Some connected to the California stem cell agency, notably its founding father Robert Klein, are fond of declaring that the $3 billion enterprise has an immutable mandate from voters to pursue its endeavors.

Well, mandates come and go.

That lesson was learned once again this morning with the results of a Field Poll that showed that another big ticket effort, the California high speed rail project which was approved by 53 percent of voters, has lost not only its luster but its support. According to the poll, 64 percent of voters would now like another chance to vote on it. And 59 percent would reject it.

The reasons for the change of heart? Severe economic conditions in California, increased mainstream media coverage of high speed rail's deficiencies and bungling by its management.

While a San Francisco Chronicle columnist last summer called CIRM "the high speed rail of medicine," the stem cell agency has not suffered from the same sort of heavy and critical media attention. CIRM is all but invisible to the public. But agency is now is embarking on an ambitious PR effort to raise its profile and to move forward to win voter approval of another multibillion bond measure. Otherwise it will run out of funds in 2017.

CIRM must tread carefully with its new communications campaign. It has a legitimate responsibility to better inform Californians, and its PR could be more robust(which is a sort of the word of the day at CIRM).

But downsides do exist. With a possible ballot measure coming up, some ungenerous folks might construe aggressive CIRM PR as electioneering at taxpayer expense, including its subsidies of patient advocate activities, such as attendance at conventions. Even without a looming election campaign, the high speed rail project's $12.5 million PR effort attracted negative attention in at least two major newspapers just this week(see here and here).

Klein, who led the campaign that created CIRM and served as its chairman for seven years, is now gone, but his footprints remain. The agency, however, cannot assume that voter support seven years ago, in a much, much different world, translates to support today.

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The California stem cell agency is readying a long list of changes that will affect all of its 453 grant recipients and all future awards.

Many of the changes are minor. Some have been requested by grantees. Others are aimed at dealing with issues posed by larger grants. Some reflect the agency's move to more streamlined reporting.

Amy Lewis, CIRM's grant management officer, has prepared an introductory memo along with the proposed changes for discussion at Thursday's board meeting in Los Angeles. She said the proposal is in its early stages and will not require a vote this week.But it would behoove those affected to carefully check the grant administration policy to see how it might alter their lives.

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Interviews with Deepak Srivastava, Shinya Yamanaka and Robert Mahley on Dr. Yamanaka's discovery and future directions in stem cell research.

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Advances in Stem Cell Research: Shinya Yamanaka - Video

The 2011 World Stem Cell Summit (Genetics Policy Institute Project) took place in Pasadena from October 3rd to 5th. Over 2000 stakeholders from 25 nations gathered to share everything from cutting-edge research, to industry solutions and critical societal issues as they related to 2011's theme: Translational Regenerative Medicine.

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2011 World Stem Cell Summit Open Comments

A new study published in the peer-reviewed journal of the American Cancer Society (ACS) Cancer has found that current ovarian cancer screening technologies do virtually nothing to decrease the overall death rate from the disease. Laura Havrilesky, MD, MHSc, and her team from Duke University Medical Center in Durham, North Carolina, discovered that in many cases, ovarian cancer progresses so fast that screenings are unable to detect a problem until it is too late.

"If we assume ovarian cancers grow and spread at different rates, the best screening strategy available will only reduce the number of women dying from this cancer by 11 percent," Havrilesky is quoted as saying. "This is partially because the slower growing cancers are more likely to be caught by a screening test."

So the team has concluded that the best way to deal with ovarian cancer is to try harder to prevent it, and develop better methods of treating it. Because there is really one no way to determine the nature of ovarian cancer from patient to patient, there is also no single conventional method that effectively recognizes each unique type and its eventual progression rate. Read more...

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William Bruyea, host of StemCellTV talks to Michael Werner, co-founder and executive director of Alliance for Regenerative Medicine at the Meeting on the Mesa partnering forum at Sanford Consortium in La Jolla, CA.

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StemCellTV Talks to Michael Werner of Alliance for Regenerative Medicine at Meeting on the Mesa - Video

Post Stem Cell Therapy Testimony of Cerebral Palsy Stem cell therapy done at neurogen brain and spine institute pvt ltd. Tell: +91 9920 200 400 , 022 25281610 , 022 25283706

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Stem Cell Therapy for Cerebral Palsy, Mumbai - Video

Any cells derived from embryonic stem cells that are transplanted as a therapy will likely be rejected by the immune system much like a transplanted heart or liver. Dr. Jeffrey Bluestone has been studying ways of achieving transplantation with little or no drugs.

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Jeff Bluestone: Immune rejection of stem cell transplants - Video

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Stem Cell Therapy for Spinal Cord Injury, Mumbai - Video

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Stem Cell Therapy for Spinal Cord Injury after Car Accident, Mumbai - Video

Ian Wilmut discusses stem cell and direct cellular transformation therapy at the 2011 Stem Cell Meeting on the Mesa at the Salk Institute, Nov.

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Ian Wilmut discusses stem cell and direct cellular transformation therapy - Video

Dr Nandini talking about Stem Cell Therapy for Brain and Spine Disorders on DD Sahyadri. Stem cell therapy done at neurogen brain and spine institute pvt ltd

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Stem Cell Therapy for Brain and Spine Disorders, Mumbai - Video

Stem cell treatment for muscular dystrophy Improvement seen in Duchenne Muscular Dystrophy after Stem Cell Therapy Treatment at Neurogen Brain and Spine Institute. Tell: +91 9920 200 400 , 022 25281610 , 022 25283706

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Stem Cell Therapy for Duchenne Muscular Dystrophy, Mumbai - Video

Huntington's disease is an inherited neurodegenerative disorder that typically strikes in a person's thirties and leads to death about 10 to 15 years later. No effective therapy exists for the disease. Jan Nolta, director of the UC Davis Stem Cell Program and Institute for Regenerative Cures, has a CIRM Early Translational Award to develop stem cell-based therapies for Huntington's disease.

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Stem Cell Research: Huntington's Disease - Video

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Stem Cell Therapy for Spinal Cord Injury Children, Mumbai - Video

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Stem Cell Therapy for Cerebellar Ataxia, Mumbai - Video

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Stem Cell Therapy for Spinal Cord Injury Kid, Mumbai - Video

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Stem Cells Therapy for Spinal Cord Injury, Mumbai - Video

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Spinal Cord Injury Improves after Stem Cell Therapy, Mumbai - Video

Coast to Coast AM Regenerative Medicine/ Dulce Base Date: 11-15-11 Host: George Noory Guests: Anthony F. Sanchez, Christian Wilde News segment guests: Nick Begich, Dr. Robert Manning [Quick Info] First Half: Researcher Christian Wilde talks about the emerging field of regenerative medicine; scientists are actually building replacement body parts with stem cells.

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C2CAM - 2011.11.15 - Dulce Base - Regenerative Medicine - Video