Heres an interesting project: somebody has been growing a human hand in a lab and displaying it for the world to see.

We live in a time where the meaning of impossible needs to be updated.

As we make new discoveries, new possibilities open up to us. And if you want a good example of that, just look at how advanced prosthetics have become in the last decade. Soon, you might be able to grow a humanhand like a Chia pet.

Or take a look at Dr. Sergio Canavero, who plans to perform a full-on head transplant later this year.

But that example may be a little extreme.

See, theres something miraculous about giving something vital like a limb or an organ to someone to needs it. In the past, it couldnt be done, but with the future in sight, were slowly changing our minds on that.

So, the future can be full of hope. And when one of us loses a hand, possibly due to someone we have only just learned is our father, we wont have to worry too hard.

Ok, heres a better example of the kind of future Im talking about.

Artist Amy Karle has an interesting new project that combines 3D printing with stem cell research. The idea is to grow a functional human hand, and if it works she wants to make the design free and open source.

And trust me, that will be one weird-yet-cool day for the people who frequent Instructables.com.

Karle may be an artist, but shes no amateur. She works with nonprofit groups that design 3D printed prosthetic arms, and she has help from a team of scientists.

The project is called Regenerative Reliquary, and it is being displayed in San Franciscos Pier 9 space while it grows. Or, to be more accurate, while part of it grows.

Karle has designed a 3D printed trellis in CAD which was printed using a cellular growth medium called pegda. Over several weeks, the pegda trellis was grown in a bioreactor on display. The next step will be to grow a cell line on the trellis, something Karle is culturing stem cells for now.

The team is using stem cells extracted from bone marrow, and with any luck, the idea will bear fruit and be released to the public.

I like the sound of an open source prosthetic design, especially considering how much more of an option 3D printing is these days. Lose a limb, and you may one day be able to make a replacement within the comfort of your own garage.

For now, though, were still waiting to see if Karles project will work. According to the artist, Well see if the cells have a mind of their own. I like to step back and let the artwork take over.

Now you know how Karle plans to grow a human hand. Lets rewind a bit, back to where I mentioned Dr. Canavero and his upcoming head transplant.

As crazy as it sounds, if Canaveros plan works science will have taken a big step toward manipulating the central nervous system. And thats really, really important. If scientists can connect a head to a spine, and they can grow a limb in a tank, it follows that they may one day be able to attach that limb as a replacement.

And that doesnt just apply to limbs, either. Scientists have been looking into growing replacement organs for years, just look at this article from way back in 2014.

We may be on the verge of the ability to reproduce and replace parts of the human body. And at this rate, who knows what kind of effect this can have on the survivability rate of human beings in the future.

Im sure well never resurrect the dead or anything, but I think the fictional Dr. Frankenstein would be proud.

Creating replacement body parts is something that has been a mainstay of science fiction, and it isnt crazy any longer to think that it may become a reality. So, like I said earlier, we may need to push the goal posts back on the word impossible.

View post:
How to Grow a Human Hand - Edgy Labs (blog)

Photo of Patrick Soon-Shiong courtesy NHS Confederation

Billionaire physician Patrick Soon-Shiong's company NantWorks has acquired a majority stake in Integrity Healthcare, the company that manages nonprofit Verity Health System. Terms of the deal were disclosed, but the transaction puts Soon-Shiong's company in place as the new operator of Verity's six California hospitals.

Verity Health employs more than 6,000 staff statewide. Their hospitals include 1,650 inpatient beds, six active emergency rooms, a trauma center and medical specialties including tertiary and quaternary care.

The system's Southern California hospitals include St. Francis Medical Center in Lynwood and St. Vincent Medical Center in Los Angeles. Their Northern California facilities are O'Connor Hospital in San Jose, St. Louise Regional Hospital in Gilroy, Seton Medical Center in Daly City and Seton Coastside in Moss Beach, Verity said in a statement.

New York hedge fund BlueMountain Capital Management formed Integrity Healthcare and is their former majority owner. They, along with NantWorks have committed to continue investing in Verity's revitalization efforts. BlueMountain is making additional funds available for that effort, and will maintain a minority interest in Integrity, Verity said.

Soon-Shiong will join Verity's Board of Investors.

The collaboration between Integrity and NantWorks is expected to yield will include major technological improvements for the hospitals such as diagnostic and imaging services and next generation stem cell therapy. Expanded oncology, cardiac, orthopedic, neurology, urology, transplant and pediatric services are also forecasted, Verity said.

However, the billionaire doctor's activities, including his philanthropic efforts, have been under a cloud of suspicion.

Soon-Shiong and two other pharma executives are being sued by attorneys Boyden Gray and Adam Waldman of Washington, D.C., for allegedly attempting to acquire Altor Bioscience through a sweetheart deal. Altor is a 15-year-old immunotherapy company, with 12 ongoing human clinical trials.

The lawsuit, filed June 21, asserts the deal in place benefits Soon-Shiong, Hing C. Wong and Fred Middleton all board members of Altor Bioscience. The deal comes at the expense of the minority shareholders, which breaches their fiduciary duty.

The connections between his philanthropic efforts and his for-profit businesses have also been under scrutiny after STAT News and Politico investigations.

Both news outlets pointed to possible improprieties stemming from a $12 million dollar donation to the University of Utah made by Soon-Shiong's research foundation, the Chan Soon-Shiong NantHealth Foundation.

Politico's investigation foundthat the foundation contributed $3 million out of the $12 million donated by Soon-Shiong-controlled businesses to a university program to that sought to map the genomes of 1,000 state residents.

"University officials say they let Soon-Shiong's entities write the grant specifications. The specifications gave a major advantage to his for-profit firms, which got the $10 million gene-mapping contract," Politico said.

The investigation also showed that a large portion of the Foundation's expenditures from 2010 to 2015 went to Soon-Shiong-affiliated nonprofits and for-profits, as well as companies that do business with his for-profit entities.

Also, the investigation said six employees of Soon-Shiong's for-profit businesses were paid with Foundation money, which raises questions about the flow of money between the entities.

Soon-Shiong denied any wrongdoing to Politico and STAT.

U.S. House Speaker Paul Ryan appointed the biotech mogul to the Health IT Advisory Committee. The 25-member committee, established through the 21st Century Cures Act, will advise the president and his administration on health IT policy.

Bill Siwicki contributed to this report.

Twitter: @BethJSanborn

See the article here:
NantWorks acquires majority stake in Integrity Healthcare, will take over 6 Los Angeles hospitals - Healthcare Finance News

Major Headlines

11:55 am | These guests basically utilize the beach at night as their own personal entertainment venue....

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09:45 am | The building provides a base of operations for collaborating scientists from around the world....

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12:55 am | There have been 46 commission races for seats in the five town districts since 2000. Of those, 72 percent, or 33 of them, having only a single...

12:51 am | Town Manager Dave Bullock found the next Public Works Director for Longboat Key close to home....

12:02 am | Rotary Club honors those who protect and serve our island as residents and families show support....

11:51 pm | More stringent ordinance enacted due to LBK having highest number of disorientations in area....

11:48 pm | The Unstoppable Wasp is about females in science working together for a common cause....

11:31 pm | There is no better place Ive run across where residents are as smart, rationally informed and care so much about where they live....

11:28 pm | Im not sure weve thought through the ramifications, said Commissioner Randy Clair....

11:25 pm | Mote Marine Laboratory documented the first three local sea turtle nests of 2017 two on Sunday, April 30, and one on Monday, May 1 in Venice,...

01:58 pm | The stakes could not be higher. The future look of the island, the evolution of property values and the protection of development rights all intersect. ...

01:54 pm | Mote tags 34 sharks in mission to understand habitat, patterns and populations....

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Proventil hfa ventolin hfa - Proventil inhaler dosage for adults - Longboat Key News

LONDON Stem-cell tourism involving patients who travel to developing countries for treatment with unproven and potentially risky therapies should be more tightly regulated, international health experts said on Wednesday.

With hundreds of medical centers around the world claiming to be able to repair damaged tissue in conditions such as multiple sclerosis and Parkinson's disease, tackling unscrupulous advertising of such procedures is crucial.

These therapies are advertised directly to patients with the promise of a cure, but there is often little or no evidence to show they will help, or that they will not cause harm, the 15 experts wrote in the journal Science Translational Medicine.

Some types of stem cell transplant mainly using blood and skin stem cells have been approved by regulators after full clinical trials found they could treat certain types of cancer and grow skin grafts for burns patients.

But many other potential therapies are only in the earliest stages of development and have not been approved by international regulators.

"Stem cell therapies hold a lot of promise, but we need rigorous clinical trials and regulatory processes to determine whether a proposed treatment is safe, effective and better than existing treatments," said one of the 15, Sarah Chan of Britain's University of Edinburgh.

The experts called for global action, led by the World Health Organization, to introduce controls on advertising and agree international standards for the manufacture and testing of cell and tissue-based therapies.

"The globalization of health markets and the specific tensions surrounding stem cell research and its applications

have made this a difficult challenge," they wrote. "However, the stakes are too high not to take a united stance."

(Reporting by Kate Kelland, editing by John Stonestreet)

ZURICH Novartis said that the Committee for Medicinal Products for Human Use (CHMP) has approved a label update for Cosentyx (secukinumab), the first interleukin-17A (IL-17A) approved to treat psoriasis.

(Reuters Health) - After weight-loss surgery, people who get cosmetic procedures to remove excess tissue may have a better quality of life than those who don't get this additional work done, a recent study suggests.

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'Stem-cell tourism' needs tighter controls, say medical experts ... - Reuters

Sure, the main purpose of sex isprocreation, but according to one researcher, in as little as 30 years, we may have more efficient and cheaper ways of making babiesthangood ole fashioned intercourse. According to Hank Greely, the director of StanfordLaw Schools Center for Law and Biosciences, human reproductionmay become automated faster than you realize.

Greely believes that within three decades, people will no longer have sex as a way to reproduce, and instead relyongenetically edited embryos grown from skin-derived stem cells, not the combination of an egg or sperm, The Independent reported. According to Greely, this processensures that the embryo is free from any devastating genetic diseases, and wouldalso be cheaper in the long run because of the money it would save in healthcare over the years. Whats more, Greely predicts that couples would be able to choose other genetic traits in their children, such as physical features and intelligence.

Read: What Is A Three Parent IVF Technique? Worlds First Baby Born Using DNA From Three Parents, But How?

I dont think were going to be able to say this embryo will get a 1550 on its two-part SAT, Greely said this week at Aspen Ideas Festival, Quartz reported, But, this embryo has a 60% chance of being in the top half, this embryo has a 13% chance of being in the top 10%I think thats really possible.

The idea may soundfar-out, but according to Quartz, it already happens on a much smaller and limited scale as a way to prevent certain diseases. Although extremely expensive at the moment, advances in stem cell technology willhelp to drive down the cost. In addition, the amount that the government would save on not having to take care of sick babies would also make this more cost-efficient.

Making babies from skin cellsrather than a traditional egg fertilized with spermmaysound like its straight out of Hollywood, butthetechnology is quickly advancing. The skin cells, one from the mother and the other from the father, are coaxed into becoming an egg or sperm cell, The New York Times reported. This also means that one day same-sex couples may be able to have biologically related children. So far, vitro gametogenesis (IVG), or making sex cells from stem cells, has only worked on mice.

Theres also the worry that being able to genetically manipulate your offspring may lead to a eugenicssituation where less favorable traits get written out of the human genome forever. However, Greely also believes this is not the case.

This is not designer babies or super babies, said Greely, Quartz reported. This is selecting embryos. You take two people, all you can get out of a baby is what those two people have.

Just because well no longer need sex for procreation doesnt mean the activity is going out of fashion anytime soon. It's agreat way to createfuture generations, and sexis also good for your physical and mental health, as well as keeping couples together.

See Also:

Designer Babies: The Truth Behind Preimplantation Genetic Diagnosis

Scientists Edit Human Embryo Genes For First Time Ever: A Step Toward Disease-Free Future?

Link:
Sex For Reproduction May Be Obsolete Within 30 Years Thanks To New Technology, Professor Predicts - Medical Daily

Stem cells have long been used to treat blood cancers and some immune diseases. But some doctors are offering stem cell treatments for diseases still under clinical trial. Photograph: Mauricio Lima/AFP/Getty Images

Medical and legal experts from around the world have united to call for more stringent regulation of stem cell therapies to prevent people pursuing unproven and potentially deadly treatments overseas.

In a perspective piece for the US journal Science Translational Medicine, 15 experts from countries including the UK, the US, Canada, Belgium, Italy and Japan wrote that national efforts alone would not be enough to counter an industry offering unproven treatments to vulnerable patients.

Stem cell-based interventions are classified under diverse and potentially incompatible national regulatory frameworks, the authors wrote.

Approaches for international regulation not only need to develop consistent rules over the commercialisation of medical practices and products but also need to give them teeth by developing cross-border partnerships for compliance.

Stem cells found in bone marrow and umbilical cord blood have long been used to successfully treat blood cancers including leukaemia and some immune diseases. But those are among the few proven treatments. Legitimate and ethics-approved clinical trials by academic centres are also occurring, exploring the potential of stem cells to treat a wider range of diseases.

But some doctors are directly offering to the general public stem cell treatments for diseases still under clinical trial or for which no evidence exists and for which the safety and efficacy is as yet unproven.

Deaths as a result of stem cell treatments have already occurred. In 2013 Sheila Drysdale died in a New South Wales nursing home after undergoing an unproven liposuction stem-cell therapy at a western Sydney clinic. Following Drysldales death, her doctor, Ralph Bright, gave a statement to police in which he claimed that stem-cell treatment could improve comorbidities and that stem cells could move from joints to other parts of the body to improve disease in distant sites including lungs and brain, vision, mentation and pain.

In his report into Drysdales death, the coroner Hugh Dillon wrote that he could not say what motivated Dr Bright to perform this unproven, dubious procedure on Sheila Drysdale.

But regardless of his motivation, Dr Brights performance as a medical practitioner was, for the reasons outlined above, poor and resulted in Sheila Drysdales death.

The Medical Council of NSW investigated Bright and placed a number of restrictions on his right to practice. Bright is still authorised to practise stem cell therapy for patients with osteoarthritis or who are taking part in research studies approved by an ethics committee. He is also still allowed to treat patients returning for remaining injections of stored cells.

In 2013 a Queensland woman, Kellie van Meurs, died when she travelled to Russia to undergo stem-cell treatment for a rare neurological disorder. She died of a heart attack as a result.

Australias drug regulator, the Therapeutic Goods Administration, last year sought feedback on the regulation of autologous stem-cell therapies but is yet to publish those submissions. The TGA now considers autologous treatments, which involve treating someone with their own tissue or cells, to be a therapeutic good and, therefore, does not regulate them. Stem cells used for medical practice and therapeutic purposes are covered by different regulatory frameworks.

Associate Professor Megan Munsie, a University of Melbourne stem cell scientist and a co-author of the paper, said: The idea that stem cells are magical holds court in the community, along with this idea the advances in treatment are being held up by red tape.

Unethical health practitioners exploited this, she said, along with the vulnerability of patients with difficult-to-treat or incurable conditions.

There is a precedent for international regulation of this industry because regulations already exist around drugs the way they are manufactured, she said.

This could be extended to the regulation to the stem cell and tissue-based therapies. This international stance would then force or encourage stronger local regulations.

There have been successful efforts by scientists to push back against unscrupulous doctors. In Italy scientists and regulators highlighted the unproven yet government-subsidised treatments being offered by the entrepreneur Davide Vannoni and fought to stop him. He was convicted of criminal charges but the sentence was later suspended.

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Stem cell therapies: medical experts call for strict international rules - The Guardian

Sergey with his wife and son

ABMDR salutes young officer and celebrates its 30th life saved through a transplant

LOS ANGELESThe Armenian Bone Marrow Donor Registry (ABMDR) announced that it has facilitated its 30th bone marrow stem cell transplant, thanks to stem cells harvested from a young ABMDR matched donor. The stem cells of the donor, Sergey, who is a 23 year-old army officer serving on the frontline in Artsakh, were utilized to save the life of a cancer patient in Iran.

On July 3, 2017, Sergey became the 30th ABMDR donor to experience the joy of saving the life of someone he had never met, said ABMDR President Dr. Frieda Jordan.

Dr. Sevak Avagyan, Sergey, Dr. Andranik Mshetsyan

In 2012, Sergey had joined the ranks of ABMDRs donor registry during a recruitment drive at the Vazken Sagsyan Military Institute, in Yerevan. Five years later, he was found to be a perfect match for a patient in Iran who was suffering from leukemia and whose only hope for survival was to receive a bone marrow stem cell transplant from a compatible donor. Sergey turned out to be a perfect match for the patient. He was given a day off to leave the frontline to come to ABMDRs Stem Cell Harvesting Center in Yerevan to donate his stem cells and save a patients life.

Accompanied by his young wife and six-month old son, Sergey was greeted by ABMDR staff at the Stem Cell Harvesting Center. The painless, non-invasive harvesting procedure, performed by Dr. Andranik Mshetsyan, lasted approximately four hours. Also present at the procedure were ABMDR Executive Director Dr. Sevak Avagyan and Medical Director Dr. Mihran Nazaretyan.

Sergey, Dr. Mihran Nazaretyan, and Lab Staff Member

At the conclusion of the harvesting, as staff members performed quality-control analyses of the harvested cells and packed them for the special courier who was waiting to transport the precious gift of life to the patient in Iran, Sergey, a hero in the eyes of all, on the frontlines as well as far away from them, joined his young family while someone in Iran was about to get a second chance at life.

Established in 1999, ABMDR, a nonprofit organization, helps Armenians and non-Armenians worldwide survive life-threatening blood-related illnesses by recruiting and matching donors to those requiring bone marrow stem cell transplants. To date, the registry has recruited over 29,000 donors in 42 countries across four continents, identified over 4,190 patients, and facilitated 30 bone marrow transplants. For more information, call (323) 663-3609 or visit abmdr.am.

Original post:
Artsakh Soldier Saves Life Of Cancer Patient In Iran - Asbarez Armenian News

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See more here:
Stem cell therapies breaking barriers - Guardian (blog)

Times Now

'Custom-made' babies to be in demand in 30 years, says expert Times Now The process will involve taking a female skin sample to create stem cells, which is then used to create eggs. These eggs are then fertilised with sperm cells, resulting in a selection of embryos. While Greely does acknowledge that ethical issues could ... People will 'stop having sex to procreate within 30 years', says scientistMetro Sex Not Necessary for Reproduction: Stanford Professor's Prediction Suggests a Bizarre FutureIndia.com PLAYING GOD: 'End to sex' in 30 years as parents will DESIGN their babies in the labExpress.co.uk Christian Post -Deccan Chronicle all 11 news articles »

Continue reading here:
'Custom-made' babies to be in demand in 30 years, says expert - Times Now

This report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. Role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice.

Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation.

Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. Methods of delivery of cell therapy range from injections to surgical implantation using special devices.

Cell therapy has applications in a large number of disorders. The most important are diseases of the nervous system and cancer which are the topics for separate chapters. Other applications include cardiac disorders (myocardial infarction and heart failure), diabetes mellitus, diseases of bones and joints, genetic disorders, and wounds of the skin and soft tissues.

Regulatory and ethical issues involving cell therapy are important and are discussed. Current political debate on the use of stem cells from embryonic sources (hESCs) is also presented. Safety is an essential consideration of any new therapy and regulations for cell therapy are those for biological preparations.

The cell-based markets was analyzed for 2016, and projected to 2026. The markets are analyzed according to therapeutic categories, technologies and geographical areas. The largest expansion will be in diseases of the central nervous system, cancer and cardiovascular disorders. Skin and soft tissue repair as well as diabetes mellitus will be other major markets.

The number of companies involved in cell therapy has increased remarkably during the past few years. More than 500 companies have been identified to be involved in cell therapy and 306 of these are profiled in part II of the report along with tabulation of 291 alliances. Of these companies, 170 are involved in stem cells. Profiles of 72 academic institutions in the US involved in cell therapy are also included in part II along with their commercial collaborations. The text is supplemented with 64 Tables and 22 Figures. The bibliography contains 1,200 selected references, which are cited in the text.

Key Topics Covered:

Part I: Technologies, Ethics & Regulations

Executive Summary

1. Introduction to Cell Therapy

2. Cell Therapy Technologies

3. Stem Cells

4. Clinical Applications of Cell Therapy

5. Cell Therapy for Cardiovascular Disorders

6. Cell Therapy for Cancer

7. Cell Therapy for Neurological Disorders

8. Ethical, Legal and Political Aspects of Cell therapy

9. Safety and Regulatory Aspects of Cell Therapy

Part II: Markets, Companies & Academic Institutions

10. Markets and Future Prospects for Cell Therapy

11. Companies Involved in Cell Therapy

12. Academic Institutions

13. References

For more information about this report visit https://www.researchandmarkets.com/research/hpj9sh/cell_therapy

Source: Jain PharmaBiotech

Media Contact:

Laura Wood, Senior Manager press@researchandmarkets.com

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To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/global-cell-therapy-report-2017---technologies-markets-and-companies-2016-2026-with-profiles-of-key-companiesinstitutions-300483356.html

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Read more here:
Global Cell Therapy Report 2017 - Technologies, Markets and Companies 2016-2026 with Profiles of Key Companies ... - PR Newswire (press release)

It will provide Regenexx, a regenerative stem cells procedure to treat orthopedic and sports injuries.

Regenexx, a national network of musculoskeletal doctors specializing in the nations most advanced regenerative protocols for treating orthopedic conditions and sports injuries has entered in Mumbai. This is its second branch in Asia. It would offer two stem cell procedures using imaging and interventional orthopaedic techniques to non-surgically repair and regenerate. The first one is a same-day procedure where stem cells are harvested, isolated and re-implanted on the same day. The second one is blood-derived plasma-rich platelet procedure. They would help athletes and non-athletes overcome early, mild, moderate ortho problems in a way that is devoid of surgery.

Regenexx is the most advanced stem cell and platelet procedures for treating orthopedic injuries, arthritis and other degenerative conditions. These procedures offer non-surgical alternatives to commonly occurring musculoskeletal conditions. PatentedRegenexx procedures use precise injections of your own stem cells or blood platelets to help your body's ability to heal damaged muscles, tendons, ligaments, cartilage, spinal disc and bone.Regenexx Stem Cell Therapy and Platelet Procedures, avoid the need for invasive surgery, in turn eliminating any complications that are typically seen with surgeries.

On this occasion Dr.Venkatesh Movva, MD, Regenexx India says,The only option till now was total knee replacement. Now with this technology we can heal and regenerate the lost tissues like cartilage, meniscus and ligaments to reverse the arthritis and in turn avoid any major surgery. Patients return to their loved activities in no time. We could also treat conditions like lower back pain, hip arthritis, bulging discs, ankle and shoulder rotator cuff tears with stem cells orthopedics procedure. Majority of these are lifestyle related conditions,

Regenexx procedures are image guided needle based procedures, so the downtime for recovery is minimal or none. These are truly ambulatory procedures without the need for hospitalization. The procedure process involves harvesting bone marrow stem cells, using our sophisticated lab process to separate cells and precise image guided injections into the target joints in an outpatient setting.

Dr. Apurv Mahalle, MGIMS, says, Regenexx procedures are out-patient procedures and that patients can walk out of the treatment the same day. Physiotherapy team at Regenexx will help patients make the necessary changes to their physical movements so that the procedures are effective.

There is no alternative for arthritis patients but to wait until the joint is bad enough for a replacement and then go through a surgery. Regenexx procedures are going to help these patients get back to the normal routine without the necessity of a replacement surgery.

Original post:
RegenOrthoSport facility launched in Mumbai - BSI bureau (press release)

MIRI: The second child cancer survivor I met, Winnie Foo Hui Yii, is an encouraging story and a living proof to the community how blood stem cell transplantation could help cancer patients.

Foo, born and raised in Kuching, was 17 years old when she was diagnosed with Acute Myeloid Leukaemia (AML).

The news was definitely not something Foo and her family would have expected as she was then studying A-Level.

I looked very pale, felt drowsy, nauseous and always felt tired. It persevered for three weeks before my parents suggested a check-up with our family doctor, she said, sharing her experience with The Borneo Post during a visit to Miri recently.

A blood test, she said, showed she had AML and before she could prepare herself for anything that followed, she was already warded in Sarawak General Hospitals haematology ward and in queue for chemotherapy in two weeks time.

Thereafter, she was transferred to Hospital Ampang, one of the 11 haemopoietic transplant centres performing haemopoietic stem cell transplants in Malaysia.

The doctor told me that though my condition was at the edge of turning cancerous, there was still hope for treatment and best, a transplant. I was in a state of shock. So were my parents. They too werent prepared for anything like this.

Honestly, at first my mind kept recalling a book My Sisters Keeper that Id just finished reading right before I was diagnosed. The novel tells the story of a main character, Anna, and her sister who was suffering from leukaemia.

After my diagnosis, I really felt the dying sisters feeling and facing death isnt easy, especially for parents.

While she was on cycles of chemotherapy, her family members were tested for possibility as matching bone marrow donor.

Unfortunately, there was no match and her parents decided to seek another option.

My doctor suggested stem cell transplant, a transplant of blood-forming stem cells to restore the bone marrow. We were given option whether to search in China or Taiwan. We saw hope, however, not without expecting huge expenses, Foo said.

At the time, Taiwan seemed to be the best hope for Foo to find a matching donor, who her doctor had targeted at least 60 per cent of compatibility. A total of seven matching donors were found over the span of three months since search begun, which was splendid news for them.

Being a middle-income family, the expenses for the transplant that cost tens of thousands of ringgit were too much for my parents to bear.

It was said that if the donor happened to be amongst the patients family members, part of the cost would be covered by the government. In Foos case, she had no other choice but to seek a donor internationally.

That was when Sarawak Childrens Cancer Society stepped in to assist Foo and her family, financially and on moral support.

Before the transplant, Foo underwent rounds of chemotherapy that used higher doses of medication and radiation therapy to kill the cancer cells. The final round of chemo right before the transplant was intended to get rid of the bodys immune system, getting the body ready.

The chemotherapy resulted in Foos hair dropping severely to baldness. Initially, she felt the physical changes were interesting, however, not long after, she missed her hair terribly, but tried to put up a brave face.

After the transplant, Foo experienced post-transplant rejection, which according to her doctor is a condition known as immuno-suppression. She was put under doctors observation and prescribed medication such as steroid to stabilise her condition.

My doctor told me that after transplant, my bodys immune system was not quite ready yet. Eventually, it turned out okay for me, she said.

Now, at the age of 21 and on the road to recovery, Foo has restarted her A-Level and is now in her second year.

Looking back at these three years, it taught me a lot about life and to be appreciative. My first day back to school wasnt easy for me because I was the oldest amongst my course-mates. Handling stares is the hardest part but I managed to overcome it.

My parents went through a lot during that period. Apart from enduring the emotional roller-coaster, they made sure that I was well taken care of and not emotionally affected by my own condition. For that, I am so thankful to them.

I guess I managed my emotion well in front of them too, though I would sometimes feel so helpless and weak and at times feeling angry on why things like this happen to me.

But many a times, I told myself that I can do it, because I am still young and have the energy and time to battle against the sickness in me, Foo said.

When she isnt busy with her studies, Foo would spare her time to volunteer with SCCS.

These children with cancer, though some of them may have been in the ward for a long time, they look cheerful.

Being a volunteer, spending time with them, has taught me to be more empathetic, to be content with simple things and that there are many things in life that are more precious. Life is too short to burden yourself with negative thoughts.

This year, Foo has planned to have her head shaved in the coming Kuching leg of Go Bald campaign that will be held on July 9 at CityOne Megamall.

Stem Cell Donor Awareness campaign

President of SCCS, Jocelyn Hee, said the awareness on stem cell donation in the country, particularly Sarawak, is still at a very low level.

This is a new effort taken by SCCS to give hope and save lives of these cancer-stricken children as well as their family, Hee told The Borneo Post.

According to statistics by Malaysian Stem Cell Registry (MSCR), there are 28,500 registered volunteers and only 372 of them are of Sarawak ethnicity.

It is important to know that the diversity of race and intermarriage among Malaysians is one of the contributing factors to the low probability of finding a matching donor for a patient.

Hence, she said, an awareness campaign on stem cell is the initial step theyve taken to call on more donors.

Sarawakians are highly encouraged to pledge as blood stem cell donors, to increase the percentage in finding a compatible donor for patients from Sarawak.

Stem Cell Donor Awareness Drive and Talk will be held at CityOne Megamalls main stage on July 8 from 1.45pm to 2.30pm.

The talk will be sharing information on how stem cell donor-ship helps cancer patients, how one can be eligible to be a donor and the process to become one.

We hope that more people could come and support the good cause, and to spread the word to every member of the society, Hee said.

Link:
Cancer survivor shares how she was saved by stem cell transplant - The Borneo Post

KYOTO Embryonic stem cells for regenerative medicine will become available to medical institutions by the March 2018 end of fiscal 2017, Hirofumi Suemori, associate professor at Kyoto Universitys Institute for Frontier Life and Medical Sciences, has said.

Suemori also said Tuesday that ES cells for medical treatment, which have been approved by both the health and science ministries, would be created from October at the earliest.

To make ES cells, Kyoto University will work with Adachi Hospital in the city of Kyoto, which offers infertility treatment, to use fertilized eggs that would otherwise be disposed of.

The university hopes to obtain unwanted fertilized eggs from patients undergoing infertility treatment. The fertilized eggs are expected to be provided from around next February, the university said.

ES cells have the potential to become a variety of cell types much as induced pluripotent stem (iPS) cells do. Using ES cells, clinical trials are being conducted abroad on retinopathy, spinal cord injuries, Parkinsons disease, diabetes and cardiac disorders.

Many patients have qualms about discarding fertilized eggs, said Adachi Hospital Director Hiroshi Hatayama, who joined Suemori for a news conference. We can present an option to them, Hatayama said.

See more here:
Embryonic stem cells to be available for medical use in Japan by next March - The Japan Times

Equine mesenchymal stromal cells have been shown to have antibacterial properties, raising the possibility they could aid in healing troublesome skin wounds in humans and horses.

Mesenchymal stem cells, or MSCs, are multipotent connective-tissue cells that can differentiate into a variety of cell types, including bone cartilage, muscle and fat.

Chronic skin wounds in humans are common and their treatment is often complicated by pathogenic bacteria. Therefore, safe and innovative treatments to reduce the bacterial load in such wounds are needed.

MSCs have been reported to provide local hormonal signals that promote healing in skin wounds. However, the effects of equine MSCs on the growth of bacteria commonly found in skin wounds has not, until now, been explored.

Researchers from the College of Veterinary Medicine at New Yorks Cornell University have been the first to show that equine MSCs possess antimicrobial properties which stymied the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).

The MSCs did so in part by secreting antimicrobial peptides and depolarizing the bacterial cell membranes.

Rebecca Harman, Gerlinde Van de Walle, Steven Yang, and Megan He, writing in the journal Stem Cell Research & Therapy, said they focused on the antibacterial properties of MSCs from horses, as this animal model offered a readily translatable model for therapies in humans.

The study team described the laboratory experiment they set up, in which MSCs were isolated from the blood of healthy horses. The bacteria were cultured in the presence of MSCs and an MSC conditioned medium a processed fluid containing all factors secreted by the cells.

They found that both the MSCs and the MSC conditioning medium inhibited the growth of both bacteria, and that the conditioning medium depolarized the cell membranes of these bacteria.

The conditioning medium was found to contain four antimicrobial peptides, cystatin C, elafin, lipocalin 2, and cathelicidin. These appeared to be at least partially responsible for the antibacterial action.

They also looked for the presence of beta defensin 2 in equine MSCs since it has been found to be secreted by human umbilical cord-derived MSCs. It belongs to a widespread family of antimicrobial peptides found in most mammals, including horses. To the surprise of the research team, they could not detect beta defensin 2 in equine MSCs.

Our results, they concluded, demonstrate that equine MSCs inhibit bacterial growth and secrete factors that compromise the membrane integrity of bacteria commonly found in skin wounds.

There appeared to be a difference in the underlying mechanisms targeting each species, withdifferent secreted factors appearing to target different bacteria.

It will be interesting, they said, to study the effects of the MSC conditioning medium on additional bacterial species commonly found in equine skin wounds. The findings will likely be relevant to human as well as veterinary medicine, they said.

Since we found that equine MSCs secrete a variety of antimicrobial peptides that appear effective against both gram-positive [S. Aureus]and gram-negative [E.Coli] bacteria, these cells may serve as a broad-spectrum treatment to control bacterial growth and kill bacteria, without leading to resistance.

The study team said they now intended to evaluate the effectiveness of equine MSCs in healing both acute and chronic wounds.

Antimicrobial peptides secreted by equine mesenchymal stromal cells inhibit the growth of bacteria commonly found in skin wounds Rebecca M. Harman, Steven Yang, Megan K. He and Gerlinde R. Van de Walle Stem Cell Research & Therapy 2017 8:157 DOI: 10.1186/s13287-017-0610-6

The study, published under a Creative Commons License, can be read here.

Read more from the original source:
Mesenchymal stromal cells from horses show potential for healing skin wounds - Horsetalk

Embryo selection could become a lot cheaper and allow parents to ensure against diseases (Picture: Shutterstock)

People will stop having sex to procreate within three decades, a US professor claims.

Hank Greely, director of Stanford Law Schools Centre for Law and the Biosciences, believes more parents will end up choosing from a range of embryos created in a lab with their DNA.

Mr Greely believes the process will become a lot cheaper and couples will opt for the method to prevent diseases.

The process involves taking a female skin sample to create stem cells, which are then used to create eggs.

These are fertilised with sperm cells, resulting in a selection of embryos.

MORE: Boy, 16, wins human rights court battle after being kept in solitary confinement for over four months

Screening would pinpoint any potential diseases and eventually allow parents to determine their childs eye or hair colour.

Mr Greely said: I think one of the hardest things about this will be all the divorces that come about when she wants embryo number 15 and he wants embryo number 64.

I think the decision making will be a real challenge for people.

How do you weigh a slightly higher change of diabetes with slightly lower risk of schizophrenia against better musical ability and a much lower risk of colon cancer? Good luck.

The professor believes the method could cut healthcare costs and reduce diseases.

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Mr Greely defended embryo selection despite the murky ethical grounds.

He said: This is not designer babies or super babies. This is selecting embryos.

You take two people, all you can get out of a baby is what those two people have.

There are already concerns that CRISPR, a tool that scientists use to edit DNA, will be used to create perfect embryos.

However, Mr Greely dismissed this as unlikely and said embryo selection will begin as an infertility treatment before expanding.

MORE: Prince Charles and Camilla laugh in the faces of highly-skilled traditional Inuit throat singers

MORE: Ejaculating 21 times a month could reduce the risk of prostate cancer, suggests research

Read more from the original source:
People will 'stop having sex to procreate within 30 years', says scientist - Metro

Stem cell therapy: the next wave in regenerative medicine?

All it involved was a quick injection no different, really, than a flu shot.

A few weeks later, Bill Ambrose realized hed become significantly less reliant on taking Aleve for knee pain, and he was re-learning how to walk without shuffling his feet.

Surgery, it turned out, might not be necessary after all.

Last November, Ambrose scheduled knee surgery to alleviate discomfort in his knees caused by what orthopedic doctors called true bone-on-bone at the joint. But for one reason or another, he kept missing pre-surgery and the surgery never happened.

The next month, Ambrose met with Dr. Bill Nolan, of Cherry Street Health Group, to discuss advertising space in the Danvers Herald.

For the purpose of full disclosure, Ambrose is an employee of Gatehouse Media Company, and he works in the advertising department for Wicked Local, the local branch of GHM newspapers.

After Nolans ads ran inthe Jan. 5issue of the Herald, Ambrose said he reached out to Nolan again. This time, for himself.

Nolans practice offered a solution to his knee pain an alternative to knee surgery he had never considered before: stem cell therapy.

Essentially, the solutionCherry StreetHealth Group offered was an injection of amniotic fluid into Ambrose's knee joint. The stem cells and other growth factorsin the fluid would allow for the regeneration of the cartilage at the joint.

I became interested so I decided to go ahead with it, Ambrose said.

He brought in scans to show Nolan, who said, contrary to what orthopedic doctors had told him, he didnt have true bone on bone. There was still a small space between the bones.

I decided to have one leg done and my knee started getting much better, he said.

Satisfied with the results of the first injection, Ambrose decided to get his left knee done in April.

I still experience some pain in [the left knee], but I get up in the morning and theres very little pain at all, he said in an interview a few weeks following the appointment.

The stem cell option

In the U.S., there are three ways that stem cells are used, Nolan said. Theyre either taken from bone marrow, fat cells, or the amniotic membrane of a healthy c-section from a consenting woman.

When stem cellsare injected into the body,they're expected to increase space at the joint, rebuild cartilage, and ultimately, provide more stability in the joint. As many as 570 businesses across the country advertise some kind of stem cell therapy, according to a 2016 paper.

Stem cell therapy is not necessarily a new discovery, but it is relatively recent in the world of regenerative medicine.Stem cells were first used as much as century ago, first for eye procedures and as filler for the spinal cord, according to Regenexx, which claims to have pioneered orthopedic stem cell treatments in 2005.

Adult stem cells are retrieved directly from the patient, either frombone marrow or fat cells,and concentrated beforeits reinjectedinto the patient's site of pain.

In the case of amniotic fluid therapy,amniotic fluid, which contains stem cells and other growth factors, is injected into the site. These cellshave been shown to "expand extensively" and show "high renewal capacity,"according to research published in the National Library of Medicine.

We know that as you age, your stem cell count decreases,Nolan said, explaining the benefit of using cells from the amniotic membrane. We know that when we get it from the amniotic membrane, theres a large amount of stem cells that are present. From the amniotic membrane, there are no antibodies or antigens, so its safe for anyone to get.

At Cherry Street Health Group, theproduct usedis produced by General Surgical and distributed by RegenOMedix, according to Nolan.The product, which is called ReGen Anu RHEO, is American Tissue Bank approved and FDA cleared.

RHEO is marketed as "a human tissue allograft derived from placental tissue; amniotic membrane and amniotic fluid."Its a"powerful combination" of amniotic fluid and mesencymal stem cells, which are known to differentiate into a variety of cell types, according to RegenOMedix.It also contains growth factor proteins andis "rich" in other necessary components for tissue regeneration.

The product is non-steroidal and comes with no side effects, and the company says no adverse events have been recorded using the product.

Nolan said stem cell therapy has been offered as a treatmentat Cherry Street since 2016.

Across the U.S., there are as many as 56 businesses marketing some form of amniotic stem cellsto its consumers, according to the same paper.

At Rush University Medical Center in Chicago, for example, orthopedic surgeon Adam Yanke enrolled one of his patients into an experimental amniotic cell therapy treatment program. The woman, a 65-year-old suffering from osteoarthritis in both knees, told reporters the injections were "by far the most effective pain treatment" she had tried, and so farthat relief has lasted up to a year.

But while the use of amniotic fluid therapyas a regenerative medicine is becoming increasingly popular throughout the U.S.,the use of amniotic stemcellsdoesn't comewithout concern from some within the community.

Dr. Chris Centeno, who specializes in regenerative medicine andthe clinical use of adult stem cells, has blogged numerous times for Regenexx on the "scam" of using amniotic stem cells most recently in sharply worded post on May 22.

"Regrettably, we have an epidemic on our hands that began when sales reps began telling medical providers thattheir dead amniotic and cord tissues had loads of live cells on it," he wrote.

Nolan said he was familiar with Centeno's posts.

"A lot of the stem cell stuff is new," he said. "Some of the products out there ... They were doing testing on them and not finding cells."

Cherry Street Health Group has treatedabout 50patients with this form of regenerative medicine and had significant success, according to Nolan. Although Nolan owns the health group on Cherry Street in Danvers, the stem cell treatments are provided under the medical practice of Dr. Pat Scanlan.

Weve had really, really amazing success, Nolan said. Weve had over 95 percent success of all the patients weve had in the office. Its been a game changer from a practice standpoint.

The "worst thing" that could happen is there might not be any regeneration, he explained.

"You might get pain relief, but no regeneration," Nolan said. "But from what weve seen, there have been no negative side effects."

At Cherry Street, knees are the most commonly treated joints, followed by hips, shoulders and the lower back. The cervical spine is the least common.

"I hesitated on the surgery, and I'm gladI did," Ambrose said. "Even if[the stem cells]don't do any more than what they've done, its been well worth it."

Patients who do present with true bone on bone, however, are not candidates for this form of therapy, Nolan said.

The cost comparison

At Cherry Street Health Group, the cost of the injection comes toroughly $4,000 per knee, a cost that isn't covered by insurance. By comparison, health-care providers often charge insurers more than $18,000 for knee replacement surgeries in the Boston area, according to a report by the Blue Cross and Blue Shield Association.

The report, however, doesn't account for what the patient actually pays.

Nolan said when other factors of post-op are considered time off of work, rehabilitation time and cost the out-of-pocketcost for surgery compared to stem cell treatment is comparable.

"When you really boil it down, it can be the same or, in a lot of cases, a savings," he said.

Ambrose said it "boggles his mind" that more people don't choose this treatment over surgery.

"Why would you spend $40,000 on a car and not want to spend $4,000 on a knee?," he said."Its crazy. Yes, its out of pocket. So what? We buy a lot of stuff we dont need, and then for something like this, something that people, if they do it, theyll be glad they did it. Its just hard to convince them to do it."

In arecent report in STAT news, a health news start up of the Boston Globe, a study of orthopedic procedures in the U.S. suggested an estimated one-third of knee replacement surgeries are inappropriate. More than 640,000 of these surgeries are performed each year, making for a $10 billion dollar industry in knee surgery.

The study said that evidence isn't limited to just knee surgeries.

"There's a lot that needs to change when we look at health care in general,"Nolan said. "It's really no surprise that something like doing this regenerative medicine is going to take time for it to really take off."

Read more:
Danvers health group offers alternative solution to surgery - Wicked Local North of Boston

ANI | New Delhi [India] July 4, 2017 Last Updated at 20:22 IST

Regenexx, the world's most advanced stem cell procedures for treating orthopedic conditions and sports injuries has entered in Mumbai. This is their second branch in Asia. It would offer two stem cell procedures using imaging and interventional orthopedic techniques to non-surgically repair and regenerate.

The first one is a same-day procedure where stem cells are harvested, isolated and re-implanted on the same day. The second one is blood-derived plasma-rich platelet procedure. They would help athletes and non-athletes overcome early, mild, moderate ortho problems in a way that is devoid of surgery.

Regenexx is the most advanced stem cell and platelet procedures for treating orthopedic injuries, arthritis and other degenerative conditions. These procedures offer non-surgical alternatives to commonly occurring musculoskeletal conditions. Patented Regenexx procedures use precise injections of your own stem cells or blood platelets to help your body's ability to heal damaged muscles, tendons, ligaments, cartilage, spinal disc and bone.

Regenexx Stem Cell Therapy and Platelet Procedures, avoid the need for invasive surgery, in turn eliminating any complications that are typically seen with surgeries.

"The only option till now was total knee replacement. Now with this technology we can heal and regenerate the lost tissues like cartilage, meniscus and ligaments to reverse the arthritis and in turn avoid any major surgery. Patients return to their loved activities in no time. We could also treat conditions like lower back pain, hip arthritis, bulging discs, ankle and shoulder rotator cuff tears with stem cells orthopedics procedure. Majority of these are lifestyle related conditions," said Dr. Venkatesh Movva, MD, Regenexx India.

Regenexx procedures are image-guided needle-based procedures, so the downtime for recovery is minimal or none. These are truly ambulatory procedures without the need for hospitalisation. The procedure process involves harvesting bone marrow stem cells, using our sophisticated lab process to separate cells and precise image guided injections into the target joints in an outpatient setting.

"Regenexx procedures are out-patient procedues and that patients can walk out of the treatment the same day. Physiotherapy team at Regenexx will help patients make the necessary changes to their physical movements so that the procedures are effective," said Dr. Apurv Mahalle, MGIMS.

There is no alternative for arthritis patients but to wait until the joint is bad enough for a replacement and then go through a surgery. Regenexx procedures are going to help these patients get back to the normal routine without the necessity of a replacement surgery.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

Regenexx, the world's most advanced stem cell procedures for treating orthopedic conditions and sports injuries has entered in Mumbai. This is their second branch in Asia. It would offer two stem cell procedures using imaging and interventional orthopedic techniques to non-surgically repair and regenerate.

The first one is a same-day procedure where stem cells are harvested, isolated and re-implanted on the same day. The second one is blood-derived plasma-rich platelet procedure. They would help athletes and non-athletes overcome early, mild, moderate ortho problems in a way that is devoid of surgery.

Regenexx is the most advanced stem cell and platelet procedures for treating orthopedic injuries, arthritis and other degenerative conditions. These procedures offer non-surgical alternatives to commonly occurring musculoskeletal conditions. Patented Regenexx procedures use precise injections of your own stem cells or blood platelets to help your body's ability to heal damaged muscles, tendons, ligaments, cartilage, spinal disc and bone.

Regenexx Stem Cell Therapy and Platelet Procedures, avoid the need for invasive surgery, in turn eliminating any complications that are typically seen with surgeries.

"The only option till now was total knee replacement. Now with this technology we can heal and regenerate the lost tissues like cartilage, meniscus and ligaments to reverse the arthritis and in turn avoid any major surgery. Patients return to their loved activities in no time. We could also treat conditions like lower back pain, hip arthritis, bulging discs, ankle and shoulder rotator cuff tears with stem cells orthopedics procedure. Majority of these are lifestyle related conditions," said Dr. Venkatesh Movva, MD, Regenexx India.

Regenexx procedures are image-guided needle-based procedures, so the downtime for recovery is minimal or none. These are truly ambulatory procedures without the need for hospitalisation. The procedure process involves harvesting bone marrow stem cells, using our sophisticated lab process to separate cells and precise image guided injections into the target joints in an outpatient setting.

"Regenexx procedures are out-patient procedues and that patients can walk out of the treatment the same day. Physiotherapy team at Regenexx will help patients make the necessary changes to their physical movements so that the procedures are effective," said Dr. Apurv Mahalle, MGIMS.

There is no alternative for arthritis patients but to wait until the joint is bad enough for a replacement and then go through a surgery. Regenexx procedures are going to help these patients get back to the normal routine without the necessity of a replacement surgery.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

ANI

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Regen Ortho sport facility launched - Business Standard

Posted in: News, Police & Crime | Comments (2)

By Lieutenant D. Bittner #3252, Antioch Police Investigations Division

On Monday, July 3, 2017 at approximately 8:26 PM, a robbery and homicide occurred at the corner of Hillcrest Avenue and E. 18th Street. An officer involved shooting by an Antioch Police Department patrol officer occurred at the scene of the robbery and homicide. The homicide was not a result of the officer involved shooting. The Antioch Police Department and the Contra Costa County Office of the District Attorney are currently investigating the incident. The investigation is in its early stages and no further information will be released, at this time.

Anyone with information is asked to call the Antioch Police Department non-emergency line at (925) 778-2441. You may also text-a-tip to 274637 (CRIMES) using the key word ANTIOCH.

Publisher @ July 4, 2017

Posted in: History | Comments (0)

A copy of the Declaration of Independence.

Following is the text of the Declaration of Independence in celebration of Independence Day, July 4th, 2017:

IN CONGRESS, July 4, 1776.

The unanimous Declaration of the thirteen united States of America,

When in the Course of human events, it becomes necessary for one people to dissolve the political bands which have connected them with another, and to assume among the powers of the earth, the separate and equal station to which the Laws of Nature and of Natures God entitle them, a decent respect to the opinions of mankind requires that they should declare the causes which impel them to the separation.

We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable Rights, that among these are Life, Liberty and the pursuit of Happiness.That to secure these rights, Governments are instituted among Men, deriving their just powers from the consent of the governed, That whenever any Form of Government becomes destructive of these ends, it is the Right of the People to alter or to abolish it, and to institute new Government, laying its foundation on such principles and organizing its powers in such form, as to them shall seem most likely to effect their Safety and Happiness. Prudence, indeed, will dictate that Governments long established should not be changed for light and transient causes; and accordingly all experience hath shewn, that mankind are more disposed to suffer, while evils are sufferable, than to right themselves by abolishing the forms to which they are accustomed. But when a long train of abuses and usurpations, pursuing invariably the same Object evinces a design to reduce them under absolute Despotism, it is their right, it is their duty, to throw off such Government, and to provide new Guards for their future security.Such has been the patient sufferance of these Colonies; and such is now the necessity which constrains them to alter their former Systems of Government. The history of the present King of Great Britain is a history of repeated injuries and usurpations, all having in direct object the establishment of an absolute Tyranny over these States. To prove this, let Facts be submitted to a candid world.

He has refused his Assent to Laws, the most wholesome and necessary for the public good.

He has forbidden his Governors to pass Laws of immediate and pressing importance, unless suspended in their operation till his Assent should be obtained; and when so suspended, he has utterly neglected to attend to them.

He has refused to pass other Laws for the accommodation of large districts of people, unless those people would relinquish the right of Representation in the Legislature, a right inestimable to them and formidable to tyrants only.

He has called together legislative bodies at places unusual, uncomfortable, and distant from the depository of their public Records, for the sole purpose of fatiguing them into compliance with his measures.

He has dissolved Representative Houses repeatedly, for opposing with manly firmness his invasions on the rights of the people.

He has refused for a long time, after such dissolutions, to cause others to be elected; whereby the Legislative powers, incapable of Annihilation, have returned to the People at large for their exercise; the State remaining in the mean time exposed to all the dangers of invasion from without, and convulsions within.

He has endeavoured to prevent the population of these States; for that purpose obstructing the Laws for Naturalization of Foreigners; refusing to pass others to encourage their migrations hither, and raising the conditions of new Appropriations of Lands.

He has obstructed the Administration of Justice, by refusing his Assent to Laws for establishing Judiciary powers.

He has made Judges dependent on his Will alone, for the tenure of their offices, and the amount and payment of their salaries.

He has erected a multitude of New Offices, and sent hither swarms of Officers to harrass our people, and eat out their substance.

He has kept among us, in times of peace, Standing Armies without the Consent of our legislatures.

He has affected to render the Military independent of and superior to the Civil power.

He has combined with others to subject us to a jurisdiction foreign to our constitution, and unacknowledged by our laws; giving his Assent to their Acts of pretended Legislation:

For Quartering large bodies of armed troops among us:

For protecting them, by a mock Trial, from punishment for any Murders which they should commit on the Inhabitants of these States:

For cutting off our Trade with all parts of the world:

For imposing Taxes on us without our Consent:

For depriving us in many cases, of the benefits of Trial by Jury:

For transporting us beyond Seas to be tried for pretended offences

For abolishing the free System of English Laws in a neighbouring Province, establishing therein an Arbitrary government, and enlarging its Boundaries so as to render it at once an example and fit instrument for introducing the same absolute rule into these Colonies:

For taking away our Charters, abolishing our most valuable Laws, and altering fundamentally the Forms of our Governments:

For suspending our own Legislatures, and declaring themselves invested with power to legislate for us in all cases whatsoever.

He has abdicated Government here, by declaring us out of his Protection and waging War against us.

He has plundered our seas, ravaged our Coasts, burnt our towns, and destroyed the lives of our people.

He is at this time transporting large Armies of foreign Mercenaries to compleat the works of death, desolation and tyranny, already begun with circumstances of Cruelty & perfidy scarcely paralleled in the most barbarous ages, and totally unworthy the Head of a civilized nation. He has constrained our fellow Citizens taken Captive on the high Seas to bear Arms against their Country, to become the executioners of their friends and Brethren, or to fall themselves by their Hands. He has excited domestic insurrections amongst us, and has endeavoured to bring on the inhabitants of our frontiers, the merciless Indian Savages, whose known rule of warfare, is an undistinguished destruction of all ages, sexes and conditions.

In every stage of these Oppressions We have Petitioned for Redress in the most humble terms: Our repeated Petitions have been answered only by repeated injury. A Prince whose character is thus marked by every act which may define a Tyrant, is unfit to be the ruler of a free people.

Nor have We been wanting in attentions to our Brittish brethren. We have warned them from time to time of attempts by their legislature to extend an unwarrantable jurisdiction over us. We have reminded them of the circumstances of our emigration and settlement here. We have appealed to their native justice and magnanimity, and we have conjured them by the ties of our common kindred to disavow these usurpations, which, would inevitably interrupt our connections and correspondence. They too have been deaf to the voice of justice and of consanguinity. We must, therefore, acquiesce in the necessity, which denounces our Separation, and hold them, as we hold the rest of mankind, Enemies in War, in Peace Friends.

We, therefore, the Representatives of the united States of America, in General Congress, Assembled, appealing to the Supreme Judge of the world for the rectitude of our intentions, do, in the Name, and by Authority of the good People of these Colonies, solemnly publish and declare, That these United Colonies are, and of Right ought to be Free and Independent States; that they are Absolved from all Allegiance to the British Crown, and that all political connection between them and the State of Great Britain, is and ought to be totally dissolved; and that as Free and Independent States, they have full Power to levy War, conclude Peace, contract Alliances, establish Commerce, and to do all other Acts and Things which Independent States may of right do. And for the support of this Declaration, with a firm reliance on the protection of divine Providence, we mutually pledge to each other our Lives, our Fortunes and our sacred Honor.

The 56 signatures on the Declaration appear in the positions indicated:

Column 1

Georgia:

Button Gwinnett

Lyman Hall

George Walton

Column 2

North Carolina:

William Hooper

Joseph Hewes

John Penn

South Carolina:

Edward Rutledge

Thomas Heyward, Jr.

Thomas Lynch, Jr.

Arthur Middleton

Column 3

Massachusetts:

John Hancock

Maryland:

Samuel Chase

William Paca

Thomas Stone

Charles Carroll of Carrollton

Virginia:

George Wythe

Richard Henry Lee

Thomas Jefferson

Benjamin Harrison

Thomas Nelson, Jr.

Francis Lightfoot Lee

Carter Braxton

Column 4

Pennsylvania: Robert Morris

Benjamin Rush

Benjamin Franklin

John Morton

George Clymer

James Smith

George Taylor

James Wilson

George Ross

Delaware: Caesar Rodney

George Read

Thomas McKean

Column 5

New York:

William Floyd

Philip Livingston

Francis Lewis

Lewis Morris

New Jersey:

Richard Stockton

John Witherspoon

Francis Hopkinson

John Hart

Abraham Clark

Column 6

New Hampshire:

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Two-year-old Nathan DeAndrea who underwent two stem cell transplants to treat neuroblastoma is free of cancer, according to his mother.

Testing last week that included a CT scan and a full-body scan showed no evidence of cancer, Shannon DeAndrea said during an interview at her home Monday morning.

No more cancer! said Nathans sister, 4-year-old Kailynn.

However, the DeAndreas are awaiting the results of a bone marrow biopsy performed on Nathan last week, Shannon said. Everyone is optimistic.

The doctor said he has never seen a bone marrow biopsy come back positive when everything else is clear, she said.

Results are expected this week, Shannon said.

Nathan was diagnosed with stage 4 neuroblastoma on Aug. 23, 2016. He had a tumor in his abdomen that spread to his bone marrow. He had spots on his skull, ribs and spine. He has had several rounds of chemotherapy, radiation and two stem cell transplants.

Neuroblastomas are cancers that begin in early nerve cells of the sympathetic nervous system, according to the American Cancer Society.

The scans results brought relief to Shannon and her family.

Its like I could breathe, she said.

As Kailynn put it, We said, hooray!

The next phase of treatment will include strengthening Nathans immune system. He will be in the hospital one week a month for six months, Shannon said.

Its to keep it [the cancer] from coming back, she said.

His immune system is still compromised. The genetic makeup of Nathans tumor put him at a higher risk of relapse, Shannon said.

Nathans first transplant included four or five days of chemo. The new stem cells following the chemo that killed off his old stem cells from the transplant were like a rescue, she said.

Its wiping you out and then giving you your cells back to restart your immune system, DeAndrea said.

A second round of heavy chemo was to try to kill what was left of the cancer and replenish cells, she said.

Nathans stem cell transplants were from his own cells, Shannon said.

Two types of stem cell transplants include autologous, which uses stem cells from the patients own body, and allogeneic using stem cells from another person.

The procedure is used for conditions including multiple myeloma, lymphoma, sickle cell anemia and leukemia, and other blood and immune disorders.

Stem cell transplants began in the late 50s/early 60s with the first successful procedure done in an identical twin. However, stem cell transplants were limited until medicines that prevent rejections became available.

The number of procedures increased in the 1980s.

Betsie Letterle, community engagement representative with BeTheMatch in Burlington, North Carolina, said there are more than 14 million bone marrow/stem cell donors in the BeTheMatch registry.

Bone marrow transplants traditionally involved taking the marrow from the back of the donors hip. But since then, weve progressed tremendously, Letterle said.

The newest way is to take stem cells from a vein in the donors arm, Letterle said. The donor receives an injection of medication to help their body manufacture a large amount of stem cells, she said.

Those are taken from the vein, similar to a plasma donation. Letterle said.

Anyone aged 18-44 can join the registry, but commitment is paramount among donors, she said.

Commitment is important because patients depend on us, Letterle said. We dont want anyone whos not really sure they could donate if called.

Only about one in 540 registered donors end up donating, she said. Everyone is an active donor until they turn 61, Letterle said.

Younger donors are healthier and make the most stem cells, she said.

We want to give the patient the optimum opportunity to get the best stem cells they can, she said.

If a donor comes up as a match, they will be asked for about 20-30 hours of their time over several weeks, Letterle said.

We work around the donors schedule, she said.

They get blood work done, and a physical to make sure theyre healthy enough to donate, Letterle said.

The donor never pays for anything, she said.

The doctor determines whether the procedure would be a stem cell or a traditional bone marrow transplant. That depends on the patients or recipients age and condition, Letterle said.

About 80 percent of registered donors are Caucasian, and BeTheMatch is looking for more minority donors, Letterle said. Many minority patients have trouble finding a match, she said.

The recipients blood type becomes whatever blood type the donor has, Letterle said.

Dr. William Clark with the Massey Cancer Center at Virginia Commonwealth University will speak about bone marrow and stem cell transplants from 11:30 a.m. to 1 p.m. July 11 at Ballou Recreation Center. A bone marrow/stem cell donor drive will also be held that day.

For more information on stem cell/bone marrow transplants, call Betsie Letterle at BeTheMatch at (877) 601-1926, ext. 7721.

JohnCrane reports for the Danville Register & Bee. Contact him atjcrane@registerbee.comor(434) 791-7987.

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Emerald baseball coach Stanley Moss called current College of Charleston infielder Bradley Dixon one of the better players and kids he's ever coached.

The former Emerald standout was a slick-fielding shortstop, according to Moss, who was a cornerstone to the Emerald program.

"He was one of my favorites of all time," Moss said. "He always did what he was asked to do and went above and beyond to try to represent our program."

Dixon shared the field with current Clemson commit Sheldon Reed, who was a year under him at Emerald. Having the two of them play together was a joy and pleasure to be a part of, Moss said.

"(Dixon) and Sheldon hit in the middle of our lineup the whole time," Moss said. "They were big producers for us offensively."

Dixon's dominant play at Emerald earned him an opportunity to play Division I baseball with the Cougars. Dixon's senior season at Emerald, College of Charleston made it to a Super Regional which was just the second appearance in the program's history.

"It's what you grow up dreaming to do, playing Division I baseball," Dixon said. "Whenever you get an opportunity to do it, you take it and make the best of it."

But dreams have sometimes been met with struggles for Dixon. His freshman year in 2015 a week before opening weekend he sprained his MCL, ACL and suffered a bone contusion, forcing him to redshirt.

The following season, though, Dixon's redshirt freshman campaign, everyone got a glimpse of what he could do on the ball field when he's healthy.

Dixon started 45 games and was fourth on the team in batting average hitting .273 with a homer. They weren't the most eye-popping stats, but they proved what he was worth when on the field.

His 2017 season, however, was met with more injuries. Dixon recently had to get stem cells taken from the bone marrow in his hip and injected into the sesamoid bones in both his feet.

All the cartilage had worn down, which meant Dixon didn't have any protection around his bones. He played through the injury the entire season, hitting just .251.

Moss believes he'll be a force again once healthy.

"Bradley's work ethic has always been where you would like to be," he said. "He's that kid in the offseason. Obviously if he can get himself completely healthy he's the kind of kid that can definitely go out and have a big year for College of Charleston."

The recovery time for his injury is 12 weeks, Dixon said, which means he'll be ready for the fall.

The team put together an underwhelming year last season, going just 13-11 in the Colonial Athletic Association, 28-31 overall and losing to Northeastern in the conference tournament.

On top of that, College of Charleston's coach, Matt Heath, was fired on Friday.

Despite the setbacks, Dixon is looking help right the ship.

"I really want to increase some of the numbers I had last year," Dixon said. "And just do better for my teammates, know my role and do whatever I can to help us win."

Contact staff writer Julian McWilliams at 864-223-1814 or on Twitter @JulianMack105

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