The folk wisdom that tension and anxietycan turn your hair gray appears to be scientifically valid, according to a new study in mice.

Researchers found that the cascade of fight-or-flight hormones precipitated by stressful events eliminated many of the stem cells responsible for hair color in mice.

This group of stem cells, which have the ability to turn into many types of cells, are found in the base of each hair follicle and give hair its color by becoming pigment producing cells called melanocytes which produce brown, black, red and yellow colors in hair and skin.

The researchers found that stress causes these stem cells to convert into melanocytes en masse, only to drift away from the follicle and break down. This depletes the follicles supply and can mean the next time it makes a hair there arent enough stem cells to give it a color, producing an unpigmented gray or white hair.

After a series of experiments, the researchers narrowed down the culprit behind the destruction of the follicles pigment factories to the fight-or-flight hormone noradrenaline, or norepinephrine which is released by whats called the sympathetic nervous system.

Normally, the sympathetic nervous system is an emergency system for fight or flight, and it is supposed to be very beneficial or, at the very least, its effects are supposed to be transient and reversible, biologist Ya-Chieh Hsu, who led the study, told the New York Times.

This is the first scientific study explicitly linking stress and graying, according to Hsu.

The experiments in mice found that acute stress could wipe out all the melanocyte stem cells in just five days. Early tests suggest the same might be true in humans: When the researchers exposed human melanocyte stem cells to noradrenaline they too differentiated in large numbers.

Hsu told the Guardian the same response may drive age-related greying. There are definitely shared responses between how the melanocyte stem cells respond to stress and how they respond to aging, she said. You essentially lose the stem cell pool in aging as well.

Developing the research into an effective treatment to end graying hair will likely take years, but revealing the mechanism at work could advance our understanding of how stem cells are lost elsewhere in the body one of the hallmarks of the physical decline that accompanies aging.

This is certainly one implication that Im particularly excited about, biologist Christopher Deppmann, who was not involved in the research, told the Guardian. I believe that we have only scratched the surface of whether and how stress and fight-or-flight mechanisms deplete other stem cell populations. Whether or not this is the cause of premature aging remains to be determined, but I wouldnt bet against it.

Like any good study, it opens up at least as many questions as it answers, he added. But it may represent an important stepping stone toward rationalizing and developing pharmaceutical fountains of youth.

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If you're worried about your hair turning gray, don't stress out! - The Hill

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(Photo: Stocksy)

You either swear by facial oils or are skeptical of all the fanfare and its myriad of purported benefits. In recent years, facial oils have become a booming skincare category, taking up prominent shelf space. There are all kinds of facial oils you can choose from with ingredients like rosehip, marula and jojoba. They are also said to boast a bevy of skincare benefits like brightening, calming inflammation and minimizing the look of fine lines and wrinkles. Despite their popularity, theres also some confusion around face oils. Will they clog pores? Do they replace your moisturizer? Do you even actually need one? To help make sense of it all, we enlisted the help of two experts to break it all down, plus, the best facial oils for every skin concern.

Read this next:The 20 Best Lip Balms to Save You From Dry Winter Hell

The purpose of a facial oil is to provide moisture to the skins surface and serve as a protective layer against environmental aggressors, says Dr. Monica Li, a Vancouver-based dermatologist and clinical instructor in the department of dermatology and skin science at the University of British Columbia. Facial oils both act like an emollient (filling in the gaps between skin cells to strengthen the outer layer)and an occlusive agent (sealing water in at the skin surface), explains Li.

Our skin produces natural oilsknown as sebumwhich help retain water within the skin surface. A facial oil is basically added protection, helping supplement the oils the skin already produces and maintain a robust skin barrier function, says Li.

A face oil can be a game-changer for your skin, says Jennifer Brodeur, a Montreal-based facialist to celebs like Oprah and Michelle Obama, and founder of JB Skin Guru. The right face oil will help with skin homeostasis [its ability to maintain a stable internal environment], as it provides nutrition and hydration to the skin.

Facial oils can be beneficial for everyoneeven oily skin types. A caveat: theres no one-size-fits-all formula. As not all face oils are created equally, its important to know what face oils are right for you, says Brodeur.

Since not all oils are the same, different ones will have different skincare benefits. Beyond its hydrating and nourishing properties, a facial oil can also have anti-inflammatory, antimicrobial and antioxidant benefits, depending on the ingredients and composition, says Li. Brodeur adds: My favourites are those that contain lots of good fatty acids and vitamins. For example, sunflower seed oil, peoni root extract and rosehip seed oil. However, you also need to be mindful of your skin type.

Read this next:I Hate That I Feel Like I *Have* to Wear Makeup

For sensitive skin, Brodeur recommends steering clear of essential oils, especially citrus oils. Essential oils can be very potent, which means they can cause irritation or trigger allergies for sensitive skin. Citrus oils in particular like orange, grapefruit and bergamot can cause photosensitivity, resulting in skin irritation or discolouration. Brodeur also suggests avoiding oils with dye or fragrances.

If you have oily skin, Dr. Li recommends using an oil with a light texture like jojoba or grapeseed that will absorb more easily into the skin and wont clog pores.

For dry skin, look for a facial oil with either oat or argan oil, both of which are known for their soothing and nourishing properties. Mixing two to three drops of the facial oil with a moisturizer will have a compounded hydrating effect, says Li.

Once you choose an oil, apply it on a test spot like on the wrist or behind the ears for at least a week. Keep in mind that these natural oil ingredients may be a source of contact allergens depending on the individual, she adds. Facial oils are still a relatively new category of skincare and more research and clinical studies are l needed, so its best to consult with a board-certified dermatologist if you have any questions or concerns.

Read this next:I Have Dry Acne-Prone Skin and This Is How I Deal in Winter

The answer will vary depending on who you ask (yes, its that controversial). For the most part, experts agree that you should use a facial oil after your moisturizer as the final step in your skincare routine. Oil sits on water, so it creates a protective layer to prevent water loss, explains Brodeur. However, if your skin is on the drier side, you can apply oil first or even layer with an oil, moisturizer and then oil again. You can even mix a few drops of facial oil into your moisturizer or foundation for a dewy glow.

As a rule of thumb, serums are usually used to target specific skin concerns [such as hyperpigmentation and fine lines and wrinkles], whereas oils are primarily used to nourish and hydrate the skin, says Brodeur, meaning you can use both a serum and a facial oil.

Always apply facial oil on clean skin after youve cleansed. Brodeur recommends using two to three drops and taking the time to massage it into your skin using upward strokes.

Inner Glow Face Oil, $120, amandinesolbotanicals.com

Formulated with a blend of botanicals and essential oils like lavender and calendula sourced from the founders family farm in Ontario, this multi-tasker lends a helping hand for a healthy, glowy complexion.

Lextrait, $225, jbskincare.com

Made with a concentrated blend of sunflower seed oil, peony root extract and licorice root, this gentle oil soothes and hydrates skin.

Rosehip BioRegenerate Oil, $50, shoppersdrugmart.ca

Rosehip seed oil does all the heavy lifting in this formula with vitamins, antioxidants and essential fatty acids, which help with brightening, collagen production and fighting free radicals.

Stem Cellular Vinifera Replenishing Oil, $90, sephora.com

Jojoba, macadamia and olive squalene oils help boost the skins moisture while fruit stem cells, vitamin C and grapeseed oil to help improve skin tone and radiance.

BIO Organic Lavandin Smooth & Glow Facial Oil, $23, walmart.ca

Tapping into lavandin essential oil (a hybrid created from true lavender and spike lavender) and argan oil, this formula promises smooth, supple skin with a non-greasy finish.

Squalane + Tea Tree Balancing Oil, $65, sephora.com

Ultra-hydrating and lightweight squalene meets skin-purifying tea tree oil for a nourishing and quick-absorbing face oil.

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The Best Facial Oils and How to Use Them - FLARE

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China started off 2019 by completing the first soft landing on the far side Earths moon. It was a monumental achievement, and the months since the mission arrived at the Moon have been filled with interesting discoveries, including the discovery of a strange gel-like substance around a lunar crater.

Now, as China celebrates the one year anniversary of the Change 4 lander and Yutu-2 rover arriving at the Moon, the countrys space group has released a wealth of data, including some never-before-seen images of the far side of Earths tiny neighbor.

The images some of which benefit from post-processing at the hands of talented scientists and enthusiasts show the Moons least-studied face in stunning detail.

Image Source: CNSA / TECHNIQUES SPATIALES

The Change 4 mission included a lunar lander and a rover that explored the Moons surface. Because of the nature of day and night on the Moon, the instruments are put into a sleep mode when the far side falls into shadow, waking back up when the sun shines again.

China, which has historically lagged behind countries like the United States and Russia when it comes to space exploration, is rapidly catching up. Landing on the far side of the Moon is no easy task, and the countrys space agency pulled it off with flying colors. Going forward, China is poised to be a major player in space exploration and has even discussed the possibility of setting up semi-permanent bases on the lunar surface.

You can browse through a massive collection of these new images via a handy Google Drive link, or sift through the raw images via CNSAs web portal.

Image Source: CNSA / Techniques Spatiales

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China just released the most stunning images from the far side of the Moon - BGR

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New Delhi: On Saturday, January 18th, 2020, the Advancells Group & the International Fertility Center together ended their first workshop Sub-Specialty Training in Application of Regenerative Medicine (S.T.A.R. 2020). The three-day workshop had specialized doctors, medical practitioners, learned scientists of Advancells, the leaders in cell manufacturing & processes and IFC, one of Indias most prestigious Fertility institute who were joined by candidates with MBBS/BAMS/BHMS/BPharma & Masters degree in Life Sciences.

The key-note speaker of the workshop was Dr. Rita Bakshi, founder and chairperson of International Fertility Centre, the oldest fertility clinic and one of the most renowned IVF clinics in India, one of the organizers of the event. Participants also had a privilege to listen to Dr. Sachin Kadam, CTO, Advancells and gain hands-on experience in the preparation of PRP; Liposuction method; and Bone Marrow aspiration. All these techniques were talked about at length and demonstrated in the form of manual & kit-based models to help the candidates gain exposure.

Dr. Punit Prabha, Head of Clinical Research and Dr. Shradha Singh Gautam, Head of Lab Operations at Advancells successfully set the base of stem cell biology for the participants who were experts in gynecology field, stem cell research and pain specialist. With the help of detailed analysis of Application of PRP for Skin rejuvenation; Preparation of Micro-fragmented Adipose Tissue and Nano Fat & SVF (Stromal Vascular Fraction) from Adipose Tissue; and Cell Culturing and Expansion in a Laboratory, applicants understood the application of stem cells in aesthetics, cosmetology, and anti-aging.

Vipul Jain, Founder & CEO of Advancells Group said, Educating young scientists about stem cells is important for us. With this workshop we wanted to discuss and share the challenges and lessons we have learned in our journey of curing our customers. We wanted to establish more concrete knowledge base in the presence of subject matter experts and help our attendees in more possible ways. We are hopeful to have successfully achieved what we claimed with this workshop.

Given the resounding success of the Sub-Specialty Training in Application of Regenerative Medicine (S.T.A.R. 2020), its hoped that the future events shall offer even greater wisdom to the participants by helping them improve and the lead the community into the age of greater awareness.

Advancells Group Advancells is leading the field of stem cell therapies in India and abroad, with representative offices in Bangladesh and Australia. The company provides arrangements for stem cell banking and protocols for partner doctors and hospitals which they can use for treating the patients using regenerative medicine. With a GMP compliant research and processing center that works on different cell lines from various sources such as Bone Marrow, Adipose Tissue, Dental Pulp, Blood, Cord Tissue etc. Advancells also intends to file a patent for this processing technology soon.

For more information, visit https://www.advancells.com/

International Fertility Centre IFC is Indias leading fertility center under the leadership and guidance of Dr. Rita Bakshi. She along with her solid team of experienced doctors have create a network of 10+ IVF clinics located in India and Nepal. Their services include In-vitro Fertilization (IVF), Intrauterine Insemination (IUI), Intracytoplasmic Injection (ICSI), Egg Donation, Surrogacy, Blastocyst, Assisted Hatching, Hysteroscopy, Laparoscopy and much more.

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Advancells Group & IFC Concluded their 3-Day Workshop on Regenerative Medicine - India Education Diary

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Chronic pain cost an estimated $139.3 billion in 2018. Image: iStock, Top image: Pexels

Researchers at the University of Sydney have used human stem cells to make pain-killing neurons that provide lasting relief in mice, without side effects, in a single treatment. The next step is to perform extensive safety tests in rodents and pigs, and then move to human patients suffering chronic pain within the next five years.

If the tests are successful in humans, it could be a major breakthrough in the development of new non-opioid, non-addictive pain management strategies for patients, the researchers said.

Thanks to funding from the NSW Ministry of Health, we are already moving towards testing in humans, said Associate Professor Greg Neely, a leader in pain research at the Charles Perkins Centre and the School of Life and Environmental Sciences.

Nerve injury can lead to devastating neuropathic pain and for the majority of patients there are no effective therapies. This breakthrough means for some of these patients, we could make pain-killing transplants from their own cells, and the cells can then reverse the underlying cause of pain.

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Pain treatment using human stem cells a success - News - The University of Sydney

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Poland has emerged as Europe's leader in stem cell storage, a billion-dollar global industry that is a key part of a therapy that can treat leukaemias but raises excessive hopes.

Submerged in liquid nitrogen vapour at a temperature of minus 175 degrees Celsius, hundreds of thousands of stem cells from all over Europe bide their time in large steel barrels on the outskirts of Warsaw.

Present in blood drawn from the umbilical cord of a newborn baby, stem cells can help cure serious blood-related illnesses like leukaemias and lymphomas, as well as genetic conditions and immune system deficits.

Polish umbilical cord blood bank PBKM/FamiCord became the industry's leader in Europe after Swiss firm Cryo-Save went bankrupt early last year.

It is also the fifth-largest in the world, according to its management, after two companies in the United States, a Chinese firm and one based in Singapore.

Since the first cord blood transplant was performed in France in 1988, the sector has significantly progressed, fuelling hopes.

Mum-of-two Teresa Przeborowska has firsthand experience.

At five years old, her son Michal was diagnosed with lymphoblastic leukaemia and needed a bone marrow transplant, the entrepreneur from northern Poland said.

The most compatible donor was his younger sister, Magdalena.

When she was born, her parents had a bag of her cord blood stored at PBKM.

More than three years later, doctors injected his sister's stem cells into Michal's bloodstream.

It was not quite enough for Michal's needs but nicely supplemented harvested bone marrow.

As a result, Michal, who is nine, "is now flourishing, both intellectually and physically," his mum told AFP.

A cord blood transplant has become an alternative to a bone marrow transplant when there is no donor available, with a lower risk of complications.

Stem cells taken from umbilical cord blood are like those taken from bone marrow, capable of producing all blood cells: red cells, platelets and immune system cells.

When used, stem cells are first concentrated, then injected into the patient. Once transfused, they produce new cells of every kind.

At the PBKM laboratory, "each container holds up to 10,000 blood bags... Safe and secure, they wait to be used in the future," its head, Krzysztof Machaj, said.

The bank holds around 440,000 samples, not including those from Cryo-Save, he said.

If the need arises, the "blood will be ready to use without the whole process of looking for a compatible donor and running blood tests," the biologist told AFP.

For families who have paid an initial nearly 600 euros ($675) and then an annual 120 euros to have the blood taken from their newborns' umbilical cords preserved for around 20 years, it is a kind of health insurance promising faster and more effective treatment if illness strikes.

But researchers also warn against unrealistic expectations.

Haematologist Wieslaw Jedrzejczak, a bone marrow pioneer in Poland, describes promoters of the treatment as "sellers of hope", who "make promises that are either impossible to realise in the near future or downright impossible to realise at all for biological reasons."

He compares them to makers of beauty products who "swear their cream will rejuvenate the client by 20 years."

Various research is being done on the possibility of using the stem cells to treat other diseases, notably nervous disorders. But the EuroStemCell scientist network warns that the research is not yet conclusive.

"There is a list of almost 80 diseases for which stem cells could prove beneficial," US haematologist Roger Mrowiec, who heads the clinical laboratory of the cord blood programme Vitalant in New Jersey, told AFP.

"But given the present state of medicine, they are effective only for around a dozen of them, like leukaemia or cerebral palsy," he said.

"It's not true, as it's written sometimes, that we can already use them to fight Parkinson's disease or Alzheimer's disease or diabetes."

EuroStemCell also cautions against private blood banks that "advertise services to parents suggesting they should pay to freeze their child's cord blood... in case it's needed later in life."

"Studies show it is highly unlikely that the cord blood will ever be used for their child," the network said.

It also pointed out that there could be a risk of the child's cells not being useable anyway without reintroducing the same illness.

Some countries, such as Belgium and France, are cautious and ban the storage of cord blood for private purposes. Most EU countries, however, permit it while imposing strict controls.

In the early 2000s, Swiss company Cryo-Save enjoyed rapid growth.

Greeks, Hungarians, Italians, Spaniards and Swiss stored blood from their newborns with the company for 20 years on payment of 2,500 euros upfront.

When the firm was forced to close in early 2019, clients were left wondering where their stem cells would end up.

Under a kind of back-up agreement, the samples of some 250,000 European families were transferred for storage at PBKM.

The Polish firm, founded in 2002 with two million zlotys (around 450,000 euros, $525,000), has also grown quickly.

Present under the FamiCord brand in several countries, PBKM has some 35 per cent of the European market, excluding Cryo-Save assets.

Over the last 15 months, outside investors have contributed 63 million euros to the firm, PBKM's chief executive Jakub Baran told AFP.

But the company has not escaped controversy: the Polityka weekly recently published a critical investigative report on several private clinics that offer what was described as expensive treatment involving stem cells held by PBKM.

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Europe's guardian of stem cells and hopes, real and unrealistic - Deccan Herald

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The tiny body seemed consumed by tubes and wires and monitors.

Just one day prior, Stephanie and Cody Smith had learned the terrible truth about why their 18-month-old son, Charlie, had been so sick recently. He had neuroblastoma, a cancer that forms on the nerve endings. Scans revealed cancer was on his kidney, lungs, bone and lymph nodes.

To stem the aggressive cancer, his doctors immediately got to work, putting in catheters, taking bone marrow biopsies and preparing for the start of intense chemotherapy. Charlie lay in his hospital bed eating Cheetos Puffs, his favorite food, and sitting with his parents.

"It was hard when we got the news," Stephanie Smith said. "I tried to be calm and collected; I had to be strong for my baby. But its been hard."

Story continues below gallery

The past two months have come straight out of a nightmare for the Smith family. Since Charlie was diagnosed with Stage IV neuroblastoma in November, each day brings uncertainty.

The Franklin family has spent 49 of the last 60 days at Riley Hospital for Children at IU Health. Charlie has gone through rounds of chemotherapy, suffering through fevers, mouth sores, extreme fatigue and nausea that wracked his small body. His treatment will last over the next 18 months, and will include chemotherapy, stem cell transplants, blood transfusions, radiation and immunotherapy.

But despite everything theyve been through, the Smiths remain resolute that Charlie will get better. They have relied on their faith, and an army of supporters who have stepped forward to help them in their worst time, to get them through.

"It was amazing to see so many people come up and love on us. It has taught us to be generous people; weve always thought we were generous people, but when you see the number of people who care for you and pray for you and support you, its really amazing," Stephanie Smith said.

The Smiths have partnered with Versiti Blood Center of Indiana to host a blood drive in Greenwood Saturday. The Cheering for Charlie event will be held from 6 a.m. to 2 p.m., to help increase blood supplies for patients such as Charlie who rely on transfusions to survive.

Every two seconds, someone needs life-saving blood, whether theyre bravely battling disease like Charlie, undergoing surgery or are victims of trauma," said Duane Brodt, spokesman for Versiti. "People need people since blood cant be manufactured."

For most of his life, Charlie was a happy-go-lucky toddler. He loved to smile and laugh, beaming joy. Where his 3-year-old brother Henry was more of a wild child, Stephanie Smith said, Charlie seemed to always be in a pleasant, good mood.

His parents described him as their "happy baby."

Thats what made his lethargy, lack of appetite and gradual decline in health so concerning.

"He was learning how to walk over the summer, and started getting sick," Stephanie Smith said. "We just thought it was a virus; we didnt think of the worst."

Charlie developed a low-grade fever, wasnt eating well and was falling asleep unexpectedly while playing with toys. He wasnt acting like himself, Stephanie Smith said.

During a visit to his pediatrician, the doctor found a hard area on Charlies abdomen, and recommended doing some blood tests and taking an X-ray. Those tests only led to more questions he had severe range anemia and elevated levels of platelets in his blood. But the doctor didnt have any conclusive answers as to what was causing it.

Stephanie Smith, a nurse at Franciscan Health, started hearing warning bells in her mind. That, combined with a mothers intuition, convinced her that they needed to take Charlie to Riley Hospital for Children. After 12 hours in the emergency room, and dozens of tests, doctors found a large tumor in Charlies abdomen.

"Sometimes, when kids are diagnosed with cancer, they can go home and be in and out of the hospital for treatment, but Charlie was really sick. The tumor was pushing on his kidney, damaging his kidney, so we had to stay in the hospital," Stephanie Smith said.

The pathology lab at Riley Hospital for Children confirmed the tumor was neuroblastoma. The cancer forms in immature nerve endings, often in the adrenal glands located near the kidneys and is most common in children age 5 and under, according to the American Cancer Society.

But the cancer is very rare; only about 800 new cases are diagnosed in the U.S. each year, according to the American Cancer Society.

Neuroblastomas grow and spread very rapidly, so treatment would have to be aggressive, doctors explained to the family. Charlies oncologist recommended starting with two rounds of focused chemotherapy, followed by the extraction of his red blood cells for stem cell transplants, then another three rounds of chemotherapy.

Two different stem cell transplants would be held about a month apart, and Charlie would start radiation treatment. Immunotherapy, which jolts the immune system into targeting and killing cancer cells, would be the final part of the regimen.

Almost immediately, Charlie started his chemotherapy.

"It grows so quickly, that we had to be aggressive. The beginning was pretty intense," Stephanie Smith said.

The treatment was hard on Charlies young body. He developed mouth sores and didnt want to eat, and his nausea left him miserable. The Smith family essentially relocated to the hospital, staying with him constantly.

But at the same time, their friends and family, as well as complete strangers, stepped up to offer help. A meal train was set up to provide the family with food, and prayers came from all directions.

A GoFundMe page has raised more than $36,000 for the family. A community Facebook page has more than 5,000 members.

"We had a rally of people come around us," Stephanie Smith said. "We couldnt have done it without all of the people who have come together."

Charlie has completed his first four rounds of chemotherapy, and on Jan. 20, he was able to return home with his family to wait for surgery to remove the tumor in his abdomen. That operation is tentatively going to be early to mid February.

In the meantime, the family has been soaking in the opportunity to be together somewhere besides the hospital. They have also been working to plan the blood drive being held on Saturday.

Charlie has relied on blood transfusions throughout his treatment, and a blood drive would be a way to raise awareness of the importance of those transfusions to cancer patients, Stephanie Smith said.

"Charlie received quite a few blood products, especially early on in his treatment. He had 12 transfusions in these 2 1/2 months. For his little body, thats a lot," she said. "Being a nurse, I didnt realize the number of cancer patients who need blood products. Its so important. So this was a way to let people know that."

Stephanie Smiths sister, Shelby Richards, knew people who had organized drives with their friends and helped the family get the Cheering for Charlie drive going.

The drive is a perfect opportunity to remind people that blood donations are vitally important, Brodt said. Versiti Blood Center of Indiana needs to collect at least 560 blood donations every day to support the need at its 80 hospital partners throughout the state, he said.

"So our Cheering for Charlie will truly make a difference and help save lives," Brodt said.

For the Smith family, the drive is a way to give back for all the love theyve been shown.

"Its really cool for us to see how many people have signed up, and also be advocates for other people who need blood, to just get the word out there about how important it is," Stephanie Smith said. "Its encouraging for us to see people come out to support Charlie and kids like him."

If you go

Cheering for Charlie blood drive

What: A blood drive honoring Charlie Smith, an 18-month-old Franklin child diagnosed with neuroblastoma, a cancer of the nerve cells.

When: 6 a.m. to 2 p.m. Saturday

Where: Versiti Blood Center of Indiana, 8739 U.S. 31 S., Indianapolis

Who can donate: Generally, anyone in good health age 16 and up can donate. Make sure you do not have a cold, flu or sore throat at the time of donation.

How to schedule an appointment: Go to Versiti.org/Indiana

Information: Learn more about Charlie on the Cheering for Charlie! Facebook group page.

Excerpt from:
Blood drive to honor Franklin child with cancer - Daily Journal

Bone Marrow Stem Cells Comments Off on Blood drive to honor Franklin child with cancer – Daily Journal | January 24th, 2020

(MENAFN - ForPressRelease) 11

New Delhi 23rd January 2020 On Saturday, January 18th, 2020, the Advancells Group & the International Fertility Center together ended their first workshop Sub-Specialty Training in Application of Regenerative Medicine (S.T.A.R. 2020). The three-day workshop had specialized doctors, medical practitioners, learned scientists of Advancells, the leaders in cell manufacturing & processes and IFC, one of India's most prestigious Fertility institute who were joined by candidates with MBBS/BAMS/BHMS/BPharma & Master's degree in Life Sciences.

The key-note speaker of the workshop was Dr. Rita Bakshi, founder and chairperson of International Fertility Centre, the oldest fertility clinic and one of the most renowned IVF clinics in India, one of the organizers of the event. Participants also had a privilege to listen to Dr. Sachin Kadam, CTO, Advancells and gain hands-on experience in the preparation of PRP; Liposuction method; and Bone Marrow aspiration. All these techniques were talked about at length and demonstrated in the form of manual & kit-based models to help the candidates gain exposure.

Dr. Punit Prabha, Head of Clinical Research and Dr. Shradha Singh Gautam, Head of Lab Operations at Advancells successfully set the base of stem cell biology for the participants who were experts in gynecology field, stem cell research and pain specialist. With the help of detailed analysis of 'Application of PRP for Skin rejuvenation'; 'Preparation of Micro-fragmented Adipose Tissue and Nano Fat & SVF (Stromal Vascular Fraction) from Adipose Tissue'; and 'Cell Culturing and Expansion in a Laboratory', applicants understood the application of stem cells in aesthetics, cosmetology, and anti-aging.

Vipul Jain, Founder & CEO of Advancells Group said, 'Educating young scientists about stem cells is important for us. With this workshop we wanted to discuss and share the challenges and lessons we have learned in our journey of curing our customers. We wanted to establish more concrete knowledge base in the presence of subject matter experts and help our attendees in more possible ways. We are hopeful to have successfully achieved what we claimed with this workshop'.

Given the resounding success of the Sub-Specialty Training in Application of Regenerative Medicine (S.T.A.R. 2020), it's hoped that the future events shall offer even greater wisdom to the participants by helping them improve and the lead the community into the age of greater awareness.

Advancells Group Advancells is leading the field of stem cell therapies in India and abroad, with representative offices in Bangladesh and Australia. The company provides arrangements for stem cell banking and protocols for partner doctors and hospitals which they can use for treating the patients using regenerative medicine. With a GMP compliant research and processing center that works on different cell lines from various sources such as Bone Marrow, Adipose Tissue, Dental Pulp, Blood, Cord Tissue etc. Advancells also intends to file a patent for this processing technology soon.

User :- Ajit Singh

Email :

Mobile:- 9953809503

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Advancells Group & IFC Concluded their 3-Day Workshop on Regenerative Medicine - MENAFN.COM

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Eric Stegers heart is full, although his liver is smaller by 60%.

Steger, a 50-year-old man from Sunnydale, California, affiliated with Chabad, was in Pittsburgh earlier this month fulfilling his dream of donating an entire lobe of his liver to help save the life of another.

The liver recipient, Conservative Rabbi Jeffrey Kurtz-Lendner, 53, said he feels like he has been given a second chance at life.

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Kurtz-Lendner, who relocated to Pittsburgh from Iowa for the purpose of obtaining a transplant at UPMC, had been diagnosed with fatty liver cirrhosis, but the doctors did not know how serious it was until they were in the midst of the transplant.

I could have died before I got put onto a list, said Kurtz-Lendner, who, after the Jan. 7 surgery, is still recuperating but has been discharged from the hospital.

Steger, a math tutor at Foothill College in Northern California, has donated stem cells for a bone marrow transplant and platelets many times, and has been wanting to help save a life with one of his organs for years. He even traveled to Israel to donate a kidney, but was ultimately turned down because he had hypertension.

About a year ago, though, he saw a UPMC commercial airing in California that advertised the fact that it was now performing altruistic liver donations.

I decided to give it a try, said Steger.

He then got in touch with Chaya Lipschutz, an Orthodox woman from Brooklyn who donated a kidney to a stranger in 2005, and since then has made it her work to help others find kidney matches. She receives no money for her services.

Lipschutz had made the shidduch with the kidney patient in Israel for Steger that did not work out, he said.

As fate would have it, Lipschutz did know people who needed a live liver transplant. Steger was medically cleared for the procedure, but the first few people with whom he matched found other donors. Lipschutz then turned to message boards to post that she had an able and willing donor.

Now I was a solution in search of a problem, said Steger.

When Kurtz-Lendners sister in Teaneck, New Jersey, happened to see Lipschutzs post, the match was made.

Post-surgery, both donor and recipient are doing well.

Im feeling very positive, said Kurtz-Lendner, noting that full recovery from the procedure will take about a year. Two weeks ago, I was dying. Now, I have another 30 years.

He, his wife Robin, and his oldest daughter will remain in Pittsburgh for at least six months.

Kurtz-Lendner did not meet Steger until after the surgery, and sees him as an inspiration of a human being. I appreciate what he has done. He just saved my life.

Steger returned to California this week. During his time in Pittsburgh, he received warm hospitality from the citys Jewish community, particularly the Bikur Cholim of Pittsburgh, run by Nina Butler, he said.

Patients and families who come here from out of town always remind us of how special our community is, said Butler. As the Bikur Cholim of Pittsburgh, Im simply organizing the generosity of volunteers to provide the specific support that each patient wants. That started before Jeff or Eric arrived, answering their questions about housing, Shabbat observance and kosher food.

Eric is observant and came unaccompanied, so his housing was complicated because the Family House does not allow patients to stay completely alone, Butler explained. We provided home hospitality, and we also organized volunteers to drop off meals for Eric while his hosts were at work. Most of all, we formed relationships with both patients and Jeffs family so they knew there were Pittsburghers who had their backs.

Robin Kurtz-Lendner said that she and her husband felt so supported, even before we got here. Its been incredible. The whole community has been rallying around us and its really been appreciated.

Donating part of his liver was not easy, Steger acknowledged. Still, he wants to encourage others to consider organ donation.

Im not going to sugarcoat it, he said. It was the hardest thing Ive ever done. It was a year out of my life, one full year when I was thinking about this all the time.

There was a battery of tests, the surgery itself, and now the recovery phase, he said, which all carry physical and emotional risks.

But he is hoping what he did will help generate continued interest in organ donation.

I hope my experience will inspire other people to investigate it for themselves, he said.pjc

Toby Tabachnick can be reached atttabachnick@pittsburghjewishchronicle.org.

Link:
California man donates part of his liver to Conservative rabbi in Pittsburgh - The Australian Jewish News

Bone Marrow Stem Cells Comments Off on California man donates part of his liver to Conservative rabbi in Pittsburgh – The Australian Jewish News | January 24th, 2020

ANI | Updated: Jan 23, 2020 17:49 IST

New Delhi [India], Jan 23 (ANI/Business Wire India): On Saturday, January 18 2020, the Advancells Group and the International Fertility Center together ended their first workshop - Sub-Specialty Training in Application of Regenerative Medicine (STAR 2020).The three-day workshop had specialized doctors, medical practitioners, learned scientists of Advancells, the leaders in cell manufacturing and processes and IFC, one of India's most prestigious Fertility institutes who were joined by candidates with MBBS/BAMS/BHMS/BPharma and Master's degree in Life Sciences.The key-note speaker of the workshop was Dr Rita Bakshi, founder and chairperson of International Fertility Centre, the oldest fertility clinic and one of the most renowned IVF clinics in India, one of the organizers of the event.Participants also had a privilege to listen to Dr Sachin Kadam, CTO, Advancells and gain hands-on experience in the preparation of PRP; Liposuction method; and Bone Marrow aspiration. All these techniques were talked about at length and demonstrated in the form of manual and kit-based models to help the candidates gain exposure.Dr Punit Prabha, Head of Clinical Research and Dr Shradha Singh Gautam, Head of Lab Operations at Advancells successfully set the base of stem cell biology for the participants who were experts in gynecology field, stem cell research and pain specialist.With the help of detailed analysis of 'Application of PRP for Skin rejuvenation'; 'Preparation of Micro-fragmented Adipose Tissue and Nano Fat & SVF (Stromal Vascular Fraction) from Adipose Tissue'; and 'Cell Culturing and Expansion in a Laboratory', applicants understood the application of stem cells in aesthetics, cosmetology, and anti-ageing."Educating young scientists about stem cells is important for us. With this workshop, we wanted to discuss and share the challenges and lessons we have learned in our journey of curing our customers," said Vipul Jain, founder and CEO of Advancells Group."We wanted to establish a more concrete knowledge base in the presence of subject matter experts and help our attendees in more possible ways. We are hopeful to have successfully achieved what we claimed with this workshop," he added. Given the resounding success of the Sub-Specialty Training in Application of Regenerative Medicine (STAR 2020), it's hoped that the future events shall offer even greater wisdom to the participants by helping them improve and the lead the community into the age of greater awareness.This story is provided by BusinessWire India. ANI will not be responsible in any way for the content of this article. (ANI/BusinessWire India)

Continued here:
Advancells Group, IFC concluded their three-day workshop on Regenerative Medicine - ANI News

Bone Marrow Stem Cells Comments Off on Advancells Group, IFC concluded their three-day workshop on Regenerative Medicine – ANI News | January 24th, 2020

In 2019, the Stem Cell Therapy market is spectated to surpass ~US$ xx Mn/Bn with a CAGR of xx% over the forecast period. The Stem Cell Therapy market clicked a value of ~US$ xx Mn/Bn in 2018. Region is expected to account for a significant market share, where the Stem Cell Therapy market size is projected to inflate with a CAGR of xx% during the forecast period.

In the Stem Cell Therapy market research study, 2018 is considered as the base year, and 2019-2019 is considered as the forecast period to predict the market size. Important regions emphasized in the report include region 1 (country 1, country2), region 2 (country 1, country2), and region 3 (country 1, country2).

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Global Stem Cell Therapy market report on the basis of market players

The report examines each Stem Cell Therapy market player according to its market share, production footprint, and growth rate. SWOT analysis of the players (strengths, weaknesses, opportunities and threats) has been covered in this report. Further, the Stem Cell Therapy market study depicts the recent launches, agreements, R&D projects, and business strategies of the market players including

Key Trends

The key factors influencing the growth of the global stem cell therapy market are increasing funds in the development of new stem lines, the advent of advanced genomic procedures used in stem cell analysis, and greater emphasis on human embryonic stem cells. As the traditional organ transplantations are associated with limitations such as infection, rejection, and immunosuppression along with high reliance on organ donors, the demand for stem cell therapy is likely to soar. The growing deployment of stem cells in the treatment of wounds and damaged skin, scarring, and grafts is another prominent catalyst of the market.

On the contrary, inadequate infrastructural facilities coupled with ethical issues related to embryonic stem cells might impede the growth of the market. However, the ongoing research for the manipulation of stem cells from cord blood cells, bone marrow, and skin for the treatment of ailments including cardiovascular and diabetes will open up new doors for the advancement of the market.

Global Stem Cell Therapy Market: Market Potential

A number of new studies, research projects, and development of novel therapies have come forth in the global market for stem cell therapy. Several of these treatments are in the pipeline, while many others have received approvals by regulatory bodies.

In March 2017, Belgian biotech company TiGenix announced that its cardiac stem cell therapy, AlloCSC-01 has successfully reached its phase I/II with positive results. Subsequently, it has been approved by the U.S. FDA. If this therapy is well- received by the market, nearly 1.9 million AMI patients could be treated through this stem cell therapy.

Another significant development is the granting of a patent to Israel-based Kadimastem Ltd. for its novel stem-cell based technology to be used in the treatment of multiple sclerosis (MS) and other similar conditions of the nervous system. The companys technology used for producing supporting cells in the central nervous system, taken from human stem cells such as myelin-producing cells is also covered in the patent.

Global Stem Cell Therapy Market: Regional Outlook

The global market for stem cell therapy can be segmented into Asia Pacific, North America, Latin America, Europe, and the Middle East and Africa. North America emerged as the leading regional market, triggered by the rising incidence of chronic health conditions and government support. Europe also displays significant growth potential, as the benefits of this therapy are increasingly acknowledged.

Asia Pacific is slated for maximum growth, thanks to the massive patient pool, bulk of investments in stem cell therapy projects, and the increasing recognition of growth opportunities in countries such as China, Japan, and India by the leading market players.

Global Stem Cell Therapy Market: Competitive Analysis

Several firms are adopting strategies such as mergers and acquisitions, collaborations, and partnerships, apart from product development with a view to attain a strong foothold in the global market for stem cell therapy.

Some of the major companies operating in the global market for stem cell therapy are RTI Surgical, Inc., MEDIPOST Co., Ltd., Osiris Therapeutics, Inc., NuVasive, Inc., Pharmicell Co., Ltd., Anterogen Co., Ltd., JCR Pharmaceuticals Co., Ltd., and Holostem Terapie Avanzate S.r.l.

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The Stem Cell Therapy market report answers the following queries:

The Stem Cell Therapy market report provides the below-mentioned information:

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Research Methodology of Stem Cell Therapy Market Report

The global Stem Cell Therapy market study covers the estimation size of the market both in terms of value (Mn/Bn USD) and volume (x units). Both top-down and bottom-up approaches have been used to calculate and authenticate the market size of the Stem Cell Therapy market, and predict the scenario of various sub-markets in the overall market. Primary and secondary research has been thoroughly performed to analyze the prominent players and their market share in the Stem Cell Therapy market. Further, all the numbers, segmentation, and shares have been gathered using authentic primary and secondary sources.

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Soaring Demand for Clean-label Food Products to Trigger the Growth of the Stem Cell Therapy Market 2017 2025 - Fusion Science Academy

Cardiac Stem Cells Comments Off on Soaring Demand for Clean-label Food Products to Trigger the Growth of the Stem Cell Therapy Market 2017 2025 – Fusion Science Academy | January 24th, 2020

TheFabric Refresher Markethas grown exponentially in the last few years and this trend is projected to continue following the same trend until 2026. Based on the industrial chain, Fabric Refresher Market report mainly elaborates the definition, types, applications and major players of Fabric Refresher market in details. Deep analysis about market status (2014-2020), enterprise competition pattern, advantages and disadvantages of enterprise products, industry development trends (2020-2026), regional industrial layout characteristics and macroeconomic policies, industrial policy has also be included.

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From raw materials to downstream buyers of this industry will be analyzed scientifically, the feature of product circulation and sales channel will be presented as well. In a word, this report will help you to establish a panorama of industrial development and characteristics of the Fabric Refresher market.

Geographically,the global Fabric Refresher market is segmented into North America, Asia Pacific, Europe, Middle East & Africa and South America. This report forecasts revenue growth at a global, regional & country level, and provides an analysis of the market trends in each of the sub-segments from 2020 to 2026.

The information for each competitor includes:* Company Profile* Main Business Information* SWOT Analysis* Sales, Revenue, Price and Gross Margin* Market Share

Global Fabric Refresher Industry 2020 Market Research Report is spread across 114pages and provides exclusive vital statistics, data, information, trends and competitive landscape details in this niche sector.

The report also includesa discussion of the key vendors operating in this market. Some of the leading players in the global Fabric Refresher market are:

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CanBottle

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HomeBusiness OfficesRestaurants

This report focuses on Fabric Refresher volume and value at global level, regional level and company level. From a global perspective, this report represents overall Fabric Refresher market size by analyzing historical data and future prospect. Regionally, this report focuses on several key regions: North America, Europe, China and Japan. At company level, this report focuses on the production capacity, ex-factory price, revenue and market share for each manufacturer covered in this report.

The report is useful in providing answers to several critical questions that are important for the industry stakeholders such as manufacturers and partners, end users, etc., besides allowing them in strategizing investments and capitalizing on market opportunities.

Key Target Audience are: Manufacturers of Fabric Refresher Raw material suppliers Market research and consulting firms Government bodies such as regulating authorities and policy makers Organizations, forums and alliances related to Fabric Refresher

Major Points from Table of Contents1 Report Overview1.1 Study Scope1.2 Key Market Segments1.3 Players Covered1.4 Market Analysis by Type1.4.1 Global Fabric Refresher Market Size Growth Rate by Type (2014-2026)1.5 Market by Application1.5.1 Global Fabric Refresher Market Share by Application (2014-2026)1.5.2 Large Enterprises1.5.3 SMEs1.6 Study Objectives1.7 Years Considered

2 Global Growth Trends2.1 Fabric Refresher Market Size2.2 Fabric Refresher Growth Trends by Regions2.2.1 Fabric Refresher Market Size by Regions (2014-2026)2.2.2 Fabric Refresher Market Share by Regions (2014-2020)2.3 Industry Trends2.3.1 Market Top Trends2.3.2 Market Drivers2.3.3 Market Opportunities

3 Market Share by Key Players3.1 Fabric Refresher Market Size by Manufacturers3.1.1 Global Fabric Refresher Revenue by Manufacturers (2014-2020)3.1.2 Global Fabric Refresher Revenue Market Share by Manufacturers (2014-2020)3.1.3 Global Fabric Refresher Market Concentration Ratio (CR5 and HHI)3.2 Fabric Refresher Key Players Head office and Area Served3.3 Key Players Fabric Refresher Product/Solution/Service3.4 Date of Enter into Fabric Refresher Market3.5 Mergers & Acquisitions, Expansion Plans

4 Breakdown Data by Type and Application4.1 Global Fabric Refresher Market Size by Type (2014-2020)4.2 Global Fabric Refresher Market Size by Application (2014-2020)

5 United States5.1 United States Fabric Refresher Market Size (2014-2020)5.2 Fabric Refresher Key Players in United States5.3 United States Fabric Refresher Market Size by Type5.4 United States Fabric Refresher Market Size by Application

6 Europe6.1 Europe Fabric Refresher Market Size (2014-2020)6.2 Fabric Refresher Key Players in Europe6.3 Europe Fabric Refresher Market Size by Type6.4 Europe Fabric Refresher Market Size by Application

7 China7.1 China Fabric Refresher Market Size (2014-2020)7.2 Fabric Refresher Key Players in China7.3 China Fabric Refresher Market Size by Type7.4 China Fabric Refresher Market Size by Application

8 Japan

8.1 Japan Fabric Refresher Market Size (2014-2020)8.2 Fabric Refresher Key Players in Japan8.3 Japan Fabric Refresher Market Size by Type8.4 Japan Fabric Refresher Market Size by Application

9 Southeast Asia9.1 Southeast Asia Fabric Refresher Market Size (2014-2020)9.2 Fabric Refresher Key Players in Southeast Asia9.3 Southeast Asia Fabric Refresher Market Size by Type9.4 Southeast Asia Fabric Refresher Market Size by Application

Continued

The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: regional markets, product, and application.

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Orian Researchis one of the most comprehensive collections of market intelligence reports on the World Wide Web. Our reports repository boasts of over 500000+ industry and country research reports from over 100 top publishers. We continuously update our repository so as to provide our clients easy access to the worlds most complete and current database of expert insights on global industries, companies, and products. We also specialize in custom research in situations where our syndicate research offerings do not meet the specific requirements of our esteemed clients.

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Fabric Refresher Market 2020 Demand Analysis, Production, Revenue and Industry Share of Manufacturer - Fusion Science Academy

Cardiac Stem Cells Comments Off on Fabric Refresher Market 2020 Demand Analysis, Production, Revenue and Industry Share of Manufacturer – Fusion Science Academy | January 24th, 2020

Global Mafura Butter Market Report Market Size, Share, Price, Trends and Forecast is a professional and in-depth study on the current state of the global Mafura Butter industry.

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key players and product offerings

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Tailwinds and headwinds molding the markets trajectory Market segments based on products, technology, and applications Prospects of each segment Overall current and possible future size of the market

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Polyaspartic Coatings Market Insights on Revenue Analysis and Competitive Intelligence Study By 2026 : Key Players are Covestro AG; The...

Cardiac Stem Cells Comments Off on Polyaspartic Coatings Market Insights on Revenue Analysis and Competitive Intelligence Study By 2026 : Key Players are Covestro AG; The… | January 24th, 2020

The key-note speaker of the workshop was Dr. Rita Bakshi, founder and chairperson of International Fertility Centre, the oldest fertility clinic and one of the most renowned IVF clinics in India, one of the organizers of the event. Participants also had a privilege to listen to Dr. Sachin Kadam, CTO, Advancells and gain hands-on experience in the preparation of PRP; Liposuction method; and Bone Marrow aspiration. All these techniques were talked about at length and demonstrated in the form of manual & kit-based models to help the candidates gain exposure.

Dr. Punit Prabha, Head of Clinical Research and Dr. Shradha Singh Gautam, Head of Lab Operations at Advancells successfully set the base of stem cell biology for the participants who were experts in gynecology field, stem cell research and pain specialist. With the help of detailed analysis of Application of PRP for Skin rejuvenation; Preparation of Micro-fragmented Adipose Tissue and Nano Fat & SVF (Stromal Vascular Fraction) from Adipose Tissue; and Cell Culturing and Expansion in a Laboratory, applicants understood the application of stem cells in aesthetics, cosmetology, and anti-aging.

Vipul Jain, Founder & CEO of Advancells Group said, Educating young scientists about stem cells is important for us. With this workshop we wanted to discuss and share the challenges and lessons we have learned in our journey of curing our customers. We wanted to establish more concrete knowledge base in the presence of subject matter experts and help our attendees in more possible ways. We are hopeful to have successfully achieved what we claimed with this workshop.

Given the resounding success of the Sub-Specialty Training in Application of Regenerative Medicine (S.T.A.R. 2020), its hoped that the future events shall offer even greater wisdom to the participants by helping them improve and the lead the community into the age of greater awareness.

About Advancells Group

Advancells is leading the field of stem cell therapies in India and abroad, with representative offices in Bangladesh and Australia. The company provides arrangements for stem cell banking and protocols for partner doctors and hospitals which they can use for treating the patients using regenerative medicine. With a GMP compliant research and processing center that works on different cell lines from various sources such as Bone Marrow, Adipose Tissue, Dental Pulp, Blood, Cord Tissue etc. Advancells also intends to file a patent for this processing technology soon.

For more information, visit https://www.advancells.com/

About International Fertility Centre

IFC is Indias leading fertility center under the leadership and guidance of Dr. Rita Bakshi. She along with her solid team of experienced doctors have create a network of 10+ IVF clinics located in India and Nepal. Their services include In-vitro Fertilization (IVF), Intrauterine Insemination (IUI), Intracytoplasmic Injection (ICSI), Egg Donation, Surrogacy, Blastocyst, Assisted Hatching, Hysteroscopy, Laparoscopy and much more.

For more information, visit https://www.internationalfertilitycentre.com/

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Advancells Group & IFC Concluded their 3-Day Workshop on Regenerative Medicine - Business Wire India

Bone Marrow Stem Cells Comments Off on Advancells Group & IFC Concluded their 3-Day Workshop on Regenerative Medicine – Business Wire India | January 23rd, 2020

Debuts at the NY20 Foundation for Podiatric Medicine Meeting

HACKENSACK, N.J., Jan. 21, 2020 (GLOBE NEWSWIRE) -- Royal Biologics, an ortho-biologics company specializing in the research and advancement of novel ortho-biologics solutions, today announced the launch of Cryo-Cord, the first DMSO-free viable umbilical cord graft. The company will be showcasing Cryo-Cord along with its new portfolio of Autologous Live Cellular (ALC) technologies at the NY20 Foundation for Podiatric Medicine meeting, held January 24-26 in New York, NY for more than 1500 clinical attendees.

The company will feature its full suite of surgical biologic offerings at exhibit booth #322, and on the podium for Innovation Theater presentations at 10:30am on Friday 1/24/20 and 12pm on Saturday 1/25/20. These scientific presentations will feature several products within the Royal Biologics portfolio. At its booth, Royal Biologics will showcase its comprehensive ALC portfolio designed to personalize live regenerative healing for a wide variety of wound types across the orthopedics continuum.

The launch of Cryo-Cord enables providers with the first DMSO-free viable umbilical cord tissue. Cryo-Cord has been obtained with consent from healthy mothers during cesarean section delivery and is intended for use as a soft tissue barrier or wound dressing. Cryo-Cord is processed using aseptic techniques and frozen with a proprietary cryoprotectant.

Cryo-Cord offers a new enhancement to traditional wound care therapies and we are excited to pave the way with the first DMSO-free cryoprotectant graft on the market, said Salvatore Leo, Chief Executive Officer of Royal Biologics.

Other featured products at NY20 will include Maxx-Cell, which was launched as the world's most advanced bone marrow aspiration device. Maxx-Cell offers a new technique to a gold standard approach of aspirating a patients autologous bone marrow cells. Maxx-Cell however does not require centrifugation to deliver a final end product. The Maxx-Cell system maximizes stem and progenitor cell yields by giving the surgeon the ability to efficiently harvest bone marrow from multiple levels within the medullary space, while restricting dilution of peripheral blood. As a result, Maxx-Cell delivers a high, most pure enriched form of bone marrow aspirate without the need for centrifugation.

This month, the company has also announced the launch of MAGNUS, which is a DMSO-free viable cellular bone allograft and demos will be available during the conference. MAGNUS presents a unique solution to traditional viable cellular allograft technology as it utilizes a DMSO-free cryoprotectant. This novel approach to the viable cellular allograft market differentiates MAGNUS from other technologies currently available.

Leo added, We are excited to participate in NY20 and share how our Autologous Live Cellular based therapies give the surgeons an efficient and effective way to enhance surgical outcomes by providing alternatives to conventional therapies for bone and soft tissue related injuries. We also believe that in a cost-conscious industry, we can provide novel viable cellular products that provide value at the point of care.

To watch the latest ALC product videos and learn more about the range of regenerative medical products offered by Royal Biologics, along with a schedule of 2020 conferences, visit http://www.RoyalBiologics.com.

About Royal Biologics

Royal Biologics is an ortho-biologics company specializing in the research and advancement of Regenerative Cellular Therapy. Its primary focus is on using autologous bioactive cells to help promote healing in a wide range of clinical settings, with its portfolio of FDA-approved medical devices. For more information on its line of products, visit http://www.royalbiologics.com.

For more media information, contact:Lisa Hendrickson, LCH Communicationslisa@lchcommunications.com516-767-8390

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/ee412ed7-d46b-40b7-9322-a65f5cb26430

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Royal Biologics Announces the Launch of Cryo-Cord, the First Non-DMSO Viable Umbilical Cord Graft - Yahoo Finance

Bone Marrow Stem Cells Comments Off on Royal Biologics Announces the Launch of Cryo-Cord, the First Non-DMSO Viable Umbilical Cord Graft – Yahoo Finance | January 23rd, 2020

There is some truth to the longstanding anecdote that your locks can lose color when youre stressed.

A team of researchers has found that in mice, stressful events trigger damage the stem cells that are responsible for producing pigment in hair. These stem cells, found near the base of each hair follicle, differentiate to form more specialized cells called melanocytes, which generate the brown, black, red and yellow hues in hair and skin. Stress makes the stem cells differentiate faster, exhausting their number and resulting in strands that are more likely to be transparent gray.

The study, published Wednesday in Nature, also found that the sympathetic nervous system, which prepares the body to respond to threats, plays an important role in the graying process.

Normally, the sympathetic nervous system is an emergency system for fight or flight, and it is supposed to be very beneficial or, at the very least, its effects are supposed to be transient and reversible, said Ya-Chieh Hsu, a stem cell biologist at Harvard University who led the study.

The sympathetic nervous system helps mobilize many biological responses, including increasing the flow of blood to muscles and sharpening mental focus. But the researchers found that in some cases the same system of nerves permanently depleted the stem cell population in hair follicles.

The findings provide the first scientific link between stress and hair graying, Dr. Hsu said.

Stress affects the whole body, so the researchers had to do some sleuthing to figure out which physiological system was conveying its effects to hair follicles.

At first, the team hypothesized that stress might cause an immune attack on melanocyte stem cells. They exposed mice to acute stress by injecting the animals with an analogue of capsaicin, the chemical in chili peppers that causes irritation. But even mice that lacked immune cells ended up with gray hair.

Next, the scientists looked at the effects of the stress hormone cortisol. Mice that had their adrenal glands removed so they couldnt produce cortisol still had hair that turned gray under stress.

The system responsible for the appearance of silvery strands turns out to be the sympathetic nerves that branch out into each hair follicle in the skin.

The researchers found that the sympathetic nerve cells released a neurotransmitter called noradrenaline that was taken up by nearby melanocyte stem cells. Then a series of events unfolded in quick succession: The melanocyte stem cells proliferated and turned into specialized pigment-producing cells, which abandoned their niche near the base of the follicle and left the hair without a source of pigmentation.

In Dr. Hsus study, acute stress depleted the entire melanocyte stem cell population in mice in just five days. The researchers also found that, in petri dishes, noradrenaline prompted human melanocyte stem cells to proliferate, suggesting that the same acceleration of hair graying occurs in people, too.

I was amazed by how dramatic this change is, said Mayumi Ito, a biologist at the New York University School of Medicine who was not involved in the study. In her own research on aging mice, the graying process was gradual: The depletion of melanocyte stem cells led first to a few salt and pepper strands and then to gray or white fur, much as humans begin to see more white hair as they get older.

Dr. Itos team also found that the graying process in mice could be halted with drugs known as CDK inhibitors, which stop the proliferation of stem cells, or by blocking the release of noradrenaline.

The findings underscore the consequences of triggering a survival mechanism when the situation isnt life-threatening.

Stress is a normal part of life, but there are situations where stress is helpful and situations where it is detrimental, said Subroto Chatterjee, a biologist at Johns Hopkins University who studies the effects of stress on the cells in blood vessels.

Other studies have shown that stress is just one factor affecting how quickly hair goes gray, Dr. Chatterjee said. Genes and diet play a big role as well.

In a 2018 study, Dr. Chatterjee and his colleagues found that mice placed on the equivalent of a Western diet high in fat and cholesterol not only developed inflamed arteries, they also started going gray and experiencing hair loss. (The team also found a way to halt the process.)

But the new study is an important step toward understanding the role of stress on various tissues.

If we can know more about how our tissues and stem cells change under stress, we can eventually create treatments that can halt or reverse its detrimental impact, Dr. Hsu said.

See the original post here:
Stress Really Does Make Hair Go Gray Faster - The New York Times

Skin Stem Cells Comments Off on Stress Really Does Make Hair Go Gray Faster – The New York Times | January 23rd, 2020

By Sandy McCarty

Facelifts once had just a single focus: lifting and tightening the skin to reduce wrinkles. This resulted in a tighter but not necessarily more youthful appearance. Today, however, theres a more natural new solution: the lift-and-fill facelift. Using this technique, Dr. John Burns can lift the skin and deeper layer with less bruising, swelling, and scarring while filling areas that need volume replacement. If youre looking to refresh your appearance, you can find everything you need to know about this procedure and whether its right for you here.

What Is a Lift-and-Fill Facelift?

The lift-and-fill procedure has become increasingly popular in recent years. This procedure involves combining a facelift with the addition of volume in strategic locations, using facial fillers or a fat transfer. This approach offers outstanding outcomes, including a rejuvenated and more youthful face, eyes and neck, as well as longer-lasting results.

As your face ages, several changes take place. Years of facial movements lead to wrinkles, the skin loses elasticity, and the face loses volume due to fat atrophy and bone resorption. The combination of all these factors results in looser skin, deflation, lax tissue, with more wrinkles and lines. When it comes to facial rejuvenation, the best treatment for you depends on the amount of volume loss you have experienced. In some cases, a facelift and/or necklift alone is enough to significantly improve the contour of the face. However, when a patient has loose skin and volume loss, we can achieve much better results by combining the facelift with volume enhancement.

A few of the procedures used in conjunction with a facelift or necklift are:

Is a Lift-and-Fill Facelift Right for You?

Good candidates for facelift surgery include individuals who are in good physical health, do not smoke or use nicotine, and desire correction of facial aging due to gravity or volume loss. The combination of a facelift and/or necklift with facial fillers or fat transfer can provide the stunning results you want. Contact Dr. John Burns today to schedule your consultation to learn more about short-scar facelift and the facial rejuvenation options that are right for you.

Dr. John L. Burns, Jr., MD is a Board Certified Plastic Surgeon and is President of The Dallas Plastic Surgery Institute; one of the largest plastic surgery group practices in the United States. Dr. Burns specializes in cosmetic surgery of the face, breast, and body.

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The New Facial Aging Solution: Lift and Fill Facelift - The Dallas Morning News

Skin Stem Cells Comments Off on The New Facial Aging Solution: Lift and Fill Facelift – The Dallas Morning News | January 23rd, 2020

Luke Jefferson Day, Editor of GQ Style and Fashion Director of GQ

"Sensai's SPF 6 Bronzing Gel is my winter grooming tip. I got it from my mega make-up artist friend Gina Kane, who works with Robbie Williams. It has such a light finish but gives you a little glow during the cold months."

"My winter grooming essential has been the same for the past decade or so. Bioeffect's EGF Serum is the best cold weather skin saver bar none. It contains "epidermal growth factor", sourced from apple stem cells, an ingredient that encourages skins cells to duplicate, instantly reducing dryness and producing that dewy glow we all crave (but can never quite achieve) in the winter months. Following a slick of the serum, a spot or two of Weleda's Skin Food is ultra rich and excellently moisturising."

"My go-to product during the winter months is the exfoliating energy scrub by Tom Ford. As energy is what most of us are lacking during a long dark winter, this product helps to bring you back to life and back to the reality that summer is coming (eventually)."

"In winter I use Eve Lom Intense Hydration Serum daily to maintain skin dexterity and to avoid drying, which my skin is susceptible to, especially with the mix of harsh cold outside and synthetic heat inside. I then use Eve Lom Rescue Mask once a week to try to prevent breakouts, as it utilises ground almond to gently exfoliate, camphor to reduce redness and its clay-like formulation is an excellent de-puffer. Winter sorted."

"One product I cant do without in the winter months is hair cream. My favourite is Bumble And Bumbles BB Grooming Creme. My hairs naturally pretty curly and I look absolutely bonkers when I blow dry it or make any attempt at styling. This, I just in pop once Im out of the shower with a bit of curl cream too if Im feeling dead posh and I can spend a whole day not worrying that I might look like something a bird might nest in whenever I meet a light breeze."

"During the cooler months my skin doesnt necessarily go hard and flaky, but it does get affected by the drop in temperature and definitely feels a little more dry. After having tried quite a lot of creams, I actually bought this absolute miracle worker from Awake Organics, which got rid of not only my bags (anti-ageing vitamin C to thank here), but also provided more than enough hydration to my skin. Ive used it since November (every night) and theres no looking back. Oh and its 100 per cent natural and totally affordable, which is the direction Im moving in when it comes to stocking my bathroom cabinet."

"When it comes to winter grooming I try and keep my routine as organic and natural as possible. One of my main go-to's is Dr Jackson's Everyday Oil. I add a couple of drops three or four times a week to my facial moisturiser when my skin is feeling extra dry. It's lightweight, so it doesn't have that greasy, clogging feeling to it and is infused with baobab oil that promotes elasticity in the skin."

Meet our grooming heroes of the week

The biggest grooming trends at the 2020 menswear shows

How to look as well groomed as Luke Evans

All products featured on the website are independently selected by our Editors. However, when you buy something through our retail links, we may earn an affiliate commission.

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The GQ team reveals its winter grooming secrets - British GQ

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What if 0.2% of your skin cells determined its future? That was the question posed, and answered, by Dior as it strove for a breakthrough that would ultimately top anything the French beauty house and its scientific partners had achieved in 30 years of research and innovation.

For the first time, Dior used artificial intelligence to go beyond visible signs. It was thus able to measure what, up until now, was considered immeasurable the key to our perception of age: the faces visible health and vitality.

The result is what Dior calls a major discovery about stem cells, one so incredible that it has driven the creation of a new range focused on the restoration of cellular energy to reactivate the skins vital functions and youthful beauty.

The range is called Capture Totale C.E.L.L. Energy [the C.E.L.L. acronym stands for Cutting-Edge Long-Lasting Energy], a launch we reported earlier this month in a global exclusive. This special eZine edition of The Moodie Davitt Spotlight Series tells the story of how the new launch embodies all the values of Dior skincare, while taking the science behind it to a new level.

Its a remarkable story, which we are honoured to tell.

Note: The Moodie Davitt Report Spotlight Series offers bespoke, curated e-publications for major brand launches and campaigns; airport, store or restaurant openings; and other notable corporate or commercial developments, events and anniversaries. Please contact Martin@MoodieDavittReport.com if youre interested in taking advantage of this unrivalled communications and promotional platform.

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Dior's greatest discovery the amazing story of Capture Totale CELL Energy - The Moodie Davitt Report - The Moodie Davitt Report

Skin Stem Cells Comments Off on Dior’s greatest discovery the amazing story of Capture Totale CELL Energy – The Moodie Davitt Report – The Moodie Davitt Report | January 23rd, 2020

Point blank: Aging is a part of life. With each passing second, minute, and day, we age a little bit more. While you may not notice the signs of aging right away, there will come a day when you look in the mirror only to notice 11s and crows feet staring back at you. Of course, if you implement a quality anti-aging skincare routine before then, it may be years before you notice such things.

Intrigued? We thought you might be. Thats why we tapped some of the industrys top dermatologists to share their top 10 anti-aging skincare ingredients. By committing these ingredients to memory and adding them into your routine, youll be able to pause the clock of visible aging while making way for your bounciest, most beautiful skin yet. You can thank us later.

While there are many anti-aging ingredients on the market, dermatologists share that the following 10 are the most effective for fast-acting results.

Alpha- and beta-defensins are natural immune proteins that have been shown in in vitro studies to activate stem cells in the hair follicle, which typically helps with wound healing of the skin, says Yunyoung Claire Chang, M.D., a board-certified cosmetic dermatologist. These defensins have been shown to be effective in a new skincare product, called DefenAge. One multi-center, blinded controlled trial published in the Journal of Drugs in Dermatology in 2018 evaluated 44 patients using this new skincare product, demonstrating that this product improves brown spots and skin evenness, improves the appearance of wrinkles, and reduces visible pores. She adds that the product has retinol-like effects without the inflammation associated with retinol.

Bakuchiol is well-known for being a gentle (yet effective) retinol alternative. These findings were confirmed in a 2014 study published in the International Journal of Cosmetic Science, where researchers found that bakuchiol was able to stimulate collagen production in vivo, and found that 12-week application improved texture, tone, photo-damage, and more. While it has many of the same benefits of retinol, Dr. Chang says the most notable quality is that bakuchiol has less of the drying and irritating side effects of retinol, while still being just as effective.

Youve likely seen ceramides called out on many of the labels on the skincare products already in your routine. Thats because ceramides are intensely hydrating and effective for anti-aging.

Ceramides are a natural lipid that helps protect our skin barrier and seal in moisture. As we mature, the ceramide levels in our skin decrease, leading to drier, more sensitive skin, Dr. Chang explains. Dry skin also worsens the appearance of fine lines and uneven skin texture. Replacing ceramides using topical skincare is important to keep it hydrated, protected, and smooth.

Ginseng might be considered a Korean superfood, but were here to let you in on a little secret: It works wonders topically for your complexion, as well. Panax ginseng and ginsenosides are promising in preventing skin aging, Dr. Chang explains. Ginseng extract has been found in studies to protect against UVB-induced skin aging, reduce wrinkles, and increase moisture in the skin. However, its worth noting that most ginseng skincare studies have been small and need to be corroborated with larger clinical trials.

Take it from someone with sensitive skin who loves a gentle exfoliation: Glycolic acid is an alpha hydroxy acid (AHA) gorgeous skin dreams are made of. Dr. Chang supports this notion, explaining that glycolic acid exfoliates the top layers of the skin to improve texture and tone. Glycolic acid also has additional anti-aging benefits, including fighting UV-induced inflammation, lightening brown spots, and stimulating collagen, she adds. With glycolic acid, the higher the concentration of the product, the stronger its effects (and side effects). As such, its best to leave the higher concentrations of glycolic acid for professional use during in-office facials and treatments.

In some cases, glycolic acid (despite being fairly gentle) can be too irritating for super-sensitive skin. In these cases, you can reach for lactic acid, another AHA thats effective at resurfacing the skin.

Courtesy of First Aid Beauty

Green tea might be a super popular beverage, but its also a stellar choice for reversing the clock on your complexion. According to Dr. Chang, green tea is an abundant source of polyphenols that can help protect the skin against UV-induced skin aging and skin cancer. It has antioxidant, anti-inflammatory, and anti-wrinkle properties, she adds.

Courtesy of Innisfree

Niacinamide, also known as vitamin B3, is a water-soluble vitamin that has been shown to have anti-inflammatory and anti-aging properties, Dr. Chang explains, noting that it helps calm red, inflamed, or irritated skin. Whats more, the hydrating ingredient helps protect the lipid barrier and keep the moisture barrier intact which helps heal dry skin and prevent seasonal flaking. It has also been shown to increase collagen production as well as inhibit melanosome transfer from melanocytes to keratinocytes, allowing lightening of dark spots, Dr. Chang adds. In other words, its a multi-tasker that deserves a spot in your anti-aging routine.

Courtesy of The Ordinary

Retinoids are a derivative of vitamin A and are one of the longest-studied anti-aging ingredients. Retinoids have a long track record and clinical studies since the 1980s to back its evidence for preventing and treating skin aging, Dr. Chang explains. Retinoids increase skin cell turnover, diminish brown spots, and stimulate collagen to prevent fine lines and wrinkles.

While retinoids are undoubtedly effective, its worth noting that some versions can cause dryness and irritation, especially for those with dry or sensitive skin. Therefore, its best to start with a low percentage retinol (like 0.025 percent) before working yourself up to a stronger dose, prescription retinoid or Retin-A (like 0.5 to 2 percent).

Even when starting off with low percentages, Dr. Chang points out that retinoids tend to be drying and irritating, especially with initial use. It is important to start slow, using a small pea-size amount over the face, she says. I recommend starting two or three times per week at nighttime, and increasing the frequency of use slowly as tolerated.

Additionally, Dr. Chang says that retinoids and glycolic acid, especially when used together, may cause excessive dryness and irritation. For that reason, its best to choose between the two instead of trying to use them simultaneously.

Courtesy of Neutrogena

Sun protection is the most critical part of your anti-aging skincare routine, Dr. Chang emphasizes. Sun exposure not only causes skin burning and skin cancer but is the main culprit for accelerated skin aging. Whats more, she adds that UV exposure forms free radicals, increases brown spots, and breaks down collagen to form fine lines, wrinkles, and skin laxity. This process, termed photo-aging, is absolutely preventable with the appropriate use of sun protection and broad-spectrum sunscreen, she explains, noting that she recommends mineral sunscreens with SPF 30 or greater, including zinc oxide and titanium dioxide. Mineral sunscreens sit on the surface of the skin and act as a barrier to both UVA and UVB rays rather than being absorbed into the skin, she explains. Because it isnt absorbed into the skin, there is a lower risk of allergic reactions and it is safe in pregnant females.

And remember: Regardless of the sun protection you opt for, reapplication every few hours is key.

Vitamin C renowned for its powerful antioxidant properties and the ability to affect so many aspects of aging. For starters, adding vitamin C into your skincare routine can lead to a brighter complexion. Whats more, Dr. Chang points out that the potent ingredient can act as a free radical scavenger to neutralize oxidative damage to the skin and stimulate collagen for fine line prevention.

The biggest thing to remember when adding vitamin C to your anti-aging routine is that the ingredient is very unstable. As a result, its important to look for stabilized formulations found in opaque, air-tight bottles.

Dr. Chang also notes that some formulations of antioxidant serums containing vitamin C may irritate or cause acne for some people, so it is important to find which products work best for your skin. This may take some trial and error (or, better yet, the advice of a derm), but it will be well worth it in the long run.

Great! So now that you know which skincare ingredients to keep on your radar, heres what else you need to know about how to use them.

The anti-aging skin type debate:

After reading about these anti-aging ingredients, you might be wondering which will be best for your skin type. While some are better tolerated by some specific skin types (as mentioned above), its important to remember that skincare is subjective based on your skin type and the products already in your routine.

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At the end of the day, she says its not so much the skin type as what you are trying to address. For example, retinoids help to rejuvenate at the cellular layer, she begins. Glycolic acids helps to increase cell turnover and exfoliation.

When to add anti-aging ingredients into your skincare routine:

As much as wed like to tell you exact dates down to the day as to when to incorporate these ingredients into your routine, thats simply not realistic given that skin aging is subjective and varies from person to person. However, considering all of these ingredients are preventative, Dr. Chang says that its best to start incorporating them before or shortly after you start to notice signs of skin aging. I recommend starting anti-aging skincare in your 20s or early 30s, she adds. Some of these ingredients can be started even earlier (i.e. retinoids in teenagers with acne).

How to add anti-aging ingredients into your skincare routine:

Now, we know what youre thinking: How hard could it be? Well, if you try to add all 10 of these ingredients into your routine at once, youll seeand it wont be pretty. Since these ingredients are active, its important to ease them into your routine to avoid any sort of adverse effects.

I always recommend starting anti-aging ingredients one by one, to avoid any skin reactions or excessive irritation, Dr. Chang says. Start with a test spot before applying new products over your whole face. If one anti-aging product is tolerated, you can slowly add another one into the regimen. Additionally, she notes that not every person needs to use all of these ingredients, as many of the benefits overlap and using too many products can sometimes do more harm than good. I recommend consulting your board-certified dermatologist to develop a skincare plan tailored to your skin needs, she says.

Head-to-toe anti-aging treatments:

If you, like us, are a big believer in the beauty of cosmetic anti-aging treatments, like lasers and injectables, you might be wondering if you should supplement your anti-aging skincare routine with these in-office offerings. Considering most topicals can only penetrate the top-most layers of skin (unless, of course, its an epigenetic formulation), opting for treatments geared towards underlying causes of expression can lead to more noticeable results. For example, board-certified dermatologistJennifer MacGregor, M.D., says that Botox can smooth crepey texture in addition to lines (on the chest, for example) and can also smooth neck bands (hi, tech neck)something a cream alone may not be able to do.

As we mature, we lose fat and collagen in our face, leading to loose, sagging or hollowed skin, says Chang. Filler injections can help replace this volume and collagen in areas where topical anti-aging products would have little to no efficacy. Additionally, she points out that brown spots and photo-aging are often due to deeper pigment deposits which topicals cannot reach. Laser treatments can more effectively lighten or eliminate brown spots and signs of photo-aging, she explains. Resurfacing laser treatments, like Fraxel dual, and skin tightening treatments, like Ultherapy, can go deeper than any topical can to stimulate collagen, making these treatments essential in the anti-aging process [from head to toe].

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The only anti-aging skin care guide you'll ever need - Yahoo Lifestyle

Skin Stem Cells Comments Off on The only anti-aging skin care guide you’ll ever need – Yahoo Lifestyle | January 23rd, 2020