UPDATE on Stem Cell Therapy

7 November 2012

The Department of Health (DOH) saw the necessity to cover regulations for Stem Cell therapy. Stem Cell therapy belongs to the category of Advanced Cell therapy which includes biologics and blood. Many countries around the world apply a risk-based approach to assess the quality, efficacy and safety of advanced cell therapy. In many countries, Stem Cell is considered an investigational intervention.

Stem Cell research employs both autologous (from same person) or allogenic (from another organism like animal or another human cell or tissue sample) method. Because there are many steps in the preparation of this lab and invasive procedure, there is therefore need to have a regulatory framework to protect Filipino citizens.

Important questions were asked: is there proof of concept in animal trials where stem cell can then be applied in humans? Is there a way to ensure quality and purity of the raw materials? How safe is the procedure? How many did not benefit from the procedure? If this were investigational procedure, how will human subjects be protected?

Sec. Enrique Ona convened a consultative working task force to provide recommendations on how to proceed in the early part of the year in response to queries and mushrooming of centers here and overseas. This led to the creation of a regulatory task force to oversee the appropriate steps that will ensure quality, efficacy and safety documentation of this intervention.

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UPDATE on Stem Cell Therapy 7 November 2012

Lysosomal Storage Disorders
ll4.me Lysosomal Storage Disorders From Lysosomes to Storage Diseases and Back: A Personal Reminiscence.- Lysosomal Biogenesis and Disease.- The Concept of Treatment in Lysosomal Storage Diseases.- Complex Lipid Catabolism.- Retroviral Vectors for Gene Therapy.- Adenovirus in Gene Therapy.- Setting Back the Clock: Adenoviral-Mediated Gene Therapy for Lysosomal Storage Disorders.- Adeno-Associated Viral-Mediated Gene Therapy of Lysosomal Storage Disorders.- Herpes Simplex Virus Vectors for Gene Therapy of Lysomal Storage Disorders.- Gene Therapy of Lysosomal Storage Disorders by Lentiviral Vectors.- Substrate Reduction Therapy.- Newborn Screening for Lysosomal Storage Disorders.- Genetic Counseling for Lysosomal Storage Diseases.- Neural Stem Cell Therapy in Lysosomal Storage Disorders.- The GM1 Gangliosidoses.- The GM2 Gangliosidoses.- Acid Sphingomyelinase-Deficient Niemann-Pick Disease.- Krabbe Disease (Globoid Cell Leukodystrophy).- Metachromatic Leukodystrophy.- Fabry Disease.- Gaucher Disease: Review and Perspectives on Treatment.- Therapeutic Goals in the Treatment of Gaucher Disease.- The Neuronal Ceroid Lipofuscinoses: Clinical Features and Molecular Basis of Disease.- Mucopolysaccharidosis I.- Mucopolysaccharidosis II.- Sanfilippo Syndrome: Clinical Genetic Diagnosis and Therapies.- Mucopolysaccharidosis IV (Morquio Syndrome; MPS IV).- Mucopolysaccharidosis Type VI (MPS VI, Maroteaux-Lamy Syndrome).- Mucopolysaccharidosis Type VII (Sly Disease): Clinical, Genetic ...From:davidbrown9865Views:0 0ratingsTime:00:13More inPeople Blogs

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Lysosomal Storage Disorders - Video

Muscular Dystrophy Before and After Stem Cell Therapy
He took stem cell therapy at NeuroGen. Previously when he was climbing stairs, he was widening steps and climbing stairs. And he was taking more time, now he is taking less time. Climb stairs straight. Previously during sit to stand, he was taking support of hands and was coming up, but now he is not taking support. Previously when he was sitting on floor, he was facing in coming up and facing problem in walking few steps. But after stem cell therapy he can walk normally now. Now changes are seen. Stem Cell Treatment done at Neurogen ,Brain Spine Institute, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion-Trombay Road, Chembur,Mumbai-71. Website -- http://www.neurogen.in http://www.stemcellsmumbai.com Tel: - +91 9920 200400, 022-25283706From:neurogenbsiViews:0 0ratingsTime:00:37More inScience Technology

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Muscular Dystrophy Before and After Stem Cell Therapy - Video

The Patients of Angeles Health International
What our patients have to say about their experiences at Angeles Health International. All patients were treated for different conditions, in separate departments throughout our facilities. Angeles Health International offer cutting edge care, procedures and treatment in the following areas: Weight Loss Surgery - http://www.weightlossmex.com Stem Cell Therapy - http://www.stemcellmx.com Multiple Sclerosis Treatment - http://www.ccsvi.mx Effective Chemotherapy-free Cancer Treatment - http://www.cancertreatmentmx.com Visit the Angeles Health International website here: http://www.angeleshealth.com There are a team of healthcare professionals waiting to hear from you. Contact Angeles Health International toll free on: 1.866.668.9263From:AngelesHealthViews:5 0ratingsTime:03:06More inScience Technology

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The Patients of Angeles Health International - Video

Stem Cell Malaysia | Stem Cell Therapy
stemcellmalaysia.com Stem Cell Malaysia shares with you actual user experience on stem cell therapy. Stem Cell Malaysia also provides useful information on stem cells, stem cell therapy, stem cell research and stem cell newsFrom:stemcells2012Views:102 4ratingsTime:03:17More inHowto Style

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Stem Cell Malaysia | Stem Cell Therapy - Video

Stem Cells Doctor in Mexico Shares his Expertise
http://www.mexicohealth.com The video shows a stem cells doctor in Mexico discussing various procedures he specializes in, which notably are multiple sclerosis, brain degenerative disorders, and eye sight rectification. This stem cell specialist has treated over forty patients using cutting edge stem cell therapies. Despite cynical attitudes from different quarters, this doctor represents the vanguard for stem cell treatments for progressively degenerative conditions. To read the transcript and to get a free quote from stem cells doctor in Mexico. Click the link above. Related Searches: Stem Cell Therapy Doctors Mexico, stem cell treatment glaucoma mexico, stem cell therapy brain disorders mexico, stem cell therapy brain injury mexico, stem cell treatment spinal cord MX,From:mexicohealthViews:3 0ratingsTime:04:05More inPeople Blogs

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Stem Cells Treatment in Mexico - Reports You #39;ll Need
http://www.mexicohealth.com The video shows a top stem cell specialist emphasizing the importance of reports and records in devising a sure shot stem cell treatment. Mexico is going where others have feared to tread by investing heavily in stem cell research and development. Not all conditions are curable using stem cells. Some even require a certain degree of faith in your doctor. This doctor has helped more than 40 patients to get up on their feet. Communication is the key, as this doctor points out. If you #39;re mulling over getting a stem cell treatment in Mexico, for yourself or somebody you know, always remember to carry exhaustive reports. To get a free quote, click the link above. Related Searches: stem cell therapy specialists mexico, Stem Cell Treatment for Multiple Sclerosis Mexico, Stem Cell Therapy in Mexico for Chronic Heart Failure, Adult Stem Cell Treatment in Mexico, Stem Cell Therapy for Diabetes Mexico, stem cell treatment for brain damage Mexico, Stem Cell Treatment for Neurodegenerative Conditions mexico, Stem Cell Treatment for Eye Diseases Mexico, Stem Cell Treatment for Heart Conditions Mexico, Stem Cell Therapy for Brain Injury Mexico,From:mexicohealthViews:3 0ratingsTime:02:08More inPeople Blogs

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Stem Cells Treatment in Mexico - Reports You'll Need - Video

Autologous and Adult Stem Cells Transplant in Mexico
http://www.mexicohealth.com The video shows a top stem cell specialist in Mexico explaining why autologous stem cell treatment is a better choice than adult stem cell transplant. The doctor goes on to caution about risks of reaction in case of adult stem cells transplant. In some cases, the reaction could kill. Autologous, on the other hand, is a safe proposition. The doctor has been in the profession since 1978 and has treated over 40 patients with acute degenerative disorders like, multiple sclerosis. To read the transcript of the video about autologous and adult stem cell transplant in Mexico, click the link above. Related Searches: Autologous stem cell transplant mexico, Hematopoietic stem cell transplantation mexico, Stem Cell Transplantation in Adults mexico, Stem cell treatment ms mexico, stem cell treatment glaucoma mexico, stem cell therapy brain disorders mexico, stem cell therapy brain injury mexico, stem cell treatment spinal cord MX,From:mexicohealthViews:2 0ratingsTime:03:08More inPeople Blogs

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Autologous and Adult Stem Cells Transplant in Mexico - Video

PURTIER Live Stem Cell Therapy - 4th Edition (Chinese Version).mp4
PURTIER Live Stem Cell Therapy - 4th Edition (Chinese Version) Please contact Pearly @ +65 9338 9541 for more detailsFrom:PurtierPearlyViews:1 0ratingsTime:08:01More inPeople Blogs

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PURTIER Live Stem Cell Therapy - 4th Edition (Chinese Version).mp4 - Video

Washington, November 6 (ANI): Administering to patients stem cells derived from their own bone marrow either three or seven days after a heart attack is safe but does not improve heart function six months later, according to a clinical trial.

The results of the trial, called Transplantation In Myocardial Infarction Evaluation (TIME), mirror a previous, related study, LateTIME, which found that such cells (called autologous stem cells) given two to three weeks after a heart attack did not improve heart function.

Both TIME and LateTIME were conducted by the Cardiovascular Cell Therapy Research Network (CCTRN), sponsored by the NIH's National Heart, Lung, and Blood Institute.

"This study was extremely valuable even though it did not provide a demonstrated health benefit after six months," said Sonia Skarlatos, Ph.D., deputy director of NHLBI's Division of Cardiovascular Sciences and member of the CCTRN.

"Heart stem cell therapy research is still in its infancy, and results from early trials have varied greatly due to differences in the numbers of stem cells injected, the delivery methods used, and the compositions of the study populations. With TIME and LateTIME, we have established both safety and baseline results in two large studies that followed the same procedures for growing and then administering stem cells. This standard will inform the next steps in research on the use of stem cells to repair damaged hearts," she stated.

Fellow CCTRN member Jay Travese, M.D., of the Minneapolis Heart Institute added, "With this baseline now set, we can start to adjust some of the components of the protocol to grow and administer stem cell to find cases where the procedure may improve function."

"For example, this therapy may work better in different population groups, or we might need to use new cell types or new methods of delivery," he noted.

Skarlatos said that another advantage of the TIME study is that CCTRN is storing samples of the stem cells taken from the participants. Investigators can examine the relationship between people who showed significant improvement during the study and the characteristics of their stem cells. Such a comparison may offer insights on the cell traits that are associated with clinical improvement.

The findings will be presented at the American Heart Association (AHA) 2012 Scientific Sessions in Los Angeles and will appear concurrently in the Journal of the American Medical Association. (ANI)

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Stem cell therapy may not improve recovery after heart attack

RIO DE JANEIRO--(BUSINESS WIRE)--

CryopraxisTM/CellPraxis aims to start patient recruitment for its Phase III Refractory Angina Cell Therapy Brazilian arm clinical trial by the end of 2012 or early 2013. The phase IIA/B clinical trial study was completed in December 2011. These trials involved the use of a proprietary autologous stem cell formulation (MonocellTM) indicated for neoangiogeneses.

Safety and efficacy of this product was evaluated in patients with refractory angina, a no option disease condition, characterized by severe chest pain for which there is no efficient treatment available, says the President of both Companies, Eduardo Cruz.

ReACT, MonocellTMs derived product, showed evidence of safety and efficacy in our initial clinical trials. All patients included in this trial were classified as Class IV Angina in CCSAC* (the most severe class of chest pain). In the first group of patients, whose data was published**, there was a progressive and sustained improvement in angina symptoms, with 87.5% of the patients completing the clinical trial with a CCSAC score of 0 or 1.

Angina symptom relief began as early as 3 months post procedure with continuing improvement through the 18th month, suggesting that angiogenesis began early, and that it kept evolving 18 months after the procedure. Objective evaluation of stress myocardium perfusion (scintigraphic analysis), after 1 year of follow-up, gave indications of complete myocardial reperfusion in 75% of the patients, says Dr. Nelson Hossne, Medical Director of CellPraxis. Our conclusion was ReACT's specific cell formulation, MonoCell, had a direct correlation to myocardial neoangiogeneses.

About CryopraxisTM (www.cryopraxis.com.br) and CellPraxis (www.cellpraxis.com)

Located at Bio-Rio Biotech Cluster (Rio de Janeiro, Brazil), CryopraxisTM is the pioneer and the largest bank of umbilical cord blood in Brazil and has been in operation since 2001, with approximately 25,000 customers. CellPraxis is a bioengineering company that invests in research projects involving stem cell therapy. Some of these projects are conducted in partnership with institutions like the Federal University of Rio de Janeiro, Federal University of So Paulo, the University of South Florida and Saneron CCEL Therapeutics, Inc. (a USA based biotechnology company dedicated to stem cell research).

Forward-Looking Statement

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements reflect management's current expectations, as of the date of this press release, and involve certain risks and uncertainties. The Company's actual results could differ materially from those anticipated in these forward- looking statements as a result of various factors. The Company's further development is highly dependent on future medical and research developments and market acceptance, which is outside its control.

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Cardiac Cell Therapy Phase III Trial to Treat Refractory Angina

FAQ-10 of 19: Can Stem Cells Cause Cancer From Stem Cell Therapy?
youtu.be People ask us if stem cell therapy can CAUSE cancer, and they are wise to be wary, but stem cell therapy has been proving effective AGAINST cancer, and has not cause any known cases of cancer to-date. For more personalized information, visit StemCell-Asia.info now.From:Karridine1Views:0 0ratingsTime:01:06More inPeople Blogs

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FAQ-10 of 19: Can Stem Cells Cause Cancer From Stem Cell Therapy? - Video

FAQ-11 of 19: For Stem Cell Therapy, Why Thailand #39;s Licensed Stem Cell Treatments?
youtu.be You may wonder why coming to Thailand is a better investment of time, energy and resources, so here are some answers. For more personalized information as to how your condition might respond to stem cell therapy, go to the Apply Now page and send in copies of your medical records with an Application for Consideration. StemCell-Asia.infoFrom:Karridine1Views:0 0ratingsTime:01:16More inPeople Blogs

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FAQ-11 of 19: For Stem Cell Therapy, Why Thailand's Licensed Stem Cell Treatments? - Video

FAQ-14 of 19: Do We Provide a Guarantee for Stem Cell Therapy?
youtu.be This video addresses the ethical, practical aspects of a #39;guarantee #39; for stem cell therapy or stem cell treatments. For more detailed information concerning guarantees, stem cell therapy and your particular problem, visit bit.ly today.From:Karridine1Views:0 0ratingsTime:01:15More inPeople Blogs

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FAQ-14 of 19: Do We Provide a Guarantee for Stem Cell Therapy? - Video

FAQ-10 of 19: Do Stem Cells Cause Cancer In Stem Cell Therapy?
youtu.be People ask us if stem cell therapy can CAUSE cancer, and they are wise to be wary, but stem cell therapy has been proving effective AGAINST cancer, and has not cause any known cases of cancer to-date. For more personalized information, visit StemCell-Asia.info now.From:Harvey WallbangerViews:0 0ratingsTime:01:06More inScience Technology

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FAQ-10 of 19: Do Stem Cells Cause Cancer In Stem Cell Therapy? - Video

FAQ-11 of 19: Why Have Stem Cell Therapy in Thailand #39;s Stem Cell Clinic?
youtu.be A few gentle suggestions on why visiting the only European-licensed stem cell clinic in Thailand is a better choice for time, optimum results and budget. For more detailed answers about Thailand #39;s one licensed stem cell clinic, visit bit.lyFrom:Harvey WallbangerViews:1 0ratingsTime:01:16More inNonprofits Activism

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FAQ-11 of 19: Why Have Stem Cell Therapy in Thailand's Stem Cell Clinic? - Video

FAQ-12 of 19: Are Our Stem Cell Doctors Qualified for Stem Cell Therapy?
youtu.be The straight answer to this question might surprise you, but only if you think stem cell therapy is something that was approved for certain patients THIS year. And for more surprising, encouraging details on stem cell therapies and your particular case, visit bit.ly today.From:Harvey WallbangerViews:0 0ratingsTime:00:55More inPeople Blogs

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FAQ-12 of 19: Are Our Stem Cell Doctors Qualified for Stem Cell Therapy? - Video

FAQ-13 of 19: What Stem Cell Therapy Will Be MY Stem Cell Treatment?
youtu.be This seeks to answer the #39;what do I need for ME? #39; question, although it is a personal question not readily answerable online, so for your questions, go to bit.lyFrom:Harvey WallbangerViews:0 0ratingsTime:01:28More inEducation

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FAQ-13 of 19: What Stem Cell Therapy Will Be MY Stem Cell Treatment? - Video

FAQ-14 of 19: Do We Offer a Guarantee for Our Stem Cell Therapy?
youtu.be Yes, a reasonable guarantee is provided, and you can learn more of it in this video. When you want more than this, visit bit.ly for personalized details of how stem cell therapy can benefit you.From:Harvey WallbangerViews:0 0ratingsTime:01:15More inPeople Blogs

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FAQ-14 of 19: Do We Offer a Guarantee for Our Stem Cell Therapy? - Video

FAQ-11 of 19: Why Is Thailand My Better Stem Cell Choice for Stem Cell Therapy?
youtu.be Why is Thailand a better choice for stem cell therapy, instead of Europe? A few gentle suggestions on why visiting the only European-licensed stem cell clinic in Thailand is a better choice for time, optimum results and budget. For more detailed answers about Thailand #39;s one licensed stem cell clinic, visit bit.lyFrom:John PepperViews:0 0ratingsTime:01:16More inPeople Blogs

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FAQ-11 of 19: Why Is Thailand My Better Stem Cell Choice for Stem Cell Therapy? - Video