Light Coverage of Cellular Dynamics IPO But One Exec Says It’s Good for Stem Cell Biz
By Dr. Matthew Watson
carried stories about the public stock offering announced yesterday
by Cellular Dynamics International, Inc., a Wisconsin firm that will
benefit to the tune of $16 million-plus from the California stem cell agency.
Journal Sentinel described the company, founded by stem cell pioneer
Jamie Thomson, as in the business of making “fully functioning human cells in industrial quantities.”
Journal in Madison, where the company is based, quoted Beth Donley,
chief executive of Stemina
Biomarker Discovery, as saying,
“It can’t help but increase the
value of other stem cell companies.”
University of Wisconsin in Madison and at UC Santa Barbara, and we
queried Dennis Clegg, co-director of the Center for Stem Cell
Biology and Engineering at UC Santa Barbara, about the school's
ties to Cellular Dynamics, which hopes to take in $57 million in its public offering.
Barbara has a collaboration with Cellular Dynamics and the University
of Wisconsin to develop a vision-restoring, stem-cell-based therapy
for people with advanced retinal diseases. That $900,000 effort is financed by the Foundation Fighting Blindness.
to Cellular Dynamics is for work at the stem cell bank being created
at the Buck Institute in Novato, north of San Francisco.
Cellular Dynamics: California Stem Cell Agency Recipient Plans $57 Million IPO
By Dr. Matthew Watson
beneficiary of more than $16 million from the California stem cell
agency today announced that it intends to go public to raise $57.3
million for its iPS cell ventures.
Jamie Thomson UCSB photo |
International, Inc., and was co-founded by internationally known stem
cell scientist Jamie Thomson of the University of Wisconsin, who is
currently the company's chief scientific officer. Thomson is also a professor
at UC Santa Barbara, where he is co-director of the Center for Stem
Cell Biology and Engineering.
agency awarded a $16 million grant to Cellular Dynamics to derive
three iPS cell lines from 3,000 individuals as part of the agency's
stem cell banking initiative. (Here is a link to the grant review summary.)
filings that it also will be the prime subcontractor on a $10 million
grant that the Coriell Institute for Medical Research of Camden,
N.J., received in the agency's stem cell banking round. Cellular Dynamics said
some of the funds from the IPO will be used to complete its
California laboratory in leased space at the Buck Institute in
Novato, north of San Francisco.
and sold its first commercial product in 2010. It reported revenues
of $6.6 million in 2012 and losses of $22.3 million. It has 115
full-time and part-time employees worldwide.
“During 2011 and 2012, we had three
large biopharmaceutical customers that individually accounted for
greater than 10% of our total revenue in one or both years. Eli Lilly
and Company (Lilly) accounted for 10% of total revenue in 2011 and
18% of total revenue in 2012. Hoffmann-La Roche Inc. (Roche)
accounted for 13% of total revenue in 2011 and GlaxoSmithKline plc
(GSK) accounted for 11% of our total revenue in 2012.”
filings,
“Our total revenue grew from $2.6
million in 2011 to $6.6 million in 2012, an increase of 154%. This
growth was driven by a 247% increase in sales of our iCell products
which grew from $1.5 million in 2011 to $5.2 million in 2012. At
December 31, 2011, our backlog of revenue expected to be recognized
in 2012 was $1.1 million. At December 31, 2012, our backlog of
revenue expected to be recognized in 2013 had grown to $4.1 million.
“For the three months ended March 31,
2013 our total revenue was $2.4 million, an increase of 109% over the
corresponding period in 2012. This growth was driven primarily by an
increase in iCell product sales, which grew from $0.6 million for the
three months ended March 31, 2012 to $1.8 million for the three
months ended March 31, 2013, an increase of 173%.”
Cellular Dynamics and Japanese researcher Shinya Yamanaka, who won the Nobel Prize last year for discovering how to reprogram adult stem cells into pluripotent cells (the iPS process).
"A
recent question is the issue of who has the intellectual property
(IP) rights to iPS cell technology. People have told me in the
past that they wondered if Cellular Dynamics has unambiguous rights
to develop all of these iPS cell-based products."
“This (the IPO) looks to
be very interesting and could transform the field as it develops.”
was light, but is more expected to surface tomorrow. Here is a link to the only story that had surfaced as of this writing.
the offering.
Pomeroy on Doing the Right Thing and Foster Care
By Dr. Matthew Watson
Claire Pomeroy CIRM photo |
member of the governing board of the $3 billion California stem cell
agency, she also published an essay on the Huffington Post in which
she discussed fleeing from an abusive home at age 14.
dean of the medical school at UC Davis and now president of the Lasker Foundation in New York, wrote last month,
“For some children, the uncertainty
of life on the street is better than certainty of violence at home.
It was for me. At age 14, I escaped from an abusive home with no
money, nowhere to go and only the clothes I was wearing. I remember
staring into the night, standing somewhere between fear and freedom.
I became one of the millions of homeless teens, yet I was lucky
because foster care ultimately saved me.”“However, after an emergency
placement and three foster homes, the challenges were not over. At 17
I aged out of the foster care system early when my foster parents
moved out of state. On my own again, I had to find a job, a place to
live and finish high school. Then I climbed the next mountain to
graduate from college and medical school.”
publicly talking about her foster care experience. She said she is
doing so because “many people lack an understanding of
the harsh statistics and their impact on the country's future. The
nation faces a crisis that demands a call to action to start truly
caring about foster youth before it is too late.”
foster care system but said that many children, particularly minorities among others such as the disabled, were not as fortunate and “were failed by the system and society.” Pomeroy called them
“throwaway children” who were “robbed of their ideals, gave up
hope and struggled to find a reason to live.”
who “age out” of the system graduate from high school, she wrote. Only 3
percent to 11 percent earn a bachelor's degree. More than
400,000 children were in foster care in 2011 and have a one in 11 chance
of being homeless.
improvement of foster care across the country. “It is time to stop
forcing children to be the heroes of their own survival,” she
wrote. “Now is the time to do the right the right thing.”
grandchildren, one of whom was adopted out of foster care as a
toddler. The other was adopted at birth. Some of the siblings of
those two African-American children remain in foster care today.
Salvation, through avatars – China Daily
By Dr. Matthew Watson
China Daily | Salvation, through avatars China Daily Yet he has the attention, and in some cases the avid support, of august figures at Harvard University and the Massachusetts Institute of Technology and leaders in fields like molecular genetics and neuroprosthetics. Roughly 30 speakers from these and ... |
Puma Biotechnology Presents Positive PB272 Clinical Data at ASCO 2012 … – EON: Enhanced Online News (press release)
By Dr. Matthew Watson
Puma Biotechnology Presents Positive PB272 Clinical Data at ASCO 2012 ... EON: Enhanced Online News (press release) LOS ANGELES--(EON: Enhanced Online News)--Puma Biotechnology, Inc. (OTCBB: PBYI), a development stage biopharmaceutical company, announced that results from an ongoing Phase I clinical trial of its lead drug candidate PB272 (neratinib) given in ... |
bone marrow stem cells used for back pain – Video
By Dr. Matthew Watson
bone marrow stem cells used for back pain
Brenda Goodman writing in Healthday reported, "Medical researchers are trying a new treatment for low back pain. Their hope is that harvesting and then re-in...
By: Nathan Wei
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bone marrow stem cells used for back pain - Video
Sugar 1week post stem cell therapy – Video
By NEVAGiles23
Sugar 1week post stem cell therapy
By: Tim O #39;Neill, DVM
See more here:
Sugar 1week post stem cell therapy - Video
Streak’s Before/After Stemlogix Stem Cell Therapy – Video
By daniellenierenberg
Streak #39;s Before/After Stemlogix Stem Cell Therapy
Check out Streak #39;s amazing Post Stemlogix Stem Cell Therapy progression video from day 1 to day 37 ! The day of the stem cell therapy Streak could barely wal...
By: Stemlogix, LLC
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Streak's Before/After Stemlogix Stem Cell Therapy - Video
Stem Cell Therapy- Victoria Hicks – Video
By NEVAGiles23
Stem Cell Therapy- Victoria Hicks
By: Victoria Hicks
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Stem Cell Therapy- Victoria Hicks - Video
All About Stem Cell Therapy and Research – Video
By daniellenierenberg
All About Stem Cell Therapy and Research
Hey everyone! This is our final project, a documentary about stem cell therapy and research, the difference lines of stem cells and the dilemmas. Thank you for your interest, and if you have...
By: NVW Stem Cells
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All About Stem Cell Therapy and Research - Video
BBC iScience Stem Cell Therapy – Video
By NEVAGiles23
BBC iScience Stem Cell Therapy
A fun, engaging and relevant programme, inspiring the viewer to consider the science within and how scientific process can be used to test ideas and develop theories, rather than just looking...
By: Lammas Science
Paralyzed Dog Receives Stem Cell Therapy
By LizaAVILA
HIALEAH (CBSMiami) A team of Hialeah veterinarians performed a groundbreaking medical procedure on a dog to help him walk again.
Brando, a 9-year-old German shepherd, received an innovative two-part stem cell therapy at Paradise Animal Clinic in Hialeah on Wednesday. Its the first time this type of therapy has been performed in Florida.
The dog had been paralyzed from the waist down since January and used a doggie wheelchair to get around.
Vets said that he had a skin infection that paralyzed his lungs and then spread to a disc in his back. The infection caused 80 percent of Brandos leg muscles to weaken.
We were totally emotionally destroyed. Kids were crying, wife was upset, I was upset, said owner Manuel Bouza. Obviously the issue was he was so sick whether we put him down because hes paralyzed or whether we deal with it.
Bouza said that they wanted to do whatever they could to help him. One day, he stumbled across a video on YouTube about a dog in Great Britain who had received a stem cell treatment and he became interested.
With no proven options for recovery, they decided to try an experimental stem cell procedure never performed before in Florida.
This is a last ditch effort, said Bouza.
During the procedure, surgeons took fat from Brandos stomach and processed out the stem cells which were then re-injected into his spinal cord. They hope the cells will regenerate tissue and help Brando become more mobile.
The idea is that stem cells are able to go to a given place in the body and repair, said said animal surgeon Jose Gorostiza. Hopefully they will help the cells that are there function again, the new ones.
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Paralyzed Dog Receives Stem Cell Therapy
Lewis County man hopes for stem cell therapy
By Dr. Matthew Watson
VANCEBURG | A Lewis County man is working his way toward stem cell therapy in an attempt to help him walk again.
Jennifer Richardson, a long-time friend of Anthony Schumacher, said Schumacher was involved in an accident in December 2012, which left him paralyzed.
According to Richardson, Schumacher was in a comma for a few days and has no memory of the accident.
"He was going to work when his tire blew out and he wrecked the car," Richardson said. "He was in a coma for days and when he woke up he was paralyzed from the belly button down and couldn't remember anything."
Tammy Moore, Schumacher's mother, said he keeps a positive attitude about his situation.
"He's a happy person," she said. "He works out everyday and tries to learn new things about his situation and the procedure."
Moore said she would like to see Schumacher get the therapy.
"I don't know a lot about it. I'm still learning about it," she said. "But, from what I've seen, it's a good thing that can help him get at least some of the feeling back, if not all. I want to see him get it, if it can help."
Schumacher said he looks forward to the possibility of the procedure, too.
"I'm hopeful," he said. "I want to get it done. I've been trying to do my research and I would like to do this."
View post:
Lewis County man hopes for stem cell therapy
Cell therapy may regenerate liver cells
By Dr. Matthew Watson
Washington, June 7 (IANS) Researchers have shown that cell therapy may be used in liver disease to regenerate liver cells, says a study.
Investigators discovered that a human embryonic stem cell can be differentiated into a previously unknown liver progenitor cell, an early offspring of a stem cell, and produce mature and functional liver cells, reports Science Daily.
"The discovery of the novel progenitor represents a fundamental advance in this field and potentially to the liver regeneration field using cell therapy," said the study's senior author, Valerie Gouon-Evans, PharmD, Ph.D., assistant professor in the Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, at the Icahn School of Medicine at Mount Sinai.
"Until now, liver transplantation has been the most successful treatment for people with liver failure, but we have a drastic shortage of organs. This discovery may help circumvent that problem."
The study has been published in the journal Cell Stem Cell Friday.
Go here to read the rest:
Cell therapy may regenerate liver cells
Research and Markets: Cell Therapy – Technologies, Markets and Companies – Updated 2013-2022 Global Report
By LizaAVILA
DUBLIN--(BUSINESS WIRE)--
Research and Markets (http://www.researchandmarkets.com/research/cn2vq9/cell_therapy) has announced the addition of Jain PharmaBiotech's new report "Cell Therapy - Technologies, Markets and Companies" to their offering.
This report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. Role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice.
Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation.
Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. Methods of delivery of cell therapy range from injections to surgical implantation using special devices.
Cell therapy has applications in a large number of disorders. The most important are diseases of the nervous system and cancer which are the topics for separate chapters. Other applications include cardiac disorders (myocardial infarction and heart failure), diabetes mellitus, diseases of bones and joints, genetic disorders, and wounds of the skin and soft tissues.
Regulatory and ethical issues involving cell therapy are important and are discussed. Current political debate on the use of stem cells from embryonic sources (hESCs) is also presented. Safety is an essential consideration of any new therapy and regulations for cell therapy are those for biological preparations.
The cell-based markets was analyzed for 2012, and projected to 2022. The markets are analyzed according to therapeutic categories, technologies and geographical areas. The largest expansion will be in diseases of the central nervous system, cancer and cardiovascular disorders. Skin and soft tissue repair as well as diabetes mellitus will be other major markets.
The number of companies involved in cell therapy has increased remarkably during the past few years. More than 500 companies have been identified to be involved in cell therapy and 289 of these are profiled in part II of the report along with tabulation of 278 alliances. Of these companies, 160 are involved in stem cells. Profiles of 72 academic institutions in the US involved in cell therapy are also included in part II along with their commercial collaborations. The text is supplemented with 55 Tables and 12 Figures. The bibliography contains 1,050 selected references, which are cited in the text.
Key Topics Covered:
See the article here:
Research and Markets: Cell Therapy - Technologies, Markets and Companies - Updated 2013-2022 Global Report
Mickey’s Before
By raymumme
Mickey #39;s Before After Stemlogix Stem Cell Therapy
Mickey, a 13 year old German Shepherd torn both of his ACLs and suffered from severe arthritis. Mickey has been treated with Stemlogix Stem Cell Therapy Platelet Max Platelet Rich Plasma...
By: Stemlogix, LLC
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Mickey's Before
Stem Cell Therapy in Spinal Cord Injury – Video
By JoanneRUSSELL25
Stem Cell Therapy in Spinal Cord Injury
By: Knowlege21
Fibroblast Growth Factor FGF Stem Cell Therapy – Video
By Dr. Matthew Watson
Fibroblast Growth Factor FGF Stem Cell Therapy
Fibroblast Growth Factor Heals Heart Tissue by Feeding Stem Cells present.
By: David Dolores
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Fibroblast Growth Factor FGF Stem Cell Therapy - Video
Thumb Arthroscopy with Stem Cell Therapy – Video
By Dr. Matthew Watson
Thumb Arthroscopy with Stem Cell Therapy
Hand surgeon Dr. Michael Fitzmaurice details the thumb arthroscopy procedure that he pioneered, involving an endoscopic approach and stem cell therapy (PRP) ...
By: Michael Fitzmaurice
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Thumb Arthroscopy with Stem Cell Therapy - Video
Sarasota's Dr .Guy DaSilva Introduces Cutting-Edge Stem Cell Therapy For Degenerative Diseases
By JoanneRUSSELL25
Sarasota, Florida (PRWEB) June 03, 2013
Guy DaSilva, MD, ABAARM, will begin conducting clinical trials for many degenerative diseases using adipose-derived stem cell therapy at the DaSilva Institute in Sarasota, Florida. The independent review board of the International Stem Cell Society will oversee the trials.
Following the FDA-approved protocols, Dr. DaSilva will treat patients suffering from chronic obstructive pulmonary disease (COPD), Type 2 Diabetes, osteoarthritis, critical limb ischemia and erectile dysfunction. Furthermore, Alzheimers disease, dementia and Parkinsons disease are pending approval, and approximately five new protocols are added each month.
While stem cell therapy is most often associated with the controversial use of embryonic stem cells, Dr. DaSilva will be exclusively using adult autologous stem cells, harvested from the patients own adipose (fat) tissue or bone marrow if fat is not available. Because patients are receiving their own cells, there is no risk of rejection, and success rates are far greater compared to the more contentious therapies.
Autologous stem cell therapy works by mimicking the bodys natural healing process, but at a more potent, concentrated level. Stem cells, which are unspecialized cells with the potential to develop into any cell, are stored throughout the body. When disease or injury strikes, the body sends these cells to the area in need, and they begin repairing and replacing damaged tissue. Stem cell function decreases with age, along with ones ability to heal. But with autologous stem cell therapy, the body is once again empowered to heal and reverse disease, and with much greater magnitude.
Dr. DaSilva trained under scientist Kristin Comella, Chief Science Officer of Bioheart, CEO of Stemlogix, Chief Scientific Officer of the Ageless Regenerative Institute, and was recently named one of the 50 most influential people on stem cells. Dr. DaSilva will implement Comellas patented extraction process to precisely isolate and remove stem cells from fat tissue, allowing for an exceptionally high yield and viability.
During the in-office procedure, a mini liposuction is performed on the patient to remove 60 milliliters of fat, which produce approximately 8 million stem cells. The stem cells are isolated and injected back into the patients body at the site of injury or disease. Only local anesthesia is needed, and the patient will go home pain-free.
Over the next month, the patients body will repair and regenerate itself naturally. Dr. DaSilva will continue to treat the patient, with therapies that range from high dose IV nutrition and heavy metal chelation to bio-identical hormones. This helps the body maintain a healthy environment to further promote cellular and mitochondrial healing.
According to Dr. DaSilva, autologous stem cell therapy is very promising. He says, This extraordinary therapy is going to change the face of medicine. For example, it has the capability to completely reverse Type 2 Diabetes with a single dose, allowing patients to avoid amputations, premature death, and a life of food monitoring and injections. The results are truly remarkable, and this is only the beginning.
About Guy DaSilva, MD, ABAARM
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Sarasota's Dr .Guy DaSilva Introduces Cutting-Edge Stem Cell Therapy For Degenerative Diseases