270.00

3LAB:

3LAB Super Cream

Super Cream is a super-powered skin booster with the most advanced technology, targeted delivery system unique to 3LAB.This luxurious, ingredient-rich cream delivers elastin producing peptides and targeted repair in a matter of days. X50 and Intelligent Targeting Device (ITD) deliver antioxidants and peptides directly to the source of the problem, combating fine lines, wrinkles and skin imperfections with quick, dramatic results. Always on the cutting edge of skin care technology, 3LAB prides itself on offering serious skin care solutions that are efficacious and made with the highest quality ingredients.With Super Cream, 3LAB is one of the first to introduce smart technology to skin care.Think of it like a GPS system programmed into your skin cream. Combined with 3LABs signature Bio-Engineered Renewal Complex and Apple Stem Cell Technology, the key ingredients are encapsulated within the cream and when applied, it targets tired, stressed-out, and aged cellsonly targeting the cells that need repair. The concept was adapted from the pharmaceutical industry where smart delivery technology enables medications to target diseased cells.$900 USD

U Beauty:

"U Beauty and Artis Holiday Duo Limited Edition Set

U Beauty and Artis Holiday Duo Limited Edition Set U Beauty, the luxury, clean, science-backed skincare line dedicated to simplifying your skincare routine, and Artis, the beauty brand best known for their innovative makeup and skincare brushes, will launch a limited-edition set for the holiday 2020 season. For Holiday 2020, U Beauty is pleased to present an exclusive, limited-edition gift set in collaboration with Artis. The brands joint offering will pair U Beautys recently launched 50ml The SUPER Smart Hydrator with Artis Palm Brush Mini.Price: $168

Valmont:

A rich replenishing balm created to provide intense nourishment for even the driest skin.

Valmont - PRIMARY POMADEThis ointment immediately and intensely nourishes the skin. Thanks to the latest technology, its incredibly fine texture penetrates the skin at a rapid speed, visibly healing dry or irritated areas. It replenishes lipids, restores the skins protective barrier function, and softens dry skin. The skin is smoother, more supple and comfortable. Retail price: $275

VENeffect:

Veneffect harnesses the power of phytoestrogens to offset the signs of hormonal aging

MoisturizerVeneffect Intensive Moisturizer ($185USD) is a potent blend of plant based phytoestrogens, emollients and peptides to address the effects of hormonal aging on skin.Created by sister duo, Cecil Booth, a beauty industry veteran,and Rebecca Booth, M.D., an OB/GYN specializing in hormonal wellness,their line harnesses their experiences professionally and as women to optimize hormonal vitality throughout the month and as women uniquely age.They call this phenomenon the Venus Effect, thus their brand, Veneffect.$185 USD

VENN Skincare:

ADVANCED MULTI-PERFECTING RED OIL SERUM

VENN Skincare- A multi-correctional face oil serum, strategically formulated using 34 root extracts, botanicals, and essential oils to deliver a category-defining, comprehensive skin benefits. 100% of the formula are efficacy-driven bioactives. Inspired by Korea's traditional herbal first aid ointment, the key ingredients include Lithospermum Erythrorhizon (Gromwell) Root Extract and Angelica Gigas (Korean Angelica) Root Extract that are fermented for 150 hours at low temperature for amplified delivery and performance on the skin. Clinically tested to hydrate skin for up to 24 hours, improve skins elasticity and firmness, and instantly increase skins radiance. $115 USD

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The New Generation Of Beauty - Forbes

Skin Stem Cells Comments Off on The New Generation Of Beauty – Forbes | November 18th, 2020

HAIFA, Israel, Nov. 18, 2020 (GLOBE NEWSWIRE) -- Pluristem Therapeutics Inc. (Nasdaq:PSTI) (TASE:PSTI), a leading regenerative medicine company developing a platform of novel biological therapeutic products, today reported the first clinical results for PLX-R18 in humans from its Phase I study evaluating PLX-R18 as a treatment for incomplete hematopoietic recovery following hematopoietic cell transplantation (HCT). The initial results consisted of the analysis of the first 19 patients enrolled, and not all patients completed a one year follow up.

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Pluristem to Present Initial Results from Its Phase I HCT Study with PLX-R18 Demonstrating Safety and Efficacy at the ASH Annual Meeting

Global News Feed Comments Off on Pluristem to Present Initial Results from Its Phase I HCT Study with PLX-R18 Demonstrating Safety and Efficacy at the ASH Annual Meeting | November 18th, 2020

NEW YORK and MAINZ, GERMANY, November 18, 2020 — Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today announced that, after conducting the final efficacy analysis in their ongoing Phase 3 study, their mRNA-based COVID-19 vaccine candidate, BNT162b2, met all of the study’s primary efficacy endpoints. Analysis of the data indicates a vaccine efficacy rate of 95% (p<0.0001) in participants without prior SARS-CoV-2 infection (first primary objective) and also in participants with and without prior SARS-CoV-2 infection (second primary objective), in each case measured from 28 days after the first dose, 7 days after the second dose. The first primary objective analysis is based on 170 cases of COVID-19, as specified in the study protocol, of which 162 cases of COVID-19 were observed in the placebo group versus 8 cases in the BNT162b2 group. Efficacy was consistent across age, gender, race and ethnicity demographics. The observed efficacy in adults over 65 years of age was over 94%.

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Pfizer and BioNTech Conclude Phase 3 Study of COVID-19 Vaccine Candidate, Meeting All Primary Efficacy Endpoints

Global News Feed Comments Off on Pfizer and BioNTech Conclude Phase 3 Study of COVID-19 Vaccine Candidate, Meeting All Primary Efficacy Endpoints | November 18th, 2020

NEW YORK, Nov. 18, 2020 (GLOBE NEWSWIRE) -- Better Choice Company, Inc. (OTCQB: BTTR) (the “Company” or “Better Choice”), an animal health and wellness company, today reported its financial results for the third quarter ended September 30, 2020.

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Better Choice Company Reports Third Quarter and Year-to-Date 2020 Financial Results

Global News Feed Comments Off on Better Choice Company Reports Third Quarter and Year-to-Date 2020 Financial Results | November 18th, 2020

New York City, Nov. 18, 2020 (GLOBE NEWSWIRE) -- BetterLife Pharma Inc. (“BetterLife” or the “Company”) (CSE: BETR / OTCQB: BETRF / FRA: NPAT), an emerging biotech company focused on development and commercialization of interferon (IFN) based therapeutics, recently provided a clinical and regulatory update for its AP-003 COVID-19 clinical trials using inhaled interferon alpha 2b.  While recent advancements in vaccines may seem to provide a glimmer of hope for bringing the pandemic to a close, it remains to be seen how safe and effective they will be, and for how long. The importance of life-saving COVID-19 therapeutics is as great ever, and the support for the Company’s use of interferon as a therapeutic for COVID-19 is compelling.

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What do the Pfizer Vaccine and BetterLife Pharma have in common?

Global News Feed Comments Off on What do the Pfizer Vaccine and BetterLife Pharma have in common? | November 18th, 2020

The Company takes first step in its expansion with the addition of a 300,000 sq. ft. facility within Monterey County The Company takes first step in its expansion with the addition of a 300,000 sq. ft. facility within Monterey County

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Indus Holdings, Inc. Announces Preliminary Expansion Plans

Global News Feed Comments Off on Indus Holdings, Inc. Announces Preliminary Expansion Plans | November 18th, 2020

SANTA CLARA, Calif., Nov. 18, 2020 (GLOBE NEWSWIRE) -- Shockwave Medical, Inc. (NASDAQ: SWAV), a pioneer in the development of Intravascular Lithotripsy (IVL) to treat complex calcified cardiovascular disease, announced today that it will be participating in the Piper Sandler 32nd Annual Virtual Healthcare Conference, scheduled to be held December 1 to 3, 2020.

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Shockwave Medical to Participate in the Piper Sandler 32nd Annual Virtual Healthcare Conference

Global News Feed Comments Off on Shockwave Medical to Participate in the Piper Sandler 32nd Annual Virtual Healthcare Conference | November 18th, 2020

PRINCETON, N.J., Nov. 18, 2020 (GLOBE NEWSWIRE) -- KBP Biosciences, a clinical-stage biotechnology company dedicated to research, development, and commercialization of innovative medicines for the global market, today announced the appointment of Douglas W. Losordo, MD, FACC, FAHA to the newly created position of Chief Medical Officer, effective immediately. Dr. Losordo, who will report directly to CEO Thijs Spoor, will lead all global clinical development and regulatory initiatives for the Company. Dr. Losordo is an accomplished physician and healthcare executive with more than 20 years of academic research, clinical and corporate experience.

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KBP Biosciences Appoints Douglas Losordo Chief Medical Officer

Global News Feed Comments Off on KBP Biosciences Appoints Douglas Losordo Chief Medical Officer | November 18th, 2020

Acquired from Gilead Sciences a portfolio of SYK inhibitors, including lead investigational therapy entospletinib being developed for frontline treatment of NPM1-mutated acute myeloid leukemia

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Kronos Bio Reports Recent Business Progress and Third Quarter 2020 Financial Results

Global News Feed Comments Off on Kronos Bio Reports Recent Business Progress and Third Quarter 2020 Financial Results | November 18th, 2020