Stem Cells Portal
By Dr. Matthew Watson
Mesenchymal Stem CellDerived Extracellular Vesicles as Therapeutics and as a Drug Delivery PlatformGyuhyeon Baek, et al., STEM CELLS Translational Medicine
The future of exosome therapeutics has great potential, but several challenges, as discussed in the present study, must be overcome before exosomebased therapy will become an important option as a nextgeneration drug delivery system.
Bmi1 Overexpression in Mesenchymal Stem Cells Exerts Antiaging and Antiosteoporosis Effects by Inactivating p16/p19 Signaling and Inhibiting Oxidative StressGuangpei Chen, et al., STEM CELLS
his study demonstrates that mesenchymal stem cell (MSC) overexpressing Bmi1 exerts antiaging and antiosteoporosis effects. These findings might provide a strategy to enhance the functionality of MSCs for use in therapeutic applications. The results suggest a clinical relevance of Bmi1 in MSCs, for example, upregulation of BMI1 expression in human MSCs by hypoxiccultures or treatment with sonic hedgehog activators, then using them for bone marrow concentrate therapy to enhance MSC potency in antiaging and antiosteoporosis.
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