By Amy Adams

Sarah Heilshorn

It is a turbulent and sometimes deadly life for cells injected to heal injuries. The act of being squirted through a thin needle into the site of an injury jostles the delicate cells against each other and against the needle walls. Then, once in the site of injury, they face a biological war zone of chemicals. It's no wonder, then, that treating spinal cord injuries and other damage with injected cells has been a challenge.

Solving this problem takes more than biological know-how; it takes padding chemical padding in the form of complex molecules called polymers that bathe and protect the cells but also flow smoothly through thin needles.

Sarah Heilshorn, an associate professor of materials science and engineering at Stanford, equates these gel-like polymers to ketchup. It's pretty thick, but when you bang on the bottle the sauce flows smoothly through the neck, then firms back up on the plate a process she calls self-healing. "We want our polymers to self-heal better than ketchup," she said. "It flows a bit across the plate."

Her goal is to develop a polymer that supports the cells when they are loaded in a syringe, but then flows freely through the needle, padding and protecting the cells, then firming up quickly when it reaches the site of injury. "We don't want the cells to flow away," she says.

Heilshorn sees this technology as a platform that could be applied to a variety of cell types and injuries. Some polymers need to be firmer to support cells that like a harder environment. Others need to be softer, or contain different biochemical signals.

Neural stem cells, for example, are more likely to mature into nerves if they are in a soft environment. In a stiff environment, they tend to form supportive cells called astrocytes. Picking the right gel is critical to delivering the right kind of cells.

The biochemicals contained within the gel also matter. "We're putting in different biochemical signals that we hope the cells will respond to," Heilshorn said. "We're trying to make a biochemical home for the cells inside that lesion site."

Heilshorn is part of a team made up of Giles Plant, an associate professor of neurosurgery who is a pioneer in cell-based therapies for spinal cord injury, and Andrew Spakowitz, an associate professor of chemical engineering who is an expert in predicting polymer structures. Together, they are among the 22 teams that recently received seed grants from Stanford Bio-X to bring diverse minds to bear on complex biomedical problems.

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Gel-like padding being developed at Stanford could help cells survive injection, heal spinal cord injuries

MISSISSAUGA Dorothy Vernon-Brown is on the search of her life.

When she was diagnosed with acute myaloid leukemia in August, 2013, the Mississauga mother said it was like a huge kick in the gut.

She underwent chemotherapy shortly after the diagnosis, which helped her into remission, but to survive, she has been told her only chance is a bone marrow transplant.

Bone marrow cells rescue patients from the lethal effect of chemotherapy, says Vernon-Browns oncologist, Dr. Mark Minden.

Since starting a relationship with Canadas stem cell and marrow network, One Match, Vernon-Browns search has come up empty.

Vernon-Brown says she is desperate: Recent tests show lower white blood cell counts in her blood an indication the cancer may be coming back.

But shes also worried about how few donors are from the black community. Vernon-Brown has been told her chance of finding a compatible donor are one in 10,000.

Genetics are key in finding potential stem cell and bone marrow donors says, One Match patient and transplant liaison, MaryLynn Pride said.

There is only a 25 per cent chance that even a sibling will be a match, says Pride. We have patients from all ethnic communities that are currently in need of a stem cell transplant.

Black Canadians makes up only 1 percent of all Canadians registered as potential donors, according to Pride.

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Desperate search for bone marrow donor goes private for Mississauga woman

Written by Lidia Dinkova on September 17, 2014

A partnership between University of Miami researchers and a Georgia-based biomedical company this month made a new type of stem cell commercially available for bone regeneration and healing.

The marrow-isolated adult multi-lineage inducible cell, known as the MIAMI cell, is the result of 15 years of research by the University of Miami.

Since the stem cell was made commercially available, about 21 patients have been treated with a MIAMI cell infusion.

We are controlling the release to make sure it goes very smoothly, said Tracy S. Anderson, president and CEO of Vivex Biomedical Inc.

Vivex invested in the research and development of the cell and licensed the technology from UM for orthopedic use. The company has contracted with the universitys tissue bank to develop the cell for commercial use and pays an undisclosed royalty back to UM from sales.

Before the MIAMI cell goes to full national release in January 2015, Vivex is controlling the use of the cell.

I am going very slowly and selectively with the surgeons we are working with, Mr. Anderson said. Anytime you have a new product like this, you have to make sure that it goes smoothly.

Mr. Anderson didnt want to disclose revenue generated from the sale of the MIAMI cell, only saying that it has been significant.

So far, the MIAMI cell has been used in bone regeneration and healing in Utah, Florida, Georgia, Michigan, Illinois and Ohio.

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21 infused with new UM stem cell

ABC Ralph Bright harvests stem cells using the liposuction.

Serious questions have been raised about a stem cell doctor working in Western Sydney who charges $9,000 per procedure and uses methods that are untested by clinical trials.

An investigation by the ABC's 7.30 program has revealed that Dr Ralph Bright bought his liposuction-based technology from an American company.

The US company is now the subject of a multi-million dollar fraud action, which has revealed the cells being marketed as live were in fact dead.

Dr Bright, of Macquarie Stem Cells, is a former GP and self-taught cosmetic surgeon.

He has been working with stem cells for four years, treating more than 400 patients, including the late model Charlotte Dawson, cricketer Geoff Lawson and Olympic volleyballer Kerri Pottharst.

Dr Bright has licensed his methods to other practitioners around the country and because they use the patients' own cells he is not regulated by the Therapeutic Goods Administration (TGA).

Stem cells are often hailed as a miracle cure, but the nation's top stem cell scientists are warning that buyers should beware of these sorts of procedures, which are yet to be subjected to clinical trials.

Professor of Stem Cell Science at the University of Melbourne, Martin Pera, said almost all stem cell therapy was experimental.

"Actually, this whole science of cell therapy is relatively new and it's very, very important to understand that," he said.

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Stem cell harvesting methods used by Sydney doctor Ralph Bright untested by clinical trials

ABC Ralph Bright harvests stem cells using the liposuction.

Serious questions have been raised about a stem cell doctor working in Western Sydney who charges $9,000 per procedure and uses methods that are untested by clinical trials.

An investigation by the ABC's 7.30 program has revealed that Dr Ralph Bright bought his liposuction-based technology from an American company.

The US company is now the subject of a multi-million dollar fraud action, which has revealed the cells being marketed as live were in fact dead.

Dr Bright, of Macquarie Stem Cells, is a former GP and self-taught cosmetic surgeon.

He has been working with stem cells for four years, treating more than 400 patients, including the late model Charlotte Dawson, cricketer Geoff Lawson and Olympic volleyballer Kerri Pottharst.

Dr Bright has licensed his methods to other practitioners around the country and because they use the patients' own cells he is not regulated by the Therapeutic Goods Administration (TGA).

Stem cells are often hailed as a miracle cure, but the nation's top stem cell scientists are warning that buyers should beware of these sorts of procedures, which are yet to be subjected to clinical trials.

Professor of Stem Cell Science at the University of Melbourne, Martin Pera, said almost all stem cell therapy was experimental.

"Actually, this whole science of cell therapy is relatively new and it's very, very important to understand that," he said.

The rest is here:
Stem cells treatment used by Sydney doctor Ralph Bright 'untested' by clinical trials

A Quebec womans desperate, months-long search for a compatible stem cell or umbilical cord match is over.

Mai Duong, a 34-year-old Vietnamese-Canadian battling acute leukemia, announced Tuesday that she has finally found a match.

"I'm going to have the transplant and hopefully everything will go well and hopefully I'll have a new marrow," Duong tearfully told reporters Tuesday. "I just hope I'm going to beat cancer once and for all."

"A woman gave birth to her child and has donated her baby's umbilical cord to save another life," reads a post on the Save Mai Duong Facebook page. "Thank you dear mommy, we cannot fathom the importance of your gesture. I am very moved."

Duong beat cancer last year, after chemotherapy that she had to terminate a 15-week pregnancy to undergo.

She was in remission until May, when blood tests revealed the leukemia had returned.

"Seventy per cent of people who had that type of leukemia were just cured with chemotherapy and unfortunately I'm in the 30 per cent," she said at the time.

Doctors said Duong would need a bone marrow transplant or cord blood stem cells and she needed it fast. Despite being on the international list, doctors struggled to find a match.

Duong said, for people who aren't Caucasian, finding the right donor can be like searching for a needle-in-a-haystack.

"Less than one per cent of the 25 million donors worldwide are Vietnamese," she wrote on her website. "All ethnic communities are severely under-represented in the world donor bank, making finding a compatible donor very difficult for me and countless others who are currently waiting for a transplant."

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Quebec leukemia patient Mai Duong finds stem cell donor

St. Petersburg, FL (PRWEB) September 16, 2014

Aging skin inevitably wrinkles, thins and sags.

The main internal reason for this is loss of collagen production. By age 60, skin has 45% less collagen than it did when young due to this slow down. Collagen holds up skin structure.

In order to maintain healthy, beautiful skin, collagen production should be boosted. There are several ways to do this, but the relatively new scientific approach is through use of stem cells (non-embryonic).

"The cost is higher than other types of serums, but you also get what you pay for," says Kathy Heshelow, founder of Sublime Beauty."Stem cell serums rich in growth factors and human fibroblast conditioned media bring back firmer, younger and smoother skin."

Scientists have used these ingredients in wound repair with great success, and the crossover to skin care seemed natural. TGF-b or Transforming Growth Factor-beta is considered to be one of the most important growth factors to stimulate collagen production, promote synthesis and inhibit thinning of skin.

The Sublime Beauty serum, Cell Renewal | Fibroblast Serum, contains these very growth factors. A brochure explaining more about the ingredients is available on the product page of the company webstore.

Similar serums on the market are far more expensive the one offered by Sublime Beauty. Take 25% Off the stem cell serum at Amazon with coupon code FIBRO52V now.

ABOUT: Sublime Beauty is a quality skincare company that focuses on products to Age Younger. Ingredients help to boost collagen, hydrate, relax wrinkles and improve skin. A niche includes healthy Skin Brushes. The company webstore offers free standard shipping and a VIP Club. Sign up for Secret Sales on the site. Products also available on Amazon.

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A Superior Way to Make Skin Younger and Assure Continual Collagen Production, from Sublime Beauty

JIJI PRESS/AFP/Getty Images

Masayo Takahashi is the first to implant tissue derived from induced pluripotent stem cells into a person.

Its awesome, its amazing, Im thrilled, Ive been waiting for this, says Jeanne Loring, a stem-cell biologist at the Scripps Research Institute in La Jolla, California. She is one of several researchers around the world to welcome the news that a Japanese woman with visual impairment had become the first person to receive a therapy derived from stem cells known as induced pluripotent stem (iPS) cells.

A lot rides on this trial. If the procedure proves safe, it could soften the stance of regulatory bodies in other nations towards human trials of iPS cells, and it could pave the way for treatments for other conditions, such as Parkinsons disease and diabetes. It could also cement Japan, recently plagued by a stem-cell scandal, as a frontrunner in iPS-cell research.

Pioneered in 2006 by Shinya Yamanaka, now director of the Center for iPS Cell Research and Applications at Kyoto University, iPS cells are created by inserting certain genes into the DNA of adult cells to reprogram the cells back to an embryonic-like state. The cells can then be turned into almost any tissue type, much as embryonic stem cells can. But because iPS cells can be derived from a patients own tissue, the hope is that they will dodge some of the controversial aspects and safety concerns of those derived from embryos.

In 2012, Yamanaka received a Nobel prize for his work, and the field has now matured, with teams across the world champing at the bit to test therapies based on iPS cells in people. Loring, for example, uses the cells to create dopamine-producing neurons as a potential therapy for Parkinsons disease, and says that she will start clinical trials as soon as the US Food and Drug Administration (FDA) gives the go-ahead.

Still, tissues made from iPS cells carry their own concerns, and that had stopped any country from approving them for a clinical trial. The bodys immune system could attack them, or they might contain some cells that are still in the pluripotent state and cause cancerous growths although Loring points out that this has not happened with human trials of therapies based on embryonic stem cells, for which the same concerns would apply.

In July 2013, however, Japans regulatory authorities gave the go-ahead for a team led by ophthalmologist Masayo Takahashi at the RIKEN Center for Developmental Biology (CDB) in Kobe to collect cells to be used in a clinical iPS-cell pilot study.

His team took skin cells from the first patient, a woman in her seventies who had retinal damage owing to a condition known as age-related macular degeneration. The researchers then reprogrammed the skin cells into iPS cells and coaxed the unspecialized cells into becoming retinal tissue. On 8September, Takahashi provided evidence that those cells were genetically stable and safe, a prerequisite for them to be transplanted into the eye. The procedure took place four days later, and RIKEN has reported that the patient experienced no serious side effects.

In this instance, the womans vision is unlikely to improve. However, researchers around the world are watching to see whether the cells stop the retina from deteriorating further and whether any side effects develop. Should the woman experience serious consequences, iPS-cell research could be set back years, much as gene therapy was in 1999 when a patient died in a trial that attempted to use a modified gene to correct a type of liver disease. That wakes me up at night, Loring admits.

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Japan stem-cell trial stirs envy

Stem cells broke into the public consciousness in the early 1990s, but progress has been slow. Photo: Bloomberg

Edgar Irastorza was just 31 when his heart stopped beating in October 2008.

A Miami property manager, break-dancer and former high school wrestler, Irastorza had recently gained weight as his wife's third pregnancy progressed. "I kind of got pregnant, too," he said.

During a workout one day, he felt short of breath and insisted that friends rush him to the hospital. Minutes later, his pulse flatlined.

He survived the heart attack, but the scar tissue that resulted cut his heart's pumping ability by a third. He couldn't pick up his children. He couldn't dance. He fell asleep every night wondering if he would wake up in the morning.

Desperation motivated Irastorza to volunteer for a highly unusual medical research trial: getting stem cells injected directly into his heart.

"I just trusted my doctors and the science behind it, and said, 'This is my only chance,'" he said recently.

Over the past five years, by studying stem cells in lab dishes, test animals and intrepid patients like Irastorza, researchers have brought the vague, grandiose promises of stem cell therapies closer to reality.

Stem cells broke into the public consciousness in the early 1990s, alluring for their potential to help the body beat back diseases of degeneration like Alzheimer's, and to grow new parts to treat conditions like spinal cord injuries.

Progress has been slow. The Michael J. Fox Foundation for Parkinson's Research, an early supporter of stem cell research, pulled its financial backing two years ago, saying that it preferred to invest in research that was closer to providing immediate help for Parkinson's disease patients.

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Trials and tribulations of stem cell therapy

PUBLIC RELEASE DATE:

12-Sep-2014

Contact: Peggy Murphy pemurphy@luriechildrens.org 773-755-7485 Children's Memorial Hospital

Metastatic melanoma is a highly aggressive skin cancer whose incidence is on the rise at an alarming rate. Research has revealed that metastatic tumor cells share similar signaling pathways with embryonic stem cells to sustain plasticity and growth. However, major regulators of these pathways are often missing in tumor cells, thus allowing uncontrolled tumor growth and spreading to occur.

During early vertebrate development, Nodal, an embryonic growth factor that governs the growth, pattern and position of tissues, is critical for normal maturation. Nodal plays a significant role in maintaining the pluripotency of embryonic stem cells, meaning the ability of stem cells to differentiate into any of the three germ layers that comprise the body. The recent discovery of Nodal's re-expression in several aggressive and metastatic cancers has highlighted its critical role in self-renewal and maintenance of the stem cell-like characteristics of tumor cells such as melanoma. However, the signaling pathway receptors utilized by melanoma cells to propagate Nodal's effect remain(s) mostly anecdotal and unexplored.

The laboratory of Mary J.C. Hendrix, PhD made the novel discovery that embryonic stem cells and metastatic melanoma cells share a similar repertoire of receptors known as Type I serine/threonine kinase(s), but diverge in their Type II receptor expression. Further testing indicated that metastatic melanoma cells and embryonic stem cells use different receptors for Nodal signal transduction. These findings reveal the divergence in Nodal signaling between embryonic stem cells and metastatic melanoma that can impact new therapeutic strategies targeting the re-emergence of embryonic pathways in cancer.

This work is published in the International Journal of Cancer. Mary J.C. Hendrix, PhD points out: "Nodal-expressing tumor cells don't respond favorably to conventional therapies, supporting the premise that a combinatorial approach to targeting Nodal subpopulations within tumors, along with a front-line therapy, would constitute a more rational approach for treating aggressive cancer". Zhila Khalkhali-Ellis, PhD, senior research scientist in the Hendrix laboratory and the lead author says: "Our discoveries are important for advanced stage aggressive melanoma. Given that limited therapeutic options are currently available for this cancer, we have the opportunity to investigate whether the receptors can be modulated so that the signaling molecule can be neutralized to decrease aggressive behavior." The research was supported by the National Institutes of Health.

###

Zhila Khalkhali-Ellis, PhD is Research Associate Professor of Pediatrics at Northwestern University Feinberg School of Medicine; and a member of the Cancer Biology and Epigenomics Program of Stanley Manne Children's Research Institute, affiliated with Ann & Robert H. Lurie Children's Hospital of Chicago.

Mary J.C. Hendrix, PhD is President & Scientific Director of Manne Research Institute; Children's Research Fund Professor; William G. Swartchild, Jr. Distinguished Research Professor at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

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Re-expression of an embryonic signaling pathway in Melanoma utilizes different receptors

Laminine Testimonials stroke
Laminine is availabe in the Philippines!!! "The Closest Alternative To Stem Cell Therapy..." "The miracle formula from a 9-day-old fertilized hen eggs" For More Info About Laminine, How a...

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Laminine is availabe in the Philippines!!! "The Closest Alternative To Stem Cell Therapy..." "The miracle formula from a 9-day-old fertilized hen eggs" For More Info About Laminine, How a...

By: Karl Angelo Alipin

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Laminine Testimonial-kidney failure - Video

Albany, NY (PRWEB) September 15, 2014

Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. Stem cell therapy can be applied to treatment of cardiovascular diseases, leukemia (a kind of hematological system disease), nervous system diseases, damage or lesion of liver, kidney and other parenchymal organs, etc..

View Full Report at http://www.marketresearchreports.biz/analysis/223134

Currently, cord blood bank is the fastest-growing and relatively mature market amid stem cell upstream sectors and even the whole industry chain. In 2005, there were 23 cord blood banks worldwide and in 2013 the figure exceeded 480. Global cord blood stem cell (CBSC) storage companies can be roughly divided into two categories: the ones running in a globalized business model, such as Cryo-Cell International and Esperite (formerly known as Cryo-Save Group), and the others giving priority to regional operation e.g. Zhongyuan Union Stem Cell Bioengineering (VCANBIO), Golden Meditech and LifeCell International. However, the companies mainly engaged in cord blood bank business are currently small in scale, only a few with more than 500,000 clients.

Download Detail Report With Complete TOC at http://www.marketresearchreports.biz/sample/sample/223134

The stem cell technology and product research-oriented midstream sector is in its infancy, mostly concentrated in few countries like Europe, America and South Korea. At present, most companies in the industry chain are basically in the red for years running due to huge R&D costs. Nevertheless, attracted by the tremendous market potential in the area of stem cell therapy and enjoying the great encouragement from government policies (e.g. capital subsidy) and the capital support of significant cooperative partners, very few companies have dropped out.

Browse All Published Reports by Same Publisher at http://www.marketresearchreports.biz/publisher/67

Up to now, altogether 9 sorts of stem cell products have been approved worldwide, 3 of which are in the category of stem cell drugs developed by S. Korean companies, such as MEDIPOSTs adult stem cell drug CARTISTEM for osteoarthritis treatment and the stem cell product Prochymal (MEDIPOST obtained the product via acquiring the Therapeutics business of Osiris Therapeutics) direct at treating children suffering acute graft-versus-host disease (GVHD).

In the meantime, traditional pharmaceutical giants like Novartis are setting about quickly accessing the field through mergers and acquisitions. On Aug. 19, 2014, Novartis reached an acquisition agreement with Gamida Cell (a corporate dedicated to stem cell technology R&D and its application in stem cell transplantation for leukemia patients), which specified that Novartis spend USD35 million in acquiring 15% equity in the latter and win the option to take over the remaining equity in two years with USD165 million; in Sep. 2013, Novartis also entered a cooperation with Regenerex to jointly develop the hematopoietic stem cell platform FCRx of the latter.

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Global And China Stem Cell Industry Size 2014 Market Analysis, Growth, Trends and Forecast 2017: MarketResearchReports ...

ALAMEDA, Calif.--(BUSINESS WIRE)--BioTime, Inc. (NYSE MKT: BTX) announced that its subsidiary Asterias Biotherapeutics, Inc. (OTCBB: ASTY) has reached an agreement with Cancer Research UK and Cancer Research Technology (CRT), the charitys development and commercialization arm, to conduct a clinical trial of Asterias novel immunotherapy treatment AST-VAC2 in subjects with non-small cell lung cancer.

AST-VAC2 is a non-patient specific (allogeneic) cancer vaccine designed to stimulate patients immune systems to attack telomerase, a protein that is expressed in over 95 percent of cancers but is rarely expressed in normal adult cells.

The vaccine was developed following successful early phase clinical trials of a similar, patient specific (autologous) Asterias vaccine, called AST-VAC1, which was derived from patients blood cells and tested in prostate cancer and acute myeloid leukemia.

Unlike AST-VAC1, and other autologous (patient specific) vaccines that are developed from a patients own cells, AST-VAC2 is derived from human embryonic stem cells (hESCs), meaning it can be produced on a large scale and stored ready for use, rather than having to produce a specific version of the drug for each patient.

The trial of AST-VAC2 will evaluate the safety and toxicity of the vaccine, feasibility, stimulation of patient immune responses to telomerase and AST-VAC2, and clinical outcome after AST-VAC2 administration in patients with resected early-stage lung cancer and in patients with advanced forms of the disease.

Pedro Lichtinger, Asterias chief executive officer, said: The Asterias collaboration with Cancer Research UKs Drug Development Office and CRT represents a major step in advancing our proprietary dendritic cell platform for the potential benefit of patients.

AST-VAC2 is based on a specific mode of action that is complementary and potentially synergistic to other immune therapies. We are delighted to partner with Cancer Research UK to advance this important platform through Phase 1/2 clinical trials. Cancer Research UKs Drug Development Office has the global recognition of having the quality, capability and track record of successfully advancing development programs. We are excited about the possibility of favorably impacting the lives of patients across multiple cancers and are proud to be working with Cancer Research UK.

Under the agreement, Asterias will complete development of the manufacturing process for AST-VAC2. Cancer Research UK will then produce the vaccine and conduct the phase 1/2 clinical trial in the United Kingdom. On completion of the clinical trial, Asterias will have an exclusive first option to acquire a license to the data from the trial on pre-agreed terms including an upfront payment, milestones and royalties on sales of products. If Asterias declines this option, CRT will then have an option to obtain a license to Asterias intellectual property to continue the development and commercialization of AST-VAC2 and related products in exchange for a revenue share to Asterias of development and partnering proceeds.

Dr. Jane Lebkowski, president of research and development at Asterias, said: The use of human embryonic stem cells to derive allogeneic dendritic cells for cancer immunotherapy has the potential to dramatically improve the scalability, consistency, and feasibility of cellular cancer vaccines. We believe this collaboration will enable the acceleration of clinical studies of AST-VAC2 and the collection of important proof-of-concept data for the entire human embryonic stem cell-derived dendritic cell immunotherapy platform.

About Lung Cancer

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BioTime Subsidiary, Asterias Biotherapeutics, and Cancer Research UK and Cancer Research Technology Partner for ...

Located in beautiful Phoenix, Arizona, we are the originalStem Cell Rejuvenation Center.We havebeenperformingstem cell therapies for over 10years and all of ourprocedures are done on site atour clinic herein Phoenix. Itis our top priority to provide you a safe, clean,sterile and friendly environment.Our Treatment Center is located just 8 minutes from the Phoenix Sky Harbor International Airport and many hotels provide shuttle service to and from our clinic making it ideal for out-of-town visitors. We provide stem cell therapy for a variety of conditions byusing our revolutionarytechnology and treatments to isolate and reinfuse stem cells from a patient's own adipose stroma or fat (also called the Stromal Vascular Fraction (SVF)). We combine the best of technology, nature, and medicine to help improve the quality of our patients' lives. Stem cell therapy is offered to those who are qualified candidates and whom desire treatment.

We are aStem Cell Therapy and Treatment Center, founded in the U.S.A., and performing all therapies within the United States. Neither our patients nor the stem cells that we harvest are transported outside the United States. We use less than minimally manipulated technology to provide Autologous Stem Cell and PRP therapies originally initiated during the 1990's.

To see if you are a candidate, please fill-out this form and provide as much detail as possible.

Our Integrative staff and Physicians use a variety of modalities including Anti-aging and Eclectic medicine. These approaches are usedto treat many injuries and conditions. Below are some links toa journal database maintained by theNIH thatrelate to current research on stem cells and particular conditions......

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Stem Cell Rejuvenation Center

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Scientists are celebrating a breakthrough in stem cell research.

A type of human stem cell has been replicated in a lab for the first time in history.

The cells, previously impossible to duplicate, have been recreated to the equivalent of those between seven and nine days old the same as found in an embryo before it implants in the womb.

The creation of the human pluripotent cells opens a door for specialised cells to be created in the future for use in regenerative medicine.

The Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute led the research, which was carried out by both British and Japanese academics.

Professor Austin Smith, director, said: "Our findings suggest that it is possible to rewind the clock to achieve true ground state pluripotency in human cells.

"These cells may represent the real starting point for formation of tissues in the human embryo. We hope that in time they will allow us to unlock the fundamental biology of early development, which is impossible to study directly in people."

The "reset" cells could be used as "raw material" for therapies, as well as diagnostic tools and drug screenings.

Scientists also hope that after further studying, the cells will help them learn more about how an embryo develops correctly, and how miscarriages and developmental disorders are caused.

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Significant milestone in stem cell research at The Wellcome Trust - Medical Research Council institute

Stem Cell Therapy for Osteoarthritis
Ross Hauser, MD explains Stem Cell Prolotherapy using whole bone marrow. If you have osteoarthritis and are interested in how stem cell therapy may help you, we would love to see you in one...

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Stem Cell Therapy for Osteoarthritis - Video

Spinal cord injury - Case Study- Stem cell therapy- Giostar
a brief introduction to Giostar and its Stem cell therapy Dr.Divyang Patel (MD) a spine surgeon at Giostar- INDIA, briefs about a case of cervical spine injury, which is also examined by a...

By: Devang Parmar

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Spinal cord injury - Case Study- Stem cell therapy- Giostar - Video

TOKYO: Japanese researchers on Friday (Sep 12) conducted the world's first surgery to implant "iPS" stem cells in a human body in a major boost to regenerative medicine, two institutions involved said.

A female patient in her 70s with age-related macular degeneration (AMD), a common medical condition that can lead to blindness in older people, had a sheet of retina cells that had been created from iPS cells implanted. "It is the first time in the world that iPS cells have been transplanted into a human body," a spokeswoman for Riken, one of the research institutions, told AFP.

The research team used induced Pluripotent Stem (iPS) cells - which have the potential to develop into any cell in the body - that had originally come from the skin of the patient. Until the discovery of iPS several years ago, the only way to obtain stem cells was to harvest them from human embryos.

"We feel very much relieved," ophthalmologist Masayo Takahashi, the leader of the project at Riken, told a news conference after the surgery in Kobe. "We want to take it as a big step forward. But we must go on and on from here."

In a statement, the institution said that "no serious adverse phenomena such as excessive bleeding occurred" during the two-hour procedure. The surgery is still at an experimental stage, but if it is successful, doctors hope it will stop the deterioration in vision that comes with AMD.

The patient - one of six expected to take part in the trial - will be monitored over the next four years to determine how well the implants have performed, whether the body has accepted them and if they have become cancerous.

AMD, a condition that is incurable at present, affects mostly middle-aged and older people and can lead to blindness. It afflicts around 700,000 people in Japan alone.

The study was being carried out by researchers from government-backed research institution Riken and the Institute of Biomedical Research and Innovation Hospital.

Stem cell research is a pioneering field that has excited many in the scientific community with the potential they believe it offers. Stem cells are infant cells that can develop into any part of the body. Harvesting from human embryos is controversial because it requires the destruction of the embryo, a process to which religious conservatives, among others, object.

Groundbreaking work done in 2006 by Shinya Yamanaka at Kyoto University, a Nobel Laureate in medicine last year, succeeded in generating stem cells from adult skin tissue.

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Japan carries out first iPS stem cell retina surgery

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Study Links Sex Hormone Levels in the Blood to Risk of Sudden Cardiac Arrest Measuring the levels of sex hormones in patients blood may identify patients likely to suffer a sudden cardiac arrest, a heart rhythm disorder that is fatal in 95 percent of patients. A new study, published online by the peer-reviewed journal Heart Rhythm, shows that lower levels of testosterone, the predominant male sex hormone, were found in men who had a sudden cardiac arrest. Higher levels of estradiol, the major female sex hormone, were strongly associated with greater chances of having a sudden cardiac arrest in both men and women. CONTACT: Sally Stewart, 310-248-6566; Email sally.stewart@cshs.org

Cedars-Sinai Shortens Premature Infants Intensive Care Stays by 21 Percent in Past Three Years The amount of time premature babies spend in Cedars-Sinais Neonatal Intensive Care Unit, part of the Maxine Dunitz Childrens Health Center, has declined dramatically during the past three years, with the average length of stay dropping from 21 days to 17 days. In recent years there have been some notable medical advances, such as personalized nutrition therapy that helps the smallest infants gain weight, nonsurgical procedures to heal heart defects and new medical protocols for mothers likely to deliver a premature infant. All have contributed to more rapidly improving the health of premature infants and shortening the infants hospital stays. But one of the main reasons for the shorter hospitalizations is a renewed emphasis on coordinating each babys various and complex health needs. CONTACT: Soshea Leibler, 213-215-8000; Email soshea.leibler@cshs.org

Combining Antibodies, Iron Nanoparticles and Magnets Steers Stem Cells to Injured Organs Researchers at the Cedars-Sinai Heart Institute infused antibody-studded iron nanoparticles into the bloodstream to treat heart attack damage. The combined nanoparticle enabled precise localization of the bodys own stem cells to the injured heart muscle. The study, which focused on laboratory rats, was published in the online peer reviewed journal Nature Communications. The study addresses a central challenge in stem cell therapeutics: how to achieve targeted interactions between stem cells and injured cells. CONTACT: Sally Stewart, 310-248-6566; Email sally.stewart@cshs.org

Cedars-Sinai Presents Educational Program on Pituitary Disorders for Patients and Families Disorders of the pituitary gland often cause gradual onset of challenging and difficult-to-manage symptoms, and it is not uncommon for patients to consult doctor after doctor in search of an accurate diagnosis and the hope of treatment. In a one-day conference in Huntington Beach on Sept. 28, pituitary experts from Cedars-Sinai will provide an update for patients and their families on the most recent advances in the diagnosis and treatment of pituitary disorders. Patients will be able to engage in discussions and Q&A sessions with the faculty. CONTACT: Sandy Van, 808-526-1708; Email sandy@prpacific.com

Researchers Developing Noninvasive Method for Diagnosing Common, Painful Back Condition An interdisciplinary research team in the Cedars-Sinai Biomedical Imaging Research Institute, Department of Biomedical Sciences, Regenerative Medicine Institute and Department of Surgery received a grant from the National Institutes of Health (NIH) to develop the first imaging technique used to identify biomarkers that could indicate patients have a painful, degenerative back condition. Biomarkers are certain body substances, such as proteins or body fluids that can indicate specific health conditions. When noninvasive imaging procedures can identify exactly where the biomarkers are, researchers may alleviate the need for painful and invasive diagnostic procedures and, in the future, provide targeted, stem cell-based therapies to patients with the condition. CONTACT: Cara Martinez, 310-423-7798; Email cara.martinez@cshs.org

Cedars-Sinais New Comprehensive Transplant Center Opens The new home of the Cedars-Sinai Comprehensive Transplant Center opens Monday and consolidates the clinical and administrative services for liver, kidney, lung and pancreas transplant patients. The four programs were previously housed at several locations on the 24-acre medical center campus, but now transplant patients can have nearly all of their medical needs addressed at one location. The three-story facility covers 36,500 square feet and is located at 8900 Beverly Blvd., two blocks from the main medical center campus. The new center has 22 exam rooms, infusion therapy and phlebotomy services, patient education space and an outpatient procedure room. Two floors of underground parking and valet parking service are available to patients and their families. (High resolution photos available upon request) CONTACT: Laura Coverson, 310-423-5215; Email laura.coverson@cshs.org

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Cedars-Sinai Medical Tip Sheet for Sept. 2014